Nurix is a science-focused company that is committed to bringing novel, first-in-class therapies to patents. Nurix is a leader in discovering a new class of drugs that work by modulating E3 ubiquitin ligases within the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation – a function vital to the healthy life of a cell – offering therapeutic opportunities in multiple disease areas. Nurix’s scientific team has established an innovative drug discovery platform to identify selective inhibitors or activators of the UPS, enabling the development of novel therapeutics that can restore normal cellular homeostasis. In particular, Nurix has positioned itself as a leader in the burgeoning field of UPS degraders. Nurix was founded by internationally recognized experts in the UPS field and received its initial funding from leading life science investors, Third Rock Ventures and The Column Group. In 2015, Nurix entered into a multi-year strategic collaboration with Celgene to discover and develop next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology. Nurix is based in San Francisco’s biotechnology hub, Mission Bay – where academia and industry come together for cutting-edge life-saving research.
About the Position
We are seeking a talented and highly motivated scientist to join our Library Discovery team and help us augment our DNA encoded library collection. DEL synthesis requires a hybrid of techniques that are borrowed from chemistry environments: chemical reaction setup, LCMS analysis, SAR evaluation, split and pool library synthesis workflows, parallel reaction development, as well as from biology laboratories: aqueous buffer preparation, centrifuge use, ethanol precipitation of DNA, A260 DNA quantification, gel electrophoresis, bioanalyzer analysis, enzymatic DNA ligation. An exposure to some of these techniques is helpful in training into a DNA encoded scientist. As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators.
- B.S. or M.S. in life sciences (ex. chemistry, biochemistry, biology) with 0-5 years industrial chemistry experience (years of relevant experience will impact level of hire).
- Training in synthetic organic chemistry methods and analytical tools, in particular LCMS
- Interest in optimizing chemical reactions for use in DNA encoded library synthesis.
- High level of creativity and productivity with strong problem-solving skills.
- High level of attention to detail and good organizational skills.
- Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.
Fit with Nurix Culture and Values
- Strongly team-oriented; highly collaborative
- Hands-on approach; resourceful and open to diverse points of view