We are seeking a talented and highly-motivated individual with a background in ubiquitin biology or targeted protein degradation and an interest in drug discovery to join our collaborative team of scientists to greatly expand the toolbox of ubiquitin E3 ligases that can be used for targeted protein degradation. Currently, only a small subset of the >600 E3 ligases are harnessed for this purpose. Using Nurix’s DNA-encoded library (DEL) platform, the successful candidate will design and implement small molecules screens to identify ligands of novel E3 ligases. As part of a multidisciplinary team of biologists, medicinal chemists, and computational chemists, they will play a key role in the subsequent design, evaluation, and advancement of degrader molecules from these novel E3 binders.
- Develop rationale for the targeting of specific E3 ligases for use in targeted protein degradation
- Design and implement DNA-encoded library screens of prioritized E3 ligases to identify novel binders
- This position will offer the opportunity for the candidate to gain experience in DEL library screening. Prior experience with this technology is helpful but NOT required.
- Develop biochemical and biophysical assays in support of DEL screen design as well as small molecule binder validation and progression
- Be an active member of a team of biologists and medicinal and computation chemists that works to incorporate these newly discovered E3 ligase binders into targeted protein degradation molecules, establishing degradation of therapeutic targets both in vitro and in vivo
- Serve as an internal expert of E3 ligase function with a robust knowledge of E3 ligase biology and the targeted protein degradation field
- Communicate findings to internal stakeholders through scientific presentations
- Ph.D. scientist with 8+ years of post-degree industry experience
- In depth knowledge of ubiquitin and E3 ligase biology
- Experience in the development, optimization and execution of biochemical or biophysical assays to interrogate protein interactions and enzymatic activity
- A proven track record of understanding protein function through biochemical or structural analysis is strongly preferred.
- Familiarity with principles of targeted protein degradation is preferred.
- High level of creativity and productivity with strong problem-solving skills.
- Solid background of scientific accomplishment demonstrated by publications, patents, or presentations.
- Excellent communication skills and ability to present rationale, key data, issues and accomplishments to other members of the scientific team.
- Resourceful and open to diverse points of view
- Good fit with Nurix culture and values of highly collaborative, team-oriented research