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Clinical Trials

Investigating innovative treatments across a range of B-cell malignancies and solid tumors

Nurix is conducting three Phase 1 clinical trials across its protein modulation portfolio: two drug candidates from its protein degradation portfolio are under investigation for the treatment of relapsed/refractory B-cell malignancies, and one drug candidate from its protein elevation portfolio is under investigation for immuno-oncology indications including a range of solid tumor types and lymphoma.

A Study of NX-1607 in Adults With Advanced Malignancies

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Recruiting Status:
Recruiting

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Age:
18 Years+

Phase 1a will consist of 2 study arms: Monotherapy and Paclitaxel combo. Phase 1a dose escalation will evaluate the safety and tolerability of NX-1607 in adult patients with advanced solid tumors for which standard therapy with proven clinical benefit does not exist, is no longer effective, or is not appropriate. Indications for monotherapy include platinum […]

A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

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Recruiting Status:
Recruiting

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Age:
18 Years+

Phase 1a is a dose escalation to evaluate the safety and tolerability of NX-5948 in adult patients with relapsed/refractory (R/R) B cell malignancies who have received at least 2 prior lines of therapy and for whom no other therapies are known to provide clinical benefit. Indications include: Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), […]

A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies

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Recruiting Status:
Active, not recruiting

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Age:
18 Years+

Phase 1a is a dose escalation to evaluate the safety and tolerability of NX-2127 in adult patients with relapsed/refractory (R/R) B-cell malignancies, who have required and received at least 2 prior systemic therapies (or at least 1 prior therapy for patients with WM or PCNSL) and for whom no other therapies are known to provide […]