Important Notice to Candidates: Nurix representatives will never conduct interviews by text and will never request personal financial information or ask candidates to purchase equipment.

At Nurix, we believe in the science of possibility. We are committed to advancing groundbreaking science and innovation in targeted protein degradation to transform patients’ lives. If you’re passionate about making a real difference in healthcare, thrive in a collaborative environment, and are excited by scientific challenges, we want to hear from you. Explore our current openings below.

May, 2026

Quality

Associate Director, Computer Systems Assurance (Quality)

Location

Brisbane, CA

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

The Senior Manager / Associate Director, Computer Systems Assurance (CSA) is an important technical and operational leader within the Nurix Quality Systems organization, responsible for owning and advancing Nurix's computer systems assurance program. As a virtual drug developer, Nurix operates through a lean internal infrastructure and relies on a curated ecosystem of Software-as-a-Service (SaaS) and cloud-hosted platforms to support GxP-regulated activities across clinical development, quality operations, manufacturing oversight, and regulatory submissions. This role will serve as the primary subject matter expert and program owner for all CSA and computerized system validation (CSV) activities at Nurix.

Reporting to the Vice President / Senior Director, Quality Systems, this individual will establish and maintain Nurix's risk-based CSA framework aligned with current regulatory expectations, including the FDA's 2022 guidance on computer software assurance, GAMP 5 (2nd edition), and applicable 21 CFR Part 11 and Annex 11 requirements. The role requires an individual who combines deep technical knowledge of GxP computerized systems with practical experience in SaaS and cloud-based platform qualification, and who can translate regulatory requirements into pragmatic, fit-for-purpose validation approaches that support a modern, agile biotech environment. This is a high-impact, program-ownership role requiring both strategic vision and hands-on execution. The successful candidate will work closely with Quality, IT, Regulatory Affairs, CMC, Clinical Operations, and external vendors to ensure that all GxP-critical systems are appropriately assessed, validated, and maintained in a compliant state. The individual will champion a risk-based, science-driven approach to CSA across the organization.

Responsibilities

CSA Program Ownership and Strategy

Own and maintain Nurix's Computer Systems Assurance policy framework, SOPs, and risk-based validation strategy, aligned with FDA CSA guidance (2022), GAMP 5 (2nd edition), 21 CFR Part 11, EU Annex 11, and applicable ICH guidelines.
Define and implement a fit-for-purpose, risk-tiered approach to system qualification for SaaS and cloud-hosted GxP applications, recognizing the vendor-managed nature of modern software platforms.
Maintain the GxP system inventory; conduct and document periodic system risk assessments to classify systems and determine appropriate validation scope and rigor.
Establish and maintain processes for vendor assessment, including review of vendor SOC 2 reports, quality agreements, and audit strategies appropriate for SaaS providers.
Drive continuous improvement of the CSA program through benchmarking, regulatory intelligence, and adoption of industry best practices.

System Validation and Qualification Execution

Lead and execute validation activities for GxP SaaS platforms including, but not limited to, eQMS (e.g., Veeva Vault), electronic document management, clinical data management, regulatory information management, and laboratory information systems.
Author and review validation documentation including Validation Master Plans (VMPs), User Requirements Specifications (URS), Risk Assessments, Vendor Assessments, Validation Protocols (IQ/OQ/PQ), Traceability Matrices, and Validation Summary Reports.
Manage validation activities associated with system implementations, major configuration changes, upgrades, and periodic re-validation reviews, applying critical thinking to scope validation effort proportionate to system risk and change impact.
Coordinate validation testing activities with cross-functional stakeholders; ensure test scripts are appropriately designed to demonstrate fitness for intended use.
Review and approve validation deliverables prepared by internal teams, vendors, or external validation consultants.

21 CFR Part 11 and Data Integrity

Serve as the internal subject matter expert for 21 CFR Part 11 and EU Annex 11 requirements; assess systems for compliance and provide guidance to cross-functional partners.
Partner with IT and system owners to ensure electronic records and electronic signature controls are properly implemented and documented in all GxP systems.
Support data integrity assessments and remediation initiatives; apply ALCOA+ principles to guide compliant system design and use.

Change Management and Periodic Review

Manage the computerized systems change control process; evaluate proposed changes for validation impact and establish appropriate assessment, testing, and documentation requirements prior to implementation.
Own and execute the periodic review program for validated GxP systems; assess continued fitness for intended use and compliance with current regulatory expectations.
Maintain validation status documentation and ensure validation files are audit-ready at all times.

Inspection Readiness and Regulatory Support

Support preparation for regulatory agency inspections; serve as the CSA subject matter expert during FDA, EMA, and other Health Authority inspections and ensure validation documentation is complete, current, and accessible.
Contribute to relevant sections of regulatory submissions and respond to agency questions related to computerized systems and data integrity.
Monitor evolving regulatory guidance and industry standards related to CSA, CSV, data integrity, and cloud-based systems; proactively adapt Nurix's program to reflect current expectations.

Cross-Functional Partnership and Training

Serve as the primary point of contact and internal consultant for all GxP system owners across Quality, IT, Regulatory Affairs, CMC, and Clinical Operations.
Develop and deliver CSA training for system owners, end users, and other stakeholders to build organizational capability and awareness.
Partner with IT and vendor project teams to embed validation requirements early in system selection and implementation processes.

Required Qualifications

Bachelor's degree in computer science, information systems, life sciences, pharmaceutical sciences, or a related field.
7–10+ years of progressive experience in computer systems validation and/or computer systems assurance in a GxP-regulated pharmaceutical, biopharmaceutical, or biotechnology environment.
Demonstrated expertise in current regulatory requirements for computerized systems, including FDA 21 CFR Part 11, EU Annex 11, FDA CSA guidance (2022), and GAMP 5 (2nd edition).
Hands-on experience validating SaaS and cloud-hosted GxP platforms; understanding of vendor-managed environments and shared responsibility models.
Proficiency authoring and reviewing CSA/CSV deliverables: VMPs, URSs, Risk Assessments, IQ/OQ/PQ protocols, traceability matrices, and validation summary reports.
Strong working knowledge of data integrity principles (ALCOA+) and their application to electronic records management and GxP system design.
Experience managing system change control and periodic review programs for validated GxP systems.
Ability to operate as both program owner and individual contributor in a lean, virtual organizational model; comfortable managing validation activities without a large internal support team.
Excellent written and verbal communication skills; able to translate complex technical and regulatory requirements into practical guidance for diverse stakeholders.
Strong organizational skills and attention to detail; demonstrated ability to manage multiple concurrent programs and priorities in a fast-paced environment.

Preferred Qualifications

Experience with eQMS validation (e.g., Veeva Vault) and familiarity with Veeva's Qualified System approach and available supplier documentation.
Familiarity with clinical development platforms such as electronic data capture (EDC), regulatory information management (RIM), or clinical trial management systems (CTMS) in a validated context.
Experience supporting FDA, EMA, or equivalent Health Authority inspections as a CSA subject matter expert.
Exposure to laboratory informatics systems (LIMS, ELN) and their GxP qualification requirements.
Experience in a virtual or lean biotech environment managing validation activities through external vendors and consultants.
Working knowledge of cybersecurity frameworks and their intersection with GxP system compliance (e.g., NIST, SOC 2).
Advanced degree in a relevant scientific, engineering, or regulatory discipline.

Fit with Nurix Culture and Values

You know the regulations deeply and apply them with judgment, designing validation approaches that are rigorous where it matters and efficient everywhere else. You bring expertise with pragmatism —
You are comfortable as the go-to expert, driving the CSA program forward proactively rather than waiting for direction, and you take accountability for outcomes. You own the program —
You build trusted relationships across Quality, IT, and the business, and you understand that a well-designed, compliant systems environment is an enabler of Nurix's mission to develop important medicines for patients. You partner with purpose —

Location: Brisbane, CA - Onsite

Salary Ranges: Senior Manager, CSA(Quality) - $170,538 – $193,493
Associate Director, CSA(Quality) - $190,269 – $216,360

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).

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April, 2026

Clinical Pharmacology

Associate Director, Quantitative Pharmacology and Pharmacometrics

Location

Brisbane, CA

Associate Director, Quantitative Pharmacology and Pharmacometrics

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation.

Position

The Associate Director in the Clinical Pharmacology group will contribute to pharmacometric efforts across early and late-stage programs. As an early member of the Clinical Pharmacology group, you will have an opportunity to influence the direction of the clinical pharmacology group at Nurix. The successful applicant shall be proficient in developing and executing PK/PD modeling and simulation activities, such as but not limited to population PK/PD modeling, physiologically-based PK (PBPK) modeling and quantitative systems pharmacology (QSP) modeling. This includes data analysis and interpretation and presentation of findings to optimize doses, dosage regimens and study designs. The candidate will also author and review clinical pharmacology documents for submission and/or response to regulatory agencies. The candidate will be influential across multiple functions including individual contributors, development program teams, and the executive team.

Responsibilities

Utilize quantitative approaches to impact model-informed drug discovery and development in areas such as human dose projections, dose regimen identification and optimization
Lead and conduct pharmacometric workstreams such as but not limited to noncompartmental analyses, exposure-response analyses, population PK/PD modeling, PBPK modeling and QSP modeling, and running model-based simulations
Conduct exploratory modeling activities to support decision-making and clinical strategy
Collaborate across functions within the company and oversee contract vendors to advance pharmacometric efforts and activities
Oversee and contribute to clinical pharmacology sections of clinical study protocols, SAPs, CSRs, stand-alone PK/PD reports, Clinical development plans
Author and review clinical pharmacology documents for submission and/or response to regulatory agencies
Actively identify state-of-the-art quantitative approaches in the field for potential applications to projects, including the use of artificial intelligence/machine learning (AI/ML) techniques

Qualifications

PharmD or PhD or MS in a field related to Pharmacometrics with 8+ years of industry or similar experience in Pharmacometrics, Clinical Pharmacology or Quantitative Systems Pharmacology
Extensive hands-on experience in using modeling and simulation techniques in pharmaceutical development, such as population PK/PD modeling, PBPK modeling or QSP modeling
Exceptional oral and written communication skills and excellent problem-solving skills
Previous experience in authoring and reviewing clinical pharmacology documents for submission and/or response to regulatory agencies
Demonstrated past performance of functioning efficiently in a dynamic, cooperative, team-oriented environment showcasing emotional intelligence (respect and empathy)
High proficiency in using common software and data analysis packages (e.g., R, WinNonlin, Simcyp, GastroPlus, Monolix, NONMEM)
Nurix is headquartered in Brisbane, California. This is an onsite position.

Salary Range: 208K– 240K plus bonus & equity.

Location: Brisbane, CA – Onsite

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May, 2026

Clinical Operations

Biosample Manager

Location

Brisbane, CA

Position: Biosample Manager

Nurix Therapeutics, Inc. is seeking a Biosample Manager to join the Clinical Operations team. This is an onsite role. This individual will work cross functionally, with both internal and external stakeholders, to plan, coordinate, and oversee all operational activities required to manage the lifecycle of the clinical biosamples and support translational research.

Responsibilities:

Study Management

Provide guidance during protocol and informed consent form development to ensure logistical feasibility of biosample handling, alignment with planned analyses and ICH/GCP compliance
Participate in the CRF development process to ensure that biosample information is appropriately captured for sample tracking and reconciliation purposes
Serve as the functional lead as a member of the Clinical Study Teams and provide regular biosample metrics/trends and status updates
Partner with cross-functional teams to ensure timely delivery of biosample data to meet publication and study goals

Biosample and Vendor Management

Provides operational leadership on vendor and sample management activities, including design of central lab specifications at study start or amendments
Oversee kit design, sample processing, and sample logistics to ensure that the investigator sites can meet the sample handling needs of the study
Plan, coordinate and oversee sample shipments and query resolution at laboratory vendors
Manage the sample management system to track the life cycle of the samples, identify trends and gaps, and support sample reconciliation
Provide training and guidance to the investigator sites and study monitors for biosample collection, handling and shipment
Manage laboratory vendors, overseeing vendor selection, technology transfers, budgets, contract management, and data management
Develop and maintain biosample operations SOPs and WPs

Qualifications:

B.S. in biological sciences with 8+ years of relevant industry experience
Knowledge of FDA, ICH/GCP, and GDPR regulations and guidelines
Proven track record of sample management, data management and vendor management skills
Developed central lab specifications and logistics for global studies at study start or protocol amendments with cross-functional collaboration
Ability to develop and manage workflows and data sets
Proficiency in MS Office including with advance Excel skills
Good initiative and ability to work independently
Ability to work in a fast-paced environment
Excellent written and interpersonal communication skills
Detail oriented with the ability to manage multiple competing priorities
Effective team player and ability to collaborate with cross functional clinical study teams
Onsite role

Salary Range: 140K - 180K plus equity and bonus

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).

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March, 2026

Information Technology

Director of IT Operations

Location

Brisbane, CA

Position Summary

This role owns IT service delivery and vendor operations at Nurix. You will manage our internal service delivery team, oversee our managed service providers, and lead initiatives to improve how IT supports the business. Beyond running day-to-day operations, you will design and evolve Nurix's IT operating model as the company grows.

The goal is not simply to manage vendors, It’s to create a service experience where employees get reliable help, problems get solved quickly, and IT enables rather than slows down the work. You're empowered to restructure vendor relationships, change providers, or build internal capability as needed to achieve that outcome.

This is a growth role. In Year 1, the focus is building a strong operational foundation. As that foundation matures, the role expands toward direct engagement with lines of business as an IT strategic partner.

Responsibilities

Service Delivery

Lead the service delivery function, including the Service Delivery Manager and coordination with MSPs
Own escalations and ensure employees receive timely, quality support
Design and improve service delivery processes: documentation, knowledge
management, meaningful metrics
Evolve the operating model over time—assess what should be handled internally vs. through partners
Manage on-prem infrastructure through MSPs; build internal capability if and when it makes sense

Vendor Operations

Own vendor relationships across the IT service provider portfolio
Set clear expectations: scope, performance standards, accountability
Lead contract negotiations and renewals to improve value
Ensure vendors build our capability—we want to learn, not become dependent
Rationalize the vendor portfolio as needed to improve outcomes

Planning & Programs

Develop a technology roadmap aligned with Nurix's clinical and business milestones, including sequencing and tradeoff rationale to support leadership decision-making
Help leadership prioritize initiatives—frame options, clarify tradeoffs, recommend paths forward
Lead cross-functional projects spanning infrastructure, security, and applications
Support budget development, expense tracking, and financial reporting

Collaboration

Coordinate with Information Security on system hardening and compliance
Work with Cloud Infrastructure on AWS and cloud-first initiatives

Qualifications

10+ years in IT, including 5+ years in leadership or management roles
Experience managing vendor relationships: contracts, performance, accountability
Background in biotech, pharma, or life sciences
Track record building roadmaps and driving cross-functional alignment
Strong at translating business needs into actionable plans
Effective communicator across technical and scientific audiences
Bachelor's degree in a technical field, or equivalent experience

Preferred

Familiarity with GxP and regulated IT environments
Experience with research platforms (ELN, LIMS, scientific data systems)
AWS or cloud platform experience
Product management or digital strategy background
Coordinate with Information Security on system hardening and compliance
Work with Cloud Infrastructure on AWS and cloud-first initiatives

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative
Ability to function in a dynamic environment
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view

Salary Range: $ 214,637 – $244,431

Location: Brisbane, CA - Onsite

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May, 2026

Regulatory

Director, Regulatory Affairs

Location

Brisbane, California, United States

Position Title: Director, Regulatory Affairs (Strategy, Immunology and Inflammation)

Nurix Therapeutics, Inc. is seeking a Director, Regulatory Affairs (Strategy, I&I) to join the Regulatory team. The successful candidate will be a core member of the Regulatory team and will serve as the global regulatory lead (GRL) for the immunology and inflation therapeutic area. This role will be responsible for developing the global regulatory strategy in collaboration with key internal stakeholders, as well as tactical implementation of that strategy guiding and executing compliant, high quality, nonclinical and clinical submissions and interactions in support of early development, registration and life cycle management activities. This position works cross-functionally with regulatory affairs and clinical development organizations to facilitate the completion of regulatory filing documentation according to company timelines. It also ensures adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as required. This position is on site in the Brisbane, CA office.

Responsibilities:

Develop and implement competitive and effective global clinical & nonclinical regulatory strategies for various immunology and inflammation indications and identify potential risks and mitigation strategies associated with proposed strategies
Work in close collaboration with the SVP, Head of Regulatory Affairs and the development team leader and other cross-functional colleagues, including CROs to deliver sound, efficient development strategies and operational plans
Represent Regulatory Affairs on assigned cross-functional development teams.
Lead and manage the development and preparation of high-quality global submissions (including IND, CTAs, NDAs, and MAAs) for early and late-stage programs in collaboration with the regulatory and project teams to support and accelerate clinical development and regulatory approval, as applicable
Lead communication with global Health Authorities (HA), such as FDA and EMA, including, planning and preparing for formal meetings with regulatory agencies and interpreting HA feedback from these interactions.
Develops and executes, or oversees global regulatory strategy for long-term planning, including the potential to accommodate expedited development needs
Anticipate issues and guide cross-functional teams on risk mitigation strategies for any development challenges Provides insight and guidance on the implementation of current regulations and assesses regulatory risk based on precedence
Ensure adherence to current regulations associated with regulatory activities
Works strategically with all regulatory functions to develop detailed, actionable submission plans, tracks major submission deliverables, and ensures consistent management submission documents, health authority communications, and all other regulatory information supporting Nurix’s investigational and marketing applications
Plays an essential part in defining requirements for, implementing, and supporting future systems and tools to be employed by Nurix in the areas of document management, submission content planning, and regulatory information management
Tracks the status of major deliverables for regulatory submissions (e.g., study reports, summary documents, labeling) along with their dependencies
Develops and maintains submission plan templates to ensure Nurix regulatory submissions are consistently planned and executed across programs
Participates in cross-functional process initiatives impacting regulatory submission processes and systems
Manages consultants and contractors as needed

Requirements

Bachelor's degree in life-sciences or related scientific discipline; advanced degree preferred Manager:
Must have minimum of 12 years in Regulatory affairs strategy with significant experience in the immunology and inflammation therapeutic area
Strong demonstration of knowledge of drug development, FDA, EMA and ICH guidelines and regulations
Experience providing hands-on support for planning clinical trial and marketing applications to health authorities including but not limited to FDA, EMA
Proven track record of supporting Regulatory affairs in the planning and execution of major filings and ongoing maintenance of clinical trial and marketing applications
Strong project management and critical thinking skills
Experience applying project management techniques and tools (e.g., MS Project, Smartsheet, Excel trackers) to the planning and execution of regulatory submissions
Excellent organizational and communication skills, both written and verbal
Ability to work independently as well as part of a team environment
Positive attitude, energetic and proactive
Proven ability to manage multiple projects, identify and resolve regulatory issues
Strong interpersonal skills and the ability to effectively work with others

Salary Range: 220K – 254K plus bonus and equity.

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May, 2026

CMC

Manager, Analytical Development and Quality Control (Brisbane, CA)

Location

Brisbane, CA

Company

Position

The Manager, Analytical Development and Quality Control provides strategic and technical leadership for analytical CMC activities across multiple programs, with a strong emphasis on technology transfer and knowledge management. This role ensures successful transfer of analytical methods and associated knowledge to internal teams and external stakeholders, enabling consistent execution across development and manufacturing sites. The position requires deep expertise in analytical method development, validation, transfer, and lifecycle management in alignment with ICH guidelines, along with the ability to interpret data from a range of analytical techniques to support sound technical decision-making.

In addition, this role is responsible for establishing and clearly communicating analytical control strategies across cross-functional teams, ensuring alignment and scientific rigor. The Manager drives robust knowledge management practices through high-quality technical writing, documentation, and data governance, including authoring and reviewing validation, transfer, and investigation reports. Strong leadership, communication, and project management skills are essential to effectively coordinate internal teams and external partners, maintain continuity of analytical knowledge, and support informed decision-making.

This position is onsite at Nurix, Brisbane, CA

Required Qualifications

MS in Chemistry, Analytical Chemistry, or a related field with 8–10+ years of relevant experience, or PhD in a similar discipline with 5–8+ years of relevant experience.
Demonstrated leadership experience managing analytical CMC activities across multiple programs.
Strong expertise in analytical method development, validation, transfer, and lifecycle management in compliance with ICH guidelines.
General understanding of key analytical methods (e.g., HPLC/UPLC, GC, KF, ICP-MS, IC, XRPD, PSD) with the ability to interpret data and guide technical decisions.
Proven experience authoring, reviewing, and approving analytical sections of regulatory submissions (INDs, IMPDs, NDAs, and global filings).
Significant experience supporting NDA submissions and interacting with regulatory agencies.
Strong technical writing skills for preparation of validation reports, transfer reports, investigation reports, and regulatory documentation.
Ability to effectively communicate and justify analytical control strategies within cross-functional teams (Quality, Regulatory, Process Development) and with external stakeholders.
Experience overseeing external partners (e.g., CDMOs) and managing outsourced analytical activities.
Strong leadership, communication, and project management skills in a cross-functional environment.
Strong technical writing and authorship skills, with the ability to prepare, review, and approve analytical reports and CMC documentation to support internal decision-making and knowledge management.

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view

Salary Range:

Manager: $147,341 – 171,488

Senior Manager: $174,036 – 198,405

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

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May, 2026

Clinical Development & Safety

Medical Director, Drug Safety

Location

Brisbane, CA

Title: Medical Director, Drug Safety

Position:

As a Medical Director, Drug Safety you will play a key role in ensuring the safety of patients in Nurix’s clinical trials. You will apply your clinical expertise to evaluate safety data, guide benefit–risk assessments and help shape the pharmacovigilance strategy for Nurix’s emerging therapies. You will report to the VP of pharmacovigilance and work closely with colleagues in clinicaldevelopment, regulatory affairs, and clinical research to interpret emerging safety signals, support regulatory submissions, and maintain a strong safety framework during clinical development and transition into the post-marketing phase. Your insights will help inform critical decisions about patient safety, risk management, and the overall development strategy for our products. This role is well suited for a physician who enjoys working at the intersection of non-clinical data, clinical medicine, data interpretation, and drug development, and who wants to have a meaningful impact on how new therapies are evaluated and brought to patients.

Responsibilities:

Medical Safety Leadership

Serve as the medical safety lead for assigned products, providing clinical and pharmacovigilance expertise to safety strategy and activities.
Lead aggregate safety data analysis for signal detection, signal evaluation, and risk characterization.
Conduct medical review and interpretation of safety data, contributing to benefit–risk assessments.
Monitor emerging safety signals and proactively address potential safety risks through appropriate internal and external communication.

Regulatory and Safety Documentation

Contribute to safety responses to regulatory authorities and participate in regulatory interactions.
Provide clinical leadership during inspections and audits related to safety and risk management.
Author and review regulatory safety documents, including:
- DSURs
- Safety sections of INDs, and regulatory briefing books.

Clinical Development Support

Provide clinical input into safety aspects of clinical trial protocols, informed consent forms, and investigator brochures.
Collaborate with clinical development, regulatory affairs, medical affairs, and other stakeholders to ensure a consistent global safety strategy.
Governance and Cross-Functional Collaboration
Serve on safety governance committees, supporting strategic decision-making for risk mitigation and benefit–risk evaluation

Requirements:

Medical degree (MD) is required
Clinical experience preferred
10+ years of experience in pharmacovigilance/ drug safety within the pharmaceutical or biotechnology industry
Demonstrated expertise in aggregate safety analysis and benefit–risk evaluation
Strong knowledge of global pharmacovigilance regulations and guidance (ICH, FDA, EMA, MHRA)
Experience supporting early and late-stage clinical development, regulatory submissions, and product launch
Experience in post-marketing safety surveillance and risk management
Experience interacting with global health authorities on safety matters
Familiarity with signal detection and safety surveillance tools and databases
Strong communication, collaboration, and cross-functional leadership skills
Ability to interpret complex clinical and safety data and translate insights into regulatory and business strategy
Ability to work effectively and collaboratively in a fast-paced, growing organization
This is an onsite position located in Brisbane, CA.

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view

Salary Range: 307K - 351K plus bonus & equity

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

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May, 2026

Medicinal Chemistry

Principal Scientist - Medicinal Chemistry

Location

Houston, TX

Principal Scientist - Medicinal Chemistry

Location: Houston, TX

Position

We are seeking a talented and highly motivated individual with a strong background in synthetic organic chemistry to join our medicinal chemistry group in the pursuit of degrader-based small molecules to treat patients with unmet medical needs. This individual will design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics and in vivo efficacy, and will engage in rational structure-based drug discovery enabled by our computational and structural biology groups. As a member of a dynamic multi-disciplinary team, this person will collaborate with a broad group of scientists within Nurix and with external collaborators. Additionally, they will contribute to patent, report and scientific publication writing. Furthermore, they will initiate and/or lead process improvements within the chemistry department or cross-functionally.

Qualifications

BS or MS in degree with 10+ years pharmaceutical medicinal chemistry industrial experience; Ph.D. in synthetic organic chemistry with 8+ years pharmaceutical medicinal chemistry industrial experience
Track record of delivering advanced leads/ development candidates.
Excellent knowledge of medicinal chemistry principles with a solid understanding of the biology and pharmacology of programs, ADME concepts, and series SAR. Able to effectively integrate this knowledge to direct drug discovery programs to phase transitions or series go/no go decisions.
Strong working knowledge of protein-ligand interactions, conformational and structural analysis. Experienced in partnering closely with computational chemists in the use of computational tools, models and visualization applications.
Expert in organic synthesis, knowledgeable of the current literature, with strong synthetic problem-solving skills.
Proven leadership capability in a cross-functional team setting, either as project team leader or co-lead.
Ability to make inventive contributions towards new chemical target structures or templates for programs and evaluate early screening or literature hits.
Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings and using this information to guide program strategy.
Excellent communication skills and the ability to present rationale, key data, issues and accomplishments to the company.
Experience supervising direct reports to a high level of productivity and mentoring for career development is a plus.
Ability to manage priorities and advance multiple projects simultaneously.
Strong evidence of conceptual thinking and active follow through, recognized by establishing new projects or new directions within projects, new strategies and/or enabling technologies for drug discovery.

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative
Ability to function in a dynamic environment
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view

Salary Range:

Principal Scientist: $155,579 – $179,450 + Bonus and Equity

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May, 2026

CMC

Scientist, Analytical Development and Quality Control

Location

Brisbane, CA

Company

Position

Nurix Therapeutics seeks an experienced Scientist to join the Analytical Development and Quality Control group. The Scientist will conduct analytical method development and material characterization studies to inform drug substance and drug product development. They will also provide operational oversight at external CDMO/CTL partners, manage reference standards and impurity markers, collaborate in CMC risk management, and author technical reports.

In Nurix’s laboratories, the Scientist will characterize material attributes and impurities by high resolution mass spectrometric and multidimensional chromatographic techniques. They will determine impurity structures, characterize material stability, and elucidate mechanisms of degradation. They will employ state of the art QbD approaches to develop and troubleshoot chromatographic test methods to accelerate and derisk QC activities performed externally at CDMOs and CTLs. The Scientist will critically evaluate characterization data and communicate results in multidisciplinary teams.

The ideal candidate must have demonstrated expertise in mass spectrometry and hands-on experience with liquid chromatography. Hands-on experience with two-dimensional liquid chromatography is a plus.

This position is onsite at Nurix headquarters in Brisbane, CA.

Key responsibilities

Characterization and development studies at our internal laboratory:

2D-LC for impurity profiling of complex samples, derisking HPLC test procedures, and adaptation of incompatible methods to mass spectrometry
Structural elucidation by high resolution Orbitrap Tribrid Mass Spectrometry
QbD HPLC method development using multivariate DOE software
Forced degradation and elucidation of degradation mechanisms
Accelerated predictive stability studies and modeling of packaging configurations and long term stability

Authorship of technical documents such as analytical development reports, stability reports, and storage statements
Management of reference standards and impurity markers
Manage and organize documentation and data
Contribute to protocol development and oversight/troubleshooting of method transfers
Liaise with Medicinal Chemistry, Bioanalytical, DMPK, and Preclinical departments
Compliance with cGMP quality standards and internal SOPs
Travel up to 5%

Required Qualifications

Advanced degree in a relevant discipline (Chemistry, Pharmaceutics, or related field). BS with 10+ years, MS degree with 6+ years, or PhD with up to 4 years of relevant experience
Expertise in operation and maintenance of mass spectrometers
Experience in HPLC operation and method development
Ability to critically interpret data and articulate technical concepts in cross functional teams
Ability to ensure assigned activities are completed to the satisfaction of project timelines
Strong interpersonal skills that foster collaboration within and outside of the organization

Bonus Qualifications

Experience with accurate mass instrumentation such as Orbitrap Tribrid mass spectrometers
Experience in operation of 2D-LC
Experience in the determination of structures of small molecule impurities and/or metabolites
Experience protein and/or ADC characterization by mass spectrometry
Familiarity with gas chromatography, NMR, particle size analysis, solid state characterization, dissolution, ICP-MS/OES, and/or FTIR
Experience with reference standard management, stability programs, and/or method validation
Familiarity with ICH guidelines, cGMPs, and pharmacopeial chapters

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view

Salary Range

Scientist I : $123,841--$144,272

Scientist II: $143,260 –$161,064

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

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May, 2026

Drug Discovery Technologies

Scientist II - Structural Biology

Location

Brisbane, CA

Company

Position Summary

This role is located at the interface of Nurix’s DEL driven drug discovery engine and preclinical drug development platform. The strategic impact of this role is the elucidation and communication of small molecule interactions with drug targets to provide mechanistic understanding and guide design of clinical drug candidates. As a member of the early discovery department, you will make key contributions to validation and characterization of novel chemical matter for our targeted protein degradation platform. In addition to that, you will participate in multiple small and agile teams of drug discovery veterans and help achieve discovery and development milestones.

Key Responsibilities

Design and execute end-to-end gene-to-structure workflows: construct design, protein engineering, experimental planning, and structure determination
Determine high-resolution structures of protein–ligand and protein complexes using X-ray crystallography and cryo-EM
Own all aspects of sample preparation, data collection, processing, model building, refinement, and documentation
Translate structural findings into actionable insights for project teams, and present results to colleagues and senior leadership in written and oral formats
Partner with computational chemistry and machine learning groups to drive rational drug design and enhance proprietary computational platforms
Serve as a structural biology resource across the research organization, providing mechanistic rationale to support project decisions
Maintain rigorous laboratory records and contribute to scientific reports, publications, and patent filings
Help establish and continuously improve best practices, protocols, and SOPs within the structural biology group
Build and maintain deep command of the structural mechanisms of protein ubiquitylation and degradation

Qualifications

Required:

MS with 8 or more years' relevant experience or PhD in structural biology, biochemistry, biophysics, or a related field; 4+ years of hands-on academic or industry experience. Exceptional candidates at the entry level will also be considered.
Demonstrated deep expertise in X-ray crystallography, cryo-EM, or both. Independent deployment of both technologies is strongly preferred
Full proficiency in Phenix, Coot, CryoSPARC, RELION, PyMOL, and Chimera/ChimeraX
Exceptional attention to detail, rigorous record keeping, and keen scientific curiosity
Strong scientific communication skills with the ability to present complex structural data to diverse, cross-functional audiences
Ability to work strategically, independently, and collaboratively in a fast-paced, matrix research environment

Preferred:

Experience in drug discovery or biopharmaceutical setting is highly desirable
Experience with protein degrader technologies
Working experience with ubiquitin ligases, transcription factors, or membrane proteins
Additional skills in SAXS, NMR, HDX-MS, machine learning, or computational structural biology

Fit with Nurix Culture and Values

Collaborative and team-oriented, eager to share expertise and learn from others.
Solution-driven with a hands-on and resourceful approach.
Adaptable and comfortable in a fast-paced, interdisciplinary environment.
Committed to scientific excellence and the shared goals of the team.

Salary Range:

Scientist II: $139,962--$159,890 (plus bonus, equity, and benefits)

Location: Brisbane, CA - Onsite

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

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May, 2026

Clinical Operations

Senior Clinical Trial Manager ~ Contract Position

Location

Brisbane, CA

Nurix is seeking a Senior Clinical Trial Manager to join the Clinical Operations team. This individual will be responsible for management of global regions and/or clinical programs. They will lead study team, vendors, clinical monitors and clinical sites throughout the life cycle of a clinical trial.

This individual will be able to manage clinical regions or trial(s) and have broad involvement in work central to Nurix’s strategic goals. They will apply existing technical skills, learn new skills, and play a key role in clinical development of the programs. As an early hire, they’ll be influential in championing and developing Nurix’s culture.

The Senior Clinical Trial Manager is responsible for the successful implementation of a clinical trial, independently, from start-up to close-out. Experience in managing cross-functional teams, vendor oversight, knowledge of applicable regulatory requirements and developing junior staff will be essential to the team's success. The Sr. CTM will represent Clinical Operations at Project team meetings and may represent Nurix at professional events.

Job Responsibilities:

Accountable for all operational aspects of assigned clinical trial(s) or geographical region.
Responsible for selection of vendors/CROs and provide effective ongoing management and oversight to vendors/CROs to ensure compliance and execution of deliverables within the approved budget, study timeline, and study protocol
Works closely with investigative site personnel, CROs, and other study vendors
Monitor and track clinical trial progress and provide status update to stakeholders
Manage study contracting, budget, forecasting, accruals and payment process for all clinical trial vendors including investigational sites
Collaborate with Data Management to ensure correct CRFs content is collected, prepare/implement CRF completion guidelines, and coordinate delivery of data updates, listings and study reports
Drafts and coordinates review of relevant documents including protocols, informed consents, case report forms, monitoring plans, investigator brochures and clinical study reports.
Must be able to participate in cross-functional strategic initiatives under limited supervision
Proactively identifies potential issues/risks and recommends/implements solutions
Provides leadership to the clinical operations team working on the assigned program

Experience and Skills:

B.S./ B.A. in biological sciences, advanced degree preferred with 5-10 years of relevant industry experience
Ability to travel as required for the program (10-15%)
Demonstrated knowledge of FDA, ICH and GCP regulations and guidelines
Experience in leading teams, including CROs, consultants and vendors
Must display strong analytical and problem-solving skills at a project level and collaborate with colleagues to generate solutions
Strong communication and influence skills and ability to create a clear sense of direction
Ability to deal with time demands, incomplete information or unexpected events
Outstanding organizational skills with the ability to work independently, multi-task and prioritize
Comfortable in a fast-paced small company environment and able to adjust workload based upon changing priorities

Salary Range: 172K - 199K

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May, 2026

Regulatory

Senior Director, Regulatory Affairs (Strategy, Hematology Oncology)

Location

Brisbane, California, United States

Position Title:

Senior Director, Regulatory Affairs (Strategy, Hematology Oncology)

Job Summary:

Nurix Therapeutics, Inc. is seeking a Senior Director Regulatory Affairs (Strategy, Hematology Oncology) to join the Regulatory team. The successful candidate will be a core member of the Regulatory team and will be responsible for helping build and execute on global regulatory strategy, objectives, policies and programs pertaining to development and future marketing of products for guiding and executing upon regulatory strategy of compliant, high quality, nonclinical and clinical submissions and interactions in support of early development, registration and life cycle management activities. This includes supporting regulatory activities to enable clinical development plans and studies, working cross-functionally across the organization.

Responsibilities:

Provides regulatory strategic direction and support for assigned global development programs/development program activities
Assists Sr. Regulatory Affairs staff with their development program activities and deliverables
Designs and implements regulatory strategies with Regulatory Affairs staff to obtain and maintain product investigative and marketing applications for assigned programs, as well as their life cycle management
Acts as regulatory representative on early and/or late phase clinical studies, ensuring compliant execution of trials
Strong competency in understanding regulatory requirements and emerging regulatory landscapes associated with US and global regulatory authorities
Experienced in responding to inquiries from global regulatory authorities as well as the preparation and conduct of meetings with global regulatory authorities
Assist in the preparation and maintenance of Annual Reports, Development Safety Update Reports (DSURs), Investigator’s Brochures and other documents required for INDs, CTAs, NDAs and other related regulatory development and marketing applications
Assist in the cataloging and maintenance of regulatory application submissions
Conduct research and stay up-to-date on regulatory requirements and changes
Collaborate with cross-functional teams to ensure product compliance throughout the development lifecycle
Monitor and assess regulatory risks and develop mitigation strategies
Oversee quality assurance processes to ensure compliance with regulatory standards
Review SOPs pertaining to Regulatory
Works strategically with all regulatory functions to develop detailed, actionable submission plans, tracks major submission deliverables, and ensures consistent management submission documents, health authority communications, and all other regulatory information supporting Nurix’s investigational and marketing applications
Plays an essential part in defining requirements for, implementing, and supporting future systems and tools to be employed by Nurix in the areas of document management, submission content planning, and regulatory information management
Tracks the status of major deliverables for regulatory submissions (e.g., study reports, summary documents, labeling) along with their dependencies
Develops and maintains submission plan templates to ensure Nurix regulatory submissions are consistently planned and executed across programs
Participates in cross-functional process initiatives impacting regulatory submission processes and systems
Manages consultants and contractors as needed

Experience and Skills:

Bachelor's degree in life-sciences or related scientific discipline; advanced degree preferred
Must have minimum of 12 years in Regulatory affairs strategy
Strong demonstration of knowledge of drug development, FDA, EMA and ICH guidelines and regulations
Experience providing hands-on support for planning clinical trial and marketing applications to health authorities including but not limited to FDA, EMA
Ability to read, analyze and interpret scientific and technical information, as well as regulatory
Ability to understand and explain detailed regulatory affairs and compliance programs and/or to effectively present information to senior regulatory management, other departments or external
Ability to comply with changing regulatory
Proven track record of supporting Regulatory affairs in the planning and execution of major filings and ongoing maintenance of clinical trial and marketing applications
Strong project management and critical thinking skills
Experience applying project management techniques and tools (e.g., MS Project, Smartsheet, Excel trackers) to the planning and execution of regulatory submissions
Excellent organizational and communication skills, both written and verbal
Ability to work independently as well as part of a team environment
Positive attitude, energetic and proactive
Proven ability to manage multiple projects, identify and resolve regulatory issues
Strong interpersonal skills and the ability to effectively work with others

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May, 2026

Quality

Senior Manager, Quality Operations

Location

Brisbane, CA

Senior Manager, Quality Operations

Nurix Therapeutics is a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation therapeutics. Leveraging our proprietary DELigase platform, we design small molecules that harness the body’s own protein disposal system to selectively eliminate disease-causing proteins. Our pipeline spans oncology and immune-mediated diseases, and our team is united by a commitment to scientific excellence and meaningful impact for patients.

We are a team of scientists, innovators, and problem-solvers committed to improving patient lives. We value integrity in everything we do — from the bench to the boardroom — and we foster an environment where every voice is heard and every contribution matters.

Position

The Senior Manager, Quality Operations is an important operational and technical contributor within the Nurix Quality organization, responsible for supporting the quality operations and GMP compliance activities that underpin Nurix’s clinical development programs. This role will partner closely with CMC teams, CDMOs, and internal stakeholders to ensure quality oversight across drug manufacturing, laboratory operations, auditing, and inspection readiness. Reporting to the Senior Director, Quality, the Senior Manager will execute essential quality systems activities including deviation management, change control, CAPA, batch record review, and audit support. This individual will demonstrate strong independent judgment, meticulous attention to detail, and the ability to collaborate effectively across functions in a dynamic, early to late clinical-stage environment where quality and program timelines are closely intertwined

Responsibilities

Drug Manufacturing Quality Operations

Execute and support quality systems operations for clinical development, including document management, deviation management, change control, CAPA, training, and validation activities.
Provide day-to-day quality oversight of CDMOs and contract laboratory operations, including review and approval of deviations, OOS/OOT investigations, batch records, specifications, sampling and testing plans, analytical methods, and lot disposition decisions.
Review and approve development, process transfer, and validation protocols and reports; verify process data in support of CMC regulatory submissions (INDs and NDAs).
Approve production-related activities including master batch records, change controls, stability study protocols and reports, and certificate of analysis reviews.
Participate in CMO selection, commissioning, qualification, and certification activities, support negotiation and maintenance of quality agreements with contract manufacturing partners.
Support risk management assessments of suppliers and manufacturing processes.
Manage and file quality documents in the electronic document management system; ensure timely completion of document lifecycle activities in compliance with internal procedures.

Quality Auditing

Support domestic and international GMP audits of contract manufacturers and laboratory service providers; collaborate cross-functionally with internal stakeholders to assess compliance with applicable regulations and Nurix SOPs.
Support internal quality audits to evaluate Nurix’s GMP compliance; document findings, prepare audit reports, and track corrective action commitments.
Communicate audit findings clearly to auditees and management; partner with auditees to develop thorough root cause analyses and CAPA plans.

Inspection Readiness

Support preparation and coordination for regulatory agency inspections of Nurix and contract manufacturing partners, including pre-approval inspections (PAIs).
Assist with inspection logistics, document preparation, back-room operations, and response coordination during Health Authority GMP inspections.
Contribute to ongoing inspection readiness programs, including gap assessments, mock inspection activities, and training.

Qualifications

Bachelor’s degree in chemistry, pharmaceutical sciences, life sciences, or a related field.
7+ years of progressive Quality Assurance experience in clinical or commercial pharmaceutical or biopharmaceutical operations, with demonstrated hands-on responsibility for GMP quality systems
Strong working knowledge of GMP regulations and their practical application in CMC development and CDMO management (21 CFR Parts 210/211, ICH Q7, Q8, Q9, Q10, EudraLex - Volume 4 - Good Manufacturing Practice (GMP) guidelines).
Hands-on experience with deviation investigations, CAPA management, change control processes, and batch record review and approval.
Ability to travel to CDMO and laboratory sites domestically and internationally, as needed.
Experience supporting or conducting GMP audits of contract manufacturers and laboratory service providers; ability to write clear, comprehensive audit reports.
Familiarity with regulatory submission processes and experience reviewing or contributing to CMC sections of regulatory filings.
Proficiency with eQMS platforms, electronic document management systems, and Microsoft Office suite.
Strong attention to detail and organizational skills; demonstrated ability to manage multiple concurrent priorities and deliver against deadlines.
Excellent written and verbal communication skills; able to work effectively across functions and with external manufacturing partners.
Ability to travel to CDMO and laboratory sites domestically and internationally, as needed.

Salary Range: $137,859 - $155,758 plus bonus & equity.

Location: Brisbane, CA – Onsite

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May, 2026

Regulatory

Senior Manager, Regulatory Operations

Location

Brisbane, CA

Company:

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase (BTK), a B-cell signaling protein, and an inhibitor of Casitas B-lineage lymphoma proto-oncogene-B (CBL-B), an E3 ligase that regulates T cell activation. Nurix is also progressing multiple programs through partnership, including an IRAK4 degrader in Phase 1 in partnership with Gilead and a STAT6 degrader in IND enabling studies with Sanofi. Multiple additional wholly owned and partnered programs are at various stages of preclinical development.

Position:

Reporting to the Director, Regulatory Affairs Project Management and Operations, the Senior Manager, Regulatory Operations provides key support to the Nurix Regulatory Affairs department. This position has responsibility for entry-level coordination, review, assembly and archival of regulatory submissions in Veeva RIMS and documents for health authorities (US FDA and global equivalents). The Senior Manager, Regulatory Operations will provide support for multiple regulatory activities, studies, and programs. The individual will have responsibility to understand and implement regulatory guidance and help ensure regulatory compliance for assigned projects. The Senior Manager should have 5 years’ experience in Regulatory Affairs or Regulatory Operations. Working knowledge of at least one functional discipline (e.g. Regulatory, Clinical, Nonclinical, Clinical Pharmacology or Chemistry Manufacturing and Controls) and a general knowledge of clinical development preferred. The candidate should have a can-do attitude and experience working in Veeva RIMS. Also, the candidate should be eager to learn regulatory and clinical trial requirements, best practices, and provide support for Regulatory programs and leadership.

Responsibilities:

Under the strategic direction of the SVP of Regulatory Affairs and the Director of Regulatory Affairs PM and Operations, the candidate will support the planning, coordination, tracking and execution of submissions and responses to global regulatory authorities
Assist Regulatory team, project teams and Clinical Research Organization (CRO) counterparts in the implementation of regulatory plans, timely delivery, and submission of regulatory documentation
Preparation of Regulatory submission documentation (e.g Forms, Cover Letter) as requested
Support team with formatting, QC and publishing of submission documents and packages
Manage and support Veeva RIMS processes such as HAI, SCP and Archiving
Manage authoring and review workflow in Veeva RIMS according to defined timelines
Coordinate with regulatory colleagues and cross-functional departments to prepare, compile, review, and submit documents or information necessary to health authorities in accordance with regulations, guidelines or queries IN Veeva RIMS using SCP
Maintain archival copies of health authority submissions (e.g., IND, CTA, NDA, and MAA), correspondence and a record of health authority obligations, and commitments
Maintain current knowledge of applicable US and global regulations, guidance, and standards for drug development and product registration. Participate in Regulatory Intelligence activities to help inform team members of new applicable guidelines and conduct training sessions on new guidelines/regulations if necessary
Participate in kick-off and project-based meetings related to regulatory submissions, strategy, and comment resolution. Be a reliable resource for information following such meetings
Follow general instructions from Regulatory management or company leadership for assigned projects while independently planning daily work tasks to complete projects on time. Seek guidance on project/task priorities as needed
Communicate important project decisions or challenges to Regulatory leadership
Create or contribute to Standard Operating Procedures (SOP), checklists and training Materials for Regulatory department activities
Support contracts and Purchase order for the Regulatory Affairs department

Requirements:

Bachelor's Degree in Life Sciences or relevant field
Minimum of 5 years’ experience working in Regulatory Affairs or Regulatory Operations. Additional experience in the biotechnology or pharmaceutical industry preferred
Understanding of the drug development process
Proficient knowledge of Veeva RIMS SCP, workflows, archival, reporting…
Experienced publisher (DocuBridge, GlobalSubmit, VeevaVault Submission…)
Experience successfully supporting critical deliverables while maintaining agreed timelines
Demonstrated ability to work effectively with cross-functional teams or collaborative environments.
Basic knowledge of 21 CFR and FDA, ICH, GCP, GMP, eCTD, and global guidelines.
Previous experience with building electronic submissions in compliance with Health Authority requirements is a plus.
Previous experience with maintaining in-house repository for archiving regulatory submissions and Health Authority correspondence in 21 CFR Part 11 compliant system (e.g., Veeva) is a plus.
Able to take ownership of a given assignment, proactively consulting other project team members and other department representatives for information or guidance, as necessary.
Superior communication skills: oral, written, with proven negotiation skills, and strong time-management.
Excellent Computer Skills MS Word, Excel, Power Point, Smartsheet and document management software/system, templates.
Ability to work on multiple tasks and prioritize tasks to meet company objectives. Strong attention to detail and time management skills are essential.
Nurix is located in Brisbane, CA - this is an onsite position.

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view.

Salary Range: 140K - 162K plus bonus & equity.

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May, 2026

CMC

Senior Scientist, Analytical Development and Quality Control (Drug Product)

Location

Brisbane, CA

Company

Position

Nurix Therapeutics seeks an experienced Senior Scientist to join the Analytical Development and Quality Control group. The Senior Scientist will be responsible for drug product (DP) analytical development, including method development, oversight of method validation at CDMOs, and lifecycle management in support of Nurix’s oncology and inflammation & immunology (I&I) programs.

This position provides technical oversight of analytical method development, validation, and testing conducted at external CDMO/CRO partners. The Senior Scientist will author analytical development reports and IND/IMPD/NDA sections and support late-phase tech transfer and validation activities. This role will also contribute to analytical development for new drug products and dosage forms. The Senior Scientist will work closely in cross-functional teams to ensure alignment and integration of analytical and QC strategies across development stages.

The ideal candidate will have expertise in chromatographic and dissolution method development, stability studies, and phase-appropriate validation and control strategies, along with demonstrated experience supporting late-phase development and regulatory submissions.

This position is onsite at Nurix headquarters in Brisbane, CA.

Key responsibilities include:

Lead analytical method development validation and lifecycle management for drug product formulations, including amorphous solid dispersions (ASDs) and lipid-based systems
Support PPQ activities, commercialization, commercial QC, and lifecycle management for drug product analytical methods and control strategies
Design and oversee DP development, registration batch, and commercial stability programs, including protocol development and trend analysis
Author and review DP analytical development reports to support regulatory submissions, and marketing authorization
Oversee and support analytical activities, including method development, validation, and QC testing conducted at CDMOs and contract testing laboratories (CTLs)
Contribute to investigations (e.g., OOS, OOE, OOT), root cause analysis and CAPAs
Perform critical review of analytical data, protocols, reports, specifications, and related documentation
Trend stability data and support establishment of retest periods and shelf life using statistical methods
Collaborate in the development and justification of material control strategies and specifications
Author technical documents, including analytical development reports, specifications, validation and stability protocols/reports, certificates of analysis (COAs), and storage statements
Author and review analytical sections of regulatory submissions (e.g., IND/IMPD/NDA)
Collaboratively author responses to health authority requests for information
Act as a key contributor to multidisciplinary teams, including Chemical Development, Pharmaceutical Development, Regulatory, Quality, Preclinical, Supply Chain, Medicinal Chemistry, and DMPK
Maintain and organize analytical documentation and data to ensure traceability, data integrity, and inspection readiness
Follow cGMP requirements and internal SOPs
Travel up to 5%, as required

Qualifications

Advanced degree in a relevant discipline (Chemistry, Pharmaceutics, or related field)
Senior Scientist: BS/MS degree with 14+ years or PhD with 8+ years of industrial CMC experience
Strong experience in drug product analytical development and validation
Experience with analytical development for amorphous solid dispersions (ASDs) and/or lipid-based formulations
Experience in CDMO and contract testing lab oversight
Experience supporting regulatory submissions (e.g., IND, IMPD, NDA) and global regulatory filings
Fluency with ICH guidelines, cGMPs, and pharmacopeial chapters
Ability to work effectively in a cross-functional environment
Strong technical writing skills (e.g., development reports, regulatory documents)
Ability to manage multiple priorities in a fast-paced environment
Excellent communication and cross-functional collaboration skills

Salary Range:

Senior Scientist -- $161,110 – 185, 618

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Apply for Job

May, 2026

Medicinal Chemistry

Senior Scientist - Medicinal Chemistry

Location

Houston, TX

Senior Scientist - Medicinal Chemistry

Location: Houston, TX - Onsite

Position

Qualifications

Ph.D. in synthetic organic chemistry with 8 – 10+ years pharmaceutical medicinal chemistry industrial experience.
Track record of delivering advanced leads/ development candidates.
Excellent knowledge of medicinal chemistry principles with a solid understanding of the biology and pharmacology of programs, ADME concepts, and series SAR. Able to effectively integrate this knowledge to direct drug discovery programs to phase transitions or series go/no go decisions.
Strong working knowledge of protein-ligand interactions, conformational and structural analysis. Experienced in partnering closely with computational chemists in the use of computational tools, models and visualization applications.
Expert in organic synthesis, knowledgeable of the current literature, with strong synthetic problem-solving skills.
Proven leadership capability in a cross-functional team setting, either as project team leader or co-lead.
Ability to make inventive contributions towards new chemical target structures or templates for programs and evaluate early screening or literature hits.
Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings and using this information to guide program strategy.
Excellent communication skills and the ability to present rationale, key data, issues and accomplishments to the company.
Experience supervising direct reports to a high level of productivity and mentoring for career development is a plus.
Ability to manage priorities and advance multiple projects simultaneously.
Strong evidence of conceptual thinking and active follow through, recognized by establishing new projects or new directions within projects, new strategies and/or enabling technologies for drug discovery.

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative
Ability to function in a dynamic environment
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view

Salary Range:

Senior Scientist: $138,309 – $157,498 + Bonus and Equity

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May, 2026

Discovery Chemistry

SRA DNA Encoded Library Technology - (Brisbane, CA)

Location

Brisbane, CA

Company

Research Associate III/Scientist I, DNA Encoded Library Technology – Nurix Brisbane

Position

We are seeking a talented and motivated chemist to join our Discovery Chemistry team and contribute to the design and synthesis of DNA-encoded libraries (DELs). This hands-on position offers the opportunity to shape Nurix’s DEL-based lead discovery platform, working at the interface of chemistry, biology, and automation. Key responsibilities:

Design and validate novel DEL library builds.
Develop and bring in new DNA-compatible chemical transformations that can widen the DEL chemical space.
Construct DEL libraries to support the in-house library production efforts.
Work with external partners to support our DEL synthesis and hit follow up strategies.
Engage in cross-functional team discussions that support DEL screening, data analysis, machine learning and hit-optimization.
Contribute to platform automation and technology development efforts.
Present results, document workflows, and contribute to scientific and strategic planning within the Discovery Chemistry organization.

Education and Experience

B.S. or higher in Chemistry, Biochemistry, or Medicinal Chemistry. 2–5 years of industrial experience (title determined by experience).
Strong background in synthetic organic chemistry.
Hands-on laboratory experience synthesizing DNA encoded libraries.
Familiar with the overall DNA-Encoded Library Technology workflow operations.
Experience analyzing and purifying DNA-conjugates using common analytical tools (LCMS/HPLC).

Added Qualifications

Experience working in the drug discovery field – drug design, synthesis, and SAR based hit-to-lead optimization.
Experience working with high-throughput analytical and purification systems relevant to DEL-applications.
Experience working with molecular biology tools (PCR, qPCR, Western Blot).

Fit with Nurix Culture and Values

Collaborative and team-oriented, eager to share expertise and learn from others.
Solution-driven with a hands-on and resourceful approach.
Adaptable and comfortable in a fast-paced, interdisciplinary environment.
Committed to scientific excellence and the shared goals of the team.

Location: Brisbane, CA

Salary Range:

RA III: $101,690 – 116,226
SRA: $118,893 – 139,310
Scientist I: $129,382 –146,679

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

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May, 2026

Regulatory

Sr. Director, Head of Regulatory & Medical Writing

Location

Brisbane, California, United States

Job Summary:

As a key member of the cross-functional Development Team responsible for providing regulatory writing expertise and leadership to formulate the writing strategy for key regulatory documents for submission. The Sr. Director, Head of Regulatory & Medical Writing will be responsible for providing guidance to the medical and or regulatory writing group (contractors and internal writers) assigned to deliverables and ensuring appropriate work allocation and document preparation.; will also provide review and substantive editing of documents to ensure delivery of high-quality documents. This individual will work effectively with many other functional groups, including with Clinical Scientist(s), Medical Monitors, Regulatory and other functions as applicable, and collaborate with clinical medical writing as applicable to ensure scientific excellence in the execution of clinical trials. The Head of Regulatory Writing will build a medical writing group internally when appropriate.

Reporting to the SVP, Head of Regulatory Affairs, this role will be responsible for the regulatory writing & medical writing deliverables of assigned project(s), in accordance with the agreed timelines and quality standards.

Responsibilities:

Ensure appropriate allocation of internal and external resources needed for all regulatory writing deliverables.
Hire and manage medical writers internally and manage external medical writing contractors.
Forecasting and maintaining budget for the regulatory writing team.
Assess efficiencies, help identify areas of improvement and initiate improvement processes.
Coordinate, author and edit documents used to support clinical trial conduct and reporting including but not limited to:

Clinical study protocols and clinical protocol amendments (in partnership with Clinical Science/Clinical Development)
Clinical study reports
Investigator’s brochures and annual updates
IND submissions and annual reports
Lay-person summary
Integrated summary reports
Clinical, Nonclinical and Multidisciplinary Information Amendments
NDA, BLA, MAA, (e)CTD submissions
Risk Management Plans
Health Authority responses
Briefing Documents, ODDs, BTDs/PRIME, FTD etc

Participate in relevant subteam(s) and ensure effective planning and management of timelines for all components of assigned documents across all projects.
Participate in document strategy sessions, including messaging, document flow, logic, and consistency for assigned projects.
Support and develop deliverables required for global transparency and disclosure requirements (e.g., plain language lay summary, applicable redactions to regulatory documents subject to EU posting regulations and results for EU CTR).Partner with Biometrics in developing standard TFLs and in text tables for deliverables as applicable
Maintain and support developing and reviewing standard processes and templates.
Review and edit documents as required.
Work effectively and lead in cross-functional working groups.

Qualifications:

Candidates must have a BS with 15+ years, or MS or other advanced science degree (e.g.: RN, NP, MSN, PharmD, PhD, MD) with 10+ years of experience in oncology clinical research experience as a clinical or regulatory medical writer within the pharmaceutical/biotech industry.
Prior experience leading a regulatory writing group
Experience writing/leading the writing of critical clinical documents in major regulatory filings (NDA, BLA, MAA).
Proficiency in the use and understanding of computer software e.g. word processing, graphics, reference manager, document management systems.
Familiarity with all phases of drug development processes (discovery to market), clinical study protocol design, CTA/IND submissions, investigator’s brochures and clinical study data collection and results reporting.
Advanced knowledge of routine document content preparation, including the use of style guides, medical dictionaries, and regulatory guidance documents and templates.
Experience writing, at a minimum, protocols (Phase 1-3, in oncology), investigator’s brochures, clinical study reports, Health Authority briefing packages, and Health Authority responses. Experience with Pediatric Investigational Plans (PIPs) is preferred.
Advanced understanding/knowledge of regulatory requirements and drug development processes, Good Clinical Practice (GCP), regulatory requirements and guidelines associated with regulatory documents (e.g., protocols, investigator brochures, and clinical study reports).
Ability to interpret and summarize complex tabular and graphical data presentations.
Strong organization, documentation and communication skills with an ability to multitask.
Adaptable / flexible, willing and able to adjust to multiple demands and shifting priorities; ability to meet day-to-day challenges with confidence and professionalism.
Detailed knowledge of GCP, ICH Guidelines and current US FDA regulations.

Salary Range: $254,127 - $289,388 plus bonus and equity.

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May, 2026

Commercial Strategy

Vice President, Head of Alliance Management and Program Management ~ Onsite

Location

Brisbane, CA

Vice President, Head of Alliance Management and Program Management

Nurix Therapeutics is seeking an accomplished and strategic Vice President, Head of Alliance Management and Program Management to lead both our external collaborations with pharmaceutical partners and the internal coordination of our late stage hematology/oncology program.

In addition to leading a high-impact alliance, this role will drive internal program management discipline, ensuring organizational awareness of program priorities, clear accountability for key workstreams, aligned roadmaps across functions, and transparent communication of status and risks to senior leadership. The ideal candidate is a dynamic leader who thrives in complexity, bridges science and business, and delivers executional excellence across partnerships and programs.

Key Responsibilities

Alliance Leadership and Strategy
Serve as the primary point of contact between Nurix Therapeutics and its pharmaceutical partners, fostering a transparent, collaborative, and goal-oriented relationship.
Ensure strong alignment for strategic objectives, development plans, and commercialization priorities across organizations.
Lead from the center — influence and align cross-functional teams, ensuring program success across all phases of execution.

Program Management and Execution

Working with the asset team and program management drive organization-wide alignment on program priorities, clarifying critical milestones and dependencies.
Ensure clear accountability is assigned to functional teams for program deliverables and that project management support enables planning and tracking of those deliverables.
Provide ongoing program updates to the asset team, functional leaders, and executive management.
Proactively identify risks, escalate issues where needed, and facilitate timely resolution to keep programs on track.

Governance and Committee Management

Design and manage the operational rhythm of joint governance meetings.
Ensure Nurix’s internal alignment prior to each meeting — clearly defining company objectives, decision positions, and desired outcomes.
Oversee preparation of agendas, materials, meeting minutes, and action trackers that accurately capture decisions, positions, and next steps for both parties.

Execution and Delivery

Drive accountability within Nurix for all alliance- and program-related action items, ensuring deliverables are completed on time and to standard.
Monitor and track progress against contractual and programmatic milestones, proactively identifying risks and driving timely resolution.
Partner closely with senior executives, program leaders, and functional heads (Clinical, Regulatory, CMC, Commercial, Legal, Finance) to ensure cross-functional alignment and execution excellence.

Issue Resolution and Communication

Act as the escalation point for alliance- or program-related issues; triage and navigate complex challenges toward practical solutions that preserve collaboration and forward momentum.
Communicate effectively and diplomatically at all levels — internally and externally.
Represent Nurix and the alliance in internal forums as the voice of the program and the partnerships.

Qualifications

Advanced degree (PhD, MBA, PharmD, or equivalent) preferred; strong scientific literacy in drug development required.
15+ years of biotechnology or pharmaceutical industry experience, including at least 5 years in alliance management, program management, or operations leadership overseeing major partnerships or cross-functional development programs.
Proven ability to lead across organizational lines and influence without direct authority in complex, matrixed environments.
Strong strategic and operational capability — able to zoom between big-picture program strategy and hands-on execution.
Deep understanding of program governance, milestone planning, and risk management in clinical-stage drug development.
Exceptional written and verbal communication skills; highly skilled at synthesizing complex issues and driving alignment.
Meticulous attention to detail coupled with the ability to manage multiple high-priority initiatives simultaneously.
Demonstrated experience with partnerships and programs spanning clinical development through commercialization is strongly preferred.
This is an onsite position located in Brisbane, CA.

Personal Attributes

Strategic thinker who executes decisively and pragmatically.
Diplomatic and solutions-oriented with high emotional intelligence.
Relentlessly organized and accountable, with the drive to anticipate and resolve issues before they escalate.
Collaborative leader who builds strong relationships across functions and partners.
Passionate about advancing innovative science to patients in need.

Salary Range: 314K– 360K plus bonus & equity.

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