Administrative Assistant, Clinical Development 

Be the calm, capable center of gravity for a fast-moving Clinical Development team — owning complex calendars, high-stakes logistics, and cross-functional projects for leaders who rely on you to make the day run smoothly. This role puts you at the heart of the action, trusted with real responsibility from day one.

Position Description

The Opportunity

• Partner with executives, stakeholders, and teams at every level — from the C-suite to external partners — building relationships built on trust and reliability.
• Own complex, ever-shifting calendars, and confidently reprioritize on the fly to keep the day running smoothly.
• Jump into cross-functional projects and special assignments, bringing organization and follow-through wherever they're needed.
• Plan seamless domestic and international travel, crafting detailed itineraries and adapting gracefully when plans change.
• Coordinate team meetings, events, and offsites that run smoothly from start to finish.
• Manage expense reports, purchase orders, and administrative workflows using Microsoft 365, Copilot, SharePoint, and other tools.
• Step in to support fellow EAs as needed, contributing to a collaborative team culture.

What You’ll Bring

• 8+ years supporting senior executives or C-suite leaders.
• Strong command of Microsoft Office (Outlook, Word, Excel, PowerPoint) and comfort with video conferencing and collaboration tools.
• A knack for juggling priorities, meeting deadlines, and staying organized under pressure.
• Warm, polished communication — you know how to write and speak with clarity and professionalism.
• An instinct for anticipating needs before they arise, paired with meticulous attention to detail.
• A service-minded, team-first attitude, balanced with the confidence to work independently.
• Sound judgment and discretion when handling sensitive or confidential information.
• Experience in biotech, pharma, or life sciences is a plus.

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA (5 days/week)

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Administrative Assistant, CMC

Be the calm, capable center of gravity for a fast-moving Technical Operations team — owning complex calendars, high-stakes logistics, and cross-functional projects for leaders who rely on you to make the day run smoothly. This role puts you at the heart of the action, trusted with real responsibility from day one.

Position Description

The Opportunity

• Partner with executives, stakeholders, and teams at every level — from the C-suite to external partners — building relationships built on trust and reliability.
• Own complex, ever-shifting calendars, and confidently reprioritize on the fly to keep the day running smoothly.
• Jump into cross-functional projects and special assignments, bringing organization and follow-through wherever they're needed.
• Plan seamless domestic and international travel, crafting detailed itineraries and adapting gracefully when plans change.
• Coordinate team meetings, events, and offsites that run smoothly from start to finish.
• Manage expense reports, purchase orders, and administrative workflows using Microsoft 365, Copilot, SharePoint, and other tools.
• Step in to support fellow EAs as needed, contributing to a collaborative team culture.

What You’ll Bring

• 8+ years supporting senior executives or C-suite leaders.
• Strong command of Microsoft Office (Outlook, Word, Excel, PowerPoint) and comfort with video conferencing and collaboration tools.
• A knack for juggling priorities, meeting deadlines, and staying organized under pressure.
• Warm, polished communication — you know how to write and speak with clarity and professionalism.
• An instinct for anticipating needs before they arise, paired with meticulous attention to detail.
• A service-minded, team-first attitude, balanced with the confidence to work independently.
• Sound judgment and discretion when handling sensitive or confidential information.
• Experience in biotech, pharma, or life sciences is a plus.

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA (5 days/week)

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Associate Director, Chemical Engineering

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position Description

Nurix is seeking an experienced, independent, and highly motivated individual who will be accountable for end‑to‑end chemical engineering support of bexobrutideg (NX-5948) drug substance (DS) from late‑stage development through commercial launch, including oversight of external manufacturing sites. The Associate Director, Chemical Engineering will work closely with the CMC team and colleagues in cross-functional departments to provide scientific, technical, and hands-on leadership and oversight of facility and equipment operations at Contract Development Manufacturing Organizations (CDMOs) to support bexobrutideg drug substance manufacturing process optimization and scale-up. The position will report to the Director, Chemical Development.

Responsibilities will include but are not limited to:

• Provide engineering leadership to design, develop and optimize scalable routes for small-molecule DS manufacturing, including demonstrated knowledge in unit operation design, process modeling, process equipment selection and scale-up methodologies.
• Review equipment configurations, qualification packages, and maintenance records at CDMOs to ensure equipment trains are properly qualified, maintained and operating at optimal performance to support Nurix manufacturing operations.
• Oversee equipment engineering and scale-up operations at DS CDMOs, including hands‑on process troubleshooting during engineering, clinical, registration and PPQ batches.
• Lead technology transfer to CDMOs including scale-up and demonstration of new chemical processes in development and commercial equipment.
• Coordinate with CDMOs and Nurix Quality Assurance, and Global Supply Chain functions to ensure timely manufacture and release of DS lots.
• Partner within Nurix CMC to drive process understanding (critical process parameters, critical quality attributes, control strategy) using engineering principles, DoE and QbD concepts.
• Review and approve Master Batch Records, campaign reports, deviation investigations and change controls for drug substance operations.
• Ensure manufacturing operations adhere to company quality, safety and regulatory standards (FDA, EMA, ICH, cGMP).
• Provide regular Person-In-Plant support for DS manufacturing and ongoing performance monitoring of key facility and operational KPIs across manufacturing sites, including schedule adherence, batch performance, deviation trends, and inspection readiness.
• Author and review CMC sections of regulatory filings including INDs/IMPD, and NDA/MAA, including responses to Health Authority queries.
• Define and drive the long‑term engineering strategy for bexobrutideg DS, including process robustness, lifecycle management, and cost‑of‑goods optimization.
• Represent Chemical Engineering on CMC and cross‑functional program teams, providing input to development strategy, risk assessments, and timelines.
• Manage and provide technical mentorship of scientists and engineers.

Required Qualifications

• Ph.D. in chemical engineering, or related field with at least 5 years (M.S. with 10 years or B.S. with 15 years) of industrial, late-phase, small-molecule drug substance development experience
• Extensive knowledge and experience in GMP drug substance manufacturing, characterization, process development, equipment evaluation/selection, scale up and process validation.
• Knowledge of solid‑state properties, polymorphism, and crystallization principles relevant to small‑molecule drug substance.
• Extensive third-party drug substance CDMO management experience including tech transfer activities, QbD and DoE studies, clinical supply production, registration batch production and commercial launch activities.
• In-depth knowledge of relevant cGMP, ICH, FDA and EMA guidelines.
• Proven track record of effective internal and external collaboration.
• Excellent oral and written communication skills, interpersonal skills and problem-solving abilities.
• Ability to multi-task, manage conflict and work in a fast-paced environment.
• Ability to travel up to 25% of their time.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:   $189,800 - $216,700

Location:         Brisbane, CA - Onsite 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

The Associate Director, Computer Systems Assurance (CSA) is an important technical and operational leader within the Nurix Quality Systems organization, responsible for owning and advancing Nurix's computer systems assurance program. As a virtual drug developer, Nurix operates through a lean internal infrastructure and relies on a curated ecosystem of Software-as-a-Service (SaaS) and cloud-hosted platforms to support GxP-regulated activities across clinical development, quality operations, manufacturing oversight, and regulatory submissions. This role will serve as the primary subject matter expert and program owner for all CSA and computerized system validation (CSV) activities at Nurix.

Reporting to the Senior Director, Quality Systems, this individual will establish and maintain Nurix's risk-based CSA framework aligned with current regulatory expectations, including the FDA's 2022 guidance on computer software assurance, GAMP 5 (2nd edition), and applicable 21 CFR Part 11 and Annex 11 requirements. The role requires an individual who combines deep technical knowledge of GxP computerized systems with practical experience in SaaS and cloud-based platform qualification, and who can translate regulatory requirements into pragmatic, fit-for-purpose validation approaches that support a modern, agile biotech environment. This is a high-impact, program-ownership role requiring both strategic vision and hands-on execution. The successful candidate will work closely with Quality, IT, Regulatory Affairs, CMC, Clinical Operations, and external vendors to ensure that all GxP-critical systems are appropriately assessed, validated, and maintained in a compliant state. The individual will champion a risk-based, science-driven approach to CSA across the organization.

Responsibilities

CSA Program Ownership and Strategy

• Own and maintain Nurix's Computer Systems Assurance policy framework, SOPs, and risk-based validation strategy, aligned with FDA CSA guidance (2022), GAMP 5 (2nd edition), 21 CFR Part 11, EU Annex 11, and applicable ICH guidelines.
• Define and implement a fit-for-purpose, risk-tiered approach to system qualification for SaaS and cloud-hosted GxP applications, recognizing the vendor-managed nature of modern software platforms.
• Maintain the GxP system inventory; conduct and document periodic system risk assessments to classify systems and determine appropriate validation scope and rigor.
• Establish and maintain processes for vendor assessment, including review of vendor SOC 2 reports, quality agreements, and audit strategies appropriate for SaaS providers.
• Drive continuous improvement of the CSA program through benchmarking, regulatory intelligence, and adoption of industry best practices.

System Validation and Qualification Execution

• Lead and execute validation activities for GxP SaaS platforms including, but not limited to, eQMS (e.g., Veeva Vault), electronic document management, clinical data management, regulatory information management, and laboratory information systems.
• Author and review validation documentation including Validation Master Plans (VMPs), User Requirements Specifications (URS), Risk Assessments, Vendor Assessments, Validation Protocols (IQ/OQ/PQ), Traceability Matrices, and Validation Summary Reports.
• Manage validation activities associated with system implementations, major configuration changes, upgrades, and periodic re-validation reviews, applying critical thinking to scope validation effort proportionate to system risk and change impact.
• Coordinate validation testing activities with cross-functional stakeholders; ensure test scripts are appropriately designed to demonstrate fitness for intended use.
• Review and approve validation deliverables prepared by internal teams, vendors, or external validation consultants.

21 CFR Part 11 and Data Integrity

• Serve as the internal subject matter expert for 21 CFR Part 11 and EU Annex 11 requirements; assess systems for compliance and provide guidance to cross-functional partners.
• Partner with IT and system owners to ensure electronic records and electronic signature controls are properly implemented and documented in all GxP systems.
• Support data integrity assessments and remediation initiatives; apply ALCOA+ principles to guide compliant system design and use.

Change Management and Periodic Review

• Manage the computerized systems change control process; evaluate proposed changes for validation impact and establish appropriate assessment, testing, and documentation requirements prior to implementation.
• Own and execute the periodic review program for validated GxP systems; assess continued fitness for intended use and compliance with current regulatory expectations.
• Maintain validation status documentation and ensure validation files are audit-ready at all times.

Inspection Readiness and Regulatory Support

• Support preparation for regulatory agency inspections; serve as the CSA subject matter expert during FDA, EMA, and other Health Authority inspections and ensure validation documentation is complete, current, and accessible.
• Contribute to relevant sections of regulatory submissions and respond to agency questions related to computerized systems and data integrity.
• Monitor evolving regulatory guidance and industry standards related to CSA, CSV, data integrity, and cloud-based systems; proactively adapt Nurix's program to reflect current expectations.

Cross-Functional Partnership and Training

• Serve as the primary point of contact and internal consultant for all GxP system owners across Quality, IT, Regulatory Affairs, CMC, and Clinical Operations.
• Develop and deliver CSA training for system owners, end users, and other stakeholders to build organizational capability and awareness.
• Partner with IT and vendor project teams to embed validation requirements early in system selection and implementation processes.

Required Qualifications

• Bachelor's degree in computer science, information systems, life sciences, pharmaceutical sciences, or a related field.
• 7–10+ years of progressive experience in computer systems validation and/or computer systems assurance in a GxP-regulated pharmaceutical, biopharmaceutical, or biotechnology environment.
• Demonstrated expertise in current regulatory requirements for computerized systems, including FDA 21 CFR Part 11, EU Annex 11, FDA CSA guidance (2022), and GAMP 5 (2nd edition).
• Hands-on experience validating SaaS and cloud-hosted GxP platforms; understanding of vendor-managed environments and shared responsibility models.
• Proficiency authoring and reviewing CSA/CSV deliverables: VMPs, URSs, Risk Assessments, IQ/OQ/PQ protocols, traceability matrices, and validation summary reports.
• Strong working knowledge of data integrity principles (ALCOA+) and their application to electronic records management and GxP system design.
• Experience managing system change control and periodic review programs for validated GxP systems.
• Ability to operate as both program owner and individual contributor in a lean, virtual organizational model; comfortable managing validation activities without a large internal support team.
• Excellent written and verbal communication skills; able to translate complex technical and regulatory requirements into practical guidance for diverse stakeholders.
• Strong organizational skills and attention to detail; demonstrated ability to manage multiple concurrent programs and priorities in a fast-paced environment.

Preferred Qualifications

• Experience with eQMS validation (e.g., Veeva Vault) and familiarity with Veeva's Qualified System approach and available supplier documentation.
• Familiarity with clinical development platforms such as electronic data capture (EDC), regulatory information management (RIM), or clinical trial management systems (CTMS) in a validated context.
• Experience supporting FDA, EMA, or equivalent Health Authority inspections as a CSA subject matter expert.
• Exposure to laboratory informatics systems (LIMS, ELN) and their GxP qualification requirements.
• Experience in a virtual or lean biotech environment managing validation activities through external vendors and consultants.
• Working knowledge of cybersecurity frameworks and their intersection with GxP system compliance (e.g., NIST, SOC 2).
• Advanced degree in a relevant scientific, engineering, or regulatory discipline.

Fit with Nurix Culture and Values

• You know the regulations deeply and apply them with judgment, designing validation approaches that are rigorous where it matters and efficient everywhere else. You bring expertise with pragmatism —
• You are comfortable as the go-to expert, driving the CSA program forward proactively rather than waiting for direction, and you take accountability for outcomes. You own the program —
• You build trusted relationships across Quality, IT, and the business, and you understand that a well-designed, compliant systems environment is an enabler of Nurix's mission to develop important medicines for patients. You partner with purpose —

Location: Brisbane, CA - Onsite 

Salary Ranges:  190K - 217K                                     

Associate Director, Regulatory & Medical Writing

Help shape how Nurix communicates its science to health authorities and the world. As Associate Director, Regulatory & Medical Writing, you’ll independently lead the authoring, review, and approval of critical regulatory documents across our pipeline — from clinical protocols to health authority submissions. It’s a chance to bring clarity and strategic messaging to the documents that move our therapies through development and toward patients.

Position Description

The Opportunity

• Author and manage authoring of Regulatory & Medical Writing documents together with cross-functional collaborators; ensure content consistency within a document and across documents for a particular asset, including the development of strategic messaging and data presentation in accordance with Nurix standards and health authority requirements, for documents such as:
• Clinical study protocols and clinical protocol amendments
• Clinical study reports
• Investigator’s brochures and annual updates
• IND submissions and annual reports
• Lay-person summaries
• Integrated summary reports
• Clinical, nonclinical, and multidisciplinary information amendments
• NDA, BLA, MAA, and (e)CTD submissions
• Risk Management Plans
• Health authority responses
• Briefing documents, ODDs, BTDs/PRIME, FTD, and similar designations
• Review, edit, and QC documents developed by other authors or medical writers
• Manage the author, review, and approval process for multiple deliverables at a given time; ensure quality and timely completion, with attention to consistency of content, messaging, format, and style
• Lead Regulatory & Medical Writing activities for assigned programs, including partnering with the Head of Regulatory & Medical Writing on resource planning, document timelines, issue resolution, and process improvement initiatives
• Represent Regulatory & Medical Writing on interdisciplinary teams for assigned programs/projects, providing strategic input and status updates
• Manage external Regulatory & Medical Writing resources for assigned programs/projects, as needed

What You’ll Bring

• 6 to 8+ years of Regulatory and/or Medical Writing, or other relevant pharmaceutical/biotechnology industry experience in the Clinical Development phase, authoring and overseeing documents submitted to health authorities
• Experience identifying and interpreting information/data for inclusion in documents such as clinical study protocols, Investigator’s Brochures, clinical study reports, Lay Summaries, and ICFs
• Involvement with ex-US submissions for clinical trial applications and marketing applications is a plus
• Ability to work effectively and lead in cross-functional working groups
• Excellent communication skills, organizational skills, and attention to detail
• Adaptable and flexible, willing and able to adjust to multiple demands and shifting priorities; ability to meet day-to-day challenges with confidence and professionalism
• Knowledge of health authority requirements, ICH guidelines, and submission-ready standards relevant to document authoring, including eCTD and submission lifecycle management
• Proficiency in project planning tools such as MS Project or Smartsheet, collaborative authoring or document review tools, and Veeva RIM Suite
• Expertise in Microsoft Word (including use of customized toolbars/templates) and document management systems

Salary Range:  $216,400 - $234,800

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

 Clinical Trial Manager (CTM)

You’ll take full ownership of your assigned trial(s) — from protocol development to close-out — with the autonomy to make daily calls and the support of an experienced team when it counts.

Position Description

This individual is responsible for the management of assigned clinical trial(s), leading the study team, vendors, clinical monitors, and clinical sites throughout the trial lifecycle.

The Opportunity

• Own all operational aspects of your assigned clinical trial(s)
• Manage day-to-day CRO/vendor relationships to keep deliverables on budget, timeline, and protocol
• Build strong working relationships with site investigators and study coordinators
• Track trial progress and keep stakeholders updated on status
• Monitor enrollment and address recruitment challenges as they arise
• Manage study budget, forecasting, accruals, and vendor payments for your trial(s)
• Partner with Data Management on CRF content, completion guidelines, and data deliverables
• Draft and coordinate review of protocols, informed consents, CRFs, monitoring plans, and study reports
• Prepare for and support regulatory agency audits and inspections
• Flag risks early and recommend solutions before they become problems
• Represent Clinical Operations at project team meetings

What You’ll Bring

• S./B.A. in biological sciences with 5+ years of relevant industry experience
• Ability to travel as required for the program (25%)
• Working knowledge of FDA, EMA, ICH, and GCP regulations and guidelines
• Experience managing trials independently from start-up through close-out
• Comfortable leading day-to-day CRO/vendor relationships
• Strong analytical and problem-solving skills
• Clear, confident communicator who can create direction for a study team
• Ability to manage time demands, incomplete information, and shifting priorities
• Highly organized, able to multi-task and prioritize independently
• Thrives in a fast-paced, small-company environment

Salary Range:  $157,700 - $168,200 annually

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Director, Drug Safety

Join Nurix’s pharmacovigilance team to help ensure patient safety across our clinical pipeline of targeted protein degradation therapies. As Director, Drug Safety, you’ll lead aggregate safety analysis, benefit–risk assessments, and safety strategy for assigned programs — shaping how we evaluate risk and bring new medicines safely to patients. It’s a chance to influence critical safety decisions at the intersection of clinical medicine, data, and drug development.

The Opportunity

Medical Safety Leadership

• Serve as the medical safety lead for assigned products, providing clinical and pharmacovigilance expertise to safety strategy and activities
• Lead aggregate safety data analysis for signal detection, signal evaluation, and risk characterization
• Conduct medical review and interpretation of safety data, contributing to benefit–risk assessments
• Monitor emerging safety signals and proactively address potential safety risks through appropriate internal and external communication

Regulatory and Safety Documentation

• Oversee medical review of Individual Case Safety Reports (ICSRs)
• Author and review regulatory safety documents, including Development Safety Update Reports (DSURs) and safety sections of INDs and regulatory briefing books
• Contribute to safety responses to regulatory authorities and participate in regulatory interactions
• Provide clinical leadership during inspections and audits related to safety and risk management

Clinical Development Support

• Provide clinical input into safety aspects of clinical trial protocols, informed consent forms, and investigator brochures
• Collaborate with clinical development, regulatory affairs, medical affairs, and other stakeholders to ensure a consistent global safety strategy

Governance and Cross-Functional Collaboration

• Serve on safety governance committees, supporting strategic decision-making for risk mitigation and benefit–risk evaluation

What You’ll Bring

• Advanced clinical or scientific degree, such as MD, DO, PharmD, or equivalent relevant training and experience
• Clinical experience preferred
• 5–10 years of experience in pharmacovigilance/drug safety within the pharmaceutical or biotechnology industry
• Experience supporting early clinical development and small biotechnology companies
• Demonstrated expertise in aggregate safety analysis and benefit–risk evaluation
• Strong knowledge of global pharmacovigilance regulations and guidance (ICH, FDA, EMA, MHRA)
• Experience interacting with global health authorities on safety matters
• Familiarity with signal detection and safety surveillance tools and databases
• Strong communication, collaboration, and cross-functional leadership skills
• Ability to interpret complex clinical and safety data and translate insights into regulatory and business strategy
• Ability to work effectively and collaboratively in a fast-paced, growing organization across functional boundaries

Salary Range:  Non-MD $247,300 - $280,400 |  MD  $295,000 - $317,100

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

 Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

About the role

This is the operating leader for IT infrastructure and operations at Nurix, reporting to the SVP of Information Technology. You will own the function end to end: infrastructure, cybersecurity operations, end user services, and IT service management as one integrated scope. You partner with a fractional CISO on security strategy and policy while owning the operational execution. You work closely with the IT business partner leaders who own the application portfolios and partner directly with R&D and the broader scientific organization on their infrastructure needs.

You lead a team that spans enterprise architecture, system administration, and cybersecurity operations, with the service desk delivered through a mix of staff and managed service providers. You will manage both individual contributors and managers from day one. You set the standards and delegate delivery across this hybrid team of internal staff and managed service providers, empowering the people below you rather than running their queues, to support a fast-moving enterprise.

What you'll do

In your first year you will:

• Consolidate the managed service provider portfolio across infrastructure, security, and the help desk into a smaller, more accountable set of partners.
• Build a cybersecurity operations function from current contractor and MDR coverage.
• Establish a governance model with research and scientific computing, and bring research infrastructure into IT alignment. Working with the enterprise architect, inventory and remediate AWS systems: ParallelCluster and other HPC, container platforms (EKS, ECS), SageMaker, and identity bridges.
• Own a formal identity and access management program, including clean handoffs to IT operations and the business partner teams.
• Refresh the service experience end to end and raise vendor management discipline as scope grows.

Requirements:

• 12+ years of progressive technology services leadership, including 5+ years at the Director or Senior Director level.
• Direct experience leading multi-function technology services (infrastructure, cyber operations, and ITSM) as one integrated scope rather than separate towers.
• Comfort partnering with a CISO or fractional CISO on policy while owning operational execution. We are looking for an operator who builds security in partnership, not someone who pushes controls through operations.
• Deep experience across AWS plus the Microsoft Entra and Microsoft 365 stack.
• Familiarity with the infrastructure behind scientific and ML computing, AWS ParallelCluster and HPC, SageMaker, EKS and ECS, and DevOps and infrastructure-as-code practices, at a level sufficient to set standards and partner credibly with the scientific organization.
• A measurable track record managing a managed service provider portfolio, including real consolidation or vendor transitions with accountability for outcomes.
• Experience building out infrastructure in fast-moving, resource-constrained environments.
• Experience in a regulated industry (biotech, pharma, medical device, healthcare, financial services, or comparable).
• Bachelor's degree or equivalent practical experience.

Nice to have

• Biotech or pharmaceutical industry experience.
• Support for an FDA Pre-Approval Inspection or BIMO inspection in an IT or security capacity.
• Experience standing up a security operations function from contractor or MSP coverage.
• Partnership with a separate scientific computing organization (informatics, bioinformatics, cheminformatics, machine learning).
• Hands-on with an MDR provider such as RedCanary, Kroll, or Arctic Wolf.
• Jira Service Management or ServiceNow at scale.
• Public company SOX IT general controls experience.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Ability to function in a dynamic environment
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range: $ 260K – $300K plus bonus and equity

Location: Brisbane, CA - Onsite 

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Director, Nonclinical Toxicology Operations 

Nurix Therapetics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position Summary:

Nurix Therapeutics is seeking a Director of Preclinical Safety and Toxicology Operations to drive planning and execution of nonclinical safety and toxicology activities within our Research and Early Development division. The role will be responsible for operations activities including owning timelines, budgets, contracts, and cross-functional coordination for a portfolio of targeted protein degradation programs.  The ideal candidate will be adept at partnering closely with subject matter experts, preclinical Project Leads, clinical Asset Team Leaders, and the SVP of Preclinical Toxicology who will provide oversight and scientific direction.

The role has two complementary halves. The first is operational support to the nonclinical Safety and Toxicology function — helping study directors and toxicology leads scope and design studies, selecting and managing CROs, negotiating and administering contracts, and keeping study execution on schedule and on budget. The second is program-level project management for drug discovery projects as they transition from late lead optimization through IND filing, integrating chemistry, DMPK, pharmacology, safety, CMC, and regulatory timelines into a single credible plan.

You will thrive here if you are highly organized, scientifically fluent, comfortable holding teams and stakeholders to a schedule, and energized by turning complex, interdependent work into clear milestones and decisions.

Key Responsibilities:

Toxicology study support and vendor management 

• Partner with Toxicology Leads and Study Directors to scope, design, and schedule GLP and non-GLP in vivo and in vitro safety studies, including exploratory tox, DRF, GLP repeat-dose toxicology, safety pharmacology, and genetic toxicology.
• Identify, qualify, and manage CROs and specialty vendors; coordinate bid solicitation, bid defense, and vendor selection in partnership with Toxicology, Procurement, and Legal.
• Own the contract lifecycle: draft and route work orders, MSAs, change orders, and amendments; track scope changes against budget; reconcile invoices and support accruals and forecasting.
• Build and maintain integrated study timelines; monitor study milestones, sample logistics, bioanalytical turnaround, and report delivery, escalating slippage early with options rather than surprises.
• Coordinate protocol and report review cycles, ensuring documents move efficiently through internal review, QA, and sign-off.
• Track deliverables required for regulatory submissions, including study reports, certificates of analysis, and test article documentation.
• Demonstrated ability to ensure safety issues are communicated rapidly and with appropriate escalation to the drug safety/project team, leadership and relevant agencies.

Program management, late lead optimization to IND

• Serve as project manager for assigned discovery and development programs from late lead optimization through candidate selection, IND-enabling studies, and IND filing.
• Develop and maintain integrated program plans, critical paths, and resource views spanning medicinal chemistry, analytical chemistry, computational chemistry, DMPK, pharmacology, toxicology, CMC, and regulatory.
• Run project team meetings: set agendas, capture actions and decision rationale in meeting minutes, and follow through to closure.
• Maintain program dashboards, milestone trackers, and risk registers; surface risks with mitigation and contingency plans.
• Prepare materials and pre-reads for portfolio reviews, governance meetings, and leadership updates; ensure a single, consistent version of program status.
• Coordinate scenario and what-if planning to support go/no-go decisions, candidate selection, and IND timing.

Cross-functional leadership and process 

• Act as a connective hub across functions and sites, resolving interface issues before they become timeline issues.
• Contribute to continuous improvement of project management practices, templates, and tools within the group.

Qualifications: 

Education 

• Required: M.S. or Ph.D. in a life sciences discipline (toxicology, pharmacology, biology, chemistry, pharmaceutical sciences, or related).
• Preferred: formal project management credential such as PMP.

Experience 

• Typically, 10+ years of relevant biotech or pharmaceutical experience, including demonstrable project management ownership of multidisciplinary programs.
• Track record managing CROs and external vendors, including contracting, budget tracking, and performance management.
• Direct experience supporting and coordinating IND-enabling activities
• Working knowledge of small molecule drug discovery and development, nonclinical safety assessment, and GLP requirements, with scientific fluency sufficient to plan, question, and integrate the work.
• Experience in targeted protein degradation, oncology, or immunology is an advantage.

Skills and attributes 

• Proficiency with project management tools and methods, including integrated timelines, critical path analysis, and resource planning (e.g., MS Project, Smartsheet, Planisware, or equivalent). Familiarity with AI tools a plus.
• Exceptional organizational skills and attention to detail, with the judgment to know what matters and what does not.
• Clear, concise written and verbal communication; able to present status and risk to senior leadership without embellishment.
• Ability to influence and drive accountability without direct authority across a group of senior, highly experienced scientists.
• Comfort with ambiguity and shifting priorities in a fast-moving discovery environment.

Reporting and Location 

• Reporting to SVP of Nonclinical Toxicology, Based at Nurix Therapeutics, Brisbane, CA, with on-site presence expected to support close partnership with laboratory and program teams.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:   $220,700 - $252,667

Location:         Brisbane, CA - Onsite 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position:

Nurix Therapeutics, Inc. is seeking a highly experienced Director of Pharmaceutical Development. The role leads small molecule drug product development focused on oral and topical dosage forms. Responsibilities span QbD-based formulation and process development from early phase through commercial launch. The position requires strong cross-functional collaboration and hands-on CDMO management. 

Responsibilities:

Formulation & Process Development

• Lead QbD-based formulation and process development for small molecule drug programs with a focus on oral and topical dosage forms across all development phases.
• Apply expertise in BCS Class II/IV compound development and enabling formulation technologies, including amorphous solid dispersions (spray-dried dispersions, hot-melt extrusion), lipid-based drug delivery systems (SMEDDS, SEDDS, lipid suspensions), and nano-formulations to address solubility and bioavailability challenges.
• Define and document the Quality Target Product Profile (QTPP) and identify Critical Quality Attributes (CQAs) to guide formulation strategy.
• Conduct systematic risk assessments to identify Critical Material Attributes (CMAs) and Critical Process Parameters (CPPs) using FMEA and other risk assessment tools.
• Develop and optimize manufacturing processes appropriate to the dosage form, ensuring scalability and process robustness.

Scale-Up & Technology Transfer

• Lead manufacturing scale-up activities from laboratory to pilot and commercial scale, ensuring robust and reproducible processes.
• Troubleshoot manufacturing deviations, out-of-specification results, and process failures; drive root cause analysis and implement corrective actions.

Late-Stage Development & Regulatory

• Drive late-stage development activities (Phase 2b through commercial launch) including clinical supply manufacturing, process performance qualification (PPQ), and continued process verification (CPV).
• Author and review CMC sections of regulatory submissions including INDs, NDAs, and MAAs.
• Ensure all development activities comply with current GMP regulations and internal quality standards.

CDMO Management & Cross-Functional Leadership

• Manage external CDMO partnerships, including vendor qualification, technical oversight, and performance governance to ensure project timelines, quality standards, and budget commitments are met.
• Serve as the primary technical point of contact between pharmaceutical development and cross-functional teams including Analytical Development, Clinical Operations, Regulatory Affairs, Quality, Supply Chain, and Commercial.
• Provide scientific leadership and mentorship to junior scientists, associates, and project team members.

Requirements

• Ph.D. in Pharmaceutical Sciences, Pharmaceutics, Chemical Engineering, Chemistry, or a closely related discipline strongly preferred with 12 years of industry experience.
• 12+ years of progressive pharmaceutical development experience in an industry setting (biotechnology, pharmaceutical, or CDMO).
• Deep expertise in small molecule drug product development with a focus on oral and topical dosage forms, especially enabled formulation development (e.g., amorphous solid dispersions, lipid-based systems, nano-formulations).
• Comprehensive hands-on experience with QbD methodologies: QTPP definition, CQA identification, CMA/CPP risk assessment, DoE, design space development, and control strategy establishment.
• Significant late-stage development experience (Phase 2b/3 and NDA/MAA submission) is required.
• Proven track record of authoring and/or reviewing CMC regulatory submissions (INDs, NDAs, CTDs) and successfully responding to agency queries.
• Direct CDMO management experience, including technical oversight, project governance, and relationship management.
• Knowledge of lifecycle management, post-approval changes, and SUPAC guidance.
• For the Director level: demonstrated people management experience leading a team of scientists/managers, department-level strategic planning, and budget/resource ownership across multiple concurrent programs.
• Primarily office and laboratory environment; occasional GMP manufacturing facility access required.
• Approximately 25% travel required, including domestic and international trips to CDMO sites, clinical manufacturing sites, regulatory agency meetings, and scientific conferences.
• Must be able to gown for cleanroom/GMP environments

Core Competencies

• Scientific Leadership — Recognized internal and external thought leader in pharmaceutical development; drives scientific innovation and excellence.
• Strategic Thinking — Ability to anticipate technical and regulatory risks and develop proactive mitigation strategies that protect project timelines.
• Cross-Functional Collaboration — Demonstrated ability to build strong working relationships and influence without authority across diverse internal and external stakeholders.
• Project Management — Experienced in managing multiple complex projects simultaneously in a fast-paced, deadline-driven environment.
• Communication — Exceptional written and verbal communication skills; able to present complex scientific data clearly to both technical and non-technical audiences, including senior leadership and regulatory agencies.
• People Development — Commitment to mentoring and developing scientific talent within the organization. 

Salary Range:  $218,000 – 260,000

Location:  This position is on site in the Brisbane, CA office.

Fit with Nurix Culture and Values:

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Director, Regulatory Affairs - Strategy, Autoimmune Disease (AID)

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Nurix Therapeutics, Inc. is seeking a Director, Regulatory Affairs (Strategy, AID) to join the Regulatory team.  The successful candidate will be a core member of the Regulatory team and will serve as the global regulatory lead (GRL) for the immunology and inflation therapeutic area. This role will be responsible for developing the global regulatory strategy in collaboration with key internal stakeholders, as well as tactical implementation of that strategy guiding and executing compliant, high quality, nonclinical and clinical submissions and interactions in support of early development, registration and life cycle management activities.  This position works cross-functionally with regulatory affairs and clinical development organizations to facilitate the completion of regulatory filing documentation according to company timelines. It also ensures adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as required. This position is on site in the Brisbane, CA office.

Responsibilities:

• Develop and implement competitive and effective global clinical & nonclinical regulatory strategies for various immunology and inflammation indications and identify potential risks and mitigation strategies associated with proposed strategies
• Work in close collaboration with the SVP, Head of Regulatory Affairs and the development team leader and other cross-functional colleagues, including CROs to deliver sound, efficient development strategies and operational plans
• Represent Regulatory Affairs on assigned cross-functional development teams.
• Lead and manage the development and preparation of high-quality global submissions (including IND, CTAs, NDAs, and MAAs) for early and late-stage programs in collaboration with the regulatory and project teams to support and accelerate clinical development and regulatory approval, as applicable
• Lead communication with global Health Authorities (HA), such as FDA and EMA, including, planning and preparing for formal meetings with regulatory agencies and interpreting HA feedback from these interactions.
• Develops and executes, or oversees global regulatory strategy for long-term planning, including the potential to accommodate expedited development needs
• Anticipate issues and guide cross-functional teams on risk mitigation strategies for any development challenges Provides insight and guidance on the implementation of current regulations and assesses regulatory risk based on precedence
• Ensure adherence to current regulations associated with regulatory activities
• Works strategically with all regulatory functions to develop detailed, actionable submission plans, tracks major submission deliverables, and ensures consistent management submission documents, health authority communications, and all other regulatory information supporting Nurix’s investigational and marketing applications
• Plays an essential part in defining requirements for, implementing, and supporting future systems and tools to be employed by Nurix in the areas of document management, submission content planning, and regulatory information management
• Tracks the status of major deliverables for regulatory submissions (e.g., study reports, summary documents, labeling) along with their dependencies
• Develops and maintains submission plan templates to ensure Nurix regulatory submissions are consistently planned and executed across programs
• Participates in cross-functional process initiatives impacting regulatory submission processes and systems
• Manages consultants and contractors as needed

Requirements:

• Bachelor's degree in life-sciences or related scientific discipline; advanced degree preferred
• Must have minimum of 12 years in Regulatory affairs strategy with significant experience in the immunology and inflammation therapeutic area
• Strong demonstration of knowledge of drug development, FDA, EMA and ICH guidelines and regulations
• Experience providing hands-on support for planning clinical trial and marketing applications to health authorities including but not limited to FDA, EMA
• Proven track record of supporting Regulatory affairs in the planning and execution of major filings and ongoing maintenance of clinical trial and marketing applications
• Strong project management and critical thinking skills
• Experience applying project management techniques and tools (e.g., MS Project, Smartsheet, Excel trackers) to the planning and execution of regulatory submissions
• Excellent organizational and communication skills, both written and verbal
• Ability to work independently as well as part of a team environment
• Positive attitude, energetic and proactive
• Proven ability to manage multiple projects, identify and resolve regulatory issues
• Strong interpersonal skills and the ability to effectively work with others

Salary Range:  $220,000 – $254,000

Location:  Onsite Brisbane, California

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Job Summary:

Nurix Therapeutics, Inc. is seeking a Director/ Sr. Director, Regulatory Affairs (Strategy, Oncology – Solid Tumors) to join the Regulatory team.  The successful candidate will be a core member of the Regulatory team working in close collaboration with the SVP, Head of Regulatory Affairs and other cross-functional colleagues. This role will be responsible for developing and executing the global regulatory strategy in collaboration with key internal stakeholders, as well as tactical implementation of that strategy, guiding and executing compliant, high quality, nonclinical and clinical submissions and interactions in support of registration and life cycle management activities.  This position works cross-functionally with regulatory affairs and clinical development organizations to facilitate the completion of regulatory filing documentation according to company timelines. It also ensures adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as required.

Responsibilities:

• Develop a comprehensive regulatory strategy that takes into account worldwide regulatory requirements to drive product development, global registration, achievement and maintenance of desired regional labeling, and effective regulatory agency interactions
• Identify potential risks and mitigation strategies associated with proposed strategies
• Represent Regulatory Affairs on assigned cross-functional development teams.
• Lead and manage the development and preparation of high-quality global submissions (including IND, CTAs, NDAs, and MAAs) for early and late-stage programs in collaboration with the regulatory and project teams to support and accelerate clinical development and regulatory approval, as applicable
• Support communication with global Health Authorities (HA), such as FDA and EMA, including, planning and preparing for formal meetings with regulatory agencies and interpreting HA feedback from these interactions.
• Develops and executes, or oversees global regulatory strategy for long-term planning, including the potential to accommodate expedited development needs
• Anticipate issues and guide cross-functional teams on risk mitigation strategies for any development challenges Provides insight and guidance on the implementation of current regulations and assesses regulatory risk based on precedence
• Ensure adherence to current regulations associated with regulatory activities
• Works strategically with all regulatory functions to develop detailed, actionable submission plans, tracks major submission deliverables, and ensures consistent management submission documents, health authority communications, and all other regulatory information supporting Nurix’s investigational and marketing applications
• Plays an essential part in defining requirements for, implementing, and supporting future systems and tools to be employed by Nurix in the areas of document management, submission content planning, and regulatory information management
• Tracks the status of major deliverables for regulatory submissions (e.g., study reports, summary documents, labeling) along with their dependencies
• Develops and maintains submission plan templates to ensure Nurix regulatory submissions are consistently planned and executed across programs
• Participates in cross-functional process initiatives impacting regulatory submission processes and systems
• Manage consultants and contractors as needed

Experience and Skills:

• Bachelor's degree in life-sciences or related scientific discipline; advanced degree preferred
• Must have minimum of 12 years in Regulatory affairs strategy with significant experience in the oncology (solid tumors) therapeutic area
• Strong demonstration of knowledge of drug development, FDA, EMA and ICH guidelines and regulations
• Experience providing hands-on support for planning clinical trial and marketing applications to health authorities including but not limited to FDA, EMA
• Proven track record of supporting Regulatory affairs in the planning and execution of major filings and ongoing maintenance of clinical trial and marketing applications
• Strong project management and critical thinking skills
• Experience applying project management techniques and tools (e.g., Veeva RIM, Smartsheet, Excel trackers, etc) to the planning and execution of regulatory submissions
• Excellent organizational and communication skills, both written and verbal
• Ability to work independently as well as part of a team environment
• Positive attitude, energetic and proactive
• Proven ability to manage multiple projects, identify and resolve regulatory issues
• Strong interpersonal skills and the ability to effectively work with others

Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:    Director: $232K - $274K

                           Senior Director: $279K - $331K

Location:            Brisbane, CA (Onsite role)

 Director, Total Rewards

Position Description

Nurix is seeking a Director, Total Rewards to lead the strategy, design, and execution of our compensation and benefits programs. This is a high-visibility, high-impact role reporting directly to the Chief Human Resources Officer, with the opportunity to shape and scale total rewards infrastructure. The ideal candidate combines deep technical expertise in compensation and benefits with strong business acumen and sound judgment.

The Opportunity

Compensation Strategy & Programs

• Own the design, implementation, and administration of Nurix’s base pay, incentive compensation, equity, and executive compensation programs
• Partner with the CHRO to lead annual compensation cycles, including merit increases, bonus funding and payout, and equity refresh grants
• Conduct and manage market benchmarking and job leveling to ensure competitive, equitable pay practices across the organization
• Monitor pay equity across the organization and lead proactive pay equity analyses and remediation
• Stay current on evolving compensation regulations (e.g., pay transparency, pay equity laws) and ensure company practices remain compliant across jurisdictions

Benefits Strategy & Programs

• Design and manage a competitive, cost-effective benefits portfolio, including health and welfare plans, retirement programs (401(k)), leave policies, and wellness offerings
• Own vendor and broker relationships, lead renewal negotiations, and evaluate new offerings to ensure programs remain market-competitive and fiscally responsible
• Ensure benefits programs are compliant with ERISA, ACA, ADA, FMLA, COBRA, and other applicable federal and state regulations
• Lead open enrollment planning and execution, including employee communication and education strategies

Leadership & Cross-Functional Partnership

• Serve as the subject-matter expert (SME) and trusted advisor to the CHRO, Head of Talent, HRBPs, and people managers on compensation and benefits matters
• Partner closely with Finance on compensation budgeting, forecasting, and equity/stock plan expense modeling
• Partner with Legal on equity plan administration, 409A matters, and regulatory compliance
• Develop and deliver clear, effective communications and training to help managers and employees understand total rewards programs
• In partnership with Head of HR Operations, evaluate and implement HRIS/compensation tools and systems to improve efficiency, data integrity, and reporting capabilities

What You’ll Bring

• Bachelor’s degree required; advanced degree or relevant certification (CCP, CBP, CEBS) preferred
• 8-10+ years of progressive experience in compensation and benefits, including at least 3-5 years in a total rewards leadership role
• Prior experience in biotech, pharmaceutical, or life sciences companies strongly preferred; experience in a clinical-stage or newly commercial company is a plus
• Deep knowledge of equity compensation structures (RSUs, ISOs/NSOs, ESPP) common in biotech
• Strong analytical skills with the ability to translate complex data into clear insights and recommendations
• Excellent judgment and discretion when handling highly sensitive compensation and personnel data
• Proven ability to build programs and processes in a growing, fast-paced environment
• Strong communication and stakeholder management skills, with the ability to influence at all levels of the organization, including the Board

Salary Range:  $250,800 – $278,800 annually

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:        Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Executive Assistant to the CHRO – Contract to Perm

Nurix Therapeutics is a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Make an Impact

As Executive Assistant to our Chief Human Resources Officer (CHRO), you'll be a highly trusted partner who helps drive organizational effectiveness and enables our HR leadership team to operate at their best. This is more than a traditional administrative role—you'll play a key part in helping shape team rhythms, coordinating strategic priorities, and ensuring seamless execution across a growing biotech company.  You are a culture ambassador/champion who enjoys being the organizational glue, event strategist, and culture catalyst behind a growing company's employee experience. 

You'll work with highly sensitive information, exercise sound judgment, and build strong relationships across the organization. If you're proactive, resourceful, exceptionally organized, and thrive in a fast-paced environment, this is an opportunity to make a meaningful impact while partnering closely with executive leadership. -

What You'll Do

• Act as a primary point of contact for the CHRO, responding to or appropriately routing inquiries with professionalism and discretion.
• Serve as a trusted liaison for communications, approvals, and follow-up actions, ensuring priorities move forward efficiently.
• Manage the CHRO's complex calendar, prioritizing activities and proactively resolving scheduling conflicts.
• Play a lead role in the planning and execution of company events and employee experiences, including town halls, team offsites, cultural celebrations, recognition events, holiday gatherings, volunteer activities, and other employee engagement programs.
• Serve as a culture champion, helping foster a positive, inclusive, and connected workplace by supporting programs and initiatives that enhance the employee experience and bring Nurix values to life.
• Manage expense reports, purchase orders, and administrative processes while leveraging tools such as Microsoft 365, Copilot, SharePoint, and other business systems.
• Build strong partnerships across the organization and collaborate with fellow Executive Assistants to support a connected, high-performing culture.
• Contribute to special projects and strategic initiatives that help advance HR and company objectives.
• Arrange domestic and international travel, build detailed itineraries, and navigate changes seamlessly when plans shift.

What You Bring

• 8+ years of experience supporting senior executives, ideally at the C-suite level.
• Exceptional written and verbal communication skills.
• Advanced proficiency with Microsoft Office, including Outlook, Word, and Excel.
• Fluency with AI tools (Claude and Copilot in particular)
• Proven experience planning and executing onsite and offsite events, ranging from executive meetings and team offsites to large-scale company gatherings and employee engagement programs.
• Strong project management skills with the ability to manage multiple events, stakeholders, vendor relationships, budgets, and timelines simultaneously.
• A demonstrated ability to handle confidential and sensitive information with the highest level of discretion and integrity.
• Bachelor's degree is a plus.
• Strong judgment, emotional intelligence, and professionalism when navigating complex situations and competing priorities.
• Outstanding organizational skills, attention to detail, and the ability to anticipate needs before they arise.
• An enthusiastic, positive, and approachable presence with a genuine passion for creating exceptional employee experiences and fostering an engaging workplace culture.
• A collaborative, service-oriented mindset, balanced with confidence working independently.
• Experience building effective relationships with executives, employees, external partners, and stakeholders at all levels.
• A natural culture builder who enjoys bringing people together, creating memorable experiences, and contributing to a fun, inclusive, and high-performing work environment.
• Experience supporting executives within a biotechnology, pharmaceutical, or life sciences organization is a plus.

Location:          Brisbane, California

This role follows an onsite schedule of five days a week in our Brisbane headquarters.  

Executive Business Partner

Position Description

The Executive Business Partner (EBP) provides high-level administrative support and strategic project ownership to the Chief Scientific Officer (CSO) of a growing mid-sized pharmaceutical company. This position requires a highly organized, detail-oriented, and proactive individual who can handle complex scheduling, manage multiple priorities, and communicate effectively across various levels of the organization while also owning discrete strategic and operational initiatives on the CSO's behalf, acting as a trusted proxy in cross-functional settings, and providing leadership to the administrative function supporting Research department leaders. The ideal candidate will have exceptional problem-solving abilities, strong written and verbal communication skills, sound independent judgment, and experience managing both the daily operations and selecting strategic priorities of a senior executive's office. This position plays a crucial role in ensuring the smooth and efficient functioning of the CSO's office, driving forward initiatives that extend the CSO's reach and impact across the organization, and building a cohesive, high-functioning administrative team across Research.

The Opportunity

• Calendaring and time management: Own and prioritize the CSO’s calendar, scheduling meetings, travel, and appointments. Proactively resolve scheduling conflicts without letting deadlines slip and keep appointments on track.
• Communication and information triage: Serve as the primary point of contact between the CSO and both internal and external stakeholders. Draft and edit correspondence and presentations. Use AI-assisted summarization and triage to reduce a high-volume inbox and document flow into a prioritized, decision-ready view.
• Strategic and project support:
  • Lead or co-lead discrete cross-functional projects assigned by the CSO — such as offsite strategy, advisory board content, or org initiatives — from scoping through execution.
  • Act as a proxy for the CSO in selecting internal meetings: representing priorities, capturing decisions, and driving follow-through without requiring the CSO’s direct involvement.
  • Partner with functional leaders across HR, Finance, IT, and Facilities to problem-solve operational issues before they reach the CSO.
• Team leadership and administrative function oversight:
  • Manage and mentor one direct report — Administrative role dedicated to supporting Research department leaders — including workload distribution, performance management, and professional development.
  • Establish shared standards, tools, and processes across the Research administrative team to ensure consistency, coverage, and quality regardless of which leader is being supported.
  • Serve as the escalation point for scheduling conflicts, resourcing gaps, or coverage needs across the team, and coordinate backup support during absences.
  • Build a cohesive administrative function across Research that operates as a unified team rather than siloed 1:1 support — sharing best practices, cross-training on key processes, and presenting consistent experience to Research leadership.
• Travel and logistics: Coordinate complex domestic and international travel arrangements, including flights, accommodations, ground transportation, and itineraries, ensuring optimal time management.
• Meeting support: Plan and organize meetings, including preparing agendas, gathering materials, and taking detailed minutes. Follow up on action items and ensure timely completion.
• Document management: Maintain and organize files and documents, ensuring quick retrieval and confidentiality. Handle sensitive information with discretion.
• Office operations and ad hoc support: Assist in organizing R&D events, advisory boards, offsites, conferences, or seminars, including logistics, materials preparation, and on-site support. Coordinate with executive assistants across the leadership team and take on discrete projects on the CSO’s behalf.

What You’ll Bring

• Minimum of associate’s degree required. Bachelor's Degree preferred.
• At least 8+ years of experience in an executive administrative or business partner role, including at least 3 years supporting a C-level or functional-head role in the pharmaceutical, healthcare, or scientific industry.
• Prior experience managing or mentoring administrative staff, with the ability to set standards and coach for consistency across a team.
• Demonstrated ability to exercise independent judgment on behalf of an executive, including representing their priorities and making decisions in their absence.
• Strong organizational and multitasking skills and attention to detail, with a keen ability to prioritize tasks and meet deadlines.
• Proven experience managing complex calendars and schedules for senior executives, as well as leading discrete projects with cross-functional stakeholders.
• Exceptional written and verbal communication skills, with the ability to liaise professionally with all levels of the organization.
• Advanced proficiency in Microsoft 365 Suite (Outlook, Teams, PowerPoint, Word, Excel, OneNote, SharePoint, and To Do), as well as travel systems like Navan and expense trackers like Expensify.
• Ability to work independently and as part of a team, demonstrating initiative and problem-solving skills.
• Ability to maintain confidentiality and exercise discretion.
• Flexible and adaptable to changing priorities in a fast-paced environment.
• A proactive approach to anticipating the needs of the CSO and offering solutions in advance.

Additional Skills (Preferred):

• AI fluency — comfort using AI assistants (e.g., Claude, Copilot) to draft, summarize, and triage high volumes of email and documents, and a track record of adopting new tools quickly.
• Comfort with scientific vocabulary — you do not need a science background, but you do need to be unbothered by learning the language of drug discovery and clinical development.

Salary Range:  $163,700 – $180,538

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Medical Director / Senior Medical Director   

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

As an integral member of the Clinical Development Team, this person will work closely in collaboration with the study teams providing scientific guidance and support.

This role will report to the Chief Medical Officer and will be responsible for developing and contributing to the strategy to advance molecules through the Nurix clinical pipeline. This role will work cross-functionally and participate in the execution of clinical studies including protocols, provide scientific expertise to support site and CRA training, data cleaning/analysis, investigator interaction and support of regulatory filings. In collaboration with the Medical Monitor and Safety team this role will be responsible for safety oversight of clinical trials.

Job Responsibilities:

• Participate, contribute and/or lead cross-functional clinical development teams with strong ability to work closely with all team members, address study or other program-specific questions.
• Develop the Global Development plan with senior clinical development staff
• Implement Global Development Plan with strategic clinical science support
• Lead in reviewing and authoring clinical protocols. Read and interpret scientific and medical literature for the use in clinical documents and to assist clinical team decision making.
• Prepare clinical portions of all relevant regulatory filings and meeting packages (INDs, Annual Reports, meeting requests, NDAs, etc.) for US and ex-US Health Authorities.
• Integrate scientific knowledge and operational expertise to ensure translation of clinical research plans into efficiently delivered high-quality studies.
• Acquire and utilize knowledge of clinical trial design and relevant disease indications to assist in study concept and protocol development. Contribute to discussions concerning scientific and procedural aspects of study design. Coordinate with departments to produce the final protocol and informed consent documents.
• Contribute and review medical data review plans, Data Safety Monitoring Board (DSMB)/Safety Review Committee (SRC) charters, and specific sections of study manuals and investigator meeting materials.
• Contribute to the development of CRFs, data edit checks, patient profile design, ongoing data cleaning (query generation, coding review, SAE reconciliation) and data trend analysis.
• Lead internal clinical data review meetings in conjunction with the medical monitor; lead the data preparation effort for dose escalation meeting, as applicable to study stage.
• Coordinate and manage external medical advisory committees for the study team such as DSMBs and Scientific Steering Committees, in conjunction with the medical monitor.
• Research and summarize published literature for continual learning and to prepare training materials for other clinical team members.
• Contribute to statistical analysis plans, table, listing, figure design and the preparation of manuscripts and other presentations of study data, as appropriate.
• Address investigator questions regarding protocol and related scientific issues and attend site initiation visits (SIVs), in coordination with the medical monitor.
• Assist in determining the activities to support a project's priorities within functional area
• Train other clinical scientists as needed.
• Medical monitoring duties may be considered depending on degree (e.g., PharmD, MD or other clinical advanced degree) and previous experience.
• Support business development activities as needed serving as scientific/subject matter Expert
• Up to 25% travel (US and International)

Basic Qualifications

• Advanced degree in clinical or biological sciences (MD, PhD, or PharmD preferred) 15+ years (Executive Director) relevant drug development experience with minimum of 5 years’ experience in oncology clinical trials.

Preferred Qualifications

• Experience in the clinical science role, in an oncology indication for first-in-human and proof of concept studies in small molecules, biologics and/or cell therapy. Registrational or Phase 3 study experience is desired.
• In depth understanding of clinical operations and translational medicine.
• Excellent interpersonal and communication skills.
• Able to translate technical concepts into accessible language and direction for the broader study team.
• Excellent attention to detail, collaboration and initiative, with flexibility to adapt to the needs of the organization; maintain meticulous attention to project deadlines.
• Experienced in Microsoft Office (Excel, Word, PowerPoint, OneNote), and ideally also with job related programs such as Spotfire and Medidata Rave or similar.
• Strong understanding of ICH GCP, as well as general knowledge of industry practices and Standards
• Commitment to patient safety and clinical compliance.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Ranges:    $285,000 to $390,000

Location:   Brisbane, CA - Onsite 

Medical Director / Senior Medical Director   

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

As an integral member of the Clinical Development Team, this person will work closely in collaboration with the study teams providing scientific guidance and support.

This role will report to the Chief Medical Officer and will be responsible for developing and contributing to the strategy to advance molecules through the Nurix clinical pipeline. This role will work cross-functionally and participate in the execution of clinical studies including protocols, provide scientific expertise to support site and CRA training, data cleaning/analysis, investigator interaction and support of regulatory filings. In collaboration with the Medical Monitor and Safety team this role will be responsible for safety oversight of clinical trials.

Job Responsibilities:

• Participate, contribute and/or lead cross-functional clinical development teams with strong ability to work closely with all team members, address study or other program-specific questions.
• Develop the Global Development plan with senior clinical development staff
• Implement Global Development Plan with strategic clinical science support
• Lead in reviewing and authoring clinical protocols. Read and interpret scientific and medical literature for the use in clinical documents and to assist clinical team decision making.
• Prepare clinical portions of all relevant regulatory filings and meeting packages (INDs, Annual Reports, meeting requests, NDAs, etc.) for US and ex-US Health Authorities.
• Integrate scientific knowledge and operational expertise to ensure translation of clinical research plans into efficiently delivered high-quality studies.
• Acquire and utilize knowledge of clinical trial design and relevant disease indications to assist in study concept and protocol development. Contribute to discussions concerning scientific and procedural aspects of study design. Coordinate with departments to produce the final protocol and informed consent documents.
• Contribute and review medical data review plans, Data Safety Monitoring Board (DSMB)/Safety Review Committee (SRC) charters, and specific sections of study manuals and investigator meeting materials.
• Contribute to the development of CRFs, data edit checks, patient profile design, ongoing data cleaning (query generation, coding review, SAE reconciliation) and data trend analysis.
• Lead internal clinical data review meetings in conjunction with the medical monitor; lead the data preparation effort for dose escalation meeting, as applicable to study stage.
• Coordinate and manage external medical advisory committees for the study team such as DSMBs and Scientific Steering Committees, in conjunction with the medical monitor.
• Research and summarize published literature for continual learning and to prepare training materials for other clinical team members.
• Contribute to statistical analysis plans, table, listing, figure design and the preparation of manuscripts and other presentations of study data, as appropriate.
• Address investigator questions regarding protocol and related scientific issues and attend site initiation visits (SIVs), in coordination with the medical monitor.
• Assist in determining the activities to support a project's priorities within functional area
• Train other clinical scientists as needed.
• Medical monitoring duties may be considered depending on degree (e.g., PharmD, MD or other clinical advanced degree) and previous experience.
• Support business development activities as needed serving as scientific/subject matter Expert
• Up to 25% travel (US and International)

Basic Qualifications

• Advanced degree in clinical or biological sciences (MD, PhD, or PharmD preferred) 15+ years (Executive Director) relevant drug development experience with minimum of 5 years’ experience in oncology clinical trials.

Preferred Qualifications

• Experience in the clinical science role, in an oncology indication for first-in-human and proof of concept studies in small molecules, biologics and/or cell therapy. Registrational or Phase 3 study experience is desired.
• In depth understanding of clinical operations and translational medicine.
• Excellent interpersonal and communication skills.
• Able to translate technical concepts into accessible language and direction for the broader study team.
• Excellent attention to detail, collaboration and initiative, with flexibility to adapt to the needs of the organization; maintain meticulous attention to project deadlines.
• Experienced in Microsoft Office (Excel, Word, PowerPoint, OneNote), and ideally also with job related programs such as Spotfire and Medidata Rave or similar.
• Strong understanding of ICH GCP, as well as general knowledge of industry practices and Standards
• Commitment to patient safety and clinical compliance.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Ranges: $285,000 to $390,000

Location:  Brisbane, CA - Onsite 

Medical Director / Senior Medical Director   5948-306

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

As an integral member of the Clinical Development Team, this person will work closely in collaboration with the study teams providing scientific guidance and support.

This role will report to the Chief Medical Officer and will be responsible for developing and contributing to the strategy to advance molecules through the Nurix clinical pipeline. This role will work cross-functionally and participate in the execution of clinical studies including protocols, provide scientific expertise to support site and CRA training, data cleaning/analysis, investigator interaction and support of regulatory filings. In collaboration with the Medical Monitor and Safety team this role will be responsible for safety oversight of clinical trials.

Job Responsibilities:

• Participate, contribute and/or lead cross-functional clinical development teams with strong ability to work closely with all team members, address study or other program-specific questions.
• Develop the Global Development plan with senior clinical development staff
• Implement Global Development Plan with strategic clinical science support
• Lead in reviewing and authoring clinical protocols. Read and interpret scientific and medical literature for the use in clinical documents and to assist clinical team decision making.
• Prepare clinical portions of all relevant regulatory filings and meeting packages (INDs, Annual Reports, meeting requests, NDAs, etc.) for US and ex-US Health Authorities.
• Integrate scientific knowledge and operational expertise to ensure translation of clinical research plans into efficiently delivered high-quality studies.
• Acquire and utilize knowledge of clinical trial design and relevant disease indications to assist in study concept and protocol development. Contribute to discussions concerning scientific and procedural aspects of study design. Coordinate with departments to produce the final protocol and informed consent documents.
• Contribute and review medical data review plans, Data Safety Monitoring Board (DSMB)/Safety Review Committee (SRC) charters, and specific sections of study manuals and investigator meeting materials.
• Contribute to the development of CRFs, data edit checks, patient profile design, ongoing data cleaning (query generation, coding review, SAE reconciliation) and data trend analysis.
• Lead internal clinical data review meetings in conjunction with the medical monitor; lead the data preparation effort for dose escalation meeting, as applicable to study stage.
• Coordinate and manage external medical advisory committees for the study team such as DSMBs and Scientific Steering Committees, in conjunction with the medical monitor.
• Research and summarize published literature for continual learning and to prepare training materials for other clinical team members.
• Contribute to statistical analysis plans, table, listing, figure design and the preparation of manuscripts and other presentations of study data, as appropriate.
• Address investigator questions regarding protocol and related scientific issues and attend site initiation visits (SIVs), in coordination with the medical monitor.
• Assist in determining the activities to support a project's priorities within functional area
• Train other clinical scientists as needed.
• Medical monitoring duties may be considered depending on degree (e.g., PharmD, MD or other clinical advanced degree) and previous experience.
• Support business development activities as needed serving as scientific/subject matter Expert
• Up to 25% travel (US and International)

Basic Qualifications

• Advanced degree in clinical or biological sciences (MD, PhD, or PharmD preferred) 15+ years (Executive Director) relevant drug development experience with minimum of 5 years’ experience in oncology clinical trials.

Preferred Qualifications

• Experience in the clinical science role, in an oncology indication for first-in-human and proof of concept studies in small molecules, biologics and/or cell therapy. Registrational or Phase 3 study experience is desired.
• In depth understanding of clinical operations and translational medicine.
• Excellent interpersonal and communication skills.
• Able to translate technical concepts into accessible language and direction for the broader study team.
• Excellent attention to detail, collaboration and initiative, with flexibility to adapt to the needs of the organization; maintain meticulous attention to project deadlines.
• Experienced in Microsoft Office (Excel, Word, PowerPoint, OneNote), and ideally also with job related programs such as Spotfire and Medidata Rave or similar.
• Strong understanding of ICH GCP, as well as general knowledge of industry practices and Standards
• Commitment to patient safety and clinical compliance.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Ranges:            $285,000 to $390,000

Location:                         Brisbane, CA - Onsite 

Principal Engineer, Pharmaceutical Development Engineering

Own the hands-on engineering that turns a promising molecule into a manufacturable drug product — leading process development, scale-up, and CDMO operations for Nurix's late-stage clinical and commercial programs. This is a highly technical, high-autonomy role with direct impact on getting real treatments to patients.

Position Description

The Opportunity

• Provide engineering leadership for small-molecule drug product manufacturing process development and optimization to facilitate process transfer to CDMOs and scale-up.
• Lead equipment engineering and operations at drug product CDMOs, including technology transfer, CTM production, process troubleshooting, QBD, DOEs and PAR studies, registration batch production, and process validation.
• Coordinate with CDMOs and Nurix QA, Chemical Development, and Global Supply Chain functions to ensure timely manufacture and release of DP lots.
• Partner with Nurix Chemical Development and Analytical Development & Quality Control to identify critical process parameters of associated equipment and facility, and overall control strategies.
• Ensure adherence to applicable regulations including FDA, EMA, ICH, GCP, GMP and Nurix policies and procedures.
• Provide Person-In-Plant support for drug product manufacturing and ongoing performance monitoring of key facility and operational KPIs across manufacturing sites, including schedule adherence, batch performance, deviation trends, and inspection readiness.
• Support operational execution related to equipment scheduling, manufacturing, and coordination, supporting both clinical and commercial production requirements.
• Write and review CMC sections of regulatory filings, including INDs, IND amendments, and NDAs.
• Ensure all equipment trains at CDMOs are properly qualified, maintained, and operating at optimal performance to support Nurix manufacturing operations.
• Provide technical mentorship and guidance to scientists and engineers.

What You’ll Bring

• Ph.D. in chemical engineering or a related field with at least 8 years (M.S. with 12 years, or B.S. with 16 years) of industrial, late-phase, small-molecule drug product development experience.
• Extensive knowledge and experience in GMP oral solid dose form manufacturing (spray drying, tableting, and encapsulation), characterization, process development, equipment evaluation/selection, scale-up, and process validation.
• Extensive third-party drug product CDMO management experience, including tech transfer activities, QBD and DOE studies, clinical supply production, registration batch production, and commercial launch activities.
• Knowledge and understanding of product/packaging interactions, barrier properties, stability, global pharmaceutical packaging regulations, and package testing.
• In-depth knowledge of relevant cGMP, ICH, FDA, and EMA guidelines.
• Proven track record of effective internal and external collaboration.
• Excellent oral/written communication skills, interpersonal skills, and problem-solving abilities.
• Ability to multi-task, manage conflict, and work in a fast-paced environment.
• Ability to travel up to 25% of time.

Salary Range:  $195,300 - 222,900

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Recruiting Coordinator (Contract)

Help build the teams advancing groundbreaking therapies for patients. As Recruiting Coordinator, you’ll sit at the center of the hiring process — creating exceptional candidate experiences, partnering with recruiters and hiring managers, and keeping every interview running seamlessly. If you’re highly organized and energized by connecting people with meaningful opportunities, we’d love to meet you.

Position Description

The Opportunity

• Serve as the primary point of contact for candidates throughout the interview process, creating a welcoming, professional, and engaging experience
• Coordinate and schedule interviews across multiple teams, managing complex calendars and shifting priorities with accuracy and efficiency
• Arrange candidate travel, onsite visits, and interview logistics as needed
• Partner closely with recruiters, hiring managers, executives, and interview teams to ensure a seamless hiring process from application through offer
• Own day-to-day administration of the Greenhouse applicant tracking system (ATS) — posting and updating job requisitions, entering and maintaining candidate data, and moving candidates through each stage of the hiring pipeline
• Maintain candidate records, interview feedback, requisitions, and templates within Greenhouse and other talent systems, monitoring recruiting activity to ensure data accuracy, process compliance, and timely follow-up throughout the hiring lifecycle
• Identify opportunities to improve recruiting processes, enhance efficiency, and elevate the candidate and hiring manager experience
• Support talent acquisition projects, reporting, recruiting events, and employer branding initiatives as needed
• Help create an inclusive, positive, and consistent experience for every candidate who engages with Nurix

What You’ll Bring

• 2+ years of recruiting coordination, talent acquisition, HR, administrative, or related experience, preferably within biotechnology, life sciences, healthcare, or a fast-paced corporate environment
• Experience supporting high-volume recruiting activity while maintaining exceptional attention to detail
• Strong organizational and time-management skills with the ability to prioritize multiple requests and deadlines simultaneously
• Excellent written and verbal communication skills and a customer-service mindset
• Experience working with Applicant Tracking Systems (ATS)
• Proficiency with Microsoft Outlook, Microsoft Office, and general business applications
• A high level of accuracy, professionalism, discretion, and follow-through
• A collaborative approach and the ability to build strong working relationships across all levels of the organization
• A passion for delivering an outstanding candidate experience and supporting inclusive hiring practices
• Good to have: prior experience with Greenhouse

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Research Associate II, Bioanalytical/In Vitro ADME/DMPK

Company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position 

Nurix Therapeutics is searching for a motivated Research Associate II to join our Bioanalytical-In Vitro DMPK team. The successful candidate will contribute to the bioanalytical efforts to support Nurix drug discovery programs involving in vivo and in vitro studies. We are seeking a highly motivated research associate to characterize the in vitro and in vivo ADME properties of drug candidates. The primary responsibilities will be to conduct bioanalysis for in vivo samples and to conduct in vitro experiments.  The scope of the daily responsibilities for this position includes, but is not limited to, developing bioanalytical methods, quantitating drug candidates and their metabolites, endogenous biomarkers in biological matrices (e.g. blood, plasma, tissue, tumor, CSF, etc.), reporting bioanalytical results and managing projects outsourced in CROs to support all in vitro and in vivo studies. The successful candidate will have extensive experience in bioanalytical method development and sample analysis using LC-MS/MS and other analytical techniques.

Responsibilities

• Provide bioanalytical support for in-house PK, non-GLP safety TK
• Conduct bioanalytical method development and qualification to support drug, metabolite and biomarker analysis
• Independently develop LC-MS/MS methods to quantitate small molecules in in vitro and in vivo samples
• Conduct in-vitro stability assays to understand metabolism of drugs
• Perform metabolic identification (MetID) using LC-QTOF MS/MS, including accurate mass analysis, fragment interpretation and biotransformation pathway assignment
• Independently operate, troubleshoot and maintain LC-MS/MS systems
• Participate in multidisciplinary project teams and collaborate with other departments to understand bioanalytical needs for both PK and PD support
• Manage projects conducted at CROs to ensure high quality bioanalytical data is delivered to meet project timelines
• Maintain accurate and detailed scientific electronic laboratory notebooks
• Perform all duties in keeping with the Company’s core values, policies and all applicable regulations

Preferred Qualifications & Experience

• Experience with H/UPLC and mass spectrometry
• Good working knowledge of SCIEX LC-MS/MS systems for small molecule quantitation
• PK analysis using Phoenix or other data management software
• Management experience with CROs for outsourcing BA activities is preferred
• Provide sample analysis to support PK, PK/PD, PK/efficacy, distribution, metabolism, and non-GLP toxicology studies
• Identify issues and troubleshoot scientific equipment including LC-MS/MS, select and develop appropriate methods to perform experiments, analyze data and prepare related reports.
• Excellent oral and written communication skills

Minimum Requirements

• BS or master’s with 4 years’ experience working in a discovery setting using LC-MS/MS within a pharmaceutical/biotechnology company
• Broad experience in small molecule drug candidate bioanalytical assay development/sample analysis in different biological matrices using LC-MS/MS
• Experience with AB SCIEX mass spectrometry software
• Excellent written, verbal communications and interpersonal skills to collaborate with internal and external partners in a matrix environment

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Location  Brisbane, CA - Onsite 

Salary Range    93K - 107K 

Scientist I, Bioanalytical – Drug Antibody Conjugates (DACs)

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position:

Nurix Therapeutics is seeking a Scientist to lead bioanalytical strategies supporting the discovery and development of next-generation degrader antibody conjugates (DACs). This role will focus on LC-MS/MS and hybrid assay strategies for quantitative and qualitative analysis of complex bioconjugates across in vitro and in vivo studies to understand DAC pharmacokinetics, pharmacodynamics, and biotransformation.

The successful candidate will operate at the interface of small and large molecule bioanalysis, and will contribute to assay development, method qualification, and execution, applying advanced LC-MS/MS and hybrid approaches to support in vitro and in vivo studies across discovery and early development

Key Responsibilities:

• Lead the development, qualification, and execution of bioanalytical methods for DAC modalities, including intact conjugates, total antibody, conjugated payload, and released degrader species in complex biological matrices.
• Design and implement LC-MS/MS-based workflows using Sciex platforms for sensitive and selective quantitation of small molecule payloads, linker-derived species, and catabolites
• Apply high-resolution mass spectrometry platforms for DAC characterization and metabolite identification
• Develop hybrid LBA–LC-MS/MS strategies to address challenges in conjugate quantitation and differentiation of molecular species.
• Design, execute and interpret in vitro studies, including plasma and lysosomal stability, linker cleavage kinetics, protease-mediated processing, and degradation assays.
• Lead bioanalytical support for in vivo studies, including PK, tissue distribution, and tumor exposure in preclinical species integrating DAC components to inform exposure-response relationships.
• Characterize biotransformation pathways of DACs, including identification of linker cleavage products, payload metabolites, and antibody modifications.
• Partner closely with DMPK, Proteomics, Pharmacology and Chemistry teams to inform molecular design through data-driven insights on stability, exposure, and degradation efficiency.
• Author and review technical reports, regulatory documentation, and study summaries with a high level of scientific rigor and clarity.
• Troubleshoot analytical challenges related to matrix effects, low-level quantitation, and conjugate heterogeneity.
• Mentor junior scientists and contribute to building bioanalytical capabilities and best practices within the organization.
• Evaluate and implement emerging technologies to advance characterization of targeted protein degrader modalities.
• Lead the identification, selection, and oversight of contract research organizations (CROs) for bioanalytical method development, assay transfer, and phase‑appropriate qualification.

Preferred Qualifications & Experience:

• Experience in targeted protein degradation or heterobifunctional degrader platforms.
• Experience with hybrid LBA–LC-MS/MS assays and ligand-binding assays (ELISA, MSD).
• Understanding of linker chemistry, conjugation strategies, and degradation mechanisms for bioconjugates.
• Exposure to regulatory bioanalytical guidance (FDA, EMA) for large molecules and conjugates.

Requirements:

• Ph.D. with 5+ years or M.S. with 8+ years of relevant industry experience in Bioanalysis, Analytical chemistry, or related field.
• Deep expertise in LC-MS/MS bioanalysis, including method development, qualification/validation, and troubleshooting for complex modalities.
• Proven experience with Sciex platforms (e.g., 7600 ZenoTOF, 6500+, 7500) and high-resolution MS.
• Strong background in ADCs, DACs, or related bioconjugates, including characterization and payload quantitation.
• Experience supporting both in vitro ADME and in vivo PK studies, with demonstrated ability to interpret integrated datasets.
• Proficiency in sample preparation techniques for large molecules and bioconjugates (e.g., immunocapture, enzymatic digestion, hybrid workflows).
• Strong data analysis, visualization, and reporting skills (e.g., vendor software, GraphPad Prism).
• Excellent written and verbal communication skills, with experience in technical documentation.
• Ability to work in a fast-paced, collaborative environment and manage multiple priorities.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:   $123,800 - $143,100

Location:         Brisbane, CA - Onsite 

Scientist I, Medicinal Chemistry

Join Nurix's medicinal chemistry group to design and synthesize novel small molecules for patients with unmet medical needs. You'll apply structure-based drug design, supported by our computational and structural biology teams, as part of a dynamic, multidisciplinary project team.

Position Description

The Opportunity

• Design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics, and in vivo efficacy, using modern synthetic methods and creative strategies to access challenging molecules
• Engage in rational structure-based drug discovery enabled by our computational and structural biology group
• Apply strong problem-solving skills to troubleshoot challenges and identify practical solutions
• Design and execute high-quality experiments, critically analyze results, and use data to form hypotheses and guide next steps
• Advance structure-activity relationship (SAR) studies by contributing to compound design
• Collaborate with scientists in computational chemistry, structural biology, biochemistry and biophysics, cellular biology, pharmacology, DMPK, and toxicology, as well as external collaborators, to integrate multidisciplinary data and advance project objectives
• Stay current with advances in synthetic and medicinal chemistry and apply relevant methods to project work
• Communicate scientific rationale, results, challenges, and recommendations clearly to chemistry colleagues and cross-functional project teams

What You’ll Bring

• PhD with up to 4 years of relevant experience, MS with 6 or more years of relevant experience, or BS or equivalent with 10 or more years of relevant experience
• Strong expertise in synthetic organic chemistry, with demonstrated ability to design and execute complex, multistep organic synthesis
• Strong scientific and synthetic problem-solving skills and the ability to independently troubleshoot challenging chemistry
• Scientific curiosity, creativity, and the ability to rapidly learn and apply new concepts, technologies, and approaches
• Strong interpersonal and teamwork skills, with demonstrated ability to contribute in a collaborative, multidisciplinary research environment
• Excellent written and verbal communication skills, with the ability to clearly communicate scientific concepts, results, and conclusions
• Knowledge of medicinal chemistry principles, structure-based drug design, pharmacology, and/or ADME/PK, consistent with prior experience

Salary Range:  $130,200 - $141,400

The posted range applies to roles based in The Woodlands, TX area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – The Woodlands, TX

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Senior Analyst, FP&A

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

In this role you will own FP&A and finance business-partner support for Nurix's Research and G&A functions, including budgeting, forecasting, reporting, variance analysis, and accounting close support. It is a high-ownership individual-contributor role for someone who wants to take full responsibility for their areas while partnering closely across the organization.

Nurix is a late-stage clinical organization developing targeted protein degradation medicines across a wholly owned and partnered pipeline, so the right candidate is comfortable in a fast-paced, evolving environment and eager to take on new scope as the business grows. Strong attention to detail, cross-functional partnering, problem-solving, and time management are essential. Must be proactive, deadline-oriented, and a self-starter.

Essential Duties / Responsibilities

• Own the budgeting and forecasting process for Research and G&A in partnership with department and functional leaders
• Deliver timely, accurate quarterly reporting and budget-vs-actual analysis for assigned areas with clear variance commentary, and partner with the business monthly to review forecast changes
• Manage the quarterly accrual close for Research, working with business partners and external vendors to develop and validate accruals in line with SOX controls and GAAP
• Own revenue recognition for Research collaboration agreements (ASC 606), partnering with Accounting
• Support the annual financial planning and long-range planning processes
• Partner across Finance, Accounting, Research, and G&A functions to support decision-making and ad-hoc analysis
• Build and improve financial models and scenario analyses for Research and G&A, including program-level budget and resource-allocation scenarios
• Evaluate current processes and systems and drive efficiency improvements, including through automation and AI tooling

Experience, Knowledge and Skills

• 3+ years of experience in an FP&A or Finance function; biotech/pharma a plus
• Willingness to learn paired with a genuine appetite to take ownership of their areas
• Experience with Planful (or a comparable FP&A planning platform) and NetSuite (or a comparable ERP) a plus
• Interest in improving processes through automation/AI a plus
• High proficiency in Excel and PowerPoint
• Excellent written and verbal communication and presentation skills
• Analytical, resilient, and flexible, with a solutions and implementation focus, able to work with minimal supervision in a demanding environment

Education

• Bachelor's in Finance, Economics, Accounting, or a related field
• CPA or MBA a plus

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary:       $130,000 - $158,900

Location:    Brisbane, CA - Onsite 

 Senior Clinical Trial Associate (Sr. CTA) NX-1607

You’ve done this before — now do it with more ownership. You’ll run the TMF for your studies end-to-end, work directly with CROs to resolve problems before they become problems, and help the CTAs around you get better at the job.

Position Description

You’ll independently own key operational pieces of our trials — from TMF integrity to vendor coordination — and mentor junior team members along the way.

The Opportunity

• Own the study TMF plan end-to-end: development, tracking, and archiving of Essential Documents across the trial lifecycle
• Lead quality reviews of the TMF and resolve discrepancies directly with the CRO
• Draft and finalize study documents — plans, manuals, CRFs, and patient materials — with minimal oversight
• Serve as a go-to resource for junior CTAs, providing informal mentorship and process guidance
• Independently manage clinical supply and lab sample coordination, flagging risks before they escalate
• Own data reconciliation issues across systems, looping in Data Management only when needed
• Represent Clinical Operations at portions of team meetings and Investigator Meetings
• Help shape training materials and SOPs used across the broader CTA team

What You’ll Bring

• Bachelor’s degree (BS/BA) or equivalent combination of education and work experience in a science-related field
• 3–5+ years of Clinical Operations or clinical research-related experience
• Demonstrated ownership of a TMF or vendor relationship from start to finish
• Comfortable resolving routine CRO/vendor issues independently before escalating
• Experience mentoring or informally guiding junior team members
• Excellent verbal and written communication skills
• Proficiency with MS Word, Excel, Outlook, and PowerPoint

Salary Range:  $134,500 - $146,600 annually

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite - Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Senior Clinical Trial Manager (Sr CTM) 

You’ve run trials well — now run more of them, and help others do the same. You’ll manage a portfolio of trials or a full region, own vendor strategy end-to-end, and become the person other CTMs turn to when something’s stuck.

Position Description

This individual manages clinical regions and/or multiple trials simultaneously, with broad involvement in work central to Nurix’s strategic goals, and plays a key role in developing junior clinical operations staff.

The Opportunity

• Own operational strategy across multiple clinical trials and/or a full geographic region
• Shape protocol strategy and provide senior input on study design and data collection approach
• Lead vendor/CRO selection strategy and own contract negotiation leverage across trials
• Serve as the escalation point for vendor or site issues CTMs can’t resolve on their own
• Own program-level budget forecasting and proactively flag financial risk across the portfolio
• Mentor and develop CTMs and CTAs, providing hands-on guidance and informal supervision
• Lead audit readiness strategy and serve as the point person across multiple trials during inspections
• Represent Clinical Operations at the program or franchise level, and represent Nurix externally at professional events
• Anticipate risk across the trial portfolio and shape process or strategy to prevent issues before they surface
• Lead cross-functional strategic initiatives rather than simply participating in them

What You’ll Bring

• S./B.A. in biological sciences with 8-10+ years of relevant industry experience
• Ability to travel as required for the program (25%)
• Deep working knowledge of FDA, EMA, ICH, and GCP regulations and guidelines
• Proven experience managing global trials or multi-region programs
• Track record leading vendor/CRO relationships at a strategic, not just operational, level
• Experience mentoring or developing junior CTMs/CTAs
• Strong executive presence and ability to influence without direct authority
• Comfortable operating with minimal oversight and setting direction for others
• Outstanding organizational skills, able to manage a portfolio of trials simultaneously
• Thrives in a fast-paced, small-company environment, adjusting priorities as needed

Salary Range:  $181,900 – $193.827 annually

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Senior Director, Head of Pharmacovigilance Operations

Build and lead the pharmacovigilance operations that carry Nurix's growing clinical portfolio toward commercialization. You'll own the end-to-end ICSR model, safety systems, vendor oversight, and inspection readiness, with the chance to set strategy while staying hands-on and to build the function and team from the ground up.

Position Description

The Opportunity

• Report to the Head of PV and define and execute the short- and long-term PVO strategy, goals, and operating model in alignment with the PV department and corporate objectives
• Grow, mentor, and develop the PVO team, setting priorities and ensuring coverage across a growing portfolio; partner with the Head of PV on departmental planning, headcount, and budget
• Provide PVO updates and escalate risks, issues, and compliance trends to PV and executive leadership as appropriate
• Oversee the end-to-end ICSR management framework (intake, processing, in-stream quality review, regulatory submission oversight, and retrospective quality review), ensuring timeliness, accuracy, and compliance with global regulations (21 CFR, EU GVP, ICH E2 series)
• Define, monitor, and report case processing metrics (KPIs/KQIs), drive root cause analysis and resolution of quality or timeliness issues, and oversee the drug safety mailbox
• Oversee SAE reconciliation with Clinical Operations and Data Management and Reference Safety Information (RSI) tracking and dissemination, and ensure PVO input into the safety content of clinical documents (protocols, ICFs, IBs/RSI, and CSRs)
• Ensure the integrity of safety data outputs from the Global Safety Database for aggregate reports, signal assessments, health authority requests, and other safety needs
• Oversee operational delivery of aggregate safety reports (e.g., DSUR, PBRER/PSUR), and partner with Medical Safety, Regulatory Affairs, and Biostatistics to support signal management and benefit-risk evaluation
• Own the strategy, validation, and lifecycle management of the Global Safety Database (e.g., Argus or equivalent) and related PV systems, including configuration, upgrades, and E2B gateway/electronic submission
• Lead system selection, implementation, and transition projects, including safety database migrations and vendor changes, and drive automation and process improvements such as reconciliation tools, intake portals, and reporting and analytics capabilities
• Lead oversight of outsourced PV activities and the CROs and vendors that support them, establishing governance, KPIs/KQIs, scorecards, and performance reviews, and driving corrective actions when performance falls short
• Own PV budget planning, forecasting, and invoice review, identifying opportunities for cost optimization without compromising compliance
• Lead the strategy and management of PV Agreements and Safety Data Exchange Agreements (SDEAs) with license partners, collaborators, and distributors
• Own PVO inspection readiness and launch readiness, and lead PVO participation in internal audits, vendor audits, and regulatory inspections, including front-room/back-room support and CAPA development and tracking through closure
• Develop, maintain, and continuously improve PVO and compliance-related SOPs, work instructions, and process documentation, and monitor the evolving global regulatory landscape so PVO processes adapt to new requirements
• Act as the senior PVO liaison to Clinical Operations, Data Management, Regulatory Affairs, Quality, Biostatistics, and Medical Safety, and support PV input into due diligence, in-licensing, and business development activities as needed

What You’ll Bring

• Bachelor's degree in Life Sciences, Pharmacy, Nursing, or a related field required; an advanced degree (PharmD, MS, PhD, MBA) is preferred
• Minimum of 12 years of pharmacovigilance/drug safety experience in biotech or pharma, including in a leadership role managing PV operations and people
• Deep experience in PV operations and ICSR management across clinical development, with commercial readiness experience
• Demonstrated experience building, scaling, or transforming PV operations, ideally in a growing biotech environment
• Significant experience managing PV vendors and CROs, including KPI/KQI development, governance, and performance management
• Experience owning PV budgets, forecasting, and invoicing
• Experience leading or substantially supporting regulatory inspections and audits (FDA, EMA, or other health authorities), including CAPA management
• Experience with safety database implementations, upgrades, or transitions
• Proven experience authoring and governing SOPs, work instructions, and quality system documentation
• Experience negotiating and managing PVAs/SDEAs with license partners
• Strong leadership, coaching, and talent development skills, with the ability to build high-performing teams
• Excellent communication and influencing skills, with the ability to work effectively with executive leadership and cross-functional partners
• Strong analytical, organizational, and project management skills, with the ability to manage multiple products and priorities at once
• Quality and compliance mindset with strong attention to detail
• Comfort operating in a fast-paced, evolving environment, including through organizational change

Salary Range:  $ $288,100 - $325,700

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Remote or Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Senior Director, Quality Control

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position Description

Nurix Therapeutics is seeking an experienced Senior Director, Quality Control to join the Analytical Development and Quality Control group. This individual will establish and lead a QC operational function, establishing operations, systems, and a team to support programs from CMC development through commercial manufacturing.

The ideal candidate brings deep expertise in small molecule QC, strong regulatory acumen, and proven experience managing external CDMO and CTL relationships. This role will represent QC in health authority inspections and audits, and will work cross-functionally with Quality, Analytical Development, and Manufacturing to ensure product quality and patient safety across the portfolio.

Key responsibilities

• Build and lead the QC function: Establish QC systems and infrastructure; recruit, manage, and mentor internal QC staff and contractors
• Set QC strategy across the product lifecycle: Define and execute QC strategy spanning CMC development through commercial programs, ensuring alignment with company milestones and submission timelines
• Oversee QC operations internally and externally: Direct method validation, release and stability testing, data review, deviations, investigations, change control, and CAPA internally and at CDMOs, and CTLs
• Identify and manage quality risk: Proactively identify, assess, and escalate risks related to patient safety, product quality, shelf life, supply continuity, or GMP compliance; drive risk mitigation strategies in partnership with Analytical Development, Quality, and Manufacturing functions
• Lead QC through audits and inspections: Serve as QC lead during health authority inspections and internal audits; collaborate with Quality to conduct audits of GMP manufacturing and testing sites, including CDMOs and CTLs
• Support regulatory submissions and health authority interactions: Contribute to global regulatory filings; collaborate on responses to health authority information requests, regulatory commitments, and post-approval changes
• Direct stability programs: Develop and execute stability strategy in collaboration with Analytical Development leads, ensuring alignment with ICH guidelines and regional regulatory requirements
• Manage reference materials and retains: Oversee qualification and inventory of reference standards; develop sampling plans and manage sample retain programs
• Drive continuous improvement: Identify and implement process improvements, data integrity enhancements, and quality system upgrades (e.g., eQMS) to support a scalable, inspection-ready QC organization
• Travel up to 15% to CDMO, CTL, and manufacturing sites and supplier and scientific conferences

Qualifications

• Advanced degree in Chemistry, Pharmaceutics, Chemical Engineering, or related discipline. BS/MS with 16+ years of relevant experience, or PhD with 14+ years of relevant experience
• 5+ years in a QC leadership or management role, with demonstrated ability to build and mentor teams
• Deep experience in small molecule pharmaceutical development, including method lifecycle management and oversight of validation, release, and stability operations
• Proven experience managing external manufacturing and testing operations at CDMOs and CTLs
• Expertise with analytical methods such as HPLC, GC, dissolution, and microbiological testing
• Direct experience leading through health authority inspections and internal audits and conducting audits of manufacturing and testing sites.
• Deep working knowledge of cGMP, ICH guidelines, and USP/EP/JP compendial standards
• Experience contributing to global regulatory filings and health authority correspondence (e.g., responses to information requests, post-approval changes)
• Strong interpersonal and cross-functional collaboration skills, with the ability to influence and build consensus across Quality, Supply Chain, Analytical Development, and Manufacturing functions

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:   $280,200 - $319,800

Location:         Woodlands TX or Brisbane, CA - Onsite 

Senior Director, Translational Medicine and Clinical Biomarkers

Own the translational science that decides which patients get treated and how — leading biomarker strategy across Nurix’s entire oncology and immunology portfolio. This is a senior, portfolio-level role with direct influence on trial design, dosing decisions, and executive strategy from day one.

The Opportunity

• Own and evolve the clinical biomarker strategy across Nurix's full clinical portfolio, setting priorities that inform patient stratification, response prediction, and resistance mechanisms for multiple concurrent programs (not a single franchise or indication).
• Provide scientific interpretation of biomarker data, informed by a strong understanding of cell and tumor biology, molecular biology, inflammation, and immuno-oncology, helping translate those insights into patient-selection, dose-selection, go/no-go, and program-level development decisions.
• Direct the build-out and governance of biomarker assay capabilities across the portfolio, including assay qualification standards, platform strategy, and vendor/CRO oversight, to ensure consistent, scalable execution across programs rather than one-off, program-specific solutions.
• Set the strategic direction for evaluation and adoption of novel biomarker technologies and platforms, positioning Nurix's biomarker capabilities ahead of program needs rather than reacting to them.
• Lead and integrate cross-functional, matrixed teams spanning clinical development, research, regulatory, and external collaborators, ensuring biomarker data is embedded in clinical development plans and regulatory strategy at the portfolio level.
• Provide senior scientific and strategic input into clinical trial design across programs, influencing go/no-go and dose-selection decisions where biomarker data is a critical input.
• Directly manage and develop at least one direct report, with responsibility for hiring and scaling the team as pipeline needs grow.
• Act as a key scientific stakeholder in due diligence, business development, and external partnership discussions where biomarker strategy or capabilities are relevant.
• Model strong executive presence and sound judgment under ambiguity, translating complex biomarker science for scientific and non-scientific audiences alike, including executive leadership and the Board.

What You’ll Bring

• Advanced degree (Ph.D. or MD strongly preferred) with 12+ years of experience in a relevant scientific area within the pharmaceutical or biotech industry, including significant experience in clinical-stage drug development; deep translational biomarker expertise in Immunology, Oncology, or Hematology strongly preferred.
• Demonstrated track record of developing and leading biomarker strategy across a clinical portfolio — spanning multiple programs or indications — with direct experience influencing clinical trial design and regulatory submissions.
• Extensive technical depth across diverse platforms — flow cytometry, molecular biology, proteomics, and tissue-based assays — with the judgment to know when to engage personally versus direct through the team.
• Proven people leadership experience, with at least one direct report managed to date, and demonstrated ability to scale a team in a fast-growing biotech environment.
• Extensive experience in the design and authoring of clinical study protocols, informed consent forms (ICFs), laboratory manuals, and investigator meeting materials is required. Proven experience contributing to clinical study reports and supporting interactions with regulatory authorities is highly desirable.
• Executive-level communication skills, with a demonstrated ability to influence senior leadership, Board members, and external partners on biomarker strategy and its implications for program decisions.
• Strong strategic and organizational judgment, with experience balancing portfolio-level priorities against individual program needs in a resource-constrained environment.
• A track record of operating effectively in ambiguity, with the credibility and gravitas to be a trusted senior partner to clinical, research, and executive leadership.

Salary Range:  $280,400 - $316,500

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:        Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Senior Manager,  Analytical Development and Quality Control - Drug Product

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position:

Nurix Therapeutics seeks an experienced Senior Manager to join the Analytical Development and Quality Control group. The Senior Manager will be responsible for drug product (DP) analytical development, including method development, oversight of method validation at CDMOs, and lifecycle management in support of Nurix’s oncology and inflammation & immunology (I&I) programs.

This position provides technical oversight of analytical method development, validation, and testing conducted at external CDMO/CRO partners. The Senior Manager will author analytical development reports and IND/IMPD/NDA sections and support late-phase tech transfer and validation activities. This role will also contribute to analytical development for new drug products and dosage forms. The Senior Manager will work closely in cross-functional teams to ensure alignment and integration of analytical and QC strategies across development stages.

The ideal candidate will have expertise in chromatographic and dissolution method development, stability studies, and phase-appropriate validation and control strategies, along with demonstrated experience supporting late-phase development and regulatory submissions.

This position is onsite at Nurix headquarters in Brisbane, CA.

Responsibilities:

• Lead analytical method development validation and lifecycle management for drug product formulations, including amorphous solid dispersions (ASDs) and lipid-based systems
• Support PPQ activities, commercialization, commercial QC, and lifecycle management for drug product analytical methods and control strategies
• Design and oversee DP development, registration batch, and commercial stability programs, including protocol development and trend analysis
• Author and review DP analytical development reports to support regulatory submissions, and marketing authorization
• Oversee and support analytical activities, including method development, validation, and QC testing conducted at CDMOs and contract testing laboratories (CTLs)
• Contribute to investigations (e.g., OOS, OOE, OOT), root cause analysis and CAPAs
• Perform critical review of analytical data, protocols, reports, specifications, and related documentation
• Trend stability data and support establishment of retest periods and shelf life using statistical methods
• Collaborate in the development and justification of material control strategies and specifications
• Author technical documents, including analytical development reports, specifications, validation and stability protocols/reports, certificates of analysis (COAs), and storage statements
• Author and review analytical sections of regulatory submissions (e.g., IND/IMPD/NDA)
• Collaboratively author responses to health authority requests for information
• Act as a key contributor to multidisciplinary teams, including Chemical Development, Pharmaceutical Development, Regulatory, Quality, Preclinical, Supply Chain, Medicinal Chemistry, and DMPK
• Maintain and organize analytical documentation and data to ensure traceability, data integrity, and inspection readiness
• Follow cGMP requirements and internal SOPs
• Travel up to 5%, as required

Qualifications:

• Advanced degree in a relevant discipline (Chemistry, Pharmaceutics, or related field)
• Senior Manager: PhD with 8+ years of industrial CMC experience
• Strong experience in drug product analytical development and validation
• Experience with analytical development for amorphous solid dispersions (ASDs) and/or lipid-based formulations
• Experience in CDMO and contract testing lab oversight
• Experience supporting regulatory submissions (e.g., IND, IMPD, NDA) and global regulatory filings
• Fluency with ICH guidelines, cGMPs, and pharmacopeial chapters
• Ability to work effectively in a cross-functional environment
• Strong technical writing skills (e.g., development reports, regulatory documents)
• Ability to manage multiple priorities in a fast-paced environment
• Excellent communication and cross-functional collaboration skills

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:  $161,100 – $185,600

Location: Brisbane, CA - Onsite

Senior Manager / Associate Director, Publications and Medical Information (Contract)

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Job Responsitities:

Publications

• Contribute to development of Publication Strategy and Publication Plan (in coordination with the Publications Working Team)
• Execute publication tactics and the Publication Plan
• Manage the drafting process for clinical publications (with vendor/agency), tracking timelines and ensuring timely reviews, approvals, and submissions
• Interact with internal and external authors/KOLs related to clinical publications
• Manage record keeping and digital storage for publications-related materials, including publications metrics

Data Reviews

• Contribute to development of data review slide decks and derivative materials (with vendor/agency)
• Support data presentation-related AI projects

Congress Support

• Support booth staffing, congress materials, and presentation logistics (in coordination with Medical Affairs Operations)
• Provide dedicated congress/booth Medical Information support

Medical Information

• Draft Standard Response Letters and manage related Medical and Legal review
• Ensure timely responses to medical inquiries; coordinate with the Medical Information team at a partner company and track inquiry volumes
• Create FAQs and reference materials (in coordination with internal Subject Matter Experts)
• Support Medical Information-related AI projects

Education:

• Doctoral degree in a medical, biological, or related discipline (PhD, PharmD, MD; MS with relevant experience considered)

Experience:

• 3-4 years of experience (Sr. Manager) or 4-5 years of experience (Associate Director) in Medical Affairs, Medical Communications, Clinical Publications, or Medical Information
• Demonstrated experience managing scientific/clinical publications end-to-end
• Familiarity with publication management and MLR processes/procedures
• Experience with medical information operations and Standard Response Letter (SRL) development

Skills:

• Strong working knowledge of GPP, ICMJE, and industry compliance requirements
• Excellent scientific writing, editing, and critical literature-review skills
• Excellent communication skills
• Project management and time management skills, with the ability to operate within multiple concurrent timelines
• Cross-functional collaboration skills, with the ability to align with internal teams of Subject Matter Experts representing different functions

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Location:          Brisbane, CA - Onsite 

Senior Manager / Associate Director, Regulatory Affairs CMC (Small Molecules)

Shape the CMC regulatory path for Nurix's small molecule portfolio, from clinical development through marketed lifecycle. You'll combine hands-on authoring of Module 3 (Quality) content with real strategic influence as the CMC regulatory voice on cross-functional teams, with room at the Associate Director level to own strategy and mentor junior regulatory staff.

Position Description

The Opportunity

• Report to the Senior Director, Regulatory Affairs CMC (Head of Regulatory CMC, Small Molecules) as a key member of the Regulatory Affairs team
• Develop, communicate, and execute global CMC regulatory strategies for assigned programs (drug substance and drug product) across the product lifecycle
• Author, review, and compile high-quality CMC (Module 3 / Quality) content for regulatory submissions, including IND/IMPD and equivalent global filings, amendments, annual reports, and responses to health authority questions
• Assess the regulatory impact of manufacturing, analytical, formulation, and supply chain changes, and recommend filing strategies and categorization (e.g., substantial, non-substantial, annual reportable)
• Provide proactive CMC regulatory guidance and risk assessment to development, technical operations, and commercial teams
• Partner with Technical Operations/Manufacturing, Analytical Development, Quality Control, Quality Assurance, Supply Chain, and CMOs/CDMOs (where applicable) to align technical activities with regulatory requirements
• Represent CMC Regulatory on project and CMC sub-teams, and manage submission timelines and deliverables in coordination with regulatory operations and publishing
• Ensure submission content is accurate, consistent, scientifically sound, and compliant with ICH guidelines and regional requirements (FDA, EMA, and other markets relevant to the portfolio)
• Contribute to regulatory intelligence by monitoring evolving guidance and precedent and translating it into practical advice
• Oversee quality assurance processes to ensure compliance with regulatory standards, and participate in cross-functional initiatives that improve regulatory submission processes and systems
• At the Associate Director level, take greater strategic ownership and, where applicable, provide line management or mentoring of junior regulatory staff

What You’ll Bring

• Bachelor's degree in chemistry, pharmacy, pharmaceutical sciences, chemical engineering, or a related life sciences field is required; an advanced degree (M.S., Ph.D., or Pharm.D.) is preferred
• Minimum 6+ years in regulatory affairs with a substantial focus on CMC, and 10+ years of overall pharmaceutical/biotech industry experience
• Demonstrated experience authoring and/or compiling CMC (Module 3) content for regulatory submissions for small molecule products
• Working knowledge of ICH quality guidelines and of FDA and/or EMA CMC requirements; familiarity with other global regions is a plus
• Solid understanding of pharmaceutical development, manufacturing processes, and analytical methods for small molecules
• Strong written communication and scientific/technical writing skills
• Ability to manage multiple projects and competing timelines with attention to detail
• Effective cross-functional collaboration and stakeholder management
• Comfort operating with autonomy while escalating appropriately

Salary Range:  $187,800 - $208,600

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Senior Manager / Associate Director, Regulatory Affairs (Strategy, Hematology Oncology) 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Job Summary:

In this role, you will be a core member of the Regulatory team and will be responsible for helping build and execute on global regulatory strategy, objectives, policies and programs pertaining to development and future marketing of products.

Responsibilities:

• Provides regulatory strategic direction and support for assigned global development programs/development program activities
• Assists Sr. Regulatory Affairs staff with their development program activities and deliverables
• Designs and implements regulatory strategies with Regulatory Affairs staff to obtain and maintain product investigative and marketing applications for assigned programs, as well as their life cycle management
• Acts as regulatory representative on early and/or late phase clinical studies, ensuring compliant execution of trials
• Strong competency in understanding regulatory requirements and emerging regulatory landscapes associated with US and global regulatory authorities
• Experienced in responding to inquiries from global regulatory authorities as well as the preparation and conduct of meetings with global regulatory authorities
• Assist in the preparation and maintenance of Annual Reports, Development Safety Update Reports (DSURs), Investigator’s Brochures and other documents required for INDs, CTAs, NDAs and other related regulatory development and marketing applications
• Assist in the cataloging and maintenance of regulatory application submissions
• Conduct research and stay up-to-date on regulatory requirements and changes
• Collaborate with cross-functional teams to ensure product compliance throughout the development lifecycle
• Monitor and assess regulatory risks and develop mitigation strategies
• Oversee quality assurance processes to ensure compliance with regulatory standards
• Review SOPs pertaining to Regulatory
• Works strategically with all regulatory functions to develop detailed, actionable submission plans, tracks major submission deliverables, and ensures consistent management submission documents, health authority communications, and all other regulatory information supporting Nurix’s investigational and marketing applications
• Plays an essential part in defining requirements for, implementing, and supporting future systems and tools to be employed by Nurix in the areas of document management, submission content planning, and regulatory information management
• Tracks the status of major deliverables for regulatory submissions (e.g., study reports, summary documents, labeling) along with their dependencies
• Develops and maintains submission plan templates to ensure Nurix regulatory submissions are consistently planned and executed across programs
• Participates in cross-functional process initiatives impacting regulatory submission processes and systems
• Manages consultants and contractors as needed

Experience and Skills:

• Bachelor's degree in life-sciences or related scientific discipline; advanced degree preferred Manager:
• Must have minimum of 8 years in Regulatory affairs strategy
• Strong demonstration of knowledge of drug development, FDA, EMA and ICH guidelines and regulations
• Experience providing hands-on support for planning clinical trial and marketing applications to health authorities including but not limited to FDA, EMA
• Ability to read, analyze and interpret scientific and technical information, as well as regulatory
• Ability to understand and explain detailed regulatory affairs and compliance programs and/or to effectively present information to senior regulatory management, other departments or external
• Ability to comply with changing regulatory
• Proven track record of supporting Regulatory affairs in the planning and execution of major filings and ongoing maintenance of clinical trial and marketing applications
• Strong project management and critical thinking skills
• Experience applying project management techniques and tools (e.g., MS Project, Smartsheet, Excel trackers) to the planning and execution of regulatory submissions
• Excellent organizational and communication skills, both written and verbal
• Ability to work independently as well as part of a team environment
• Positive attitude, energetic and proactive
• Proven ability to manage multiple projects, identify and resolve regulatory issues
• Strong interpersonal skills and the ability to effectively work with others

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:   SM $187,800 - $208,638   AD $199,500 - $231,200

Location:          Brisbane, CA - Onsite 

Senior Manager, electronic Quality Management System (eQMS)

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Job Summary:

We are seeking a Senior Manager, electronic Quality Management System (eQMS) to provide quality expertise supporting the development and commercialization of Nurix’s products in compliance with relevant US, EU, and ICH requirements. In this role, you will be responsible for actively managing, developing, implementing, and reporting on Quality Systems, including Deviations, Investigations, CAPAs, Change Controls, Complaints, Quality Metrics, and electronic Quality Management Systems (eQMS).  You will serve as a subject matter expert (SME) and strategic partner across Technical Operations, Clinical, Regulatory Affairs, and other cross-functional teams, with overall responsibility for the execution, scalability, and continuous improvement of Nurix’s Quality Management System as the organization grows and matures.

Job Responsibilities:

• Manage and maintain processes, SOPs, and workflows for Deviations, Investigations, CAPA, Change Control, Complaints, Quality Metrics, and other core QMS programs.
• Led end-to-end implementation and deployment of Veeva Vault eQMS replacing legacy systems and aligning core quality processes (CAPA, Change Control, Deviations, and Audits) across enterprise sites.
• Lead or support the implementation, configuration, validation, and optimization of the electronic Quality Management System (eQMS), ensuring phase-appropriate design and scalability.
• Provide hands-on expertise in the day-to-day execution, review, and management of QMS records within the eQMS.
• Partner with internal stakeholders to define data governance, system configuration, user roles, and reporting requirements for quality systems.
• Ensure data integrity, traceability, and compliance of quality system data in accordance with regulatory expectations (e.g., ALCOA+ principles).
• Monitor overall quality system effectiveness, identify gaps or inefficiencies, and drive continuous improvement initiatives.
• Recommend updates to quality policies and procedures and implement process improvements aligned with organizational growth and regulatory readiness.
• Develop, compile, analyze, and present quality metrics and KPIs for routine management review.
• Perform trending and data analysis to identify risks, systemic issues, and opportunities for improvement.
• Create and deliver training programs related to QMS processes, data integrity, and eQMS functionality.
• Support inspection readiness and ensure adherence to cGMPs, regulatory mandates, and internal quality standards.
• Build and maintain strong cross-functional relationships and foster a culture of engagement, transparency, and quality ownership.
• Perform other duties as assigned.

Experience and Skills:

• Bachelor’s degree in Computer Science, Life Sciences, or a related field, or equivalent relevant experience.
• Demonstrated experience implementing, administering, and improving an eQMS, including system configuration, validation support, and lifecycle management.
• Minimum of 6 years of experience in the pharmaceutical or biotechnology industry, including 4+ years in Quality Systems / Quality Assurance.
• Strong working knowledge of quality system data management, reporting, and data integrity principles.
• First-hand experience managing and reviewing deviations, investigations, CAPAs, and change controls in a regulated environment.
• Experience using validated computerized systems to manage regulated quality records.
• Proven ability to develop and implement enhancements to electronic Quality Systems to improve usability, compliance, and reporting.
• Strong proficiency with Microsoft Office Suite and related business applications.
• Ability to manage multiple priorities in a fast-paced, evolving environment with strong attention to detail.
• Highly organized, self-motivated, and capable of working independently while effectively collaborating cross-functionally.
• Excellent written and verbal communication skills, with the ability to influence and interact effectively at all levels of the organization.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:   $158,700 - $172,100

Location:          Brisbane, CA - Onsite 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

About the Position:

The Senior Manager, Supply Chain Quality Assurance is responsible for ensuring the quality and compliance of materials, products, and distribution activities throughout the global supply chain.  This position provides quality oversight of contract manufacturers, suppliers, warehouses, packaging operations, depots and logistics providers to ensure compliance with applicable GMP, GDP, GCP (where applicable) and company quality standards. 

This role partners with Supply Chain, Manufacturing, Regulatory Affairs, Technical Operations, Clinical, CMC, and external business partners ensuring the quality, compliance, and timely supply of clinical materials across Nurix’s pipeline programs.

Reporting to the Senior Director, Quality Assurance, the Senior Manager will apply sound independent judgment to drive timely identification, investigation, and resolution of quality events, while building a culture of continuous improvement and cross-functional collaboration.

Responsibilities:

• Provide Quality oversight of global supply chain operations supporting early and late-stage clinical programs.
• Ensure quality requirements are incorporated into procurement, manufacturing, packaging, storage, transportation and distribution activities.
• Oversee quality aspects of warehousing and distribution operations.
• Qualify, monitor, and maintain approval status of suppliers, CMOs, laboratories depots and logistics providers.
• Participate in supplier audits and quality risk assessments.
• Manager supplier quality agreements and ensure periodic review.
• Ensure compliance with Good Distribution Practices.
• Oversee qualification of shipping lanes and transportation providers.
• Review shipping validation documentation.
• Assess quality impact of shipping deviations through the review of shipping deviations, including review of temperature excursion investigations and product impact assessments.
• Identify continuous improvement opportunities to simply quality processes while maintaining compliance.
• Maintain current knowledge of evolving regulatory expectations and industry standards; translate requirements into practical operational guidance for the organization.

Required Qualifications:

• Bachelor’s degree in chemistry, pharmaceutical sciences, life sciences, engineering or a related
• 5+ years of progressive Supply Chain or Supply Chain Quality Assurance experience in the pharmaceutical or biopharmaceutical industry with global distribution activities.
• Demonstrated experience managing and directing activities of outsourced manufacturing, testing, packaging and labeling and distribution operations.
• Thorough knowledge of FDA regulations (21 CFR Parts 210/211) and ICH guidelines (Q7, Q8, Q9, Q10, Q11), and EudraLex - Volume 4 - Good Manufacturing Practice (GMP) and their practical application to CMC development.
• Proven track record managing quality events, deviations, CAPA programs, and change control in a clinical or commercial pharmaceutical setting.
• Experience supporting regulatory agency inspections (FDA, EMA, or equivalent).
• Excellent project management skills with the ability to manage multiple high-priority deliverables simultaneously.
• Strong verbal and written communication skills; able to present complex quality and compliance topics clearly to diverse stakeholders.
• Willingness to travel to CDMO and laboratory sites domestically and internationally, as

Preferred Qualifications:

• Experience in a clinical-stage biotech environment scaling quality operations through late-stage development and toward commercialization.
• Experience with electronic QMS platforms (e.g., Veeva Vault) and document management
• Expertise in both development-phase and pre-commercial-phase quality assurance standards and expectations.

Salary: $173,000 - $199,00

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

 Company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Senior Research Associate, DNA Encoded Library Technology – Nurix Brisbane

Position

We are seeking a talented and motivated chemist to join our Discovery Chemistry team and contribute to the design and synthesis of DNA-encoded libraries (DELs). This hands-on position offers the opportunity to shape Nurix’s DEL-based lead discovery platform, working at the interface of chemistry, biology, and automation. Key responsibilities:

• Design and validate novel DEL library builds.
• Develop and bring in new DNA-compatible chemical transformations that can widen the DEL chemical space.
• Construct DEL libraries to support the in-house library production efforts.
• Work with external partners to support our DEL synthesis and hit follow up strategies.
• Engage in cross-functional team discussions that support DEL screening, data analysis, machine learning and hit-optimization.
• Contribute to platform automation and technology development efforts.
• Present results, document workflows, and contribute to scientific and strategic planning within the Discovery Chemistry organization.

Education and Experience

• B.S. or higher in Chemistry, Biochemistry, or Medicinal Chemistry with 5 years of industrial experience (title determined by experience).
• Strong background in synthetic organic chemistry.
• Hands-on laboratory experience synthesizing DNA encoded libraries.
• Familiar with the overall DNA-Encoded Library Technology workflow operations.
• Experience analyzing and purifying DNA-conjugates using common analytical tools (LCMS/HPLC).

Added Qualifications

• Experience working in the drug discovery field – drug design, synthesis, and SAR based hit-to-lead optimization.
• Experience working with high-throughput analytical and purification systems relevant to DEL-applications.
• Experience working with molecular biology tools (PCR, qPCR, Western Blot).

Fit with Nurix Culture and Values

• Collaborative and team-oriented, eager to share expertise and learn from others.
• Solution-driven with a hands-on and resourceful approach.
• Adaptable and comfortable in a fast-paced, interdisciplinary environment.
• Committed to scientific excellence and the shared goals of the team.

Location: Brisbane, CA

Salary Range:  $119K  – $139K 

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Senior Research Associate, Preclinical Pharmacology

Run in vivo studies that move Nurix's degrader programs toward the clinic. You'll execute mouse efficacy, PK/PD, and mechanism-of-action studies in oncology and inflammation models and generate the Western blot and flow cytometry data that show how our molecules work.

Position Description

 The Opportunity

• Join the Research – Preclinical Pharmacology team as a full-time, onsite, hands-on member, reporting to a Scientist / Principal Scientist, Preclinical Pharmacology
• Perform mouse handling and in-life procedures, including dosing by oral (PO), intraperitoneal (IP), subcutaneous (SC), and intravenous (IV) routes, tumor cell implantation, tumor and body-weight measurements, and in-life and terminal blood collection
• Execute PK/PD, tolerability, and efficacy studies in oncology xenograft/syngeneic models and in murine models of inflammation, under the direction of study leads
• Prepare and formulate test articles and vehicles for dosing; monitor animal health, document observations, and escalate adverse events promptly
• Perform necropsy and collect, process, and bank tissues and blood for downstream biomarker and pharmacodynamic analyses
• Prepare tissue and cell lysates and perform Western blotting (including quantitative and automated capillary formats) to measure target degradation and pathway modulation
• Develop, run, and analyze multi-color flow cytometry panels for immune and tumor-cell phenotyping from blood, spleen, tumor, and other tissues
• Maintain and expand cell lines using sterile cell culture technique; support cell-based assays and the generation of cells for in vivo implantation
• Record experiments accurately and in a timely manner in the electronic lab notebook; analyze, graph, and summarize data and present results at team meetings
• Collaborate with Biology, Chemistry, DMPK, and Translational teams to design studies and troubleshoot models and assays
• Adhere to IACUC protocols, animal welfare regulations, and laboratory safety requirements, and maintain required training and certifications
• Contribute to the optimization and qualification of new models and assays and to the training of junior team members
• Maintain laboratory equipment and supplies and support vivarium coordination, including occasional weekend or off-shift study coverage; other essential duties as assigned; minimal travel (<5%)

What You’ll Bring

• BS/MS in Biology, Pharmacology, Immunology, Cancer Biology, or a related field, with a BS or equivalent plus 8 or more years of relevant experience, or an MS plus 4 or more years of relevant experience
• Industry (biotech or pharma) experience conducting in vivo pharmacology studies in mice
• Proficiency in mouse handling and dosing by PO, IP, SC, and IV routes, as well as blood collection and tissue harvest
• Hands-on experience with oncology models (e.g., xenograft, syngeneic) and with murine models of inflammation or immunology
• Demonstrated proficiency in Western blotting and flow cytometry, including sample preparation, staining, and data analysis
• Proficiency in sterile mammalian cell culture technique
• Working knowledge of IACUC regulations and humane animal care practices
• Strong organizational and documentation skills, with attention to detail and the ability to manage multiple studies simultaneously
• Collaborative, adaptable, and comfortable in a fast-paced, team-oriented research environment
• Ability to work in an animal facility and tolerate exposure to laboratory animals, and to work occasional weekends or off-shift hours as studies require
• Bonus: experience with targeted protein degradation (molecular glues, PROTACs) or other small-molecule oncology or immunology programs
• Bonus: experience with multi-spectral flow cytometry, automated Western (e.g., Jess/Wes), ELISA, or MSD cytokine/biomarker assays
• Bonus: experience with orthotopic, disseminated, PDX, or humanized mouse models, or with in vivo imaging
• Bonus: experience with inflammation models such as collagen-induced arthritis, colitis, or cytokine-challenge models
• Bonus: familiarity with PK/PD relationships, compound formulation, and dose-response study design
• Bonus: proficiency with GraphPad Prism and electronic lab notebook systems

Salary Range:  $131,400 - $139,900

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

Nurix Therapeutics seeks an experienced Senior Scientist to join the Analytical Development and Quality Control group. The Senior Scientist will lead analytical and QC activities in IND-enabling and early phase clinical studies. The Senior Scientist will develop analytical test methods, characterize drug substance and drug product attributes, identify and characterize technical risk, and collaborate in risk mitigation work. The Senior Scientist will oversee and execute analytical development, validation, and testing both internally and at external CDMO/CRO partners and author relevant sections of regulatory filings.

The ideal candidate must have expertise in chromatographic method development, stability studies, and phase-appropriate validation and control. The ideal candidate should have a record of contribution to first-in-human INDs and experience in vendor oversight..

This position is onsite at Nurix headquarters in Brisbane, CA.

Responsibilities:

• Characterization of drug substance and drug product attributes, identification of technical risks, and collaboration towards risk mitigation strategy
• Method development for and analytical characterization of drug substances, drug products, and product stability
• Management and/or execution of method development internally and at CDMOs/CTLs
• Management of method validation, QC testing, and reference standards at CDMOs/CTLs
• Management of forced degradation, long term stability, and predictive stability studies
• Contribution to OOS/OOE/OOT investigations
• Critical review of data, protocols, reports, specifications, and other documentation
• Trending stability data and establishing retest periods/shelf life using statistical methods
• Collaboration in the development of material control strategies and specifications
• Follow cGMP requirements and internal SOPs

Qualifications:

• Advanced degree in a relevant discipline (Chemistry, Pharmaceutics, or related field)
• Senior Scientist: BS/MS degree with 14+ years or PhD with 8+ years of industrial CMC experience
• Expertise in HPLC method development is essential
• Additional experience in techniques such as gas chromatography, NMR, mass spectrometry, particle size analysis, solid state characterization, dissolution, ICP-MS/OES, and/or FTIR
• Experience in analytical method development and validation
• Experience in management of analytical activities at CDMOs/CROs
• Solid understanding of control strategy, method validation, and retest/expiry
• Experience managing stability programs, reference standards, and retest/expiry
• Familiarity with ICH guidelines, cGMPs, and pharmacopeial chapters
• Familiarity with deviation management and change control
• Ability to critically interpret data and articulate technical concepts in multidisciplinary settings
• Ability to ensure assigned activities are completed in satisfaction of project timelines
• Strong interpersonal skills that foster collaboration within and outside of the organization
• Ability to travel domestically and internationally

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:  $162K – $186K 

Senior Scientist, Medicinal Chemistry

 Drive medicinal chemistry strategy for Nurix's discovery programs, from hit optimization through development candidate nomination. You'll design novel compounds, interpret complex SAR across multidisciplinary datasets, and help set new scientific directions, with opportunities to lead chemistry workstreams and mentor colleagues.

Position Description

The Opportunity

• Design novel chemical entities and medicinal chemistry strategies, applying structure-based drug design to optimize potency, selectivity, physicochemical properties, ADME/PK, safety, and in vivo efficacy
• Design synthetic strategies for complex molecules using modern and creative synthetic methods
• Develop and interpret SAR by integrating chemical, structural, computational, biochemical, cellular, pharmacological, and ADME/PK data; independently identify key questions, design experiments, and recommend compound or series advancement, redesign, or termination
• Partner closely with computational chemists, structural biologists, and colleagues across biology, pharmacology, and DMPK to advance project objectives
• Develop innovative concepts that establish new directions and address complex challenges, drawing on emerging literature, patents, and competitive intelligence to inform compound design and strategy
• Lead chemistry workstreams within multidisciplinary teams, independently manage priorities and external collaborations, and contribute to project strategy and key scientific decisions
• Provide scientific guidance, coaching, and mentorship to other scientists
• Communicate scientific rationale, data, and recommendations clearly to project teams, leadership, and broader scientific audiences
• Contribute to intellectual property generation, patent preparation, and scientific publications; represent assigned projects at external forums; and lead improvements in laboratory practices and workflows

What You’ll Bring

• BS or MS with 14+ years of relevant experience, or PhD with 8+ years of relevant experience
• Strong expertise in medicinal chemistry and synthetic organic chemistry, with demonstrated ability to apply synthetic strategies to complex discovery challenges, including compound design, SAR development, multiparameter optimization, and structure-based drug design in close collaboration with computational chemistry and structural biology
• Ability to integrate potency, selectivity, structural, physicochemical, ADME/PK, and pharmacology data, with a solid understanding of biology and pharmacology, to guide compound design and project strategy
• Scientific creativity and a track record of innovation, including advancement of chemical series, advanced leads, or development candidates
• Strong problem-solving and project management skills: identifying critical questions, forming hypotheses, designing experiments, and translating results into actionable strategies across projects of significant scope and complexity
• Ability to establish new chemical, scientific, or strategic directions from experimental data, structural insights, literature, patents, and emerging science, and to influence decisions within multidisciplinary teams
• Experience providing scientific guidance, coaching, or mentorship, with strong skills in applying literature, patent, and competitive intelligence to program strategy
• Excellent written and verbal communication skills for multidisciplinary teams, senior leadership, and external audiences

Salary Range:  $147,500 - $157,500

The posted range applies to roles based in The Woodlands, TX area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – The Woodlands, TX

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

 Talent Acquisition Analyst - Contract

Recruiting data tells a story — you’re the one who makes leadership actually see it. You’ll move fluidly between building dashboards, crafting the decks that shape hiring strategy, and jumping in on scheduling when the team needs an extra hand, with a front-row seat to how a growing biotech scales its talent function.

Position Description

This role sits at the intersection of recruiting operations, analytics, and executive reporting — turning recruiting data into clear insights for leadership and building the tools that inform hiring strategy. It’s a great fit for someone who enjoys variety and is comfortable moving between data analysis, presentation-building, and hands-on coordination.

The Opportunity

Analytics & Reporting

• Build, maintain, and distribute recruiting dashboards and reports, including pipeline metrics, time-to-fill, source effectiveness, and offer acceptance rates
• Monitor and audit data integrity across the Applicant Tracking System (Greenhouse) and related recruiting platforms, flagging discrepancies and recommending corrections
• Analyze recruiting funnel data to identify trends, bottlenecks, and opportunities for process improvement
• Partner with the Head of Talent Acquisition to prepare ad hoc analyses and data visualizations for leadership and Board-level reporting

Presentations & Executive Support

• Create polished PowerPoint decks and other materials to communicate hiring progress, headcount trends, and talent acquisition strategy to senior leadership
• Translate complex recruiting data into clear, compelling narratives for non-technical and executive audiences
• Support special projects and initiatives led by the Head of Talent Acquisition, including workforce planning and org design analyses

Recruiting Operations & Process

• Maintain and improve Talent Acquisition process documentation, SOPs, and quick-reference guides
• Support system enhancements and evaluate new tools to improve efficiency and data quality across the recruiting lifecycle
• Identify opportunities to leverage automation and AI tools to streamline recruiting workflows

Interview Scheduling Backup

• Provide backup support for phone, Zoom, and onsite interview scheduling during peak volume or Recruiting Coordinator absences
• Partner closely with the Recruiting Coordinator to ensure a seamless, consistent candidate experience across all scheduling touchpoints

What You’ll Bring

• Bachelor’s degree in Business, Data Analytics, Information Systems, or a related field or equivalent expereince
• 2-4 years of experience in talent acquisition, recruiting operations, HR analytics, or a related function; biotech/pharma or life sciences experience preferred
• Strong Excel/Google Sheets skills and experience building polished PowerPoint presentations for leadership audiences
• Hands-on experience with an ATS (Greenhouse strongly preferred) and comfort pulling, cleaning, and interpreting recruiting data
• Excellent attention to detail and data accuracy, with the ability to spot and resolve inconsistencies
• Strong organizational and time management skills, with the ability to juggle multiple concurrent priorities
• Clear, confident communication skills, with the ability to present data-driven insights to non-technical audiences
• A flexible, team-oriented mindset and willingness to step into scheduling/coordination work as needed

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position Overview

Nurix Therapeutics is seeking a Vice President, Medical Affairs, Hematology-Oncology to build, expand, and lead a best-in-class Medical Affairs organization supporting the company’s transition from a clinical-stage biotechnology company toward commercialization as its hematology-oncology portfolio advances into late-stage clinical development.

This executive will provide strategic and operational leadership across the full Medical Affairs function, including medical strategy, field medical, scientific communications, evidence generation, thought leader engagement, medical information, and launch readiness. The role will play a central role in shaping the scientific and medical strategy for Nurix’s targeted protein degradation portfolio and helping define the company’s external scientific leadership in hematologic malignancies.

The role will be a key cross-functional partner to Clinical Development, Commercial, Market Access, Regulatory, Legal, and Compliance as Nurix plans and executes future commercialization activities. This leader will contribute broadly to portfolio strategy, lifecycle planning, and enterprise-level decision making as a member of the senior leadership team.

Responsibilities

• Lead and scale the Medical Affairs function to support the progression of Nurix’s hematology-oncology programs into late-stage clinical development and future commercial readiness.
• Own the overall Medical Affairs strategy for the hematology-oncology portfolio, ensuring alignment with development plans, portfolio priorities, and corporate objectives.
• Lead development of the scientific platform and differentiated medical narrative for Nurix hematology-oncology programs within rapidly evolving treatment landscapes.
• Partner closely with Clinical Development to shape late-stage medical strategy, including data generation priorities, scientific narrative, external engagement plans, and lifecycle opportunities.
• Develop and execute integrated medical plans across field medical, scientific communications, publications, medical education, medical information, insight gathering, and evidence generation.
• Expand and lead a high-performing MSL organization focused on credible scientific exchange, compliant insight capture, and strong engagement with key external experts, investigators, and treatment centers.
• Lead external engagement in hematologic malignancies, including advisory boards, investigator relationships, disease-area thought leader engagement, and interactions with cooperative groups and broader scientific communities.
• Serve as a senior medical representative of the company with external experts, investigators, and scientific leaders, helping establish Nurix as a credible scientific leader in hematologic malignancies and targeted protein degradation.
• Direct publication and scientific communication strategy for key clinical data, congress presentations, medical content, symposia, and educational initiatives.
• Lead integrated evidence generation strategies spanning registrational support, post-marketing evidence development, real-world evidence, health economics and outcomes research, treatment sequencing, and product differentiation opportunities.
• Partner with Commercial and Market Access to ensure medical strategy informs launch readiness, access planning, scientific platform development, training initiatives, and broader commercialization strategy.
• Monitor the external hematology-oncology landscape, including standard-of-care evolution, competitor data, treatment guidelines, and emerging scientific trends, and translate insights into actionable medical strategy.
• Ensure all Medical Affairs activities are conducted in compliance with applicable legal, regulatory, and company standards.
• Provide medical and scientific leadership to executive governance discussions related to portfolio prioritization, lifecycle strategy, label expansion opportunities, external partnerships, and commercialization readiness.
• Support global Medical Affairs planning and coordination, including scientific congress strategy, evidence generation activities, and external engagement initiatives across key regions.

Qualifications

• MD, PhD, DO, or PharmD required; oncology/hematology experience
• 15+ years of biopharmaceutical Medical Affairs experience with significant leadership responsibility, including direct accountability for launch and post-approval
• Demonstrated leadership experience supporting late-stage development and commercialization of hematology-oncology therapies, including launch planning, scientific positioning, and post-approval medical strategy.
• Demonstrated expertise in evidence generation (Phase 3b/4, RWE, HEOR), scientific communications, MSL leadership, and cross-functional launch planning.
• Strong understanding of global and US. regulatory, compliance, and payer environments related to medical activities and drug promotion.
• Experience in highly innovative therapeutic platforms, first-in-class mechanisms, or rapidly evolving treatment landscapes strongly preferred.
• Excellent leadership, communication, and collaboration skills, with the ability to operate strategically while remaining hands-on in a fast-moving pre-commercial and launch environment.
• Demonstrated ability to build and scale high-performing Medical Affairs organizations in emerging biotechnology or growth-stage commercial settings preferred.

Salary Range:  $348,000 - $399,000 

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Vice President / Senior Vice President, Global Development Leader (Bexobrutideg) 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

We are seeking a brilliant, organized and highly motivated leader who will provide strategic and tactical medical leadership and will deliver key clinical and scientific leadership to clinical development programs while ensuring the highest standard for safety and compliance with regulatory requirements and standard procedures. The ideal candidate should have experience working in a fast-paced dynamic environment.  The successful candidate will report to the Chief Medical Officer.  The responsibilities of this leader are listed below. 

• Lead one or more Program teams comprised of functional representatives from Clinical Development (Clinical Operations, Medical Monitoring, Clinical Science), Research and Translational Medicine, Regulatory, Technical Operations, Quality, and Commercial from phase 1  through phase 3 and through approval and launch; serve as the single point of accountability for the BTK Program Global Development Team (GDT), and to create and drive key program decisions through appropriate governance forums, where appropriate 
• As a member of the Clinical Executive Management Team, partner with stakeholders to set clear direction and execute against goals for a portfolio of clinical stage therapies, ensuring the development and execution of program strategy is in line with corporate strategy and goals 
• Drive the development and communication of program plans and development plan in partnership with the asset teams and program management 
• Facilitate cross-functional communication; drive strategic and operational alignment with the Program team, functional leads, and Executive Management Team 
• Identify challenges and risks and prepare the team with mitigations to navigate through technical and program challenges as they arise 
• Develop or participate in the refinement/update of the Clinical Development Plan (CDP); act as or oversee the clinical leads for protocols and supportive activities to meet the CDP objectives  
• Provide medical oversight for ongoing clinical trials including regular review of clinical data to improve understanding of the molecule profile, including but not limited to safety and activity 
• Provide clinical oversight for Company operational staff and contract research organizations (CROs) in all areas related to the execution of therapeutic programs 
• Provide and or oversee training and ongoing input to all members of the clinical team on medical and scientific issues related to the appropriate therapeutic field 
• Provide medical support for all relevant regulatory discussions and activities, such as IND’s and NDA/MAAs 
• Interact with principal investigators and opinion leaders to facilitate clinical trials research 
• Refine and or establish processes and methods for design and implementation of applicable clinical protocols, data collection systems and final reports 
• Data presentation to executive leaders, internal and external medical colleagues in one on one or large group settings (50+). 

Required Qualifications 

• MD, board certified preferably in hematology/oncology 
• Requires at least 10 years’ clinical trial experience in the setting of pharmaceutical industry with demonstrated experience and involvement in clinical trial design or execution. In particular, Ph3 clinical trial planning and execution. 
• Relevant clinical research experience in academic settings will be reviewed in light of clinical development experience 
• Excellent communicator with proven leadership skills and the ability to interact in a cross functional environment 
• Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities 
• Proven leadership experience leading high performing teams and individuals 
• Hands on leadership approach will be best suited for this critical role 
• Experience working in a highly productive and high achieving collaboration 

Fit with Nurix Culture and Values 

• Strong team orientation; highly collaborative 
• Solutions and results-oriented focus 
• Hands-on approach; resourceful and open to diverse points of view