Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

The Senior Manager / Associate Director, Computer Systems Assurance (CSA) is an important technical and operational leader within the Nurix Quality Systems organization, responsible for owning and advancing Nurix's computer systems assurance program. As a virtual drug developer, Nurix operates through a lean internal infrastructure and relies on a curated ecosystem of Software-as-a-Service (SaaS) and cloud-hosted platforms to support GxP-regulated activities across clinical development, quality operations, manufacturing oversight, and regulatory submissions. This role will serve as the primary subject matter expert and program owner for all CSA and computerized system validation (CSV) activities at Nurix.

Reporting to the Vice President / Senior Director, Quality Systems, this individual will establish and maintain Nurix's risk-based CSA framework aligned with current regulatory expectations, including the FDA's 2022 guidance on computer software assurance, GAMP 5 (2nd edition), and applicable 21 CFR Part 11 and Annex 11 requirements. The role requires an individual who combines deep technical knowledge of GxP computerized systems with practical experience in SaaS and cloud-based platform qualification, and who can translate regulatory requirements into pragmatic, fit-for-purpose validation approaches that support a modern, agile biotech environment. This is a high-impact, program-ownership role requiring both strategic vision and hands-on execution. The successful candidate will work closely with Quality, IT, Regulatory Affairs, CMC, Clinical Operations, and external vendors to ensure that all GxP-critical systems are appropriately assessed, validated, and maintained in a compliant state. The individual will champion a risk-based, science-driven approach to CSA across the organization.

Responsibilities

CSA Program Ownership and Strategy

• Own and maintain Nurix's Computer Systems Assurance policy framework, SOPs, and risk-based validation strategy, aligned with FDA CSA guidance (2022), GAMP 5 (2nd edition), 21 CFR Part 11, EU Annex 11, and applicable ICH guidelines.
• Define and implement a fit-for-purpose, risk-tiered approach to system qualification for SaaS and cloud-hosted GxP applications, recognizing the vendor-managed nature of modern software platforms.
• Maintain the GxP system inventory; conduct and document periodic system risk assessments to classify systems and determine appropriate validation scope and rigor.
• Establish and maintain processes for vendor assessment, including review of vendor SOC 2 reports, quality agreements, and audit strategies appropriate for SaaS providers.
• Drive continuous improvement of the CSA program through benchmarking, regulatory intelligence, and adoption of industry best practices.

System Validation and Qualification Execution

• Lead and execute validation activities for GxP SaaS platforms including, but not limited to, eQMS (e.g., Veeva Vault), electronic document management, clinical data management, regulatory information management, and laboratory information systems.
• Author and review validation documentation including Validation Master Plans (VMPs), User Requirements Specifications (URS), Risk Assessments, Vendor Assessments, Validation Protocols (IQ/OQ/PQ), Traceability Matrices, and Validation Summary Reports.
• Manage validation activities associated with system implementations, major configuration changes, upgrades, and periodic re-validation reviews, applying critical thinking to scope validation effort proportionate to system risk and change impact.
• Coordinate validation testing activities with cross-functional stakeholders; ensure test scripts are appropriately designed to demonstrate fitness for intended use.
• Review and approve validation deliverables prepared by internal teams, vendors, or external validation consultants.

21 CFR Part 11 and Data Integrity

• Serve as the internal subject matter expert for 21 CFR Part 11 and EU Annex 11 requirements; assess systems for compliance and provide guidance to cross-functional partners.
• Partner with IT and system owners to ensure electronic records and electronic signature controls are properly implemented and documented in all GxP systems.
• Support data integrity assessments and remediation initiatives; apply ALCOA+ principles to guide compliant system design and use.

Change Management and Periodic Review

• Manage the computerized systems change control process; evaluate proposed changes for validation impact and establish appropriate assessment, testing, and documentation requirements prior to implementation.
• Own and execute the periodic review program for validated GxP systems; assess continued fitness for intended use and compliance with current regulatory expectations.
• Maintain validation status documentation and ensure validation files are audit-ready at all times.

Inspection Readiness and Regulatory Support

• Support preparation for regulatory agency inspections; serve as the CSA subject matter expert during FDA, EMA, and other Health Authority inspections and ensure validation documentation is complete, current, and accessible.
• Contribute to relevant sections of regulatory submissions and respond to agency questions related to computerized systems and data integrity.
• Monitor evolving regulatory guidance and industry standards related to CSA, CSV, data integrity, and cloud-based systems; proactively adapt Nurix's program to reflect current expectations.

Cross-Functional Partnership and Training

• Serve as the primary point of contact and internal consultant for all GxP system owners across Quality, IT, Regulatory Affairs, CMC, and Clinical Operations.
• Develop and deliver CSA training for system owners, end users, and other stakeholders to build organizational capability and awareness.
• Partner with IT and vendor project teams to embed validation requirements early in system selection and implementation processes.

Required Qualifications

• Bachelor's degree in computer science, information systems, life sciences, pharmaceutical sciences, or a related field.
• 7–10+ years of progressive experience in computer systems validation and/or computer systems assurance in a GxP-regulated pharmaceutical, biopharmaceutical, or biotechnology environment.
• Demonstrated expertise in current regulatory requirements for computerized systems, including FDA 21 CFR Part 11, EU Annex 11, FDA CSA guidance (2022), and GAMP 5 (2nd edition).
• Hands-on experience validating SaaS and cloud-hosted GxP platforms; understanding of vendor-managed environments and shared responsibility models.
• Proficiency authoring and reviewing CSA/CSV deliverables: VMPs, URSs, Risk Assessments, IQ/OQ/PQ protocols, traceability matrices, and validation summary reports.
• Strong working knowledge of data integrity principles (ALCOA+) and their application to electronic records management and GxP system design.
• Experience managing system change control and periodic review programs for validated GxP systems.
• Ability to operate as both program owner and individual contributor in a lean, virtual organizational model; comfortable managing validation activities without a large internal support team.
• Excellent written and verbal communication skills; able to translate complex technical and regulatory requirements into practical guidance for diverse stakeholders.
• Strong organizational skills and attention to detail; demonstrated ability to manage multiple concurrent programs and priorities in a fast-paced environment.

Preferred Qualifications

• Experience with eQMS validation (e.g., Veeva Vault) and familiarity with Veeva's Qualified System approach and available supplier documentation.
• Familiarity with clinical development platforms such as electronic data capture (EDC), regulatory information management (RIM), or clinical trial management systems (CTMS) in a validated context.
• Experience supporting FDA, EMA, or equivalent Health Authority inspections as a CSA subject matter expert.
• Exposure to laboratory informatics systems (LIMS, ELN) and their GxP qualification requirements.
• Experience in a virtual or lean biotech environment managing validation activities through external vendors and consultants.
• Working knowledge of cybersecurity frameworks and their intersection with GxP system compliance (e.g., NIST, SOC 2).
• Advanced degree in a relevant scientific, engineering, or regulatory discipline.

Fit with Nurix Culture and Values

• You know the regulations deeply and apply them with judgment, designing validation approaches that are rigorous where it matters and efficient everywhere else. You bring expertise with pragmatism —
• You are comfortable as the go-to expert, driving the CSA program forward proactively rather than waiting for direction, and you take accountability for outcomes. You own the program —
• You build trusted relationships across Quality, IT, and the business, and you understand that a well-designed, compliant systems environment is an enabler of Nurix's mission to develop important medicines for patients. You partner with purpose —

Location: Brisbane, CA - Onsite 

Salary Ranges: Senior Manager, CSA(Quality)      - $170,538 – $193,493                                  
                           Associate Director, CSA(Quality) - $190,269 – $216,360

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

 Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position:  Biosample Manager 

Nurix Therapeutics, Inc. is seeking a Biosample Manager to join the Clinical Operations team. This is an onsite role. This individual will work cross functionally, with both internal and external stakeholders, to plan, coordinate, and oversee all operational activities required to manage the lifecycle of the clinical biosamples and support translational research.

Responsibilities:

Study Management

• Provide guidance during protocol and informed consent form development to ensure logistical feasibility of biosample handling, alignment with planned analyses and ICH/GCP compliance
• Participate in the CRF development process to ensure that biosample information is appropriately captured for sample tracking and reconciliation purposes
• Serve as the functional lead as a member of the Clinical Study Teams and provide regular biosample metrics/trends and status updates
• Partner with cross-functional teams to ensure timely delivery of biosample data to meet publication and study goals

Biosample and Vendor Management

• Provides operational leadership on vendor and sample management activities, including design of central lab specifications at study start or amendments
• Oversee kit design, sample processing, and sample logistics to ensure that the investigator sites can meet the sample handling needs of the study
• Plan, coordinate and oversee sample shipments and query resolution at laboratory vendors
• Manage the sample management system to track the life cycle of the samples, identify trends and gaps, and support sample reconciliation
• Provide training and guidance to the investigator sites and study monitors for biosample collection, handling and shipment
• Manage laboratory vendors, overseeing vendor selection, technology transfers, budgets, contract management, and data management
• Develop and maintain biosample operations SOPs and WPs

Qualifications:

• B.S. in biological sciences with 8+ years of relevant industry experience
• Knowledge of FDA, ICH/GCP, and GDPR regulations and guidelines
• Proven track record of sample management, data management and vendor management skills
• Developed central lab specifications and logistics for global studies at study start or protocol amendments with cross-functional collaboration
• Ability to develop and manage workflows and data sets
• Proficiency in MS Office including with advance Excel skills
• Good initiative and ability to work independently
• Ability to work in a fast-paced environment
• Excellent written and interpersonal communication skills
• Detail oriented with the ability to manage multiple competing priorities
• Effective team player and ability to collaborate with cross functional clinical study teams
• Onsite role 

Salary Range:  140K - 180K plus equity and bonus 

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

 Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

About the role

This is the operating leader for IT infrastructure and operations at Nurix, reporting to the SVP of Information Technology. You will own the function end to end: infrastructure, cybersecurity operations, end user services, and IT service management as one integrated scope. You partner with a fractional CISO on security strategy and policy while owning the operational execution. You work closely with the IT business partner leaders who own the application portfolios and partner directly with R&D and the broader scientific organization on their infrastructure needs.

You lead a team that spans enterprise architecture, system administration, and cybersecurity operations, with the service desk delivered through a mix of staff and managed service providers. You will manage both individual contributors and managers from day one. You set the standards and delegate delivery across this hybrid team of internal staff and managed service providers, empowering the people below you rather than running their queues, to support a fast-moving enterprise.

What you'll do

In your first year you will:

• Consolidate the managed service provider portfolio across infrastructure, security, and the help desk into a smaller, more accountable set of partners.
• Build a cybersecurity operations function from current contractor and MDR coverage.
• Establish a governance model with research and scientific computing, and bring research infrastructure into IT alignment. Working with the enterprise architect, inventory and remediate AWS systems: ParallelCluster and other HPC, container platforms (EKS, ECS), SageMaker, and identity bridges.
• Own a formal identity and access management program, including clean handoffs to IT operations and the business partner teams.
• Refresh the service experience end to end and raise vendor management discipline as scope grows.

Requirements:

• 12+ years of progressive technology services leadership, including 5+ years at the Director or Senior Director level.
• Direct experience leading multi-function technology services (infrastructure, cyber operations, and ITSM) as one integrated scope rather than separate towers.
• Comfort partnering with a CISO or fractional CISO on policy while owning operational execution. We are looking for an operator who builds security in partnership, not someone who pushes controls through operations.
• Deep experience across AWS plus the Microsoft Entra and Microsoft 365 stack.
• Familiarity with the infrastructure behind scientific and ML computing, AWS ParallelCluster and HPC, SageMaker, EKS and ECS, and DevOps and infrastructure-as-code practices, at a level sufficient to set standards and partner credibly with the scientific organization.
• A measurable track record managing a managed service provider portfolio, including real consolidation or vendor transitions with accountability for outcomes.
• Experience building out infrastructure in fast-moving, resource-constrained environments.
• Experience in a regulated industry (biotech, pharma, medical device, healthcare, financial services, or comparable).
• Bachelor's degree or equivalent practical experience.

Nice to have

• Biotech or pharmaceutical industry experience.
• Support for an FDA Pre-Approval Inspection or BIMO inspection in an IT or security capacity.
• Experience standing up a security operations function from contractor or MSP coverage.
• Partnership with a separate scientific computing organization (informatics, bioinformatics, cheminformatics, machine learning).
• Hands-on with an MDR provider such as RedCanary, Kroll, or Arctic Wolf.
• Jira Service Management or ServiceNow at scale.
• Public company SOX IT general controls experience.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Ability to function in a dynamic environment
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range: $ 260K – $300K plus bonus and equity

Location: Brisbane, CA - Onsite 

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Title:   Director, Pharmaceutical Development 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

Nurix Therapeutics, Inc. is seeking a highly experienced Director of Pharmaceutical Development. The role leads small molecule drug product development focused on oral and topical dosage forms. Responsibilities span QbD-based formulation and process development from early phase through commercial launch. The position requires strong cross-functional collaboration and hands-on CDMO management. This position is on site in the Brisbane, CA office.

Responsibilities

 Formulation & Process Development

• Lead QbD-based formulation and process development for small molecule drug programs with a focus on oral and topical dosage forms across all development phases.
• Apply expertise in BCS Class II/IV compound development and enabling formulation technologies, including amorphous solid dispersions (spray-dried dispersions, hot-melt extrusion), lipid-based drug delivery systems (SMEDDS, SEDDS, lipid suspensions), and nano-formulations to address solubility and bioavailability challenges.
• Define and document the Quality Target Product Profile (QTPP) and identify Critical Quality Attributes (CQAs) to guide formulation strategy.
• Conduct systematic risk assessments to identify Critical Material Attributes (CMAs) and Critical Process Parameters (CPPs) using FMEA and other risk assessment tools.
• Develop and optimize manufacturing processes appropriate to the dosage form, ensuring scalability and process robustness.

Scale-Up & Technology Transfer

• Lead manufacturing scale-up activities from laboratory to pilot and commercial scale, ensuring robust and reproducible processes.
• Troubleshoot manufacturing deviations, out-of-specification results, and process failures; drive root cause analysis and implement corrective actions.

Late-Stage Development & Regulatory

• Drive late-stage development activities (Phase 2b through commercial launch) including clinical supply manufacturing, process performance qualification (PPQ), and continued process verification (CPV).
• Author and review CMC sections of regulatory submissions including INDs, NDAs, and MAAs.
• Ensure all development activities comply with current GMP regulations and internal quality standards.

CDMO Management & Cross-Functional Leadership

• Manage external CDMO partnerships, including vendor qualification, technical oversight, and performance governance to ensure project timelines, quality standards, and budget commitments are met.
• Serve as the primary technical point of contact between pharmaceutical development and cross-functional teams including Analytical Development, Clinical Operations, Regulatory Affairs, Quality, Supply Chain, and Commercial.
• Provide scientific leadership and mentorship to junior scientists, associates, and project team members.

Requirements

• Ph.D. in Pharmaceutical Sciences, Pharmaceutics, Chemical Engineering, Chemistry, or a closely related discipline strongly preferred with 12 years of industry experience.
• 12+ years of progressive pharmaceutical development experience in an industry setting (biotechnology, pharmaceutical, or CDMO).
• Deep expertise in small molecule drug product development with a focus on oral and topical dosage forms, especially enabled formulation development (e.g., amorphous solid dispersions, lipid-based systems, nano-formulations).
• Comprehensive hands-on experience with QbD methodologies: QTPP definition, CQA identification, CMA/CPP risk assessment, DoE, design space development, and control strategy establishment.
• Significant late-stage development experience (Phase 2b/3 and NDA/MAA submission) is required.
• Proven track record of authoring and/or reviewing CMC regulatory submissions (INDs, NDAs, CTDs) and successfully responding to agency queries.
• Direct CDMO management experience, including technical oversight, project governance, and relationship management.
• Knowledge of lifecycle management, post-approval changes, and SUPAC guidance.
• For the Director level: demonstrated people management experience leading a team of scientists/managers, department-level strategic planning, and budget/resource ownership across multiple concurrent programs.
• Primarily office and laboratory environment; occasional GMP manufacturing facility access required.
• Approximately 25% travel required, including domestic and international trips to CDMO sites, clinical manufacturing sites, regulatory agency meetings, and scientific conferences.
• Must be able to gown for cleanroom/GMP environments

Core Competencies

• Scientific Leadership — Recognized internal and external thought leader in pharmaceutical development; drives scientific innovation and excellence.
• Strategic Thinking — Ability to anticipate technical and regulatory risks and develop proactive mitigation strategies that protect project timelines.
• Cross-Functional Collaboration — Demonstrated ability to build strong working relationships and influence without authority across diverse internal and external stakeholders.
• Project Management — Experienced in managing multiple complex projects simultaneously in a fast-paced, deadline-driven environment.
• Communication — Exceptional written and verbal communication skills; able to present complex scientific data clearly to both technical and non-technical audiences, including senior leadership and regulatory agencies.
• People Development — Commitment to mentoring and developing scientific talent within the organization. 

Salary Range:  218K – 260K plus bonus and equity.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Position Title:   Director, Regulatory Affairs (Strategy, Immunology and Inflammation)

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Nurix Therapeutics, Inc. is seeking a Director, Regulatory Affairs (Strategy, I&I) to join the Regulatory team.  The successful candidate will be a core member of the Regulatory team and will serve as the global regulatory lead (GRL) for the immunology and inflation therapeutic area. This role will be responsible for developing the global regulatory strategy in collaboration with key internal stakeholders, as well as tactical implementation of that strategy guiding and executing compliant, high quality, nonclinical and clinical submissions and interactions in support of early development, registration and life cycle management activities.  This position works cross-functionally with regulatory affairs and clinical development organizations to facilitate the completion of regulatory filing documentation according to company timelines. It also ensures adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as required. This position is on site in the Brisbane, CA office.

Responsibilities:

• Develop and implement competitive and effective global clinical & nonclinical regulatory strategies for various immunology and inflammation indications and identify potential risks and mitigation strategies associated with proposed strategies
• Work in close collaboration with the SVP, Head of Regulatory Affairs and the development team leader and other cross-functional colleagues, including CROs to deliver sound, efficient development strategies and operational plans
• Represent Regulatory Affairs on assigned cross-functional development teams.
• Lead and manage the development and preparation of high-quality global submissions (including IND, CTAs, NDAs, and MAAs) for early and late-stage programs in collaboration with the regulatory and project teams to support and accelerate clinical development and regulatory approval, as applicable
• Lead communication with global Health Authorities (HA), such as FDA and EMA, including, planning and preparing for formal meetings with regulatory agencies and interpreting HA feedback from these interactions.
• Develops and executes, or oversees global regulatory strategy for long-term planning, including the potential to accommodate expedited development needs
• Anticipate issues and guide cross-functional teams on risk mitigation strategies for any development challenges Provides insight and guidance on the implementation of current regulations and assesses regulatory risk based on precedence
• Ensure adherence to current regulations associated with regulatory activities
• Works strategically with all regulatory functions to develop detailed, actionable submission plans, tracks major submission deliverables, and ensures consistent management submission documents, health authority communications, and all other regulatory information supporting Nurix’s investigational and marketing applications
• Plays an essential part in defining requirements for, implementing, and supporting future systems and tools to be employed by Nurix in the areas of document management, submission content planning, and regulatory information management
• Tracks the status of major deliverables for regulatory submissions (e.g., study reports, summary documents, labeling) along with their dependencies
• Develops and maintains submission plan templates to ensure Nurix regulatory submissions are consistently planned and executed across programs
• Participates in cross-functional process initiatives impacting regulatory submission processes and systems
• Manages consultants and contractors as needed

Requirements

• Bachelor's degree in life-sciences or related scientific discipline; advanced degree preferred Manager:
• Must have minimum of 12 years in Regulatory affairs strategy with significant experience in the immunology and inflammation therapeutic area
• Strong demonstration of knowledge of drug development, FDA, EMA and ICH guidelines and regulations
• Experience providing hands-on support for planning clinical trial and marketing applications to health authorities including but not limited to FDA, EMA
• Proven track record of supporting Regulatory affairs in the planning and execution of major filings and ongoing maintenance of clinical trial and marketing applications
• Strong project management and critical thinking skills
• Experience applying project management techniques and tools (e.g., MS Project, Smartsheet, Excel trackers) to the planning and execution of regulatory submissions
• Excellent organizational and communication skills, both written and verbal
• Ability to work independently as well as part of a team environment
• Positive attitude, energetic and proactive
• Proven ability to manage multiple projects, identify and resolve regulatory issues
• Strong interpersonal skills and the ability to effectively work with others

Salary Range:  220K – 254K plus bonus and equity.

 Company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

 Position

The Manager, Analytical Development and Quality Control provides strategic and technical leadership for analytical CMC activities across multiple programs, with a strong emphasis on technology transfer and knowledge management. This role ensures successful transfer of analytical methods and associated knowledge to internal teams and external stakeholders, enabling consistent execution across development and manufacturing sites. The position requires deep expertise in analytical method development, validation, transfer, and lifecycle management in alignment with ICH guidelines, along with the ability to interpret data from a range of analytical techniques to support sound technical decision-making.

In addition, this role is responsible for establishing and clearly communicating analytical control strategies across cross-functional teams, ensuring alignment and scientific rigor. The Manager drives robust knowledge management practices through high-quality technical writing, documentation, and data governance, including authoring and reviewing validation, transfer, and investigation reports. Strong leadership, communication, and project management skills are essential to effectively coordinate internal teams and external partners, maintain continuity of analytical knowledge, and support informed decision-making.

This position is onsite at Nurix, Brisbane, CA

Required Qualifications

• MS in Chemistry, Analytical Chemistry, or a related field with 8–10+ years of relevant experience, or PhD in a similar discipline with 5–8+ years of relevant experience.
• Demonstrated leadership experience managing analytical CMC activities across multiple programs.
• Strong expertise in analytical method development, validation, transfer, and lifecycle management in compliance with ICH guidelines.
• General understanding of key analytical methods (e.g., HPLC/UPLC, GC, KF, ICP-MS, IC, XRPD, PSD) with the ability to interpret data and guide technical decisions.
• Proven experience authoring, reviewing, and approving analytical sections of regulatory submissions (INDs, IMPDs, NDAs, and global filings).
• Significant experience supporting NDA submissions and interacting with regulatory agencies.
• Strong technical writing skills for preparation of validation reports, transfer reports, investigation reports, and regulatory documentation.
• Ability to effectively communicate and justify analytical control strategies within cross-functional teams (Quality, Regulatory, Process Development) and with external stakeholders.
• Experience overseeing external partners (e.g., CDMOs) and managing outsourced analytical activities.
• Strong leadership, communication, and project management skills in a cross-functional environment.
• Strong technical writing and authorship skills, with the ability to prepare, review, and approve analytical reports and CMC documentation to support internal decision-making and knowledge management.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

 Salary Range: 

                               Manager: $147,341 – 171,488

                  Senior Manager:  $174,036 – 198,405

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Title:   Medical Director, Drug Safety 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position:

As a Medical Director, Drug Safety you will play a key role in ensuring the safety of patients in Nurix’s clinical trials. You will apply your clinical expertise to evaluate safety data, guide benefit–risk assessments and help shape the pharmacovigilance strategy for Nurix’s emerging therapies.  You will report to the VP of pharmacovigilance and work closely with colleagues in clinicaldevelopment, regulatory affairs, and clinical research to interpret emerging safety signals, support regulatory submissions, and maintain a strong safety framework during clinical development and transition into the post-marketing phase. Your insights will help inform critical decisions about patient safety, risk management, and the overall development strategy for our products. This role is well suited for a physician who enjoys working at the intersection of non-clinical data, clinical medicine, data interpretation, and drug development, and who wants to have a meaningful impact on how new therapies are evaluated and brought to patients.

Responsibilities: 

Medical Safety Leadership

• Serve as the medical safety lead for assigned products, providing clinical and pharmacovigilance expertise to safety strategy and activities.
• Lead aggregate safety data analysis for signal detection, signal evaluation, and risk characterization.
• Conduct medical review and interpretation of safety data, contributing to benefit–risk assessments.
• Monitor emerging safety signals and proactively address potential safety risks through appropriate internal and external communication.

Regulatory and Safety Documentation

• Contribute to safety responses to regulatory authorities and participate in regulatory interactions.
• Provide clinical leadership during inspections and audits related to safety and risk management.
• Author and review regulatory safety documents, including:
  • DSURs
  • Safety sections of INDs, and regulatory briefing books.

Clinical Development Support 

• Provide clinical input into safety aspects of clinical trial protocols, informed consent forms, and investigator brochures.
• Collaborate with clinical development, regulatory affairs, medical affairs, and other stakeholders to ensure a consistent global safety strategy.
• Governance and Cross-Functional Collaboration
• Serve on safety governance committees, supporting strategic decision-making for risk mitigation and benefit–risk evaluation

Requirements:

• Medical degree (MD) is required
• Clinical experience preferred
• 10+ years of experience in pharmacovigilance/ drug safety within the pharmaceutical or biotechnology industry
• Demonstrated expertise in aggregate safety analysis and benefit–risk evaluation
• Strong knowledge of global pharmacovigilance regulations and guidance (ICH, FDA, EMA, MHRA)
• Experience supporting early and late-stage clinical development, regulatory submissions, and product launch
• Experience in post-marketing safety surveillance and risk management
• Experience interacting with global health authorities on safety matters
• Familiarity with signal detection and safety surveillance tools and databases
• Strong communication, collaboration, and cross-functional leadership skills
• Ability to interpret complex clinical and safety data and translate insights into regulatory and business strategy
• Ability to work effectively and collaboratively in a fast-paced, growing organization
• This is an onsite position located in Brisbane, CA.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range: 307K - 351K plus bonus & equity 

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

 Company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

 Position

Nurix Therapeutics is searching for a motivated Research Associate to join our Bioanalytical-In Vitro DMPK team. The successful candidate will contribute to the bioanalytical efforts to support Nurix drug discovery programs involving in vivo and in vitro studies. We are seeking a highly motivated research associate to characterize the in vitro and in vivo ADME properties of drug candidates. The primary responsibilities will be to conduct bioanalysis for in vivo samples and to conduct in vitro experiments.  The scope of the daily responsibilities for this position includes, but is not limited to, developing bioanalytical methods, quantitating drug candidates and their metabolites, endogenous biomarkers in biological matrices (e.g. blood, plasma, tissue, tumor, CSF, etc.), reporting bioanalytical results and managing projects outsourced in CROs to support all in vitro and in vivo studies. The successful candidate will have extensive experience in bioanalytical method development and sample analysis using LC-MS/MS and other analytical techniques.

Key Responsibilities

• Provide bioanalytical support for in-house PK, non-GLP safety TK
• Conduct bioanalytical method development and qualification to support drug, metabolite and biomarker analysis
• Independently develop LC-MS/MS methods to quantitate small molecules in in vitro and in vivo samples
• Conduct in-vitro stability assays to understand metabolism of drugs
• Perform metabolic identification (MetID) using LC-QTOF MS/MS, including accurate mass analysis, fragment interpretation and biotransformation pathway assignment
• Independently operate, troubleshoot and maintain LC-MS/MS systems
• Participate in multidisciplinary project teams and collaborate with other departments to understand bioanalytical needs for both PK and PD support
• Manage projects conducted at CROs to ensure high quality bioanalytical data is delivered to meet project timelines
• Maintain accurate and detailed scientific electronic laboratory notebooks
• Perform all duties in keeping with the Company’s core values, policies and all applicable regulations

Preferred Qualifications & Experience

• Experience with H/UPLC and mass spectrometry
• Good working knowledge of SCIEX LC-MS/MS systems for small molecule quantitation
• PK analysis using Phoenix or other data management software
• Management experience with CROs for outsourcing BA activities is preferred
• Provide sample analysis to support PK, PK/PD, PK/efficacy, distribution, metabolism, and non-GLP toxicology studies
• Identify issues and troubleshoot scientific equipment including LC-MS/MS, select and develop appropriate methods to perform experiments, analyze data and prepare related reports.
• Excellent oral and written communication skills

Minimum Requirements

• BS or master’s with >4 years’ experience working in a discovery setting using LC-MS/MS within a pharmaceutical/biotechnology company
• Broad experience in small molecule drug candidate bioanalytical assay development/sample analysis in different biological matrices using LC-MS/MS
• Experience with AB SCIEX mass spectrometry software
• Excellent written, verbal communications and interpersonal skills to collaborate with internal and external partners in a matrix environment

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Location: Brisbane, CA - Onsite 

Salary Ranges:

RA II      $92,891 - $106,507

RA III    $110,101 - $124,079

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

 Company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

 Position 

Nurix Therapeutics seeks an experienced Scientist to join the Analytical Development and Quality Control group. The Scientist will conduct analytical method development and material characterization studies to inform drug substance and drug product development. They will also provide operational oversight at external CDMO/CTL partners, manage reference standards and impurity markers, collaborate in CMC risk management, and author technical reports.

In Nurix’s laboratories, the Scientist will characterize material attributes and impurities by high resolution mass spectrometric and multidimensional chromatographic techniques. They will determine impurity structures, characterize material stability, and elucidate mechanisms of degradation. They will employ state of the art QbD approaches to develop and troubleshoot chromatographic test methods to accelerate and derisk QC activities performed externally at CDMOs and CTLs. The Scientist will critically evaluate characterization data and communicate results in multidisciplinary teams.

The ideal candidate must have demonstrated expertise in mass spectrometry and hands-on experience with liquid chromatography. Hands-on experience with two-dimensional liquid chromatography is a plus.

This position is onsite at Nurix headquarters in Brisbane, CA.

Key responsibilities

• Characterization and development studies at our internal laboratory:
• 2D-LC for impurity profiling of complex samples, derisking HPLC test procedures, and adaptation of incompatible methods to mass spectrometry
• Structural elucidation by high resolution Orbitrap Tribrid Mass Spectrometry
• QbD HPLC method development using multivariate DOE software
• Forced degradation and elucidation of degradation mechanisms
• Accelerated predictive stability studies and modeling of packaging configurations and long term stability

• Authorship of technical documents such as analytical development reports, stability reports, and storage statements
• Management of reference standards and impurity markers
• Manage and organize documentation and data
• Contribute to protocol development and oversight/troubleshooting of method transfers
• Liaise with Medicinal Chemistry, Bioanalytical, DMPK, and Preclinical departments
• Compliance with cGMP quality standards and internal SOPs
• Travel up to 5%

Required Qualifications

• Advanced degree in a relevant discipline (Chemistry, Pharmaceutics, or related field). BS with 10+ years, MS degree with 6+ years, or PhD with up to 4 years of relevant experience
• Expertise in operation and maintenance of mass spectrometers
• Experience in HPLC operation and method development
• Ability to critically interpret data and articulate technical concepts in cross functional teams
• Ability to ensure assigned activities are completed to the satisfaction of project timelines
• Strong interpersonal skills that foster collaboration within and outside of the organization

Bonus Qualifications

• Experience with accurate mass instrumentation such as Orbitrap Tribrid mass spectrometers
• Experience in operation of 2D-LC
• Experience in the determination of structures of small molecule impurities and/or metabolites
• Experience protein and/or ADC characterization by mass spectrometry
• Familiarity with gas chromatography, NMR, particle size analysis, solid state characterization, dissolution, ICP-MS/OES, and/or FTIR
• Experience with reference standard management, stability programs, and/or method validation
• Familiarity with ICH guidelines, cGMPs, and pharmacopeial chapters

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range

Scientist I :  $123,841--$144,272

Scientist II:  $143,260 –$161,064

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Position Title:  Scientist I, Protein Purification & Expression 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

Nurix Therapeutics, Inc. is seeking a detail-oriented and experienced Protein Expression Scientist to join the DEL and Protein Sciences team. This individual will work cross functionally with internal stakeholders to plan, coordinate, and execute all operational activities required for analytical scale and preparative scale expression of recombinant proteins in baculovirus and mammalian cell systems. Additionally, they will be responsible for documentation of expression conditions and results in internal databases and electronic lab notebook systems.

Responsibilities:

• Highly proficient in maintaining insect cell and mammalian cell cultures.
• Excellent knowledge and high degree of familiarity with all steps in baculovirus expression of recombinant proteins, including clone design, generation and purification of bacmids, raising and titering of baculovirus, conducting MOI studies, cell culture of Sf9 and/or Tni/Hi5 cells, and harvesting of biomass on the scale of 1 L – 20 L.
• Highly proficient in maintaining insect cell and mammalian cell cultures.
• Strong working knowledge of protein characterization steps, including SDS-PAGE analysis, size exclusion chromatography, and/or thermal stability (e.g. nanoDSF).

Requirements

• Ph.D. or equivalent with 2+ years of relevant experience
• This position requires 2+ years of experience working with insect cell lines and baculovirus expression of recombinant proteins. Additional experience working with recombinant protein expression in mammalian cells (e.g. HEK293) is a plus. Industry experience preferred with exemplified ability to overexpress milligram amounts of protein for structural and functional studies for multiple protein classes.
• Able to work in dynamic, fast-paced environment with experience prioritizing work across multiple projects.
• Detail-oriented with strong record keeping skills.
• Past experience purifying recombinant proteins (e.g. affinity chromatography, ion exchange, or size exclusion chromatography) is a bonus.
• Must be able to lift 50+ pounds comfortably.
• Onsite Position 

Salary Range:  125K - 151K plus bonus and equity 

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Position Title:  

Senior Director, Regulatory Affairs (Strategy, Hematology Oncology)

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Job Summary:

Nurix Therapeutics, Inc. is seeking a Senior Director Regulatory Affairs (Strategy, Hematology Oncology) to join the Regulatory team.  The successful candidate will be a core member of the Regulatory team and will be responsible for helping build and execute on global regulatory strategy, objectives, policies and programs pertaining to development and future marketing of products for guiding and executing upon regulatory strategy of compliant, high quality, nonclinical and clinical submissions and interactions in support of early development, registration and life cycle management activities. This includes supporting regulatory activities to enable clinical development plans and studies, working cross-functionally across the organization.

Responsibilities:

• Provides regulatory strategic direction and support for assigned global development programs/development program activities
• Assists Sr. Regulatory Affairs staff with their development program activities and deliverables
• Designs and implements regulatory strategies with Regulatory Affairs staff to obtain and maintain product investigative and marketing applications for assigned programs, as well as their life cycle management
• Acts as regulatory representative on early and/or late phase clinical studies, ensuring compliant execution of trials
• Strong competency in understanding regulatory requirements and emerging regulatory landscapes associated with US and global regulatory authorities
• Experienced in responding to inquiries from global regulatory authorities as well as the preparation and conduct of meetings with global regulatory authorities
• Assist in the preparation and maintenance of Annual Reports, Development Safety Update Reports (DSURs), Investigator’s Brochures and other documents required for INDs, CTAs, NDAs and other related regulatory development and marketing applications
• Assist in the cataloging and maintenance of regulatory application submissions
• Conduct research and stay up-to-date on regulatory requirements and changes
• Collaborate with cross-functional teams to ensure product compliance throughout the development lifecycle
• Monitor and assess regulatory risks and develop mitigation strategies
• Oversee quality assurance processes to ensure compliance with regulatory standards
• Review SOPs pertaining to Regulatory
• Works strategically with all regulatory functions to develop detailed, actionable submission plans, tracks major submission deliverables, and ensures consistent management submission documents, health authority communications, and all other regulatory information supporting Nurix’s investigational and marketing applications
• Plays an essential part in defining requirements for, implementing, and supporting future systems and tools to be employed by Nurix in the areas of document management, submission content planning, and regulatory information management
• Tracks the status of major deliverables for regulatory submissions (e.g., study reports, summary documents, labeling) along with their dependencies
• Develops and maintains submission plan templates to ensure Nurix regulatory submissions are consistently planned and executed across programs
• Participates in cross-functional process initiatives impacting regulatory submission processes and systems
• Manages consultants and contractors as needed

Experience and Skills:

• Bachelor's degree in life-sciences or related scientific discipline; advanced degree preferred 
• Must have minimum of 12 years in Regulatory affairs strategy
• Strong demonstration of knowledge of drug development, FDA, EMA and ICH guidelines and regulations
• Experience providing hands-on support for planning clinical trial and marketing applications to health authorities including but not limited to FDA, EMA
• Ability to read, analyze and interpret scientific and technical information, as well as regulatory
• Ability to understand and explain detailed regulatory affairs and compliance programs and/or to effectively present information to senior regulatory management, other departments or external
• Ability to comply with changing regulatory
• Proven track record of supporting Regulatory affairs in the planning and execution of major filings and ongoing maintenance of clinical trial and marketing applications
• Strong project management and critical thinking skills
• Experience applying project management techniques and tools (e.g., MS Project, Smartsheet, Excel trackers) to the planning and execution of regulatory submissions
• Excellent organizational and communication skills, both written and verbal
• Ability to work independently as well as part of a team environment
• Positive attitude, energetic and proactive
• Proven ability to manage multiple projects, identify and resolve regulatory issues
• Strong interpersonal skills and the ability to effectively work with others

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).

Company:

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels. 

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase (BTK), a B-cell signaling protein, and an inhibitor of Casitas B-lineage lymphoma proto-oncogene-B (CBL-B), an E3 ligase that regulates T cell activation.  Nurix is also progressing multiple programs through partnership, including an IRAK4 degrader in Phase 1 in partnership with Gilead and a STAT6 degrader in IND enabling studies with Sanofi.  Multiple additional wholly owned and partnered programs are at various stages of preclinical development.

Position:

Reporting to the Director, Regulatory Affairs Project Management and Operations, the Senior Manager, Regulatory Operations provides key support to the Nurix Regulatory Affairs department. This position has responsibility for entry-level coordination, review, assembly and archival of regulatory submissions in Veeva RIMS and documents for health authorities (US FDA and global equivalents).  The Senior Manager, Regulatory Operations will provide support for multiple regulatory activities, studies, and programs. The individual will have responsibility to understand and implement regulatory guidance and help ensure regulatory compliance for assigned projects.  The Senior Manager should have 5 years’ experience in Regulatory Affairs or Regulatory Operations. Working knowledge of at least one functional discipline (e.g. Regulatory, Clinical, Nonclinical, Clinical Pharmacology or Chemistry Manufacturing and Controls) and a general knowledge of clinical development preferred.  The candidate should have a can-do attitude and experience working in Veeva RIMS. Also, the candidate should be eager to learn regulatory and clinical trial requirements, best practices, and provide support for Regulatory programs and leadership. 

Responsibilities:

• Under the strategic direction of the SVP of Regulatory Affairs and the Director of Regulatory Affairs PM and Operations, the candidate will support the planning, coordination, tracking and execution of submissions and responses to global regulatory authorities
• Assist Regulatory team, project teams and Clinical Research Organization (CRO) counterparts in the implementation of regulatory plans, timely delivery, and submission of regulatory documentation
• Preparation of Regulatory submission documentation (e.g Forms, Cover Letter) as requested
• Support team with formatting, QC and publishing of submission documents and packages
• Manage and support Veeva RIMS processes such as HAI, SCP and Archiving
• Manage authoring and review workflow in Veeva RIMS according to defined timelines
• Coordinate with regulatory colleagues and cross-functional departments to prepare, compile, review, and submit documents or information necessary to health authorities in accordance with regulations, guidelines or queries IN Veeva RIMS using SCP
• Maintain archival copies of health authority submissions (e.g., IND, CTA, NDA, and MAA), correspondence and a record of health authority obligations, and commitments
• Maintain current knowledge of applicable US and global regulations, guidance, and standards for drug development and product registration. Participate in Regulatory Intelligence activities to help inform team members of new applicable guidelines and conduct training sessions on new guidelines/regulations if necessary
• Participate in kick-off and project-based meetings related to regulatory submissions, strategy, and comment resolution. Be a reliable resource for information following such meetings
• Follow general instructions from Regulatory management or company leadership for assigned projects while independently planning daily work tasks to complete projects on time. Seek guidance on project/task priorities as needed
• Communicate important project decisions or challenges to Regulatory leadership
• Create or contribute to Standard Operating Procedures (SOP), checklists and training Materials for Regulatory department activities
• Support contracts and Purchase order for the Regulatory Affairs department

Requirements:

• Bachelor's Degree in Life Sciences or relevant field
• Minimum of 5 years’ experience working in Regulatory Affairs or Regulatory Operations. Additional experience in the biotechnology or pharmaceutical industry preferred
• Understanding of the drug development process
• Proficient knowledge of Veeva RIMS SCP, workflows, archival, reporting…
• Experienced publisher (DocuBridge, GlobalSubmit, VeevaVault Submission…)
• Experience successfully supporting critical deliverables while maintaining agreed timelines
• Demonstrated ability to work effectively with cross-functional teams or collaborative environments.
• Basic knowledge of 21 CFR and FDA, ICH, GCP, GMP, eCTD, and global guidelines.
• Previous experience with building electronic submissions in compliance with Health Authority requirements is a plus.
• Previous experience with maintaining in-house repository for archiving regulatory submissions and Health Authority correspondence in 21 CFR Part 11 compliant system (e.g., Veeva) is a plus.
• Able to take ownership of a given assignment, proactively consulting other project team members and other department representatives for information or guidance, as necessary.
• Superior communication skills: oral, written, with proven negotiation skills, and strong time-management.
• Excellent Computer Skills MS Word, Excel, Power Point, Smartsheet and document management software/system, templates.
• Ability to work on multiple tasks and prioritize tasks to meet company objectives. Strong attention to detail and time management skills are essential.
• Nurix is located in Brisbane, CA - this is an onsite position.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view.

Salary Range:   140K - 162K  plus bonus & equity.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

 Company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Senior Research Associate, DNA Encoded Library Technology – Nurix Brisbane

Position

We are seeking a talented and motivated chemist to join our Discovery Chemistry team and contribute to the design and synthesis of DNA-encoded libraries (DELs). This hands-on position offers the opportunity to shape Nurix’s DEL-based lead discovery platform, working at the interface of chemistry, biology, and automation. Key responsibilities:

• Design and validate novel DEL library builds.
• Develop and bring in new DNA-compatible chemical transformations that can widen the DEL chemical space.
• Construct DEL libraries to support the in-house library production efforts.
• Work with external partners to support our DEL synthesis and hit follow up strategies.
• Engage in cross-functional team discussions that support DEL screening, data analysis, machine learning and hit-optimization.
• Contribute to platform automation and technology development efforts.
• Present results, document workflows, and contribute to scientific and strategic planning within the Discovery Chemistry organization.

Education and Experience

• B.S. or higher in Chemistry, Biochemistry, or Medicinal Chemistry with 5 years of industrial experience (title determined by experience).
• Strong background in synthetic organic chemistry.
• Hands-on laboratory experience synthesizing DNA encoded libraries.
• Familiar with the overall DNA-Encoded Library Technology workflow operations.
• Experience analyzing and purifying DNA-conjugates using common analytical tools (LCMS/HPLC).

Added Qualifications

• Experience working in the drug discovery field – drug design, synthesis, and SAR based hit-to-lead optimization.
• Experience working with high-throughput analytical and purification systems relevant to DEL-applications.
• Experience working with molecular biology tools (PCR, qPCR, Western Blot).

Fit with Nurix Culture and Values

• Collaborative and team-oriented, eager to share expertise and learn from others.
• Solution-driven with a hands-on and resourceful approach.
• Adaptable and comfortable in a fast-paced, interdisciplinary environment.
• Committed to scientific excellence and the shared goals of the team.

Location: Brisbane, CA

Salary Range:

RA III:    $101,690 – 116,226
SRA:    $118,893 – 139,310
Scientist I:    $129,382 –146,679

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

 Company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

 Position

Nurix Therapeutics seeks an experienced Senior Scientist to join the Analytical Development and Quality Control group. The Senior Scientist will be responsible for drug product (DP) analytical development, including method development, oversight of method validation at CDMOs, and lifecycle management in support of Nurix’s oncology and inflammation & immunology (I&I) programs.

This position provides technical oversight of analytical method development, validation, and testing conducted at external CDMO/CRO partners. The Senior Scientist will author analytical development reports and IND/IMPD/NDA sections and support late-phase tech transfer and validation activities. This role will also contribute to analytical development for new drug products and dosage forms. The Senior Scientist will work closely in cross-functional teams to ensure alignment and integration of analytical and QC strategies across development stages.

The ideal candidate will have expertise in chromatographic and dissolution method development, stability studies, and phase-appropriate validation and control strategies, along with demonstrated experience supporting late-phase development and regulatory submissions.

This position is onsite at Nurix headquarters in Brisbane, CA.

Key responsibilities include:

• Lead analytical method development validation and lifecycle management for drug product formulations, including amorphous solid dispersions (ASDs) and lipid-based systems
• Support PPQ activities, commercialization, commercial QC, and lifecycle management for drug product analytical methods and control strategies
• Design and oversee DP development, registration batch, and commercial stability programs, including protocol development and trend analysis
• Author and review DP analytical development reports to support regulatory submissions, and marketing authorization
• Oversee and support analytical activities, including method development, validation, and QC testing conducted at CDMOs and contract testing laboratories (CTLs)
• Contribute to investigations (e.g., OOS, OOE, OOT), root cause analysis and CAPAs
• Perform critical review of analytical data, protocols, reports, specifications, and related documentation
• Trend stability data and support establishment of retest periods and shelf life using statistical methods
• Collaborate in the development and justification of material control strategies and specifications
• Author technical documents, including analytical development reports, specifications, validation and stability protocols/reports, certificates of analysis (COAs), and storage statements
• Author and review analytical sections of regulatory submissions (e.g., IND/IMPD/NDA)
• Collaboratively author responses to health authority requests for information
• Act as a key contributor to multidisciplinary teams, including Chemical Development, Pharmaceutical Development, Regulatory, Quality, Preclinical, Supply Chain, Medicinal Chemistry, and DMPK
• Maintain and organize analytical documentation and data to ensure traceability, data integrity, and inspection readiness
• Follow cGMP requirements and internal SOPs
• Travel up to 5%, as required

Qualifications

• Advanced degree in a relevant discipline (Chemistry, Pharmaceutics, or related field)
• Senior Scientist: BS/MS degree with 14+ years or PhD with 8+ years of industrial CMC experience
• Strong experience in drug product analytical development and validation
• Experience with analytical development for amorphous solid dispersions (ASDs) and/or lipid-based formulations
• Experience in CDMO and contract testing lab oversight
• Experience supporting regulatory submissions (e.g., IND, IMPD, NDA) and global regulatory filings
• Fluency with ICH guidelines, cGMPs, and pharmacopeial chapters
• Ability to work effectively in a cross-functional environment
• Strong technical writing skills (e.g., development reports, regulatory documents)
• Ability to manage multiple priorities in a fast-paced environment
• Excellent communication and cross-functional collaboration skills

Salary Range: 

Senior Scientist -- $161,110 – 185, 618

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

About the Role

We are growing the team with a hands-on antibody conjugation scientist who will build this capability from the ground up by developing and validating bioconjugation chemistries that are reproducible at bench scale, sufficiently robust for transfer to automated higher-throughput synthesis workflows, and scalable for preparation campaigns supporting advanced in vivo and translational studies.

This is a lab-based role for someone who wants to build a new technical capability inside an established, highly collaborative discovery organization and partner closely with medicinal chemistry, analytical chemistry, computational chemistry, protein biochemistry, and automation to move candidates from bench to study-ready material.

What You'll Do

• Develop and optimize antibody bioconjugation methods for attaching degrader payloads and linkers to antibodies.
• Design conjugation chemistry with an eye toward automation: define protocols, reagent ratios, and process parameters in a form that can be transferred to and run reliably on liquid-handling platforms.
• Execute one-off and scale-up conjugation runs (mg to multi-mg) to produce material for pharmacology, PK/PD, and other advanced studies on program timelines.
• Purify conjugates via FPLC/AKTA, TFF, and column chromatography; troubleshoot yield, homogeneity, and stability issues as they arise.
• Write clear SOPs and technical reports; train and support automation-team colleagues in executing conjugation workflows independently.
• Collaborate cross-functionally with medicinal chemists (linker/payload design), computational chemists (site selection, modeling), and external CROs/CDMOs as needed.
• Stay current on emerging bioconjugation and DAC/ADC methodology and bring forward new techniques relevant to Nurix's pipeline.

Who You Are

• A team player who works well across disciplines (chemistry, analytical, protein biochemistry, automation/engineering) and communicates clearly with both scientists and technical staff.
• Results-oriented: you drive a method from first attempt to a robust, transferable protocol, and you personally deliver material when a study needs it.
• Comfortable owning a technical area with real autonomy in a growing capability area.

Qualifications

• PhD in chemistry, biochemistry, chemical biology, or a related field preferred; MS or BS with substantial (8+ for BS/MS) hands-on industry bioconjugation experience will also be considered.
• Direct, hands-on experience with antibody/protein bioconjugation chemistry: NHS ester and maleimide coupling, click chemistry (CuAAC/SPAAC/IEDDA), engineered-cysteine or glycan/enzymatic site-specific conjugation, or unnatural-amino-acid approaches.
• Experience purifying and characterizing conjugates: FPLC/AKTA, TFF, SEC, IEX, RP-HPLC/UPLC, HIC, and LC-MS-based DAR/identity analysis.
• Experience preparing protocols for automated or semi-automated execution (e.g., liquid handlers such as Hamilton or Tecan) is a strong plus, though the successful candidate may also learn this in partnership with our automation team.
• Strong record of practical problem-solving in the lab, with the judgment to know when a result is study-ready versus needs more optimization

Why This Role

You'll be the founding technical expert for antibody conjugation at Nurix, shaping both the science and how it's automated and scaled — with direct visibility to program leadership and a fast path from method development to real studies

Salary Range:  155K - 180K plus bonus and equity

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

We are an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job within Nurix or in the course of your employment with Nurix. By applying for a position with Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/)

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Job Summary:

As a key member of the cross-functional Development Team responsible for providing regulatory writing expertise and leadership to formulate the writing strategy for key regulatory documents for submission. The Sr. Director, Head of Regulatory & Medical Writing will be responsible for providing guidance to the medical and or regulatory writing group (contractors and internal writers) assigned to deliverables and ensuring appropriate work allocation and document preparation.; will also provide review and substantive editing of documents to ensure delivery of high-quality documents. This individual will work effectively with many other functional groups, including with Clinical Scientist(s), Medical Monitors, Regulatory and other functions as applicable, and collaborate with clinical medical writing as applicable to ensure scientific excellence in the execution of clinical trials. The Head of Regulatory Writing will build a medical writing group internally when appropriate.

Reporting to the SVP, Head of Regulatory Affairs, this role will be responsible for the regulatory writing & medical writing deliverables of assigned project(s), in accordance with the agreed timelines and quality standards.

Responsibilities:

• Ensure appropriate allocation of internal and external resources needed for all regulatory writing deliverables.
• Hire and manage medical writers internally and manage external medical writing contractors.
• Forecasting and maintaining budget for the regulatory writing team.
• Assess efficiencies, help identify areas of improvement and initiate improvement processes.
• Coordinate, author and edit documents used to support clinical trial conduct and reporting including but not limited to:
• Clinical study protocols and clinical protocol amendments (in partnership with Clinical Science/Clinical Development)
• Clinical study reports
• Investigator’s brochures and annual updates
• IND submissions and annual reports
• Lay-person summary
• Integrated summary reports
• Clinical, Nonclinical and Multidisciplinary Information Amendments
• NDA, BLA, MAA, (e)CTD submissions
• Risk Management Plans
• Health Authority responses
• Briefing Documents, ODDs, BTDs/PRIME, FTD etc
• Participate in relevant subteam(s) and ensure effective planning and management of timelines for all components of assigned documents across all projects.
• Participate in document strategy sessions, including messaging, document flow, logic, and consistency for assigned projects.
• Support and develop deliverables required for global transparency and disclosure requirements (e.g., plain language lay summary, applicable redactions to regulatory documents subject to EU posting regulations and results for EU CTR).Partner with Biometrics in developing standard TFLs and in text tables for deliverables as applicable
• Maintain and support developing and reviewing standard processes and templates.
• Review and edit documents as required.
• Work effectively and lead in cross-functional working groups.

Qualifications:

• Candidates must have a BS with 15+ years, or MS or other advanced science degree (e.g.: RN, NP, MSN, PharmD, PhD, MD) with 10+ years of experience in oncology clinical research experience as a clinical or regulatory medical writer within the pharmaceutical/biotech industry.
• Prior experience leading a regulatory writing group
• Experience writing/leading the writing of critical clinical documents in major regulatory filings (NDA, BLA, MAA).
• Proficiency in the use and understanding of computer software e.g. word processing, graphics, reference manager, document management systems.
• Familiarity with all phases of drug development processes (discovery to market), clinical study protocol design, CTA/IND submissions, investigator’s brochures and clinical study data collection and results reporting.
• Advanced knowledge of routine document content preparation, including the use of style guides, medical dictionaries, and regulatory guidance documents and templates.
• Experience writing, at a minimum, protocols (Phase 1-3, in oncology), investigator’s brochures, clinical study reports, Health Authority briefing packages, and Health Authority responses. Experience with Pediatric Investigational Plans (PIPs) is preferred.
• Advanced understanding/knowledge of regulatory requirements and drug development processes, Good Clinical Practice (GCP), regulatory requirements and guidelines associated with regulatory documents (e.g., protocols, investigator brochures, and clinical study reports).
• Ability to interpret and summarize complex tabular and graphical data presentations.
• Strong organization, documentation and communication skills with an ability to multitask.
• Adaptable / flexible, willing and able to adjust to multiple demands and shifting priorities; ability to meet day-to-day challenges with confidence and professionalism.
• Detailed knowledge of GCP, ICH Guidelines and current US FDA regulations.

Salary Range:   $254,127 - $289,388 plus bonus and equity. 

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position 

The VP of Global and US Market Access is a pivotal leadership role on the Nurix Commercial Leadership Team (CLT). This leader will architect the global value, pricing, and access strategy development for the Nurix portfolio, and will co-lead the end-to-end US launch of Nurix's first hematology product, in close collaboration with a global pharmaceutical partner.

What you will own: 

• Global Value, Pricing & Access Strategy — develop and lead the overarching framework for demonstrating and communicating product value to payers, HTAs, and health systems globally; includes close coordination with a global pharmaceutical partner to align on international access strategies
• US Payer Strategy & Execution — design payer engagement strategies to secure broad, sustainable reimbursement
• Patient Support Services — build programs that remove access barriers and ensure patients can start and stay on therapy
• Pricing & Contracting — develop pricing architecture and contracting strategies that balance access, value, and business sustainability
• Trade & Channel Management — oversee specialty pharmacy, distributor, and GPO plan to ensure reliable product availability
• Health Systems & Key Accounts — Develop a strategic engagement plan with IDNs, academic medical centers, and high-value accounts

How You’ll Work

• Serve as a core member of the CLT, partnering closely with Marketing, Sales, Medical Affairs, and Analytics to align commercial strategy
• Serve as the primary Market Access point of contact with a global strategic partner, ensuring alignment on value messaging, access strategy, and access timelines
• Lead launch readiness planning across all access functions, ensuring flawless execution at launch
• Collaborate with HEOR and Medical Affairs to build a compelling value proposition, evidence generation plan, and economic models that resonate with payers
• Leverage data and analytics to continuously sharpen strategy and measure impact
• Advise senior leadership and the Board on evolving market trends, policy shifts, and their implications for the business
• Partner with Legal, Compliance, Finance, and Accounting to ensure all strategies are sound and compliant
• Contribute market access expertise to early-pipeline planning, laying groundwork for future launches

Qualifications

• 15+ years' experience in the pharma or biotech industry, with at least 5–7 years in senior market access leadership
• Deep expertise across payer strategy, pricing, contracting, trade, and patient services
• Strong hematology/oncology experience highly preferred
• Experience navigating complex partnerships or co-commercialization arrangements with large pharmaceutical companies, including alignment on access strategy, and cross-functional coordination across organizations
• Proven ability to build and lead both internal and field-based teams in fast-moving, high-growth environments
• Track record of making decisive calls while fostering a collaborative, compliant culture
• Exceptional communicator — equally effective with field teams, the C-suite, and the Board
• Location - Onsite preferred 

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:  325K – 365K plus bonus and equity.

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position Overview

Nurix Therapeutics is seeking a Vice President, Medical Affairs, Hematology-Oncology to build, expand, and lead a best-in-class Medical Affairs organization supporting the company’s transition from a clinical-stage biotechnology company toward commercialization as its hematology-oncology portfolio advances into late-stage clinical development.

This executive will provide strategic and operational leadership across the full Medical Affairs function, including medical strategy, field medical, scientific communications, evidence generation, thought leader engagement, medical information, and launch readiness. The role will play a central role in shaping the scientific and medical strategy for Nurix’s targeted protein degradation portfolio and helping define the company’s external scientific leadership in hematologic malignancies.

The role will be a key cross-functional partner to Clinical Development, Commercial, Market Access, Regulatory, Legal, and Compliance as Nurix plans and executes future commercialization activities. This leader will contribute broadly to portfolio strategy, lifecycle planning, and enterprise-level decision making as a member of the senior leadership team.

Responsibilities

• Lead and scale the Medical Affairs function to support the progression of Nurix’s hematology-oncology programs into late-stage clinical development and future commercial readiness.
• Own the overall Medical Affairs strategy for the hematology-oncology portfolio, ensuring alignment with development plans, portfolio priorities, and corporate objectives.
• Lead development of the scientific platform and differentiated medical narrative for Nurix hematology-oncology programs within rapidly evolving treatment landscapes.
• Partner closely with Clinical Development to shape late-stage medical strategy, including data generation priorities, scientific narrative, external engagement plans, and lifecycle opportunities.
• Develop and execute integrated medical plans across field medical, scientific communications, publications, medical education, medical information, insight gathering, and evidence generation.
• Expand and lead a high-performing MSL organization focused on credible scientific exchange, compliant insight capture, and strong engagement with key external experts, investigators, and treatment centers.
• Lead external engagement in hematologic malignancies, including advisory boards, investigator relationships, disease-area thought leader engagement, and interactions with cooperative groups and broader scientific communities.
• Serve as a senior medical representative of the company with external experts, investigators, and scientific leaders, helping establish Nurix as a credible scientific leader in hematologic malignancies and targeted protein degradation.
• Direct publication and scientific communication strategy for key clinical data, congress presentations, medical content, symposia, and educational initiatives.
• Lead integrated evidence generation strategies spanning registrational support, post-marketing evidence development, real-world evidence, health economics and outcomes research, treatment sequencing, and product differentiation opportunities.
• Partner with Commercial and Market Access to ensure medical strategy informs launch readiness, access planning, scientific platform development, training initiatives, and broader commercialization strategy.
• Monitor the external hematology-oncology landscape, including standard-of-care evolution, competitor data, treatment guidelines, and emerging scientific trends, and translate insights into actionable medical strategy.
• Ensure all Medical Affairs activities are conducted in compliance with applicable legal, regulatory, and company standards.
• Provide medical and scientific leadership to executive governance discussions related to portfolio prioritization, lifecycle strategy, label expansion opportunities, external partnerships, and commercialization readiness.
• Support global Medical Affairs planning and coordination, including scientific congress strategy, evidence generation activities, and external engagement initiatives across key regions.

Qualifications

• MD, PhD, DO, or PharmD required; oncology/hematology experience
• 15+ years of biopharmaceutical Medical Affairs experience with significant leadership responsibility, including direct accountability for launch and post-approval
• Demonstrated leadership experience supporting late-stage development and commercialization of hematology-oncology therapies, including launch planning, scientific positioning, and post-approval medical strategy.
• Demonstrated expertise in evidence generation (Phase 3b/4, RWE, HEOR), scientific communications, MSL leadership, and cross-functional launch planning.
• Strong understanding of global and US. regulatory, compliance, and payer environments related to medical activities and drug promotion.
• Experience in highly innovative therapeutic platforms, first-in-class mechanisms, or rapidly evolving treatment landscapes strongly preferred.
• Excellent leadership, communication, and collaboration skills, with the ability to operate strategically while remaining hands-on in a fast-moving pre-commercial and launch environment.
• Demonstrated ability to build and scale high-performing Medical Affairs organizations in emerging biotechnology or growth-stage commercial settings preferred.

Salary Range:  348K - 399K plus equity and bonus

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Nurix Therapeutics is seeking an accomplished scientific leader to serve as Vice President, Translational Medicine & Clinical Biomarkers. This executive will own the full translational medicine and clinical biomarker strategy across Nurix’s oncology and immunology pipeline, from early target engagement through late-stage clinical development and will serve as a decisive voice in portfolio-level go/no-go decisions.

Reporting to the Chief Scientific Officer, the VP will lead and scale a high-performing team, partner closely with  Research, Clinical Development, Regulatory Affairs, and Data Science, and represent Nurix externally as a  scientific leader in translational medicine. This role carries executive accountability for the translational  medicine function, including CRO and diagnostic partner strategy, and requires the rare combination of deep  scientific expertise, operational fluency, and the leadership presence to influence at the executive level.

This is a senior executive role for a builder. Someone who has led translational functions through clinical  inflection points and can define what precision medicine looks like at a biotech pioneering targeted protein  degradation.

Responsibilities

Strategic Leadership & Portfolio Ownership

• Define and own the enterprise-wide translational medicine and clinical biomarker strategy across Nurix’s  pipeline, integrating insights from discovery through Phase II/III to inform portfolio prioritization and  investment decisions.
• Design and implement predictive biomarker strategies and translational plans to support indication selection and patient enrichment for degrader therapies.
• Serve as a standing member of the R&D leadership team and program governance committees; provide executive-level input on clinical development strategy, indication selection, dose/schedule decisions, and precision medicine positioning.
• Translate the unique biology of targeted protein degradation into rigorous translational hypotheses, from  degrader-specific target engagement biomarkers to modality-specific patient stratification strategies.
• Represent Nurix in external scientific forums, KOL engagements, investigator meetings, and competitive  intelligence activities; contribute to business development diligence on potential partnerships and in-licensing candidates.

Translational Science & Biomarker Development

• Oversee the full lifecycle of biomarker program development, from preclinical discovery and assay feasibility through clinical validation, implementation, and reporting. Ensure scientific rigor and regulatory  defensibility at each stage.
• Direct design and execution of pharmacodynamic, predictive, prognostic, and safety biomarker strategies for each program; establish clear criteria for biomarker-driven decision gates.
• Integrate advanced translational data modalities, ctDNA/ctRNA, single-cell sequencing, spatial transcriptomics, computational pathology, and multiplex imaging into Nurix’s precision medicine 
• Partner with Discovery Biology to build translationally anchored preclinical models and IND-enabling data  packages that de-risk clinical hypotheses.
• Lead clinical biomarker data interpretation and synthesis across programs; translate complex datasets into actionable insights for clinical teams, executives, and regulatory agencies.

Clinical Integration & Regulatory Partnership

• Provide scientific leadership for translational and biomarker content in clinical protocols, Investigator Brochures, clinical study reports, and regulatory submissions (INDs, BLAs, briefing documents).
• Shape biomarker regulatory strategy in close collaboration with Regulatory Affairs; represent translational science in FDA and EMA interactions, including pre-IND and End-of-Phase meetings.
• Partner with Clinical Pharmacology on integrated PK/PD modeling, dose-response biomarker analysis, and  mechanism-based endpoint selection.
• Collaborate with Biostatistics and Data Science on statistical analysis plans, integrated translational datasets, and exploratory analyses that support publication and regulatory strategy.
• Provide leadership in companion diagnostic (CDx) strategy, including CRO/IVD partner selection and regulatory co-development planning where applicable.

Operational Excellence & External Partnerships

• Define and manage the translational medicine operating model, including infrastructure, technology platforms, and quality standards appropriate to Nurix’s stage and pipeline breadth.
• Evaluate, select, and govern CRO, central laboratory, and academic collaborative partnerships for biomarker assay development and clinical execution; ensure scientific and contractual accountability.
• Develop and manage the translational medicine budget and resource allocation; provide forward-looking investment guidance aligned with clinical timelines and portfolio priorities.

Team Leadership & Organizational Development

• Build, inspire, and develop a high-performing team of translational scientists and biomarker specialists; set clear goals, cultivate scientific rigor, and support career growth.
• Define team structure, roles, and growth pathways appropriate to Nurix’s pipeline stage; attract and retain top-tier scientific talent in the Bay Area biopharmaceutical market.
• Champion cross-functional collaboration and a culture of scientific excellence, intellectual curiosity, and  patient focus within the team and across the broader organization.

Requirements

• Ph.D. in Immunology, Oncology, Biochemistry, Cell Biology, or a closely related life sciences discipline required; MD/Ph.D. strongly preferred.
• Postdoctoral training or equivalent advanced research experience in translational or clinical science is highly valued.
• 15+ years of progressive experience in translational medicine and/or clinical biomarker research within the pharmaceutical or biopharmaceutical industry, with meaningful tenure in oncology.
• Minimum 10 years in a senior leadership role (Sr. Director level or above) with direct management of scientific staff and function-level accountability for deliverables and budget.
• Demonstrated track record of leading translational programs from IND through proof-of-concept (Phase  I/II), including first-in-human study design and execution.
• Experience leading or meaningfully contributing to Phase III biomarker programs, regulatory submissions, and health authority interactions (FDA, EMA).
• Proven ability to evaluate, select, and govern external CRO, central laboratory, and academic partnerships in a biomarker development context.
• Experience presenting to and influencing executive leadership, Boards, investors, or senior regulatory agencies preferred.

Scientific & Technical Expertise

• Deep expertise in translational biomarker strategy — target engagement, pharmacodynamic, predictive,  prognostic, and safety biomarkers — with command of regulatory standards governing their use in clinical    
• Hands-on expertise or strong working knowledge of quantitative and multiplex biomarker technologies:  flow cytometry, ELISA/MSD, IHC/mIF, NGS (RNAseq, scRNAseq, whole-exome), ctDNA/cfDNA, and digital      
• Familiarity with bioinformatic and computational approaches supporting multi-omic data integration and translational dataset interpretation; ability to drive computational strategy in collaboration with data  science partners.
• Knowledge of regulatory expectations for exploratory biomarkers and IVD/CDx development strategies across FDA and EMA frameworks.
• Scientific publication record and demonstrated presence in the translational medicine or oncology/immunology community (publications, conference presentations, KOL relationships).

Preferred Qualifications

• Direct experience with targeted protein degradation (PROTACs, molecular glues) or other emerging modalities, including translational challenges specific to novel mechanisms of action.
• Experience in both oncology and immunology/inflammatory disease therapeutic areas, reflecting Nurix’s evolving pipeline scope.
• Demonstrated experience building a translational medicine or clinical biomarker function from early stage, including infrastructure, platform selection, SOPs, and team design.
• Familiarity with advanced computational and AI-driven approaches in translational science, including patient stratification, multi-omic integration, and machine learning-based biomarker discovery.
• Publication record as senior or corresponding author; participation in scientific advisory boards or external translational medicine working groups.

Fit with Nurix Culture and Values

• Scientist-leader who brings equal conviction to the data and to the people — building teams and translational programs with the same rigor and care.
• Sees the intersection of targeted protein degradation and precision medicine as one of the most compelling opportunities in oncology, and is committed to defining what translational excellence looks like  in this space.
• Operates without ego at the executive table — direct, collaborative, and secure enough to be changed by data and by the perspectives of colleagues.
• Has built things: functions, teams, capabilities. Brings both the track record and the hands-on instincts to drive a program from hypothesis to regulatory submission.
• Invests in people with the same intentionality as in the science — because at Nurix, those two things are inseparable.

Salary Range:  $332,140 - $377,560 range plus bonus and equity

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).