Important Notice to Candidates: Nurix representatives will never conduct interviews by text and will never request personal financial information or ask candidates to purchase equipment.

At Nurix, we believe in the science of possibility. We are committed to advancing groundbreaking science and innovation in targeted protein degradation to transform patients’ lives. If you’re passionate about making a real difference in healthcare, thrive in a collaborative environment, and are excited by scientific challenges, we want to hear from you. Explore our current openings below.

August, 2026

Quality

Associate Director, Computer Systems Assurance (Quality)

Location

Brisbane, CA

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

The Senior Manager / Associate Director, Computer Systems Assurance (CSA) is an important technical and operational leader within the Nurix Quality Systems organization, responsible for owning and advancing Nurix's computer systems assurance program. As a virtual drug developer, Nurix operates through a lean internal infrastructure and relies on a curated ecosystem of Software-as-a-Service (SaaS) and cloud-hosted platforms to support GxP-regulated activities across clinical development, quality operations, manufacturing oversight, and regulatory submissions. This role will serve as the primary subject matter expert and program owner for all CSA and computerized system validation (CSV) activities at Nurix.

Reporting to the Vice President / Senior Director, Quality Systems, this individual will establish and maintain Nurix's risk-based CSA framework aligned with current regulatory expectations, including the FDA's 2022 guidance on computer software assurance, GAMP 5 (2nd edition), and applicable 21 CFR Part 11 and Annex 11 requirements. The role requires an individual who combines deep technical knowledge of GxP computerized systems with practical experience in SaaS and cloud-based platform qualification, and who can translate regulatory requirements into pragmatic, fit-for-purpose validation approaches that support a modern, agile biotech environment. This is a high-impact, program-ownership role requiring both strategic vision and hands-on execution. The successful candidate will work closely with Quality, IT, Regulatory Affairs, CMC, Clinical Operations, and external vendors to ensure that all GxP-critical systems are appropriately assessed, validated, and maintained in a compliant state. The individual will champion a risk-based, science-driven approach to CSA across the organization.

Responsibilities

CSA Program Ownership and Strategy

Own and maintain Nurix's Computer Systems Assurance policy framework, SOPs, and risk-based validation strategy, aligned with FDA CSA guidance (2022), GAMP 5 (2nd edition), 21 CFR Part 11, EU Annex 11, and applicable ICH guidelines.
Define and implement a fit-for-purpose, risk-tiered approach to system qualification for SaaS and cloud-hosted GxP applications, recognizing the vendor-managed nature of modern software platforms.
Maintain the GxP system inventory; conduct and document periodic system risk assessments to classify systems and determine appropriate validation scope and rigor.
Establish and maintain processes for vendor assessment, including review of vendor SOC 2 reports, quality agreements, and audit strategies appropriate for SaaS providers.
Drive continuous improvement of the CSA program through benchmarking, regulatory intelligence, and adoption of industry best practices.

System Validation and Qualification Execution

Lead and execute validation activities for GxP SaaS platforms including, but not limited to, eQMS (e.g., Veeva Vault), electronic document management, clinical data management, regulatory information management, and laboratory information systems.
Author and review validation documentation including Validation Master Plans (VMPs), User Requirements Specifications (URS), Risk Assessments, Vendor Assessments, Validation Protocols (IQ/OQ/PQ), Traceability Matrices, and Validation Summary Reports.
Manage validation activities associated with system implementations, major configuration changes, upgrades, and periodic re-validation reviews, applying critical thinking to scope validation effort proportionate to system risk and change impact.
Coordinate validation testing activities with cross-functional stakeholders; ensure test scripts are appropriately designed to demonstrate fitness for intended use.
Review and approve validation deliverables prepared by internal teams, vendors, or external validation consultants.

21 CFR Part 11 and Data Integrity

Serve as the internal subject matter expert for 21 CFR Part 11 and EU Annex 11 requirements; assess systems for compliance and provide guidance to cross-functional partners.
Partner with IT and system owners to ensure electronic records and electronic signature controls are properly implemented and documented in all GxP systems.
Support data integrity assessments and remediation initiatives; apply ALCOA+ principles to guide compliant system design and use.

Change Management and Periodic Review

Manage the computerized systems change control process; evaluate proposed changes for validation impact and establish appropriate assessment, testing, and documentation requirements prior to implementation.
Own and execute the periodic review program for validated GxP systems; assess continued fitness for intended use and compliance with current regulatory expectations.
Maintain validation status documentation and ensure validation files are audit-ready at all times.

Inspection Readiness and Regulatory Support

Support preparation for regulatory agency inspections; serve as the CSA subject matter expert during FDA, EMA, and other Health Authority inspections and ensure validation documentation is complete, current, and accessible.
Contribute to relevant sections of regulatory submissions and respond to agency questions related to computerized systems and data integrity.
Monitor evolving regulatory guidance and industry standards related to CSA, CSV, data integrity, and cloud-based systems; proactively adapt Nurix's program to reflect current expectations.

Cross-Functional Partnership and Training

Serve as the primary point of contact and internal consultant for all GxP system owners across Quality, IT, Regulatory Affairs, CMC, and Clinical Operations.
Develop and deliver CSA training for system owners, end users, and other stakeholders to build organizational capability and awareness.
Partner with IT and vendor project teams to embed validation requirements early in system selection and implementation processes.

Required Qualifications

Bachelor's degree in computer science, information systems, life sciences, pharmaceutical sciences, or a related field.
7–10+ years of progressive experience in computer systems validation and/or computer systems assurance in a GxP-regulated pharmaceutical, biopharmaceutical, or biotechnology environment.
Demonstrated expertise in current regulatory requirements for computerized systems, including FDA 21 CFR Part 11, EU Annex 11, FDA CSA guidance (2022), and GAMP 5 (2nd edition).
Hands-on experience validating SaaS and cloud-hosted GxP platforms; understanding of vendor-managed environments and shared responsibility models.
Proficiency authoring and reviewing CSA/CSV deliverables: VMPs, URSs, Risk Assessments, IQ/OQ/PQ protocols, traceability matrices, and validation summary reports.
Strong working knowledge of data integrity principles (ALCOA+) and their application to electronic records management and GxP system design.
Experience managing system change control and periodic review programs for validated GxP systems.
Ability to operate as both program owner and individual contributor in a lean, virtual organizational model; comfortable managing validation activities without a large internal support team.
Excellent written and verbal communication skills; able to translate complex technical and regulatory requirements into practical guidance for diverse stakeholders.
Strong organizational skills and attention to detail; demonstrated ability to manage multiple concurrent programs and priorities in a fast-paced environment.

Preferred Qualifications

Experience with eQMS validation (e.g., Veeva Vault) and familiarity with Veeva's Qualified System approach and available supplier documentation.
Familiarity with clinical development platforms such as electronic data capture (EDC), regulatory information management (RIM), or clinical trial management systems (CTMS) in a validated context.
Experience supporting FDA, EMA, or equivalent Health Authority inspections as a CSA subject matter expert.
Exposure to laboratory informatics systems (LIMS, ELN) and their GxP qualification requirements.
Experience in a virtual or lean biotech environment managing validation activities through external vendors and consultants.
Working knowledge of cybersecurity frameworks and their intersection with GxP system compliance (e.g., NIST, SOC 2).
Advanced degree in a relevant scientific, engineering, or regulatory discipline.

Fit with Nurix Culture and Values

You know the regulations deeply and apply them with judgment, designing validation approaches that are rigorous where it matters and efficient everywhere else. You bring expertise with pragmatism —
You are comfortable as the go-to expert, driving the CSA program forward proactively rather than waiting for direction, and you take accountability for outcomes. You own the program —
You build trusted relationships across Quality, IT, and the business, and you understand that a well-designed, compliant systems environment is an enabler of Nurix's mission to develop important medicines for patients. You partner with purpose —

Location: Brisbane, CA - Onsite

Salary Ranges: Senior Manager, CSA(Quality) - $170,538 – $193,493
Associate Director, CSA(Quality) - $190,269 – $216,360

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).

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July, 2026

Information Technology

Director, IT Infrastructure & Operations

Location

Brisbane, CA

About the role

This is the operating leader for IT infrastructure and operations at Nurix, reporting to the SVP of Information Technology. You will own the function end to end: infrastructure, cybersecurity operations, end user services, and IT service management as one integrated scope. You partner with a fractional CISO on security strategy and policy while owning the operational execution. You work closely with the IT business partner leaders who own the application portfolios and partner directly with R&D and the broader scientific organization on their infrastructure needs.

You lead a team that spans enterprise architecture, system administration, and cybersecurity operations, with the service desk delivered through a mix of staff and managed service providers. You will manage both individual contributors and managers from day one. You set the standards and delegate delivery across this hybrid team of internal staff and managed service providers, empowering the people below you rather than running their queues, to support a fast-moving enterprise.

What you'll do

In your first year you will:

Consolidate the managed service provider portfolio across infrastructure, security, and the help desk into a smaller, more accountable set of partners.
Build a cybersecurity operations function from current contractor and MDR coverage.
Establish a governance model with research and scientific computing, and bring research infrastructure into IT alignment. Working with the enterprise architect, inventory and remediate AWS systems: ParallelCluster and other HPC, container platforms (EKS, ECS), SageMaker, and identity bridges.
Own a formal identity and access management program, including clean handoffs to IT operations and the business partner teams.
Refresh the service experience end to end and raise vendor management discipline as scope grows.

Requirements:

12+ years of progressive technology services leadership, including 5+ years at the Director or Senior Director level.
Direct experience leading multi-function technology services (infrastructure, cyber operations, and ITSM) as one integrated scope rather than separate towers.
Comfort partnering with a CISO or fractional CISO on policy while owning operational execution. We are looking for an operator who builds security in partnership, not someone who pushes controls through operations.
Deep experience across AWS plus the Microsoft Entra and Microsoft 365 stack.
Familiarity with the infrastructure behind scientific and ML computing, AWS ParallelCluster and HPC, SageMaker, EKS and ECS, and DevOps and infrastructure-as-code practices, at a level sufficient to set standards and partner credibly with the scientific organization.
A measurable track record managing a managed service provider portfolio, including real consolidation or vendor transitions with accountability for outcomes.
Experience building out infrastructure in fast-moving, resource-constrained environments.
Experience in a regulated industry (biotech, pharma, medical device, healthcare, financial services, or comparable).
Bachelor's degree or equivalent practical experience.

Nice to have

Biotech or pharmaceutical industry experience.
Support for an FDA Pre-Approval Inspection or BIMO inspection in an IT or security capacity.
Experience standing up a security operations function from contractor or MSP coverage.
Partnership with a separate scientific computing organization (informatics, bioinformatics, cheminformatics, machine learning).
Hands-on with an MDR provider such as RedCanary, Kroll, or Arctic Wolf.
Jira Service Management or ServiceNow at scale.
Public company SOX IT general controls experience.

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative
Ability to function in a dynamic environment
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view

Salary Range: $ 260K – $300K plus bonus and equity

Location: Brisbane, CA - Onsite

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July, 2026

CMC

Director, Pharmaceutical Development

Location

Brisbane, CA

Title: Director, Pharmaceutical Development

Position

Nurix Therapeutics, Inc. is seeking a highly experienced Director of Pharmaceutical Development. The role leads small molecule drug product development focused on oral and topical dosage forms. Responsibilities span QbD-based formulation and process development from early phase through commercial launch. The position requires strong cross-functional collaboration and hands-on CDMO management. This position is on site in the Brisbane, CA office.

Responsibilities

Formulation & Process Development

Lead QbD-based formulation and process development for small molecule drug programs with a focus on oral and topical dosage forms across all development phases.
Apply expertise in BCS Class II/IV compound development and enabling formulation technologies, including amorphous solid dispersions (spray-dried dispersions, hot-melt extrusion), lipid-based drug delivery systems (SMEDDS, SEDDS, lipid suspensions), and nano-formulations to address solubility and bioavailability challenges.
Define and document the Quality Target Product Profile (QTPP) and identify Critical Quality Attributes (CQAs) to guide formulation strategy.
Conduct systematic risk assessments to identify Critical Material Attributes (CMAs) and Critical Process Parameters (CPPs) using FMEA and other risk assessment tools.
Develop and optimize manufacturing processes appropriate to the dosage form, ensuring scalability and process robustness.

Scale-Up & Technology Transfer

Lead manufacturing scale-up activities from laboratory to pilot and commercial scale, ensuring robust and reproducible processes.
Troubleshoot manufacturing deviations, out-of-specification results, and process failures; drive root cause analysis and implement corrective actions.

Late-Stage Development & Regulatory

Drive late-stage development activities (Phase 2b through commercial launch) including clinical supply manufacturing, process performance qualification (PPQ), and continued process verification (CPV).
Author and review CMC sections of regulatory submissions including INDs, NDAs, and MAAs.
Ensure all development activities comply with current GMP regulations and internal quality standards.

CDMO Management & Cross-Functional Leadership

Manage external CDMO partnerships, including vendor qualification, technical oversight, and performance governance to ensure project timelines, quality standards, and budget commitments are met.
Serve as the primary technical point of contact between pharmaceutical development and cross-functional teams including Analytical Development, Clinical Operations, Regulatory Affairs, Quality, Supply Chain, and Commercial.
Provide scientific leadership and mentorship to junior scientists, associates, and project team members.

Requirements

Ph.D. in Pharmaceutical Sciences, Pharmaceutics, Chemical Engineering, Chemistry, or a closely related discipline strongly preferred with 12 years of industry experience.
12+ years of progressive pharmaceutical development experience in an industry setting (biotechnology, pharmaceutical, or CDMO).
Deep expertise in small molecule drug product development with a focus on oral and topical dosage forms, especially enabled formulation development (e.g., amorphous solid dispersions, lipid-based systems, nano-formulations).
Comprehensive hands-on experience with QbD methodologies: QTPP definition, CQA identification, CMA/CPP risk assessment, DoE, design space development, and control strategy establishment.
Significant late-stage development experience (Phase 2b/3 and NDA/MAA submission) is required.
Proven track record of authoring and/or reviewing CMC regulatory submissions (INDs, NDAs, CTDs) and successfully responding to agency queries.
Direct CDMO management experience, including technical oversight, project governance, and relationship management.
Knowledge of lifecycle management, post-approval changes, and SUPAC guidance.
For the Director level: demonstrated people management experience leading a team of scientists/managers, department-level strategic planning, and budget/resource ownership across multiple concurrent programs.
Primarily office and laboratory environment; occasional GMP manufacturing facility access required.
Approximately 25% travel required, including domestic and international trips to CDMO sites, clinical manufacturing sites, regulatory agency meetings, and scientific conferences.
Must be able to gown for cleanroom/GMP environments

Core Competencies

Scientific Leadership — Recognized internal and external thought leader in pharmaceutical development; drives scientific innovation and excellence.
Strategic Thinking — Ability to anticipate technical and regulatory risks and develop proactive mitigation strategies that protect project timelines.
Cross-Functional Collaboration — Demonstrated ability to build strong working relationships and influence without authority across diverse internal and external stakeholders.
Project Management — Experienced in managing multiple complex projects simultaneously in a fast-paced, deadline-driven environment.
Communication — Exceptional written and verbal communication skills; able to present complex scientific data clearly to both technical and non-technical audiences, including senior leadership and regulatory agencies.
People Development — Commitment to mentoring and developing scientific talent within the organization.

Salary Range: 218K – 260K plus bonus and equity.

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

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August, 2026

Regulatory

Director, Regulatory Affairs (Strategy, I&I)

Location

Brisbane, California, United States

Position Title: Director, Regulatory Affairs (Strategy, Immunology and Inflammation)

Nurix Therapeutics, Inc. is seeking a Director, Regulatory Affairs (Strategy, I&I) to join the Regulatory team. The successful candidate will be a core member of the Regulatory team and will serve as the global regulatory lead (GRL) for the immunology and inflation therapeutic area. This role will be responsible for developing the global regulatory strategy in collaboration with key internal stakeholders, as well as tactical implementation of that strategy guiding and executing compliant, high quality, nonclinical and clinical submissions and interactions in support of early development, registration and life cycle management activities. This position works cross-functionally with regulatory affairs and clinical development organizations to facilitate the completion of regulatory filing documentation according to company timelines. It also ensures adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as required. This position is on site in the Brisbane, CA office.

Responsibilities:

Develop and implement competitive and effective global clinical & nonclinical regulatory strategies for various immunology and inflammation indications and identify potential risks and mitigation strategies associated with proposed strategies
Work in close collaboration with the SVP, Head of Regulatory Affairs and the development team leader and other cross-functional colleagues, including CROs to deliver sound, efficient development strategies and operational plans
Represent Regulatory Affairs on assigned cross-functional development teams.
Lead and manage the development and preparation of high-quality global submissions (including IND, CTAs, NDAs, and MAAs) for early and late-stage programs in collaboration with the regulatory and project teams to support and accelerate clinical development and regulatory approval, as applicable
Lead communication with global Health Authorities (HA), such as FDA and EMA, including, planning and preparing for formal meetings with regulatory agencies and interpreting HA feedback from these interactions.
Develops and executes, or oversees global regulatory strategy for long-term planning, including the potential to accommodate expedited development needs
Anticipate issues and guide cross-functional teams on risk mitigation strategies for any development challenges Provides insight and guidance on the implementation of current regulations and assesses regulatory risk based on precedence
Ensure adherence to current regulations associated with regulatory activities
Works strategically with all regulatory functions to develop detailed, actionable submission plans, tracks major submission deliverables, and ensures consistent management submission documents, health authority communications, and all other regulatory information supporting Nurix’s investigational and marketing applications
Plays an essential part in defining requirements for, implementing, and supporting future systems and tools to be employed by Nurix in the areas of document management, submission content planning, and regulatory information management
Tracks the status of major deliverables for regulatory submissions (e.g., study reports, summary documents, labeling) along with their dependencies
Develops and maintains submission plan templates to ensure Nurix regulatory submissions are consistently planned and executed across programs
Participates in cross-functional process initiatives impacting regulatory submission processes and systems
Manages consultants and contractors as needed

Requirements

Bachelor's degree in life-sciences or related scientific discipline; advanced degree preferred Manager:
Must have minimum of 12 years in Regulatory affairs strategy with significant experience in the immunology and inflammation therapeutic area
Strong demonstration of knowledge of drug development, FDA, EMA and ICH guidelines and regulations
Experience providing hands-on support for planning clinical trial and marketing applications to health authorities including but not limited to FDA, EMA
Proven track record of supporting Regulatory affairs in the planning and execution of major filings and ongoing maintenance of clinical trial and marketing applications
Strong project management and critical thinking skills
Experience applying project management techniques and tools (e.g., MS Project, Smartsheet, Excel trackers) to the planning and execution of regulatory submissions
Excellent organizational and communication skills, both written and verbal
Ability to work independently as well as part of a team environment
Positive attitude, energetic and proactive
Proven ability to manage multiple projects, identify and resolve regulatory issues
Strong interpersonal skills and the ability to effectively work with others

Salary Range: 220K – 254K plus bonus and equity.

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August, 2026

Regulatory

Director / Sr. Director, Regulatory Affairs (Strategy, Oncology Solid Tumors)

Location

Brisbane, California

Job Summary:

Nurix Therapeutics, Inc. is seeking a Director/ Sr. Director, Regulatory Affairs (Strategy, Oncology – Solid Tumors) to join the Regulatory team. The successful candidate will be a core member of the Regulatory team working in close collaboration with the SVP, Head of Regulatory Affairs and other cross-functional colleagues. This role will be responsible for developing and executing the global regulatory strategy in collaboration with key internal stakeholders, as well as tactical implementation of that strategy, guiding and executing compliant, high quality, nonclinical and clinical submissions and interactions in support of registration and life cycle management activities. This position works cross-functionally with regulatory affairs and clinical development organizations to facilitate the completion of regulatory filing documentation according to company timelines. It also ensures adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as required.

Responsibilities:

Develop a comprehensive regulatory strategy that takes into account worldwide regulatory requirements to drive product development, global registration, achievement and maintenance of desired regional labeling, and effective regulatory agency interactions
Identify potential risks and mitigation strategies associated with proposed strategies
Represent Regulatory Affairs on assigned cross-functional development teams.
Lead and manage the development and preparation of high-quality global submissions (including IND, CTAs, NDAs, and MAAs) for early and late-stage programs in collaboration with the regulatory and project teams to support and accelerate clinical development and regulatory approval, as applicable
Support communication with global Health Authorities (HA), such as FDA and EMA, including, planning and preparing for formal meetings with regulatory agencies and interpreting HA feedback from these interactions.
Develops and executes, or oversees global regulatory strategy for long-term planning, including the potential to accommodate expedited development needs
Anticipate issues and guide cross-functional teams on risk mitigation strategies for any development challenges Provides insight and guidance on the implementation of current regulations and assesses regulatory risk based on precedence
Ensure adherence to current regulations associated with regulatory activities
Works strategically with all regulatory functions to develop detailed, actionable submission plans, tracks major submission deliverables, and ensures consistent management submission documents, health authority communications, and all other regulatory information supporting Nurix’s investigational and marketing applications
Plays an essential part in defining requirements for, implementing, and supporting future systems and tools to be employed by Nurix in the areas of document management, submission content planning, and regulatory information management
Tracks the status of major deliverables for regulatory submissions (e.g., study reports, summary documents, labeling) along with their dependencies
Develops and maintains submission plan templates to ensure Nurix regulatory submissions are consistently planned and executed across programs
Participates in cross-functional process initiatives impacting regulatory submission processes and systems
Manage consultants and contractors as needed

Experience and Skills:

Bachelor's degree in life-sciences or related scientific discipline; advanced degree preferred
Must have minimum of 12 years in Regulatory affairs strategy with significant experience in the oncology (solid tumors) therapeutic area
Strong demonstration of knowledge of drug development, FDA, EMA and ICH guidelines and regulations
Experience providing hands-on support for planning clinical trial and marketing applications to health authorities including but not limited to FDA, EMA
Proven track record of supporting Regulatory affairs in the planning and execution of major filings and ongoing maintenance of clinical trial and marketing applications
Strong project management and critical thinking skills
Experience applying project management techniques and tools (e.g., Veeva RIM, Smartsheet, Excel trackers, etc) to the planning and execution of regulatory submissions
Excellent organizational and communication skills, both written and verbal
Ability to work independently as well as part of a team environment
Positive attitude, energetic and proactive
Proven ability to manage multiple projects, identify and resolve regulatory issues
Strong interpersonal skills and the ability to effectively work with others

Nurix Culture and Values

Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view

Salary Range: Director: $232K - $274K

Senior Director: $279K - $331K

Location: Brisbane, CA (Onsite role)

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July, 2026

Human Resources and Operations

Recruiting Coordinator (Contract)

Location

Brisbane, California

Recruiting Coordinator (Contract)

The Opportunity

At Nurix Therapeutics, you'll help build the teams advancing groundbreaking therapies for patients. As a Recruiting Coordinator (Contract), you'll be at the center of the hiring process—creating exceptional candidate experiences, partnering with recruiters and hiring managers, and ensuring every interview and interaction runs seamlessly.

If you're highly organized, thrive in a fast-paced environment, and enjoy connecting people with meaningful opportunities, we'd love to meet you.

This contract role is based onsite in our Brisbane, CA headquarters.

What You'll Do

Be the primary point of contact for candidates throughout the interview process, creating a welcoming, professional, and engaging experience.
Coordinate and schedule interviews across multiple teams, managing complex calendars and changing priorities with accuracy and efficiency.
Arrange candidate travel, onsite visits, and interview logistics as needed.
Partner closely with recruiters, hiring managers, executives, and interview teams to ensure a seamless hiring process from application through offer.
Maintain candidate records, interview feedback, requisitions, templates, and communications within Greenhouse and other talent systems.
Monitor recruiting activity and ensure data accuracy, process compliance, and timely follow-up throughout the hiring lifecycle.
Identify opportunities to improve recruiting processes, enhance efficiency, and elevate the candidate and hiring manager experience.
Support talent acquisition projects, reporting, recruiting events, and employer branding initiatives as needed.
Help create an inclusive, positive, and consistent experience for every candidate who engages with Nurix.

What You'll Bring

2+ years of recruiting coordination, talent acquisition, HR, administrative, or related experience, preferably within biotechnology, life sciences, healthcare, or a fast-paced corporate environment.
Experience supporting high-volume recruiting activity while maintaining exceptional attention to detail.
Strong organizational and time-management skills with the ability to prioritize multiple requests and deadlines simultaneously.
Excellent written and verbal communication skills and a customer-service mindset.
Experience working with Applicant Tracking Systems; Greenhouse experience is preferred.
Proficiency with Microsoft Outlook, Microsoft Office, and general business applications.
A high level of accuracy, professionalism, discretion, and follow-through.
A collaborative approach and the ability to build strong working relationships across all levels of the organization.
A passion for delivering an outstanding candidate experience and supporting inclusive hiring practices.

Why Join Nurix?

At Nurix, you'll support the growth of teams working at the forefront of targeted protein degradation and AI-powered drug discovery. Your work will directly contribute to bringing innovative therapies closer to patients while helping create an exceptional hiring experience for talent joining our mission.

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July, 2026

Analytical Chemistry

Research Associate II/III– Bioanalytical/In Vitro ADME/DMPK

Location

Brisbane, CA

Company

Position

Nurix Therapeutics is searching for a motivated Research Associate to join our Bioanalytical-In Vitro DMPK team. The successful candidate will contribute to the bioanalytical efforts to support Nurix drug discovery programs involving in vivo and in vitro studies. We are seeking a highly motivated research associate to characterize the in vitro and in vivo ADME properties of drug candidates. The primary responsibilities will be to conduct bioanalysis for in vivo samples and to conduct in vitro experiments. The scope of the daily responsibilities for this position includes, but is not limited to, developing bioanalytical methods, quantitating drug candidates and their metabolites, endogenous biomarkers in biological matrices (e.g. blood, plasma, tissue, tumor, CSF, etc.), reporting bioanalytical results and managing projects outsourced in CROs to support all in vitro and in vivo studies. The successful candidate will have extensive experience in bioanalytical method development and sample analysis using LC-MS/MS and other analytical techniques.

Key Responsibilities

Provide bioanalytical support for in-house PK, non-GLP safety TK
Conduct bioanalytical method development and qualification to support drug, metabolite and biomarker analysis
Independently develop LC-MS/MS methods to quantitate small molecules in in vitro and in vivo samples
Conduct in-vitro stability assays to understand metabolism of drugs
Perform metabolic identification (MetID) using LC-QTOF MS/MS, including accurate mass analysis, fragment interpretation and biotransformation pathway assignment
Independently operate, troubleshoot and maintain LC-MS/MS systems
Participate in multidisciplinary project teams and collaborate with other departments to understand bioanalytical needs for both PK and PD support
Manage projects conducted at CROs to ensure high quality bioanalytical data is delivered to meet project timelines
Maintain accurate and detailed scientific electronic laboratory notebooks
Perform all duties in keeping with the Company’s core values, policies and all applicable regulations

Preferred Qualifications & Experience

Experience with H/UPLC and mass spectrometry
Good working knowledge of SCIEX LC-MS/MS systems for small molecule quantitation
PK analysis using Phoenix or other data management software
Management experience with CROs for outsourcing BA activities is preferred
Provide sample analysis to support PK, PK/PD, PK/efficacy, distribution, metabolism, and non-GLP toxicology studies
Identify issues and troubleshoot scientific equipment including LC-MS/MS, select and develop appropriate methods to perform experiments, analyze data and prepare related reports.
Excellent oral and written communication skills

Minimum Requirements

BS or master’s with >4 years’ experience working in a discovery setting using LC-MS/MS within a pharmaceutical/biotechnology company
Broad experience in small molecule drug candidate bioanalytical assay development/sample analysis in different biological matrices using LC-MS/MS
Experience with AB SCIEX mass spectrometry software
Excellent written, verbal communications and interpersonal skills to collaborate with internal and external partners in a matrix environment

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view

Location: Brisbane, CA - Onsite

Salary Ranges:

RA II $92,891 - $106,507

RA III $110,101 - $124,079

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

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August, 2026

DMPK

Scientist, Bioanalytical – Drug Antibody Conjugates (DACs)

Location

Brisbane, California

Position

Nurix Therapeutics is seeking a Scientist to lead bioanalytical strategies supporting the discovery and development of next-generation degrader antibody conjugates (DACs). This role will focus on LC-MS/MS and hybrid assay strategies for quantitative and qualitative analysis of complex bioconjugates across in vitro and in vivo studies to understand DAC pharmacokinetics, pharmacodynamics, and biotransformation.

The successful candidate will operate at the interface of small and large molecule bioanalysis, and will contribute to assay development, method qualification, and execution, applying advanced LC-MS/MS and hybrid approaches to support in vitro and in vivo studies across discovery and early development

Key Responsibilities

Lead the development, qualification, and execution of bioanalytical methods for DAC modalities, including intact conjugates, total antibody, conjugated payload, and released degrader species in complex biological matrices.
Design and implement LC-MS/MS-based workflows using Sciex platforms for sensitive and selective quantitation of small molecule payloads, linker-derived species, and catabolites
Apply high-resolution mass spectrometry platforms for DAC characterization and metabolite identification
Develop hybrid LBA–LC-MS/MS strategies to address challenges in conjugate quantitation and differentiation of molecular species.
Design, execute and interpret in vitro studies, including plasma and lysosomal stability, linker cleavage kinetics, protease-mediated processing, and degradation assays.
Lead bioanalytical support for in vivo studies, including PK, tissue distribution, and tumor exposure in preclinical species integrating DAC components to inform exposure-response relationships.
Characterize biotransformation pathways of DACs, including identification of linker cleavage products, payload metabolites, and antibody modifications.
Partner closely with DMPK, Proteomics, Pharmacology and Chemistry teams to inform molecular design through data-driven insights on stability, exposure, and degradation efficiency.
Author and review technical reports, regulatory documentation, and study summaries with a high level of scientific rigor and clarity.
Troubleshoot analytical challenges related to matrix effects, low-level quantitation, and conjugate heterogeneity.
Mentor junior scientists and contribute to building bioanalytical capabilities and best practices within the organization.
Evaluate and implement emerging technologies to advance characterization of targeted protein degrader modalities.
Lead the identification, selection, and oversight of contract research organizations (CROs) for bioanalytical method development, assay transfer, and phase‑appropriate qualification.

Preferred Qualifications & Experience

Experience in targeted protein degradation or heterobifunctional degrader platforms.
Experience with hybrid LBA–LC-MS/MS assays and ligand-binding assays (ELISA, MSD).
Understanding of linker chemistry, conjugation strategies, and degradation mechanisms for bioconjugates.
Exposure to regulatory bioanalytical guidance (FDA, EMA) for large molecules and conjugates.

Requirements

Ph.D. with 5+ years or M.S. with 8+ years of relevant industry experience in Bioanalysis, Analytical chemistry, or related field.
Deep expertise in LC-MS/MS bioanalysis, including method development, qualification/validation, and troubleshooting for complex modalities.
Proven experience with Sciex platforms (e.g., 7600 ZenoTOF, 6500+, 7500) and high-resolution MS.
Strong background in ADCs, DACs, or related bioconjugates, including characterization and payload quantitation.
Experience supporting both in vitro ADME and in vivo PK studies, with demonstrated ability to interpret integrated datasets.
Proficiency in sample preparation techniques for large molecules and bioconjugates (e.g., immunocapture, enzymatic digestion, hybrid workflows).
Strong data analysis, visualization, and reporting skills (e.g., vendor software, GraphPad Prism).
Excellent written and verbal communication skills, with experience in technical documentation.
Ability to work in a fast-paced, collaborative environment and manage multiple priorities.

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

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July, 2026

Drug Discovery Technologies

Scientist I – Cell Screening and Pharmacology, Discovery Technology

Location

Brisbane, California

Scientist I – Cell Screening and Pharmacology, Discovery Technology

Position

We are growing our DAC research team with a hands-on in vitro screening and pharmacology scientist who will help build and shape the screening and pharmacological characterization capability for Degrader Antibody Conjugates (DACs). Our DAC platform pairs antibody-based targeting with our degrader expertise to direct protein degradation to specific cell types, and this scientist will play a central role in defining how candidate molecules move through the in vitro assay cascade - from primary screening through mechanistic pharmacological characterization.

This is a lab-based role for someone who wants to bring their own expertise in designing and running in vitro pharmacology studies into an established, highly collaborative discovery organization. The scientist will design, execute, and analyze cellular assays that characterize DAC activity, and will partner closely with discovery biology, conjugation chemistry, analytical biochemistry, DMPK, and automation to advance candidates from early screening. The ideal candidate will be self-driven, resourceful, and organized, and will enjoy shaping assay strategy in a dynamic team environment.

Responsibilities

Design, build, and optimize the in vitro pharmacology assay cascade for DACs and biologics, from primary screening through mechanistic and quantitative characterization.
Develop and perform cell-based assays to characterize DAC and biologic activity, including antigen binding, target engagement, and targeted protein degradation, using cutting-edge technologies and automated workflows.
Cultivate and maintain mammalian cell lines (experience manipulating cell surface antigens and engineering reporter lines used to characterize DACs is preferred).
Collaborate with team members to contribute to the design and execution of pharmacology studies to assess the biological activity and mechanism of action of lead molecules and drug candidates.
Stay current with the latest scientific literature and industry developments in the fields of ADCs, DACs, biologics, and targeted protein degradation.
Analyze, interpret, and clearly communicate results; present findings at internal meetings and contribute to scientific discussions that drive project advancement.

Qualifications

Ph.D. in a relevant scientific field (Biochemistry, Pharmacology, Biology, etc.) with a strong academic track record, or MS with 6 or more years of relevant industry experience.
Demonstrated experience designing and setting up in vitro pharmacology studies and screening cascades; prior know-how in building screening/assay cascades in the ADC or DAC field is preferred.
Hands-on experience with mammalian cell culture and the ability to independently execute, analyze, and report results of quantitative cellular assays relevant to conjugate characterization (e.g., luminescence-based degradation, viability, or internalization assays).
Experience with mechanistic assays that dissect DAC activity, such as antibody binding and intracellular drug release, is highly desired.
Familiarity with automation equipment (e.g., liquid handlers) and automated workflows.
Strong analytical and problem-solving skills, with sound judgment in evaluating and interpreting experimental

Nurix Culture and Values

Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view

Salary Range: $127K - 143K

Location: Brisbane, CA (Onsite role)

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August, 2026

Drug Discovery Technologies

Scientist II, Degrader Antibody Conjugate Characterization

Location

Brisbane, CA

Position

You will lead the development of innovative analytical workflows that support and accelerate Nurix's DAC platform, applying your expertise in ADC and/or DAC characterization to solve complex scientific challenges. This is an opportunity to shape analytical strategy for a novel therapeutic platform at the forefront of drug discovery and development.

This is a laboratory role requiring assay design, method development, hands-on execution, and scientific communication to project and platform teams. You will design and execute analytical strategies for high-throughput DAC screening, establish quality criteria that drive conjugate advancement decisions, and partner closely with conjugation chemistry, biology, and bioanalytical teams from early screening through candidate selection.

Responsibilities:

Design, execute and own the DAC screening characterization platform including DAR, aggregation, protein quantitation, and define the QC thresholds to advance conjugates for a program
Lead and conduct in-depth characterization of antibodies and advanced DACs including positional isomers, glycosylation analysis, peptide mapping, and stability
Integrate DAR, purity, hydrophobicity, and stability data into unified assessments with QC cutoffs that drive go/no-go decisions; identify structure-quality trends across antibody, linker, and payload variables
Develop, optimize, and troubleshoot LCMS and HPLC methods for throughput and robustness; establish plate-based sample preparation workflows that maintain data quality at screening scale
Present findings to project and platform teams; collaborate with conjugation chemistry, bioanalytical, and cell screening groups to align workflows, coordinate sample flow, and influence conjugate advancement decisions

Requirements:

BS/BA with 12+, MS/MA with 8+, or PhD with 4+ years of industry experience in biochemistry, analytical chemistry, or a related discipline
Expertise in ADC/DAC & antibody characterization from method development to data interpretation
Expertise with LCMS & HPLC methods for antibody and conjugate analysis, including DAR, SEC, peptide mapping, HIC, and other relevant industry leading methods
Direct experience characterizing ADCs in an industry setting with working knowledge of conjugation chemistry, DAR heterogeneity, and common quality attributes
Track record of independently designing experiments, developing analytical methods, troubleshooting assay and instrument performance, and managing priorities across multiple concurrent programs
Ability to synthesize complex analytical datasets into actionable scientific conclusions and influence project decisions through clear communication to cross-functional teams

Preferred Qualifications

Experience with native LCMS, positional isomer analysis, glycan analysis, CE-SDS for expanded conjugate or antibody characterization
Background in peptide mapping, biophysical binding assays, and thermal stability
Familiarity with developability assessment, forced degradation, or formulation-support analytics for biologics
Familiarity & experience with Agilent instrumentation & analytical software (MassHunter, Byos, or equivalent)

Culture & Team Fit:

Ability to work collaboratively across multiple groups within the organization
Excellent organization and communication with effective presentation skills
Self-driven and enthusiastic with proficiencies to deliver in a dynamic environment
Curious mindset with a willingness and flexibility to learn new skills
High level of creativity and productivity with strong problem-solving skills

Salary Range: 140K - 161K

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July, 2026

Protein Sciences

Scientist I, Protein Purification & Expression

Location

Brisbane, CA

Position Title: Scientist I, Protein Purification & Expression

Position

Nurix Therapeutics, Inc. is seeking a detail-oriented and experienced Protein Expression Scientist to join the DEL and Protein Sciences team. This individual will work cross functionally with internal stakeholders to plan, coordinate, and execute all operational activities required for analytical scale and preparative scale expression of recombinant proteins in baculovirus and mammalian cell systems. Additionally, they will be responsible for documentation of expression conditions and results in internal databases and electronic lab notebook systems.

Responsibilities:

Highly proficient in maintaining insect cell and mammalian cell cultures.
Excellent knowledge and high degree of familiarity with all steps in baculovirus expression of recombinant proteins, including clone design, generation and purification of bacmids, raising and titering of baculovirus, conducting MOI studies, cell culture of Sf9 and/or Tni/Hi5 cells, and harvesting of biomass on the scale of 1 L – 20 L.
Highly proficient in maintaining insect cell and mammalian cell cultures.
Strong working knowledge of protein characterization steps, including SDS-PAGE analysis, size exclusion chromatography, and/or thermal stability (e.g. nanoDSF).

Requirements

Ph.D. or equivalent with 2+ years of relevant experience
This position requires 2+ years of experience working with insect cell lines and baculovirus expression of recombinant proteins. Additional experience working with recombinant protein expression in mammalian cells (e.g. HEK293) is a plus. Industry experience preferred with exemplified ability to overexpress milligram amounts of protein for structural and functional studies for multiple protein classes.
Able to work in dynamic, fast-paced environment with experience prioritizing work across multiple projects.
Detail-oriented with strong record keeping skills.
Past experience purifying recombinant proteins (e.g. affinity chromatography, ion exchange, or size exclusion chromatography) is a bonus.
Must be able to lift 50+ pounds comfortably.
Onsite Position

Salary Range: 125K - 151K plus bonus and equity

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view

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August, 2026

Biometrics

Senior Director, Clinical Data Management

Location

Brisbane, California

Position:

The Senior Director of Clinical Data Management (CDM) is an extensively experienced management role responsible for the delivery and integrity of clinical data across Nurix’s multiple studies/programs. As a subject matter expert in clinical data management, this role owns the short- and long-term strategy, roadmap, budget and resource plans for the CDM function, and uses this expertise to conceive and develop new and novel ideas and infrastructure that significantly advance the function’s capabilities and performance. The ideal candidate will ensure adherence to industry guidelines (including CDASH/CDISC and GCDMP) in all clinical data management activities for assigned programs/studies and will play a leadership role—in partnership with the Head of Clinical Data Management and Head of Biometrics—in defining departmental policies, operational guidelines, and administrative structure. The successful candidate should have a successful track record managing a large or highly specialized team (including other people managers), managing vendors, and effectively leading program clinical data management activities with the anticipated growth in the product pipeline. They must also possess advanced communication skills to represent the CDM function in routine interactions with senior stakeholders, including Nurix’s Executive Management Team and external thought leaders, and to work closely with medical study directors and clinical operations to ensure high quality and integrity in clinical data.

Responsibilities:

Lead and manage assigned programs, which may consist of multiple studies, ensuring alignment and consistency in data collection and processing activities
Manage vendors that have been contracted to handle Nurix’s clinical data and ensure the data are complete, accurate and delivered within the agreed upon timelines
Ensure inspection readiness by maintaining current documentation, adherence to industry guidelines, SOPs and compliance with training
Work collaboratively with internal and external team members within the program to coordinate the planning and execution of clinical data management activities
Lead the design of the eCRFs and ensure that they align with the clinical protocol(s)
Ensure complete and accurate documentation such as eCRF specifications, eCRF completion guidelines, annotated CRFs, data validation specifications, data transfer agreements, and data management plans
Ensure data is reviewed on an on-going basis, including individual subject data within the EDC and reconciliation with external data sources
Manage timelines for data cleaning and other CDM activities in preparation for DSURs, IBs, publications and other business needs, or final CSRs
Collaborate with clinical development team and provide expertise regarding CDISC data standards, FDA and ICH guidelines, and GCDMP standards
Assist with establishing CDM processes and creating key CDM SOPs
Provide technical leadership and guidance for other clinical data managers and vendors around project conventions, standards, practices, and database specifications
May assist in forecasting and management of budgets for resources and program costs
May act as an independent contributor to perform all clinical data management activities of an assigned program or study, as necessary
May be required to mentor and develop direct employees and/or manage a group of internal and/or external team members, as the department grow

Requirements

Bachelor’s degree in a scientific discipline (computer science, mathematics, statistics, epidemiology, biology, psychology, etc.) or equivalent experience
Minimum of 15 years of clinical data management experience within pharmaceutical industry with a track record of success and progression
Direct experience working with Medidata Rave design and implementation
Direct experience with oncology studies across multiple study phases
Proficient on regulatory requirements for clinical data management and the regulatory submission process
Extensive experience working with external vendors, including but not limited to acquisition, contracting, evaluation of vendor’s capabilities and ensuring the desired high-quality deliverables
Experience managing direct reports is required, typically including some experience managing other managers
Demonstrated ability to operate and lead in a dynamic organization, build successful working relationships and effective stakeholder management in an environment that requires diverse educational and functional expertise
Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view
Self-motivated and able to operate independently

Salary Range: 246K – 310K

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view

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July, 2026

Human Resources and Operations

Senior Recruiter (Contract)

Location

Brisbane, California

Senior Recruiter (Contract)

The Opportunity

At Nurix Therapeutics, you'll play a key role in building the teams that advance breakthrough science and innovative therapies for patients. As a Contract Senior Recruiter, you'll partner closely with hiring managers and leaders across the organization to attract, engage, and hire exceptional talent. If you thrive in a fast-paced biotech environment, enjoy building relationships, and take pride in delivering an outstanding candidate experience, we'd love to hear from you.

This contract role is based onsite in our Brisbane, CA headquarters.

What You'll Do

Own full-cycle recruitment for a diverse portfolio of roles across scientific, technical, and corporate functions.
Partner with hiring managers to define hiring needs, develop search strategies, and identify the skills and experiences that drive success.
Lead intake meetings, candidate screening, interview planning, debrief discussions, and offer processes from start to finish.
Proactively source and engage top talent, including passive candidates, to build strong and diverse talent pipelines.
Serve as a trusted advisor to hiring managers by providing insights on talent market trends, candidate availability, and competitive hiring practices.
Deliver an exceptional experience for candidates and hiring teams through clear communication, collaboration, and responsiveness.
Drive efficient, compliant hiring processes while maintaining accurate candidate data and reporting within Greenhouse and other talent systems.
Contribute to continuous improvement initiatives that strengthen recruiting effectiveness, employer brand, and hiring outcomes.

What You'll Bring

6-10 years of full-cycle recruiting experience in biotechnology, biopharmaceutical, life sciences, or a similarly fast-paced, highly specialized industry.
A track record of successfully hiring across scientific disciplines (R&D, CMC, Technical Operations, Clinical, or related functions) as well as corporate teams.
Strong partnership and influencing skills, with the ability to build credibility and collaborate effectively with leaders at all levels.
Expertise in sourcing and engaging passive talent through a variety of channels and recruiting strategies.
Excellent organization, attention to detail, and the ability to manage multiple searches while maintaining a high-quality candidate experience.
Confidence balancing strategic talent acquisition work with hands-on recruiting execution and coordination.
Experience using Greenhouse or a similar applicant tracking system preferred.
A commitment to fostering inclusive hiring practices and helping create diverse, high-performing teams.

Why Join Nurix?

You'll have the opportunity to make a meaningful impact by helping build the talent behind cutting-edge drug discovery and development programs. Your work will directly support the growth of teams dedicated to advancing innovative therapies and improving the lives of patients around the world.

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August, 2026

Discovery Chemistry

Senior Research Associate, DNA Encoded Library Technology

Location

Brisbane, CA

Company

Senior Research Associate, DNA Encoded Library Technology – Nurix Brisbane

Position

We are seeking a talented and motivated chemist to join our Discovery Chemistry team and contribute to the design and synthesis of DNA-encoded libraries (DELs). This hands-on position offers the opportunity to shape Nurix’s DEL-based lead discovery platform, working at the interface of chemistry, biology, and automation. Key responsibilities:

Design and validate novel DEL library builds.
Develop and bring in new DNA-compatible chemical transformations that can widen the DEL chemical space.
Construct DEL libraries to support the in-house library production efforts.
Work with external partners to support our DEL synthesis and hit follow up strategies.
Engage in cross-functional team discussions that support DEL screening, data analysis, machine learning and hit-optimization.
Contribute to platform automation and technology development efforts.
Present results, document workflows, and contribute to scientific and strategic planning within the Discovery Chemistry organization.

Education and Experience

B.S. or higher in Chemistry, Biochemistry, or Medicinal Chemistry with 5 years of industrial experience (title determined by experience).
Strong background in synthetic organic chemistry.
Hands-on laboratory experience synthesizing DNA encoded libraries.
Familiar with the overall DNA-Encoded Library Technology workflow operations.
Experience analyzing and purifying DNA-conjugates using common analytical tools (LCMS/HPLC).

Added Qualifications

Experience working in the drug discovery field – drug design, synthesis, and SAR based hit-to-lead optimization.
Experience working with high-throughput analytical and purification systems relevant to DEL-applications.
Experience working with molecular biology tools (PCR, qPCR, Western Blot).

Fit with Nurix Culture and Values

Collaborative and team-oriented, eager to share expertise and learn from others.
Solution-driven with a hands-on and resourceful approach.
Adaptable and comfortable in a fast-paced, interdisciplinary environment.
Committed to scientific excellence and the shared goals of the team.

Location: Brisbane, CA

Salary Range:

RA III: $101,690 – 116,226
SRA: $118,893 – 139,310
Scientist I: $129,382 –146,679

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

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August, 2026

CMC

Senior Scientist, Analytical Development and Quality Control

Location

Brisbane, CA

Company

Position

Nurix Therapeutics seeks an experienced Senior Scientist to join the Analytical Development and Quality Control group. The Senior Scientist will be responsible for drug product (DP) analytical development, including method development, oversight of method validation at CDMOs, and lifecycle management in support of Nurix’s oncology and inflammation & immunology (I&I) programs.

This position provides technical oversight of analytical method development, validation, and testing conducted at external CDMO/CRO partners. The Senior Scientist will author analytical development reports and IND/IMPD/NDA sections and support late-phase tech transfer and validation activities. This role will also contribute to analytical development for new drug products and dosage forms. The Senior Scientist will work closely in cross-functional teams to ensure alignment and integration of analytical and QC strategies across development stages.

The ideal candidate will have expertise in chromatographic and dissolution method development, stability studies, and phase-appropriate validation and control strategies, along with demonstrated experience supporting late-phase development and regulatory submissions.

This position is onsite at Nurix headquarters in Brisbane, CA.

Key responsibilities include:

Lead analytical method development validation and lifecycle management for drug product formulations, including amorphous solid dispersions (ASDs) and lipid-based systems
Support PPQ activities, commercialization, commercial QC, and lifecycle management for drug product analytical methods and control strategies
Design and oversee DP development, registration batch, and commercial stability programs, including protocol development and trend analysis
Author and review DP analytical development reports to support regulatory submissions, and marketing authorization
Oversee and support analytical activities, including method development, validation, and QC testing conducted at CDMOs and contract testing laboratories (CTLs)
Contribute to investigations (e.g., OOS, OOE, OOT), root cause analysis and CAPAs
Perform critical review of analytical data, protocols, reports, specifications, and related documentation
Trend stability data and support establishment of retest periods and shelf life using statistical methods
Collaborate in the development and justification of material control strategies and specifications
Author technical documents, including analytical development reports, specifications, validation and stability protocols/reports, certificates of analysis (COAs), and storage statements
Author and review analytical sections of regulatory submissions (e.g., IND/IMPD/NDA)
Collaboratively author responses to health authority requests for information
Act as a key contributor to multidisciplinary teams, including Chemical Development, Pharmaceutical Development, Regulatory, Quality, Preclinical, Supply Chain, Medicinal Chemistry, and DMPK
Maintain and organize analytical documentation and data to ensure traceability, data integrity, and inspection readiness
Follow cGMP requirements and internal SOPs
Travel up to 5%, as required

Qualifications

Advanced degree in a relevant discipline (Chemistry, Pharmaceutics, or related field)
Senior Scientist: BS/MS degree with 14+ years or PhD with 8+ years of industrial CMC experience
Strong experience in drug product analytical development and validation
Experience with analytical development for amorphous solid dispersions (ASDs) and/or lipid-based formulations
Experience in CDMO and contract testing lab oversight
Experience supporting regulatory submissions (e.g., IND, IMPD, NDA) and global regulatory filings
Fluency with ICH guidelines, cGMPs, and pharmacopeial chapters
Ability to work effectively in a cross-functional environment
Strong technical writing skills (e.g., development reports, regulatory documents)
Ability to manage multiple priorities in a fast-paced environment
Excellent communication and cross-functional collaboration skills

Salary Range:

Senior Scientist -- $162K – $186K

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

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July, 2026

Medicinal Chemistry

Senior Scientist, Antibody Conjugation

Location

Brisbane, CA

About the Role

We are growing the team with a hands-on antibody conjugation scientist who will build this capability from the ground up by developing and validating bioconjugation chemistries that are reproducible at bench scale, sufficiently robust for transfer to automated higher-throughput synthesis workflows, and scalable for preparation campaigns supporting advanced in vivo and translational studies.

This is a lab-based role for someone who wants to build a new technical capability inside an established, highly collaborative discovery organization and partner closely with medicinal chemistry, analytical chemistry, computational chemistry, protein biochemistry, and automation to move candidates from bench to study-ready material.

What You'll Do

Develop and optimize antibody bioconjugation methods for attaching degrader payloads and linkers to antibodies.
Design conjugation chemistry with an eye toward automation: define protocols, reagent ratios, and process parameters in a form that can be transferred to and run reliably on liquid-handling platforms.
Execute one-off and scale-up conjugation runs (mg to multi-mg) to produce material for pharmacology, PK/PD, and other advanced studies on program timelines.
Purify conjugates via FPLC/AKTA, TFF, and column chromatography; troubleshoot yield, homogeneity, and stability issues as they arise.
Write clear SOPs and technical reports; train and support automation-team colleagues in executing conjugation workflows independently.
Collaborate cross-functionally with medicinal chemists (linker/payload design), computational chemists (site selection, modeling), and external CROs/CDMOs as needed.
Stay current on emerging bioconjugation and DAC/ADC methodology and bring forward new techniques relevant to Nurix's pipeline.

Who You Are

A team player who works well across disciplines (chemistry, analytical, protein biochemistry, automation/engineering) and communicates clearly with both scientists and technical staff.
Results-oriented: you drive a method from first attempt to a robust, transferable protocol, and you personally deliver material when a study needs it.
Comfortable owning a technical area with real autonomy in a growing capability area.

Qualifications

PhD in chemistry, biochemistry, chemical biology, or a related field preferred; MS or BS with substantial (8+ for BS/MS) hands-on industry bioconjugation experience will also be considered.
Direct, hands-on experience with antibody/protein bioconjugation chemistry: NHS ester and maleimide coupling, click chemistry (CuAAC/SPAAC/IEDDA), engineered-cysteine or glycan/enzymatic site-specific conjugation, or unnatural-amino-acid approaches.
Experience purifying and characterizing conjugates: FPLC/AKTA, TFF, SEC, IEX, RP-HPLC/UPLC, HIC, and LC-MS-based DAR/identity analysis.
Experience preparing protocols for automated or semi-automated execution (e.g., liquid handlers such as Hamilton or Tecan) is a strong plus, though the successful candidate may also learn this in partnership with our automation team.
Strong record of practical problem-solving in the lab, with the judgment to know when a result is study-ready versus needs more optimization

Why This Role

You'll be the founding technical expert for antibody conjugation at Nurix, shaping both the science and how it's automated and scaled — with direct visibility to program leadership and a fast path from method development to real studies

Salary Range: 155K - 180K plus bonus and equity

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view

We are an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job within Nurix or in the course of your employment with Nurix. By applying for a position with Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/)

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July, 2026

Toxicology

Senior Vice President, Preclinical Toxicology

Location

Brisbane, California

Senior Vice President, Preclinical Toxicology

Position

The Senior Vice President, Toxicology (Safety Pharmacology) leads Nurix's nonclinical safety function and reports to the Chief Scientific Officer. This role sets toxicology and safety pharmacology strategy across the portfolio, from discovery through clinical development, and represents Toxicology to senior management, the Board, external partners, and regulatory authorities.

The SVP operates across three dimensions: leading an internal team and managing the department's CRO relationships, budget, and study portfolio; setting strategic direction for nonclinical safety across programs and the portfolio; and executing with the scientific rigor and credibility to influence program-level decisions and Nurix's broader R&D direction.

Responsibilities

Set toxicology and safety pharmacology strategy across the discovery, preclinical, and clinical portfolio, and make sure nonclinical safety plans align with the company's development priorities and risk tolerance.

Represent Toxicology on the Research & Early Discovery leadership team and other internal or collaboration leadership teams, acting as a key contributor to portfolio prioritization, program governance, and related decisions.

Lead and develop an internal Toxicology team, including hiring, mentoring, and setting priorities as workload and the portfolio evolve.

Direct the design and execution of preclinical pharmacology, pharmacokinetic, mammalian toxicology, and genetic toxicology IND-enabling studies (GLP and non-GLP), ensuring packages meet regulatory filing standards.

Manage the Toxicology department budget and resourcing, including decisions about what stays in-house versus what goes to CRO partners.

Select and oversee the CRO and external partner network, including contracting, risk management, and quality oversight of outsourced GLP and non-GLP studies.

Serve as the senior toxicology representative in interactions with FDA and other health authorities, including IND, CTA, NDA, BLA, and MAA submissions and agency meetings.

Communicate toxicology findings and risk assessments clearly to program teams, senior management, and the Board, translating nonclinical safety data into practical implications for decision-making.

Provide toxicology and safety input on business development activities, including due diligence on in-licensing or partnership opportunities.

Work cross-functionally with research, CMC and clinical teams to resolve nonclinical safety issues that develop across discovery and development programs, and assess the relevance of toxicological findings to human risk.

Represent Nurix Toxicology externally, including with key opinion leaders, industry groups, and regulatory forums.

Required Qualifications

Ph.D., M.D., or D.V.M. in Toxicology, Pharmacology, or a related discipline.

Minimum 15 years of drug development experience in the pharmaceutical or biotechnology industry, including experience leading a toxicology or nonclinical safety functionTrack record advancing multiple programs from IND through Phase I, II, and III clinical development, with direct experience authoring and defending FDA and international regulatory submissions.

Experience with ADCs (Antibody-Drug Conjugate) and small molecule strongly preferred

Experience presenting toxicology and nonclinical safety strategy to senior management and external stakeholders, including investors and partners.

People-leadership experience, including hiring, developing, and managing a team, plus experience owning a department budget.

Strong knowledge of safety pharmacology and toxicology study design in compliance with GLP, ICH, FDA, and EMA guidelines across multiple therapeutic modalities.

Proven experience preparing and defending regulatory submissions (IND, CTA, NDA, BLA, MAA, etc.) in direct interactions with global regulatory authorities.

Experience contributing a toxicology and safety perspective to business development or due diligence activities preferred.

Strong communication skills, with the ability to influence senior leadership and represent the function credibly outside the company.

Certification by the American Board of Toxicology (D.A.B.T.) required or strongly preferred.

Travel required as needed.

Nurix Culture and Values

Strong team orientation; highly collaborative

Solutions and results-oriented focus

Hands-on approach; resourceful and open to diverse points of view

Salary Range: $360K – $420K

Location: Brisbane, CA (Onsite role)

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July, 2026

Regulatory

Sr. Director, Head of Regulatory & Medical Writing

Location

Brisbane, California, United States

Job Summary:

As a key member of the cross-functional Development Team responsible for providing regulatory writing expertise and leadership to formulate the writing strategy for key regulatory documents for submission. The Sr. Director, Head of Regulatory & Medical Writing will be responsible for providing guidance to the medical and or regulatory writing group (contractors and internal writers) assigned to deliverables and ensuring appropriate work allocation and document preparation.; will also provide review and substantive editing of documents to ensure delivery of high-quality documents. This individual will work effectively with many other functional groups, including with Clinical Scientist(s), Medical Monitors, Regulatory and other functions as applicable, and collaborate with clinical medical writing as applicable to ensure scientific excellence in the execution of clinical trials. The Head of Regulatory Writing will build a medical writing group internally when appropriate.

Reporting to the SVP, Head of Regulatory Affairs, this role will be responsible for the regulatory writing & medical writing deliverables of assigned project(s), in accordance with the agreed timelines and quality standards.

Responsibilities:

Ensure appropriate allocation of internal and external resources needed for all regulatory writing deliverables.
Hire and manage medical writers internally and manage external medical writing contractors.
Forecasting and maintaining budget for the regulatory writing team.
Assess efficiencies, help identify areas of improvement and initiate improvement processes.
Coordinate, author and edit documents used to support clinical trial conduct and reporting including but not limited to:

Clinical study protocols and clinical protocol amendments (in partnership with Clinical Science/Clinical Development)
Clinical study reports
Investigator’s brochures and annual updates
IND submissions and annual reports
Lay-person summary
Integrated summary reports
Clinical, Nonclinical and Multidisciplinary Information Amendments
NDA, BLA, MAA, (e)CTD submissions
Risk Management Plans
Health Authority responses
Briefing Documents, ODDs, BTDs/PRIME, FTD etc

Participate in relevant subteam(s) and ensure effective planning and management of timelines for all components of assigned documents across all projects.
Participate in document strategy sessions, including messaging, document flow, logic, and consistency for assigned projects.
Support and develop deliverables required for global transparency and disclosure requirements (e.g., plain language lay summary, applicable redactions to regulatory documents subject to EU posting regulations and results for EU CTR).Partner with Biometrics in developing standard TFLs and in text tables for deliverables as applicable
Maintain and support developing and reviewing standard processes and templates.
Review and edit documents as required.
Work effectively and lead in cross-functional working groups.

Qualifications:

Candidates must have a BS with 15+ years, or MS or other advanced science degree (e.g.: RN, NP, MSN, PharmD, PhD, MD) with 10+ years of experience in oncology clinical research experience as a clinical or regulatory medical writer within the pharmaceutical/biotech industry.
Prior experience leading a regulatory writing group
Experience writing/leading the writing of critical clinical documents in major regulatory filings (NDA, BLA, MAA).
Proficiency in the use and understanding of computer software e.g. word processing, graphics, reference manager, document management systems.
Familiarity with all phases of drug development processes (discovery to market), clinical study protocol design, CTA/IND submissions, investigator’s brochures and clinical study data collection and results reporting.
Advanced knowledge of routine document content preparation, including the use of style guides, medical dictionaries, and regulatory guidance documents and templates.
Experience writing, at a minimum, protocols (Phase 1-3, in oncology), investigator’s brochures, clinical study reports, Health Authority briefing packages, and Health Authority responses. Experience with Pediatric Investigational Plans (PIPs) is preferred.
Advanced understanding/knowledge of regulatory requirements and drug development processes, Good Clinical Practice (GCP), regulatory requirements and guidelines associated with regulatory documents (e.g., protocols, investigator brochures, and clinical study reports).
Ability to interpret and summarize complex tabular and graphical data presentations.
Strong organization, documentation and communication skills with an ability to multitask.
Adaptable / flexible, willing and able to adjust to multiple demands and shifting priorities; ability to meet day-to-day challenges with confidence and professionalism.
Detailed knowledge of GCP, ICH Guidelines and current US FDA regulations.

Salary Range: $254,127 - $289,388 plus bonus and equity.

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July, 2026

Medical Communications

Vice President, Medical Affairs – Hematology-Oncology

Location

Brisbane, CA

Position Overview

Nurix Therapeutics is seeking a Vice President, Medical Affairs, Hematology-Oncology to build, expand, and lead a best-in-class Medical Affairs organization supporting the company’s transition from a clinical-stage biotechnology company toward commercialization as its hematology-oncology portfolio advances into late-stage clinical development.

This executive will provide strategic and operational leadership across the full Medical Affairs function, including medical strategy, ﬁeld medical, scientiﬁc communications, evidence generation, thought leader engagement, medical information, and launch readiness. The role will play a central role in shaping the scientiﬁc and medical strategy for Nurix’s targeted protein degradation portfolio and helping deﬁne the company’s external scientiﬁc leadership in hematologic malignancies.

The role will be a key cross-functional partner to Clinical Development, Commercial, Market Access, Regulatory, Legal, and Compliance as Nurix plans and executes future commercialization activities. This leader will contribute broadly to portfolio strategy, lifecycle planning, and enterprise-level decision making as a member of the senior leadership team.

Responsibilities

Lead and scale the Medical Affairs function to support the progression of Nurix’s hematology-oncology programs into late-stage clinical development and future commercial readiness.
Own the overall Medical Affairs strategy for the hematology-oncology portfolio, ensuring alignment with development plans, portfolio priorities, and corporate objectives.
Lead development of the scientiﬁc platform and differentiated medical narrative for Nurix hematology-oncology programs within rapidly evolving treatment landscapes.
Partner closely with Clinical Development to shape late-stage medical strategy, including data generation priorities, scientiﬁc narrative, external engagement plans, and lifecycle opportunities.
Develop and execute integrated medical plans across ﬁeld medical, scientiﬁc communications, publications, medical education, medical information, insight gathering, and evidence generation.
Expand and lead a high-performing MSL organization focused on credible scientiﬁc exchange, compliant insight capture, and strong engagement with key external experts, investigators, and treatment centers.
Lead external engagement in hematologic malignancies, including advisory boards, investigator relationships, disease-area thought leader engagement, and interactions with cooperative groups and broader scientiﬁc communities.
Serve as a senior medical representative of the company with external experts, investigators, and scientiﬁc leaders, helping establish Nurix as a credible scientiﬁc leader in hematologic malignancies and targeted protein degradation.
Direct publication and scientiﬁc communication strategy for key clinical data, congress presentations, medical content, symposia, and educational initiatives.
Lead integrated evidence generation strategies spanning registrational support, post-marketing evidence development, real-world evidence, health economics and outcomes research, treatment sequencing, and product differentiation opportunities.
Partner with Commercial and Market Access to ensure medical strategy informs launch readiness, access planning, scientiﬁc platform development, training initiatives, and broader commercialization strategy.
Monitor the external hematology-oncology landscape, including standard-of-care evolution, competitor data, treatment guidelines, and emerging scientiﬁc trends, and translate insights into actionable medical strategy.
Ensure all Medical Affairs activities are conducted in compliance with applicable legal, regulatory, and company standards.
Provide medical and scientiﬁc leadership to executive governance discussions related to portfolio prioritization, lifecycle strategy, label expansion opportunities, external partnerships, and commercialization readiness.
Support global Medical Affairs planning and coordination, including scientiﬁc congress strategy, evidence generation activities, and external engagement initiatives across key regions.

Qualiﬁcations

MD, PhD, DO, or PharmD required; oncology/hematology experience
15+ years of biopharmaceutical Medical Affairs experience with signiﬁcant leadership responsibility, including direct accountability for launch and post-approval
Demonstrated leadership experience supporting late-stage development and commercialization of hematology-oncology therapies, including launch planning, scientiﬁc positioning, and post-approval medical strategy.
Demonstrated expertise in evidence generation (Phase 3b/4, RWE, HEOR), scientiﬁc communications, MSL leadership, and cross-functional launch planning.
Strong understanding of global and US. regulatory, compliance, and payer environments related to medical activities and drug promotion.
Experience in highly innovative therapeutic platforms, ﬁrst-in-class mechanisms, or rapidly evolving treatment landscapes strongly preferred.
Excellent leadership, communication, and collaboration skills, with the ability to operate strategically while remaining hands-on in a fast-moving pre-commercial and launch environment.
Demonstrated ability to build and scale high-performing Medical Affairs organizations in emerging biotechnology or growth-stage commercial settings preferred.

Salary Range: 348K - 399K plus equity and bonus

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August, 2026

Translational

Vice President, Translational Medicine & Clinical Biomarkers

Location

Brisbane, California

Nurix Therapeutics is seeking an accomplished scientific leader to serve as Vice President, Translational Medicine & Clinical Biomarkers. This executive will own the full translational medicine and clinical biomarker strategy across Nurix’s oncology and immunology pipeline, from early target engagement through late-stage clinical development and will serve as a decisive voice in portfolio-level go/no-go decisions.

Reporting to the Chief Scientific Officer, the VP will lead and scale a high-performing team, partner closely with Research, Clinical Development, Regulatory Affairs, and Data Science, and represent Nurix externally as a scientific leader in translational medicine. This role carries executive accountability for the translational medicine function, including CRO and diagnostic partner strategy, and requires the rare combination of deep scientific expertise, operational fluency, and the leadership presence to influence at the executive level.

This is a senior executive role for a builder. Someone who has led translational functions through clinical inflection points and can define what precision medicine looks like at a biotech pioneering targeted protein degradation.

Responsibilities

Strategic Leadership & Portfolio Ownership

Define and own the enterprise-wide translational medicine and clinical biomarker strategy across Nurix’s pipeline, integrating insights from discovery through Phase II/III to inform portfolio prioritization and investment decisions.
Design and implement predictive biomarker strategies and translational plans to support indication selection and patient enrichment for degrader therapies.
Serve as a standing member of the R&D leadership team and program governance committees; provide executive-level input on clinical development strategy, indication selection, dose/schedule decisions, and precision medicine positioning.
Translate the unique biology of targeted protein degradation into rigorous translational hypotheses, from degrader-specific target engagement biomarkers to modality-specific patient stratification strategies.
Represent Nurix in external scientific forums, KOL engagements, investigator meetings, and competitive intelligence activities; contribute to business development diligence on potential partnerships and in-licensing candidates.

Translational Science & Biomarker Development

Oversee the full lifecycle of biomarker program development, from preclinical discovery and assay feasibility through clinical validation, implementation, and reporting. Ensure scientific rigor and regulatory defensibility at each stage.
Direct design and execution of pharmacodynamic, predictive, prognostic, and safety biomarker strategies for each program; establish clear criteria for biomarker-driven decision gates.
Integrate advanced translational data modalities, ctDNA/ctRNA, single-cell sequencing, spatial transcriptomics, computational pathology, and multiplex imaging into Nurix’s precision medicine
Partner with Discovery Biology to build translationally anchored preclinical models and IND-enabling data packages that de-risk clinical hypotheses.
Lead clinical biomarker data interpretation and synthesis across programs; translate complex datasets into actionable insights for clinical teams, executives, and regulatory agencies.

Clinical Integration & Regulatory Partnership

Provide scientific leadership for translational and biomarker content in clinical protocols, Investigator Brochures, clinical study reports, and regulatory submissions (INDs, BLAs, briefing documents).
Shape biomarker regulatory strategy in close collaboration with Regulatory Affairs; represent translational science in FDA and EMA interactions, including pre-IND and End-of-Phase meetings.
Partner with Clinical Pharmacology on integrated PK/PD modeling, dose-response biomarker analysis, and mechanism-based endpoint selection.
Collaborate with Biostatistics and Data Science on statistical analysis plans, integrated translational datasets, and exploratory analyses that support publication and regulatory strategy.
Provide leadership in companion diagnostic (CDx) strategy, including CRO/IVD partner selection and regulatory co-development planning where applicable.

Operational Excellence & External Partnerships

Define and manage the translational medicine operating model, including infrastructure, technology platforms, and quality standards appropriate to Nurix’s stage and pipeline breadth.
Evaluate, select, and govern CRO, central laboratory, and academic collaborative partnerships for biomarker assay development and clinical execution; ensure scientific and contractual accountability.
Develop and manage the translational medicine budget and resource allocation; provide forward-looking investment guidance aligned with clinical timelines and portfolio priorities.

Team Leadership & Organizational Development

Build, inspire, and develop a high-performing team of translational scientists and biomarker specialists; set clear goals, cultivate scientific rigor, and support career growth.
Define team structure, roles, and growth pathways appropriate to Nurix’s pipeline stage; attract and retain top-tier scientific talent in the Bay Area biopharmaceutical market.
Champion cross-functional collaboration and a culture of scientific excellence, intellectual curiosity, and patient focus within the team and across the broader organization.

Requirements

Ph.D. in Immunology, Oncology, Biochemistry, Cell Biology, or a closely related life sciences discipline required; MD/Ph.D. strongly preferred.
Postdoctoral training or equivalent advanced research experience in translational or clinical science is highly valued.
15+ years of progressive experience in translational medicine and/or clinical biomarker research within the pharmaceutical or biopharmaceutical industry, with meaningful tenure in oncology.
Minimum 10 years in a senior leadership role (Sr. Director level or above) with direct management of scientific staff and function-level accountability for deliverables and budget.
Demonstrated track record of leading translational programs from IND through proof-of-concept (Phase I/II), including first-in-human study design and execution.
Experience leading or meaningfully contributing to Phase III biomarker programs, regulatory submissions, and health authority interactions (FDA, EMA).
Proven ability to evaluate, select, and govern external CRO, central laboratory, and academic partnerships in a biomarker development context.
Experience presenting to and influencing executive leadership, Boards, investors, or senior regulatory agencies preferred.

Scientific & Technical Expertise

Deep expertise in translational biomarker strategy — target engagement, pharmacodynamic, predictive, prognostic, and safety biomarkers — with command of regulatory standards governing their use in clinical
Hands-on expertise or strong working knowledge of quantitative and multiplex biomarker technologies: flow cytometry, ELISA/MSD, IHC/mIF, NGS (RNAseq, scRNAseq, whole-exome), ctDNA/cfDNA, and digital
Familiarity with bioinformatic and computational approaches supporting multi-omic data integration and translational dataset interpretation; ability to drive computational strategy in collaboration with data science partners.
Knowledge of regulatory expectations for exploratory biomarkers and IVD/CDx development strategies across FDA and EMA frameworks.
Scientific publication record and demonstrated presence in the translational medicine or oncology/immunology community (publications, conference presentations, KOL relationships).

Preferred Qualifications

Direct experience with targeted protein degradation (PROTACs, molecular glues) or other emerging modalities, including translational challenges specific to novel mechanisms of action.
Experience in both oncology and immunology/inflammatory disease therapeutic areas, reflecting Nurix’s evolving pipeline scope.
Demonstrated experience building a translational medicine or clinical biomarker function from early stage, including infrastructure, platform selection, SOPs, and team design.
Familiarity with advanced computational and AI-driven approaches in translational science, including patient stratification, multi-omic integration, and machine learning-based biomarker discovery.
Publication record as senior or corresponding author; participation in scientific advisory boards or external translational medicine working groups.

Fit with Nurix Culture and Values

Scientist-leader who brings equal conviction to the data and to the people — building teams and translational programs with the same rigor and care.
Sees the intersection of targeted protein degradation and precision medicine as one of the most compelling opportunities in oncology, and is committed to defining what translational excellence looks like in this space.
Operates without ego at the executive table — direct, collaborative, and secure enough to be changed by data and by the perspectives of colleagues.
Has built things: functions, teams, capabilities. Brings both the track record and the hands-on instincts to drive a program from hypothesis to regulatory submission.
Invests in people with the same intentionality as in the science — because at Nurix, those two things are inseparable.

Salary Range: $332,140 - $377,560 range plus bonus and equity

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

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Surpass possible

Surpass possible

Associate Director, Computer Systems Assurance (Quality)

Position

Responsibilities

CSA Program Ownership and Strategy

System Validation and Qualification Execution

21 CFR Part 11 and Data Integrity

Change Management and Periodic Review

Inspection Readiness and Regulatory Support

Cross-Functional Partnership and Training

Required Qualifications

Preferred Qualifications

Fit with Nurix Culture and Values

Director, IT Infrastructure & Operations

Director, Pharmaceutical Development

Director, Regulatory Affairs (Strategy, I&I)

Director / Sr. Director, Regulatory Affairs (Strategy, Oncology Solid Tumors)

Recruiting Coordinator (Contract)

Research Associate II/III– Bioanalytical/In Vitro ADME/DMPK

Scientist, Bioanalytical – Drug Antibody Conjugates (DACs)

Scientist I – Cell Screening and Pharmacology, Discovery Technology

Scientist II, Degrader Antibody Conjugate Characterization

Scientist I, Protein Purification & Expression

Senior Director, Clinical Data Management

Senior Recruiter (Contract)

Senior Research Associate, DNA Encoded Library Technology

Senior Scientist, Analytical Development and Quality Control

Senior Scientist, Antibody Conjugation

About the Role

What You'll Do

Who You Are

Qualifications

Why This Role

Senior Vice President, Preclinical Toxicology

Sr. Director, Head of Regulatory & Medical Writing

Vice President, Medical Affairs – Hematology-Oncology

Qualiﬁcations

Vice President, Translational Medicine & Clinical Biomarkers