Culture & Careers

Job Openings

To be a part of our dynamic team of skilled scientific investigators and talented work force, please check our open positions.

Director/Senior Director, Clinical Scientist

Nurix has a place for an extraordinary, highly motivated, and accomplished Director/Senior Director, Clinical Scientist.

As an integral member of the Clinical Development Team, this person will help to develop innovative solutions for the clinical development of Nurix’s pioneering protein modulation programs in hematology, oncology, and cell therapy. Working in close collaboration with the study teams, the incumbent will provide scientific guidance and support.

This role will is responsible for various aspects of clinical study design and execution including: protocol writing, building study infrastructure, staff training, data cleaning/analysis, investigator interaction and support of regulatory filings. In addition, this role will be responsible for providing supporting rationale for clinical development working closely with the Head of Development.

Job Responsibilities:

  • Participate in and contribute to cross-functional clinical development teams with strong ability to work closely with all team members, address study or other program-specific questions.
  • Develop the Global Development plan with senior clinical development staff
  • Implement Global Development Plan with strategic clinical science support
  • Assist in reviewing and authoring clinical protocol.  Read and interpret scientific and medical literature for the use in clinical documents and to assist clinical team decision making.
  • Prepare clinical portions of all relevant regulatory filings and meeting packages (INDs, Annual Reports, meeting requests, NDAs, etc.) for US and ex-US Health Authorities.
  • Integrate scientific knowledge and operational expertise to ensure translation of clinical research plans into efficiently delivered, high quality studies.
  • Acquire and utilize knowledge of clinical trial design and relevant disease indications to assist in study concept and protocol development. Contribute to discussions concerning scientific and procedural aspects of study design. Coordinate with departments to produce the final protocol and informed consent documents.
  • Compose medical data review plans, Data Safety Monitoring Board (DSMB), Safety Review Committee (SRC) charters, and specific sections of study manuals and investigator meeting materials.
  • Contribute significantly to the development of CRFs, data edit checks, patient profile design, ongoing data cleaning (query generation, coding review, SAE reconciliation) and data trend analysis.
  • Lead internal clinical data review meetings in conjunction with the medical monitor; lead the data preparation effort for dose escalation meeting, as applicable to study stage.
  • Coordinate and manage external medical advisory committees for the study team such as DSMBs and Scientific Steering Committees, in conjunction with the medical monitor.
  • Research and summarize published literature for continual learning and to prepare training materials for other clinical team members.
  • Contribute to statistical analysis plans, table, listing, figure design and the preparation of manuscripts and other presentations of study data, as appropriate.
  • Address investigator questions regarding protocol and related scientific issues and attend site initiation visits (SIVs), in coordination with the medical monitor.
  • Assist in determining the activities to support a project’s priorities within functional area
  • Trains other clinical scientists as needed.

Basic Qualifications

Advanced degree (MD, PhD, or PharmD) and 8+ year’s relevant drug development experience

Preferred Qualifications

  • Experience directly in the clinical science role, in a hematology/oncology indication for first-in-human and proof of concept studies in small molecules and/or cell therapy. Registrational or Phase 3 study experience is preferred.
  • In depth understanding of clinical operations and translational medicine.
  • Excellent interpersonal skills.
  • Able to translate technical concepts into accessible language and direction for the broader study team.
  • Excellent attention to detail, partnership and initiative, with flexibility to adapt to the needs of the organization; maintain meticulous attention to project deadlines.
  • Experienced in Microsoft Office (Excel, Word, PowerPoint, OneNote), and ideally also with job related programs such as Spotfire and Medidata Rave or similar.
  • Strong understanding of ICH GCP, as well as general knowledge of industry practices and standards
  • Commitment to patient safety and clinical compliance.

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view 

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Research Associate/Scientist, Encoded Library Technology Development

We are seeking a talented and highly motivated scientist to join our Library Discovery team and help us augment our DNA encoded library technology platform.  The key objective for this position is to identify and solve key bottlenecks in the DEL pipeline and develop innovative next generation improvements to the underlying technology.  Broad scientific interests spanning biology, chemistry, and drug discovery a plus.  Responsibilities may also include library development and selection analysis.

Qualifications

  • MS or PhD in life sciences (ex. chemistry, biochemistry, biology) with 0-5 years industrial experience (years of relevant experience will impact level of hire).
  • Training in molecular biology methods, high throughput assay development, NGS preps desirable
  • Interest and background in organic chemistry is a plus
  • Interest and ability to apply solutions from disparate fields of science and engineering to solve problems in the DEL technology platform and drug discovery in general
  • Must have ability to work independently; Be highly self-directed and self-motivated
  • High level of creativity and productivity with strong problem-solving skills.
  • High level of attention to detail and good organizational skills.
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments to other members of the department.

Fit with Nurix Culture and Values

  • Strongly team-oriented; highly collaborative
  • Hands-on approach; resourceful and open to diverse points of view

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Principal Scientist – Discovery Biology

We are seeking a highly skilled and motivated cell biologist/immunologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. The senior scientist/associate director is an experienced immunologist that will perform and oversee lead optimization of novel compounds and the characterization of their MOA on immune cells. The candidate must be self-driven, organized, able to manage junior scientists, and able to thrive in an exciting environment in a rapidly-growing company.

Qualifications

  • D. in immunology or cancer biology with 8+ years of relevant industry experience.
  • Research experience in the field of immunology with a focus on either inflammation and autoimmunity, or immunoncology.
  • Strong background in small molecule drug discovery and lead optimization of molecules; experience with bi-functional degrader compounds is a plus.
  • Demonstrated experience in leading small team of scientists.
  • Ability to manage multiple projects simultaneously
  • Hands on experience in development, optimization and execution of high-dimensional flow cytometry to phenotypically characterize immune cells, ELISA, Western and multiplexing technologies
  • Excellent written and verbal communication skills across cross-functional teams
  • Background in ubiquitin biology with past experience is a plus
  • Ideal candidate can develop novel ideas/technologies and is eager to learn, innovate

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative; solutions and results-oriented focus
  • Strong scientific curiosity and initiative; hands-on and resourceful
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Scientist, DNA Encoded Chemistry, Library Discovery

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

About the Position

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry and familiarity with the application of DNA encoded chemistry to join our Library Discovery team. You will join a group with two objectives:  1) Design and synthesize DNA encoded libraries and 2) Utilize these libraries to identify novel chemical matter with the potential to modulate the activity of UPS targets.

You will have demonstrated experience in synthetic organic chemistry and analytical methods. Experience with DNA encoded library synthesis, parallel reaction chemistry, split/pool methods, aqueous chemistry and linker chemistry related to the synthesis of drug conjugates are all valued skills.  Understanding of the physicochemical properties that drive drug discovery are desired.  As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators.

Qualifications

  • Ph.D. in synthetic organic chemistry with 0-5 years industrial chemistry experience (years of relevant experience will impact level of hire).
  • Expert in synthetic organic chemistry methods and analytical tools, in particular LCMS
  • High level of creativity and productivity with strong synthetic problem-solving skills.
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.
  • Familiarity with principles of combinatorial chemistry and DNA encoded library technology
  • Interest in optimizing chemical reactions for use in DNA encoded library synthesis.
  • Familiarity with working with large data sets and the tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making.

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Research Associate/Senior RA, DNA Encoded Scientist, Library Discovery

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

About the Position

We are seeking a talented and highly motivated scientist to join our Library Discovery team and help us augment our DNA encoded library collection. DEL synthesis requires a hybrid of techniques that are borrowed from chemistry environments: chemical reaction setup, LCMS analysis, SAR evaluation, split and pool library synthesis workflows, parallel reaction development, as well as from biology laboratories:  aqueous buffer preparation, centrifuge use, ethanol precipitation of DNA, A260 DNA quantification, gel electrophoresis, bioanalyzer analysis, enzymatic DNA ligation.  An exposure to some of these techniques is helpful in training into a DNA encoded scientist.  As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators.

Qualifications

  • B.S. or M.S. in life sciences (ex. chemistry, biochemistry, biology) with 0-5 years industrial chemistry experience (years of relevant experience will impact level of hire).
  • Training in synthetic organic chemistry methods and analytical tools, in particular LCMS
  • Interest in optimizing chemical reactions for use in DNA encoded library synthesis.
  • High level of creativity and productivity with strong problem-solving skills.
  • High level of attention to detail and good organizational skills.
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.

Fit with Nurix Culture and Values

  • Strongly team-oriented; highly collaborative
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Director/Senior Director, Data Management and Computational Resources

Candidate with a demonstrated experience (20 years+) managing large data-centric projects in drug discovery/pharmaceutical/biomedical industry, with proven skills in R&D data management, business intelligence/analytics, database administration and information infrastructure, software development, and cloud-based computational technologies.

The position consists of evaluating, proposing, and implementing cost effective, cross functional data management, high performance solutions to serve all Research, Clinical Development, and Business teams data and providing relevant information for any decision-making requirements. The candidate must have a passion for solving technical challenges and building collaborative, cross functional relationships with peers, supervisors, and team members.

Responsibilities:

  • Executive Management of all computational resources, private clouds, internal databases and information repository, with proven experience managing AWS Services, Public/Private/Hybrid Clouds strategy, configuration and administration.
  • Databases and related Data Services Administration, Monitoring, Optimization, and Support to ensure 24/7 uptime. While Nurix utilizes all database servers flavors, a strong Oracle DBA experience is required for this position.
  • Harmonization & Normalization of all key Drug Discovery and Research data w/ a central Master Data Management Plan, and centralization of all information in Nurix Proprietary databases (i.e. NxVision).
  • Complete Data Management Support for all Business, Alliance Management, Research, Clinical Development teams including support for: Data Capture, Data Reporting & Dashboarding, ad-hoc Import/Export for any data requests. Working closely with the Biometrics and Clinical teams to ensure data availability, quality, compliance, and security.
  • Evaluation, implementation, support, and management of all company private and vendor cloud solutions (AWS, Oracle, Microsoft, SaaS solutions, etc.) and management of all Data Integrations between these solutions (Research, Clinical, GxP).
  • Provide technical data management and databases support for all Software Development initiatives; Delphi, NxVision, LIMS, or any Lab Systems and Research Operations Development. This including ensuring data availability for any Software Development, Testing, UAT, Training.
  • Support CMC Technical Lead for Investigational Drug Supply Chain, Distribution, GMP Manufacturing & Inventory Distribution information (purchasing, sales, inventory, shipping, track-trace, raw material to finished goods to sales.
  • Extensive knowledge of many information systems used in Drug Discovery, Research, Genomics, ChemInformatics, Clinical Development, and Clinical Informatics, Quality Assurance, Software and Data, including Public Databases Integration and Support.
  • Participate as needed in any Clinical and Drug Safety data reporting/analytics to support the Nurix Preclinical and Clinical studies.

Company:

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Research Associate – Analytical Chemistry – Contract

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Position

This temporary position will perform a variety of in-vitro screening assays for Nurix’s growing ADME (Absorption, Distribution, Metabolism, Excretion) group. The daily tasks will include optimizing compounds for mass spectrometry, perform assigned assays, quantitate by UPLC-MS/MS and report the data to scientists in the medicinal chemistry group. The in-vitro assays will explore physical properties of compounds such as; solubility, stability and permeability, using enzymatic and cell-based platforms. Samples will be prepared manually or through a liquid handling robot. The work from this position will provide critical information for the company’s medicinal chemistry projects.

Required Qualifications

  • Bachelor’s Degree (BS/BA) or equivalent in a scientific related discipline with 1-3 years of laboratory experience.
  • Understanding of high-performance liquid chromatography (HPLC) and mass spectrometry
  • Basic understanding of ADME screens
  • Working knowledge of Microsoft Office products including Word, Excel, PowerPoint
  • Ability to work in a fast-paced environment

Bonus Qualifications

  • Coding skills preferably in the Python language
  • Some experience with Microsoft SharePoint
  • Some experience with Hamilton or Tecan liquid handlers

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Apply Now

Protein Sciences – Research Associate to Research Associate III

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Position

We are seeking a highly skilled and motivated Scientist with expertise in Protein Sciences to join Nurix’s Protein Sciences group. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in the areas of oncology and immuno-oncology, by utilizing the mechanistic and structural insights to guide drug discovery efforts. The successful candidate will provide hands-on experience in Nurix’s protein production efforts to support biochemical, biophysical and structural efforts. This individual will work closely with an experienced team of interdisciplinary scientists and have regular opportunities to present findings to the project team and senior management. The candidate should have a strong desire to learn new techniques and the ability to incorporate new methodologies into their work. The ideal candidate will be self-driven, resourceful, organized, focused, and enjoy working in a dynamic team environment driven to deliver quality proteins to enable existing drug discovery platforms.

Required Qualifications

  • Undergraduate degree in Biophysics, Biochemistry, Cell and Molecular Biology or related field.
  • Hands-on expertise on purification of proteins from bacterial, mammalian or insect expression systems for structural and functional applications,
  • Knowledge in the operation of purification instrumentation (e.g. AKTA, ultracentrifugation) and purification techniques including but not limited to affinity chromatography, SEC, Ion-Exchange chromatography,
  • The candidate should be enthusiastic, driven, have the ability to work independently in a team environment and thrive in a dynamic start-up environment,
  • The successful candidate will be aligned to Nurix’s culture and values; they will be team oriented and highly collaborative with a hands-on approach.

Preferred Qualifications

  • General knowledge of immuno-oncology, structural biology, and drug discovery, or
  • General knowledge of protein ubiquitylation biochemistry and pathways, or
  • Experience with production of membrane associated proteins requiring the use of surfactants for purification, or
  • Hands-on knowledge of protein purification automation (e.g. AKTA programming for multi-step purifications), or
  • Have a record of published work and of presentation at conferences.

Apply Now

Senior Director/Director, Head of Clinical and Regulatory Informatics

Nurix is seeking an experienced candidate to provide the guidance, strategy, implementation and management of Nurix Clinical Development and Regulatory Information Infrastructure, and support the company’s growing clinical pipeline.

The Head of Clinical and Regulatory Informatics will evaluate, propose timely, strategic implementation roadmaps and budgets, and implement a Nurix long-term, high-performance, and cost-effective Clinical Informatics Strategy to support all Nurix Management, Clinical, and Regulatory teams. He/she will be responsible for executing this strategy, ensuring the utmost availability and reliability of all clinical information management systems, data, and processes, and lead a cross-functional Clinical Informatics team ready to support all Nurix Clinical Development goals.

The successful candidate will have a passion for solving technical challenges and build collaborative relationships with members of all Nurix Clinical Teams; Program Management, Clinical Operations, Pharmacovigilance, Quality Assurance & Regulatory Affairs, Clinical Research, Translational Science, Biometrics & Biostatistics, CMC & Drug Supply Logistics, including with external CROs and collaborators.

The COVID-19 pandemic resiliency has demonstrated that teleworking has become a huge part of many companies’ futures. Nurix’s strategy is to favor remote work for this position whenever possible, with occasional meetings or retreats scheduled for the teams to interact in person as necessary.

Job Responsibilities:

  • Lead the strategic development and management of Nurix Clinical Information and Data Infrastructure to support all Nurix short and long-term Clinical Development and Regulatory goals.
  • Evaluate, propose, implement, and manage all Nurix Clinical and Regulatory Information Systems as needed to support Nurix Clinical Programs and Processes.
  • Ensure the utmost data quality, compliance, confidentiality, security, and availability of all Nurix Clinical Data and Systems, and facilitate all Regulatory Information exchanges between all clinical development stakeholders, Partners, CROs, and consultants.
  • Work with the Quality Assurance and Compliance Team to develop strong IT Access Control and Validation SOPs and support any “open” and “closed” systems in Nurix Clinical and Regulatory Information Infrastructure. Develop key relationships with all Nurix best-in-class clinical software vendors and CROs IT Teams, to coordinate validation activities of clinical data or regulatory information exchanges.
  • Provide first line of technical support for all clinical, regulatory systems and processes, clinical data collection, integration, reporting, exchange, and implement efficient and reliable validation, due diligence, audit, and regulatory submission processes.
  • Facilitate and ensure the harmonization, normalization, and efficient exchanges of all Nurix Clinical, Translational Research, Pharmacovigilance, Biostatistics and Biometrics data, using industry data standards and formats supported by regulatory agencies.

Required Qualifications:

  • Bachelor’s degree (BS/BA), with extensive clinical systems and data management experience supporting clinical trials and approval of pharmaceutical products.
  • Demonstrated experience (15/10yr+) in a leadership management role building and providing guidance to cross-functional teams to support Clinical Programs Development and Regulatory efforts.
  • Extensive knowledge of many information systems and vendors used to support Clinical Programs Development, Clinical Operations, Clinical Data Management, Regulatory Publishing, Quality Assurance & Compliance Management.
  • Collaborative spirit and ability to work with project teams, external investigators, and contract research organizations.
  • Highly motivated, innovative, and strong team player, with a solutions and results-oriented focus.
  • Excellent organizational skills and project management required.
  • Excellent verbal and written communication skills

Company:

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Scientist II/Senior Scientist, Preclinical Pharmacology

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Job Summary:

We are seeking a highly skilled and motivated in vivo pharmacologist to lead efforts in oncology, immuno-oncology, and inflammation. The ideal candidate will have expertise in small molecule PK/PD studies, xenograft and syngeneic tumor models, inflammatory disease models, and immune cell profiling by flow cytometry. This role will support novel drug development projects from early lead optimization through clinical candidate selection. Duties include planning, execution and analysis of in vivo experiments, management of work within the preclinical pharmacology team, and management of projects at CROs. This individual will work closely with scientists from cross-functional disciplines and present findings to project teams. The candidate must be self-driven, highly organized, and enjoy working in a creative and dynamic team environment. 

If you are intrigued by the opportunity to work with a passionate team of scientists focused on improving patient’s lives with first-in-class therapies, please consider applying.

Qualifications:

  • Ph.D. in pharmacology, immunology, cancer biology or a related field. Scientist II requires 3+ years of industry experience; Senior Scientist requires 6+ years
  • Expertise in oncology, immuno-oncology, inflammation and in vivo models of disease
  • Proven ability to identify and develop disease models for preclinical drug development
  • Management experience of direct reports required
  • Experience as lead pharmacology representative on project teams required
  • Expertise with flow cytometer-based profiling of immune cells required
  • Expertise in small molecule drug development and PK/PD assay technologies
  • Expertise with hit-to-lead optimization and establishment of PK/PD relationships
  • Knowledge of transgenic model generation and phenotypic characterization desired
  • Experience writing preclinical reports for IND filings desired
  • Requires excellent communication and presentation skills

Apply Now

Small Molecule CMC QA Director

Company:

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Job Summary:

Candidate will provide a high level of independent judgment and discretion in the timely identification, investigation and resolution of events impacting the Quality of products and processes. Quality oversight responsibilities include ensuring adherence to SOPs and requirements, track appropriate training, proper change control process, corrective action and preventive action plans (CAPA)/Deviation management, impact assessments for changes to equipment and processes, risk management, and to ensure documentation and investigations meet regulatory standards. The successful candidate will be required to make difficult decisions which may have a direct impact on active manufacturing operations, the release of equipment, systems, or areas. The successful candidate will be responsible for implementing continuous improvement efforts as it relates to QA activities and fostering quality collaboration among partners and internal customers.

Responsibilities:

  • Responsible for both executing and overseeing the tactical operations, assess, evaluate, and review operations against cGMPs, issue identification/ resolution including proper and timely documentation. Provide guidance to all GMP areas to ensure compliance with all applicable regulations and assists in resolution of issues identified. Information must be pro-actively shared across QA and the business.
  • Identifies, classifies and reports deviations, as appropriate and typically works on complex Major deviations and/or complaints. Oversees execution of remediation/CAPA activities required to continue production or move a process to the next milestone. Works closely with others to determine root cause and potential preventative/corrective actions. Ensures support for the timely closure of investigations.
  • Ensures that all personnel engaged in GMP/GLP activities are properly trained, and the training is appropriately documented
  • Will communicate with clients, external vendors, external services to resolve investigations as warranted to ensure compliance to regulations and local procedures.
  • Responsible for providing quality oversight to the change management system. This includes providing plan creation oversight, verifying that changes adhere to local SOPs and regulatory compliance and ensuring communication/escalation of potential issues of broader impact to the business.
  • Performs independent technical review of documentation during and post-execution of cGMP activities. Ensures all specifications are met and that applicable requirements are completed and acceptable. Ensures all issues/documentation associated with each process in assigned area have been resolved and Approved prior to release to the next step and are compliant with cGMPs and SOPs and current manufacturing regulations and site procedures. Analyzes and reports findings to appropriate departments.
  • Works closely with others in the assigned area to recognize opportunities for improvement and drive change.
  • Will serve as Subject Matter Expert for internal or external matters. Participates in inspection readiness activities and is significantly involved in inspections by regulatory agencies.
  • Models effective and constructive communication behaviors and interactions with technical departments, senior business leaders, both orally and in writing; maintain acceptable proficiency in technical and non-technical (e.g. interpersonal) skills.
  • Is proficient in technical and non-technical (e.g. interpersonal) skills to ensure the continued success of the department and quality of oversight provided to the business.
  • Creates and establishes processes and procedures to ensure compliance and adherence to regulated QA activities for cGMP operations.

Requirements:

  • Requires a bachelor’s or higher degree from an accredited institution preferably in sciences.
  • Requires a minimum of twelve (12) years of experience working in the Quality aspects at a pharmaceutical or biopharmaceutical company, preferably with a focus on small molecules .
  • Must have demonstrated ability to execute against the strategic and tactical objectives provided by senior leaders both within Quality and outside of the function.
  • Strong independent judgment and decision-making abilities required.
  • Thorough knowledge of relevant regulations and guidances required in order to act as a resource for colleagues.
  • Proven project-management skills required. Must be able to manage multiple projects against given timelines.
  • Demonstrated hard-working and productive work ethic in an ambiguous environment strongly preferred.
  • Proven problem-resolution skills required
  • Possesses strong conflict resolution and negotiation skills
  • Must possess demonstrated organizational skills that have proven results in the ability to be self-directed while managing multiple projects.
  • Must possess excellent verbal and written communication skills; outstanding interpersonal skills.
  • Must have experience ensuring respectful interactions with individuals with diverse views or backgrounds.
  • Ability to work independently.
  • Some travel to CDMO sites may be required, to perform Quality oversight activities

Apply Now

Purification Lab Contractor

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Job Summary

We are seeking a highly motivated individual with 0-2 years of lab experience to join the small molecule purification group at Nurix.

This position will perform purifications of small molecule libraries by mass directed HPLC, run routine purity checks and submit samples for analysis by NMR. The candidate requires the ability to work in a fast-paced laboratory setting using state of the art analytical and preparative equipment. This role also requires basic lab/chemical handling safety and the ability to lift 40 lbs.

The candidate should have a strong desire to learn new techniques stay up to date with purification trends and an aptitude for robotic automation workflows. The ideal candidate will be self-driven, resourceful, organized, focused, and enjoy working in the dynamic team environment here at Nurix.

Required Qualifications

Minimum qualifications include a B.S. or equivalent degree in chemistry, analytical chemistry, or related field, with 0-2 years of industrial experience in purification of small molecules.

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Apply Now

Paralegal/Senior Paralegal

Our new Paralegal/Senior Paralegal will become the fifth member of our Legal Department and function as a key member of the team. The Paralegal/Senior Paralegal will support our contracting process, corporate governance and corporate filings.

Duties/Responsibilities:

  • Assist with the contracts process including maintaining the contracts system
  • Prepare and review confidentiality agreements with attorney supervision
  • Assist and maintain all corporate records
  • Assist in the development of corporate policies, procedures and programs and in their trainings and compliance thereof
  • Assist attorneys with transaction closings and maintenance of corporate records
  • Provide administrative support for attorneys
  • Successfully complete special projects and other assignments as requested

Required Skills/Abilities:

  • Excellent verbal and written communication skills
  • Understanding of legal language and principles, research methods, contracts, and other related matters
  • Excellent interpersonal and customer service skills
  • Excellent organizational skills and attention to detail
  • Excellent time management skills with a proven ability to meet deadlines
  • Strong analytical and problem-solving skills
  • Ability to function well in a high-paced and at times stressful environment
  • Ability to maintain confidentiality, and to exercise discretion and good judgment
  • Proficient with Microsoft Office Suite or related software

Education and Experience:

  • Qualified candidate must have a minimum of 5 years of experience as a contracts and/or corporate paralegal, with a focus on pharmaceutical and/or biotechnology products preferred.
  • Bachelor’s Degree required. Paralegal Certification preferred.
  • Other competencies sought:
    • Experience preparing confidentiality, consulting, master services agreements and the like
    • Familiarity with records retention policies and document management systems
    • Understanding of corporate formalities and related state-level reporting
    • Some exposure to compliance programs in a pharmaceutical or biotech organization
    • Ability to successfully balance the need to complete assigned tasks while limiting risk to the Company with the goal of supporting the creativity, enthusiasm and pace of internal business units at this growing pharmaceutical company

Fit with Nurix Culture and Values:

  • Strong team orientation, highly collaborative and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view
  • Excellent interpersonal skills
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Company:

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Research Associate/Senior Research Associate, Discovery Biology

We are seeking a skilled and motivated individual with expertise in cell biology and immunology to join our Discovery Biology team. The successful candidate will support early drug discovery efforts in Immunology, Oncology, and Immunoncology. These duties will include planning, execution and analysis of in vitro cellular assays to support small molecule discovery efforts, mechanistic studies, and new target identification. This individual will work closely with scientists from cross-functional disciplines and present findings to project teams. The ideal candidate will be self-driven, eager to learn new techniques, highly organized, focused, and enjoy working in a creative and dynamic team environment.

Required Qualifications

  • For RA: Bachelor’s or Master’s degree with 2-5 years of industry experience
  • For SRA: Master’s degree in Biochemistry, Cell and Molecular Biology, or related field with 6+ years industry experience (or Bachelor’s degree with 8+ years of industry experience)
  • Extensive hands-on experience with cell culture (cell lines or primary cells) and good aseptic technique
  • Hands-on experience in development, optimization and execution of cellular assays including primary cell isolation, ELISA, and western blot
  • Experience with molecular biology techniques and shRNA/CRISPR knockdown is a plus
  • Prior experience with quantitative medium-to-high throughput assays to support small molecule drug discovery (e.g. FRET-based assays, luminescence assays, flow cytometry, MesoScale)
  • Strong organizational skills and experience presenting results to multi-disciplinary scientific teams

Bonus Qualifications

  • Flow cytometry experience strongly desired
  • Experience performing functional immune assays (e.g. migration, activation, cytokine secretion, differentiation, target cell killing) with primary human cells
  • Experience with additional cellular and molecular techniques such as high-content imaging or RNA-seq
  • Background in ubiquitin biology or targeted protein degradation

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Senior Scientist/Associate Director, Lead Discovery

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

The Position

We are seeking an experienced biochemist to lead our small molecule profiling group at Nurix. As leader of this group you will work collaboratively on multiple programs, partnering with your peers across Nurix’s discovery platform, including Protein Sciences, DNA Encoded Chemistry and Screening, Medicinal Chemistry, Cellular Biology, and in vivo Pharmacology to identify, characterize and advance novel small molecules directed against a range of therapeutic targets.

Responsibilities

  • Responsible for leading an internal team of 3-5 scientists in the development and implementation of biochemical assays to support on-going small molecule discovery efforts
  • Contribute to the design and development of assays for the characterization of protein-protein and enzymatic activities of therapeutic targets across a wide range of protein families and functions and manage the application of those assays for:
    • qualification of target proteins for DNA encoded library screens
    • hit confirmation and prioritization for follow up chemistry
    • advancement of lead molecules for heterobifunctional degrader synthesis
  • Development of biochemical assays to characterize and advance the degrader properties of heterobifunctional degrader molecules
  • Manage prioritization of the profiling activities within a matrixed organization, supporting multiple internal and external collaboration projects simultaneously
  • Communicate scientific results to internal and external stakeholders

Qualifications

  • Ph.D. in Biochemistry, Structural Biology, Biophysics or related field with 8+ years of post-degree experience
  • Expertise in the development and implementation of various biochemical and enzymatic assays for the characterization of protein activities and the effects of small molecules on those activities
    • Expertise in broad range of biochemical and biophysical techniques for assessing protein-protein and protein-small molecule interactions
    • In particular, experience in the use of time-resolved FRET and fluorescence polarization-based technologies is preferred
  • Demonstrated track record of successfully applying biochemical and biophysical characterization to the advancement of chemical matter through SAR improvement campaigns
  • Demonstrated ability to guide reports in the development and implementation of biochemical assays and a strong desire to grow and develop the careers of team members
  • Experience with drug discovery project leadership is preferred
  • Excellent written and oral communication skills
  • Aligned to Nurix’s culture and values; team-oriented and highly collaborative with a hands-on approach

Apply Now

Chemical Informatics and Laboratory Automation Specialist

Nurix is looking for a Chemical Informatics and Laboratory Automation Specialist to join our growing automated chemistry team. The successful candidate will design and implement tools and applications for chemists to manage the planning and execution of automated, high throughput compound synthesis.  You will partner with chemists, data science, software development, informatics, and IT to create database backed workflows and processes to streamline: 

  • Enumeration of virtual libraries
  • Stepwise management of library compound synthesis including:
    • Instrument worklist generation
    • Instrument output processing
  • Compound registration
  • Sample Management
  • Management of chemical building blocks
  • Management of reaction schemes 

Your solutions will enable chemists and management to track libraries as they progress from idea through synthesis, purification, analysis and into inventory, as well as provide metrics that enable assessment of library quality, efficiency, and capacity.   

Required Qualifications

  • BS or higher in Chemistry
  • Strong background in computerized chemical representation and transformation with an emphasis on stereochemistry – SDF (V2000/V3000), SMILES/SMARTS/SMIRKS, RDF                                                                                                                                           
  • Expertise authoring requirements/specifications, workflow/process diagrams, and project plans
  • Minimum 5 years experience with industry standard applications such as ChemCart, Dotmatics, GeneData, Benchling, Sample Manager, LabWare, and/or LabVantage
  • Demonstrated programming expertise in the following:
    • SQL (Oracle, PostgreSQL)
    • Visual Basic/VBA
    • Python/Perl/Java 
  • Excellent verbal and written communication skills
  • Experience in managing contractors and vendors
  • Expertise in MS Office (Excel, Word, PowerPoint, Visio)

Preferred Skills

  • Experience working with data-analysis/pipelining/visualization tools and applications such as Pipeline Pilot, Knime, R/Shiny, Spotfire, and/or Tableau 
  • Minimum 2 years experience programming Lab instruments
    • Hamilton Vantage liquid handler
    • Waters/Agilent LCMS and preparative HPLC
  • Strong QA background

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Apply Now

Sr. Sci/Pri. Sci, Medicinal Chemistry

We are seeking a curious and motivated individual to join the Medicinal Chemistry group. The successful candidate will lead projects at various stages from hit-to-lead, through clinical candidate nomination.  With a strong background in synthetic organic chemistry, the successful candidate will have experience in early-stage hit-to-lead optimization, structure-based drug design, and the ability to push multiple projects within the platform simultaneously.  As members of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix including the DNA-encoded library, biophysics, biochemistry, and cellular pharmacology groups. Additionally, they will contribute effectively to patent, report and scientific publication writing.

Qualifications

  • Ph.D. in synthetic organic chemistry with 6+ years of medicinal chemistry experience
  • Successful application of structure-based drug design leading to advanced leads, and/or development candidates. Strong working knowledge of protein-ligand interactions, conformational and structural analysis, experienced in partnering closely with computational chemists through appropriate use of computational tools, models and visualization applications.
  • Ability to lead/manage multiple projects simultaneously
  • High level of creativity and productivity with strong synthetic problem-solving skills
  • Excellent scientific expertise in organic synthesis, conversant with the current literature
  • Ability to champion the chemistry efforts into new directions to achieve project milestones.
  • Solid track record of innovation and impact on programs, with direct contributions to company pipelines (including both successful advances and smart terminations).
  • Proven leadership capability in cross-functional team setting, either as project team leader or co-lead.
  • Strong evidence of conceptual thinking and active follow through, recognized by establishing new projects or new directions within projects, new strategies and/or enabling technologies for drug discovery. Vigorous scientific curiosity evidenced by contributions to diverse medicinal chemistry strategies.
  • Excellent knowledge of medicinal chemistry principles with a solid understanding of the basic biology and pharmacology of programs, the ADME issues, and series SAR. Able to effectively integrate this knowledge and apply the key principles of medicinal chemistry, literature precedent, and drug design to direct medicinal chemistry programs to phase transitions or series go/no go decisions
  • Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings and using this information to guide program strategy
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department

Fit with Nurix Culture and Values

  • Strong team orientation and highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Apply Now

Director, Discovery Pharmacology

We are seeking a highly motivated and experienced drug discovery scientist to lead our in vitro discovery pharmacology group at Nurix. As leader of this group you will work collaboratively with your peers across Nurix’s discovery platform, including Protein Sciences, DNA Encoded Chemistry and Screening, Medicinal Chemistry, Cellular Biology, and in vivo Pharmacology to identify, characterize and advance novel small molecule binders and inhibitors directed against a range of therapeutic targets. The successful candidate will have deep expertise in the design, development & execution of a variety of biophysical and biochemical assays for both classic as well as difficult to drug targets. A keen sense of curiosity, broad scientific interests, and critical experimental rigor are key to this role.

  • Responsible for leading a multifunction, internal team of 10-15 scientists focused on the characterization of small molecule ligands using a variety of high throughput and precision structural, biophysical, and biochemical methodologies.
  • Contribute to the design and development of target profiling cascades for the characterization of protein ligand interactions for therapeutic targets across a wide range of protein families and functions for:
    • Qualification of target proteins for DNA encoded library screens
    • Hit qualification and prioritization for follow up assays and chemistry
    • Elucidation of mechanisms of action and target modulation by hit compounds
    • Advancement of lead molecules for heterobifunctional degrader synthesis
  • Manage prioritization of the profiling activities within a matrixed organization, supporting multiple internal and external collaboration projects simultaneously
  • Communicate scientific results to internal and external stakeholders

Qualifications

  • Ph.D. in Biochemistry, Structural Biology, Biophysics or related field with 10+ years of post-degree experience
  • Expertise in broad range of biochemical, structural and biophysical techniques for assessing protein-protein and protein-small molecule interactions
  • Experience with high throughput biophysical hit qualification techniques (AS-MS, SPR, etc.)
  • Demonstrated track record of successfully applying biochemical and biophysical characterization to the advancement of chemical matter through SAR improvement campaigns
  • A track record of leading multiple functions and strong desire to grow and develop the careers of team members.
  • Experience with drug discovery project leadership is preferred
  • Excellent written and oral communication skills
  • Aligned to Nurix’s culture and values; team-oriented and highly collaborative with a hands-on approach

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Apply Now

Scientist I/Senior Research Associate – Discovery Biology

We are seeking a highly skilled and motivated cell biologist or immunologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. This individual will work closely with our drug discovery project scientists on lead optimization of novel compounds to evaluate the impact on immune cells and characterize their MOA. The candidate must be self-driven, organized, able to work well with other scientists, and able to thrive in an exciting environment in a rapidly-growing company.  

Qualifications

  • Ph.D. in immunology, cancer biology or related field with 0-2+ years of industry experience for Scientist I level position (or Master’s/Bachelor’s degree with > 6-10 years industry experience)
    • SRA (Master’s/Bachelor’s degree with > 4-8 years industry experience)
  • Research experience in the field of immunology with a focus on T cell or myeloid cell biology
  • Expertise in functional assays measuring cellular activation, cytokine release, proliferation, and cell killing
  • Hands on experience in high-dimensional flow cytometry to phenotypically characterize immune cells including both surface and intracellular staining
  • Background in ubiquitin biology and targeted degraders is a plus
  • Develop novel ideas/technologies, eager to learn, innovate.
  • Propose and implement resolutions to technical problems/issues.
  • Work with departmental and/or cross functional peers to execute on assignments

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative; solutions and results-oriented focus
  • Strong scientific curiosity and initiative; hands-on and resourceful
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Apply Now

Senior Research Associate/Scientist I, Medicinal Chemistry

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry to join our Medicinal Chemistry team. You will work with a highly dynamic group that is focused on moving projects from the hit identification stage to the discovery of clinical candidates. The Nurix mission is to control protein fate to treat human diseases leveraging exciting technologies to target protein degradation.

The successful applicant will have demonstrated substantial experience in modern synthetic organic chemistry and standard analytical methods. Having developed an understanding of the physicochemical properties that drive drug discovery are highly desired.

As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of highly experienced scientists within Nurix as well as with external collaborators.

Qualifications

  • Ph.D. in synthetic organic chemistry with 0-4 years industrial chemistry experience, MS with typically 6+ years of relevant experience or BA/BS or equivalent with typically 10+ years of relevant experience (years of relevant experience will impact level of hire)
  • Creative skills in the design, performance and interpretation of chemistry experiments with strong synthetic problem-solving skills using a hypothesis-based approach
  • Excellent communication of project rationale, key experimental results, issues and accomplishments in appropriate verbal and written form
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Maintains an excellent scientific expertise in organic synthesis and a good knowledge of key medicinal chemistry principles
  • Good ability to manage own priorities and deliverables, both independently and in the team setting
  • Familiarity with tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making a strong plus but not required

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Apply Now

Research Associate/Senior Research Associate, Medicinal Chemistry

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry to join our Medicinal Chemistry team. You will work with a highly dynamic group that is focused on moving projects from the hit identification stage to the discovery of clinical candidates. The Nurix mission is to control protein fate to treat human diseases leveraging exciting technologies to target protein degradation.

The successful applicant will have demonstrated substantial experience in modern synthetic organic chemistry and standard analytical methods. Having developed an understanding of the physicochemical properties that drive drug discovery are highly desired.

As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of highly experienced scientists within Nurix as well as with external collaborators.

Required Qualifications

  • BA/BS or equivalent with typically 4+ years of relevant experience or MS with typically 2+ years of relevant experience (years of relevant experience will impact level of hire)
  • Creative skills in the design, performance and interpretation of chemistry experiments with strong synthetic problem-solving skills using a hypothesis-based approach
  • Excellent communication of project rationale, key experimental results, issues and accomplishments in appropriate verbal and written form
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Maintains an excellent scientific expertise in organic synthesis and a good knowledge of key medicinal chemistry principles
  • Good ability to manage own priorities and deliverables, both independently and in the team setting
  • Familiarity with tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making a strong plus but not required

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Apply Now

Associate Director/Director, Clinical Data Management

Nurix has a place for an extraordinary, highly motivated, self-starter and accomplished Associate Director/Director of Clinical Data Management to become a part of the growing biometrics organization.

Summary

The Associate Director/Director of Clinical Data Management (CDM) will be responsible for the delivery and integrity of clinical data across Nurix’s multiple studies/programs. The role will also be supporting process development and improvement in building clinical data management infrastructure. The ideal candidate will ensure adherence to industry guidelines in all clinical data management activities for assigned programs, as well as assisting the Head of Biometrics in the development and implementation of departmental policies, operational guidelines, and administrative structure. They will also serve as the Clinical Data Management specialist within Global Clinical Development (GCD) and will lead the team with expertise in CDISC and GCDMP standards. The successful candidate should have a successful track record in managing vendors and effectively leading program clinical data management activities with the anticipated growth in the product pipeline. They must also possess excellent communication skills to interface with senior leadership and study teams on behalf of the department and work closely with medical study directors and clinical operations to provide and receive direction to ensure high quality and integrity in clinical data.

Additional key representative responsibilities will include, but not necessarily be limited to, the following:

Job Responsibilities

  • Manage vendors that have been contracted to handle Nurix’s clinical data and ensure the data are complete, accurate and delivered within the agreed upon timelines
  • Ensure inspection readiness by maintaining current documentation, adherence to industry guidelines, SOPs and compliance with training
  • Work collaboratively with internal and external team members within the program to coordinate the planning and execution of clinical data management activities
  • Create strategies for rapid study start and database lock to increase clinical data management productivity
  • Lead the design of the eCRFs and ensure that they align with the clinical protocol(s)
  • Ensure complete and accurate documentation such as eCRF specifications, eCRF completion guidelines, annotated CRFs, data validation specifications, data transfer agreements, and data management plans
  • Ensure data is reviewed on an on-going basis, including individual subject data within the EDC, datasets, TLFs, etc. that are generated for CSRs, DSURs, IBs, and other business needs
  • Collaborate with clinical development team and provide expertise regarding CDISC data standards, FDA and ICH guidelines, and GCDMP standards
  • Help establishing CDM processes, create key clinical data management SOPs
  • Provide technical leadership and guidance for clinical data management team and vendors around project conventions, standards, practices, and database specifications
  • Accountable for forecasting and management of budgets for resources and program costs
  • Hire, develop and supervise clinical data management resources, employees and consultants within area of responsibility; Sets training standards
  • Act as an independent contributor to perform all clinical data management activities of an assigned program, as necessary
  • Manages group of internal and/or external team members. Mentors and develops direct employees

Qualifications

  • Bachelor’s degree in a scientific discipline or equivalent (computer science, mathematics, statistics, epidemiology, biology, psychology). A Master’s degree in a related science field is preferred
  • Minimum of 15 years (for Director or 10 years for Associate Director) of clinical data management experience within pharmaceutical industry with a track record of success and progression
  • Direct experience working with Medidata Rave design and implementation
  • Proficient on regulatory requirements for clinical data management and the regulatory submission process
  • Extensive experience working with external vendors, including but not limited to acquisition, contracting, evaluation of vendor’s capabilities and ensuring the desired high-quality deliverables
  • Experience in managing direct reports is required
  • Demonstrated ability to operate and lead in a dynamic organization, build successful working relationships and effective stakeholder management in an environment that requires diverse educational and functional expertise

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Manager/Senior Manager, PV Operations

This remote position will see the incumbent support the implementation of PV Quality Management System (QMS). Responsible for managing and supporting pharmacovigilance (PV) vendor oversight activities and tracking key performance indicators (KPIs), compliance and quality of work performed for contracted PV services. The incumbent will also support safety database integration and data migration.

Job Responsibilities

  • Support the development and maintenance of PV department procedures in alignment with PV regulations.
  • Support regulatory compliance and inspection readiness of outsourced PV services.
  • Manage case processing activities by functioning as a subject matter expert in ICSR case processing of both clinical and spontaneous cases.
  • Oversee the QC of ICSRs and responds to ICSR related inquiries.
  • Provide support for expansion of business activities and ensures that PV processes are established, and all applicable regulatory requirements are met.
  • Maintain oversight of contracted PV services and training of PV Vendors and Nurix staff.
  • Participate in process improvement and vendor-client meetings
  • Support activities related to business integration including safety database integration, data migration, and integrating new assets or companies into Nurix system.
  • Participate in the development or revision of SOPs, work instructions, guidance documents and safety management plans (SMP)
  • Support the development of SDEAs or pharmacovigilance agreement with Nurix partners and vendors for specific obligations for safety data exchange and reporting.
  • Contribute to inspection readiness and support Health Authority inspections of Nurix’s pharmacovigilance function.
  • May assist with managing PV budgets, MSAs and SOWs with PV vendors.
  • Oversee the collection and review of pharmacovigilance compliance metrics related to PV activities.

Required Qualifications

  • Bachelor’s degree in healthcare related field required.  RN, R.Ph., or Pharm D. degree highly preferred.
  • Minimum of 5 years’ progressive experience in pharmacovigilance in a pharmaceutical, biotech or related environment.
  • In-depth knowledge of relevant Food and Drug Administration (FDA), European Union (EU) and International Conference on Harmonization (ICH) guidelines, initiatives, and regulations governing pharmacovigilance.
  • Experience with safety database implementation and data migration.
  • Knowledge of adverse event reporting and processing in a clinical trial and post marketing setting.
  • Experience monitoring health authority submissions and compliance.
  • Experience leading and contributing to process improvements, quality management system, inspection readiness, Health Authority audits, standardization of safety reports, SDEA/PVA/SMP, vendor management, etc.

Bonus Qualifications

  • Effective time management and organization skills
  • Ability to effectively communicate, collaborate, and deliver excellent work in a fast-paced, and rapidly growing department and organization.
  • Knowledge of MedDRA and WHO Drug dictionaries
  • Ability to work independently with minimal supervision
  • Vendor onboarding experience

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Senior Research Associate – Bioanalytical/Pharmacokinetics

Nurix Therapeutics is searching for a motivated RA/SRA to join our growing Bioanalytical-DMPK team. The successful candidate will contribute to the bioanalytical efforts to support Nurix drug discovery programs involving in vivo and in vitro studies. The scope of the daily responsibilities for this position includes, but is not limited to, developing bioanalytical methods, quantitating drug candidates and their metabolites, endogenous biomarkers in biological matrix (e.g. blood, plasma, tissue/tumor, CSF, bone marrow etc.), reporting bioanalytical results and managing projects outsourced in CROs to support all in vitro and in vivo studies. The successful candidate will have extensive experience in bioanalytical method development and sample analysis using LC-MS/MS and other analytical techniques.

Key Responsibilities

  • Conduct bioanalytical method development and qualification/validation to support drug/metabolites and biomarker analysis
  • Perform biological sample analysis in a timely manner to meet projects needs
  • Work with cross-functional teams to understand bioanalytical needs for both PK and PD support
  • Manage projects conducted in CROs to ensure high quality bioanalytical data delivered to meet project timelines
  • Assist with daily lab operations to keep up with internal bioanalytical demands

Preferred Qualifications

  • Hands-on experience in developing and implementing LC-MS(/MS) based assays for proteins in biological matrices
  • Working knowledge of Phoenix WinNonLin for PK analysis preferred
  • Excellent inter-personal skills to fit in a matrix team environment
  • Ability to fit in a fast pace environment with the capability of multi-tasking
  • Experience in GLP regulated environment

Minimum Requirements

  • BS or Master’s with >3 years’ experience working in a discovery setting using LC-MS/MS within a pharmaceutical/biotechnology company
  • Broad experience in small molecule biomarkers as well as drug candidate bioanalytical assay development/sample analysis in different biological matrix using LC-MS/MS
  • Extensive experience with AB Sciex mass spectrometry software
  • Excellent written, verbal communications and interpersonal skills to collaborate with internal and external partners in a matrix environment

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Apply Now

Associate Director/Director, Program and Portfolio Management

The Director of Program Management, provides project management expertise to cross functional Asset and Clinical Teams to advance an asset(s) through clinical, technical development, regulatory submission, manufacturing and commercialization. This includes, but is not limited to, the oversight and facilitation of team interactions related to project operations and delivering on key program milestones, the development and management of project plans/timeline, issue and risk management, Asset Team coordination, facilitation and documentation of Asset Team meetings. The initial focus of this position will be to support the strategic planning and execution of early development oncology projects and Nurix’s flagship assets.  This role requires a leader who has deep understanding of advancing complex and innovative oncology therapies and exceptional ability to drive collaboration in a high matrix environment.

Job Responsibilities

  • Proactively plans, coordinates and tracks the progress of IND stage and clinical stage cross-functional programs. Responsible for the initiation, planning, execution, monitoring, and closure of activities at the Asset Team level, including identification of risks and mitigation strategies/recommendations.
  • Ensures effective, accurate, and timely communication across functional areas within the program, serves as a point of contact across multiple functions for program-related issues, including escalation of programs issues to ensure resolution.
  • Lead the development of vision and strategy for the asset and road map that are in alignment with corporate business objectives.
  • Partners with Program Team Leads to drive appropriate clinical development discussions at the cross-functional Asset Team level; responsible for agendas, minutes, action items tracking, and timelines to support productive Asset Team discussions.
  • Partners with Clinical Development lead to drive appropriate discussions at the Clinical Team level.
  • Partners with Regulatory lead to drive appropriate discussions supportive of regulatory submissions (e.g., IND, CTA, EOPX meetings, etc.); drives operational activities in support of regulatory submissions, including timeline creation and management.
  • Serves as thought-partner to Program Team and Clinical Development Leads and VP Program Management and Asset Strategy to drive creative thinking, formulate scenario-based development planning and strategy, and proactively identify and address programmatic gaps in thinking, process, or efficiency with a solution-based mindset.
  • Creates and maintains global program plans, including near-term and long-term development timelines, budgets, resource projections, and project reporting supportive of the development strategy of clinical-stage assets (e.g. Product Development Plans, Target Product Profile).
  • Contributes to discussions or materials supportive of Executive Management Team (EMT) meetings, and/or Board of Directors (BoD) meetings.
  • Demonstrates an empathic approach to problem-solving, with a willingness to work across all levels of leadership and functional areas in a growing, changing, and fast-moving environment
  • Demonstrates an ability to influence without authority in a grounded manner that results in productive discussions, effective decision-making and cultivate a high-performance team culture.
  • Leads Program Management efforts for multiple assets for one or more disease areas.

Qualifications

  • 10+ years of experience in drug development, preferably in oncology; and at least 6 years of experience in project management.
  • Depth of project management and oncology drug development knowledge sufficient to allow her/him/them to drive activities with a high degree of independence; previous work and leadership experience across early to mid-stage clinical development preferred.
  • Given start-up nature of organization, must be willing and able to perform both tactical, operational work (agendas, minutes, timelines) as well as engage and drive strategic dialogue across all stages of development and all levels of leadership.
  • Demonstrated experience leading cross-functional teams; possesses a refined understanding of team dynamics, influencing without authority, motivating teams.
  • Comfortable with change, readily adaptable and the ability to professionally navigate success and failure.

Education and Skills

  • BS in a scientific discipline; advanced degree (MS, PhD, MBA) preferred.
  • PMP or advanced project management training/certificate preferred.
  • Proficient in relevant software, including but not limited to MS Project, MS Office Suite, Smartsheets.
  • Experience in oncology and autoimmune diseases preferred.

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Medical Writer

Job Responsibilities

  • Supports the clinical development team to develop high-quality, scientifically accurate medical communications materials including, but not limited to: protocols, ICFs, Investigator Brochures, clinical study reports, abstracts, posters, presentations, White Papers and manuscripts.
  • Organizes the team meetings for document review; leads the adjudication of comments and edits; prepares pre-meeting agenda, key points for discussion, and meeting minutes.
  • Partners with data managers and biostatisticians to engage early in the planning of mock and/or blinded tables, figures, and listings (TFLs), and narrative planning for relevant documents.
  • Works closely with clinicians, clinical scientists, biostatisticians, and pharmacokineticists to ensure that results descriptions and messages in clinical documents accurately reflect the data in TFLs and statistical analyses.
  • Builds timelines for deliverables with the study teams and adheres to agreed timelines.
  • Follows SOPs and regulatory compliance; contributes to SOP development and standardization of templates and related processes, and internal best practices and processes for critical document development.
  • Follows International Conference on Harmonization (ICH) and other applicable regulatory guidelines.
  • Ensures that appropriate documented quality control (QC) checks are performed on medical writing deliverables, responds to findings, and recommends quality process improvements.

Minimum Requirements

  • Degree in life-sciences or medical-related studies; graduate degree preferred (Master’s or PhD).
  • Five years of relevant medical writing experience in the pharmaceutical industry; experience in oncology related medical writing preferred.
  • Experienced in medical writing responsibilities associated with various development stages. Excellent writing ability with strong editorial and formatting skills.
  • Experience writing clinical study reports, protocols, ICFs, investigator’s brochures, safety reports, publications, abstracts.
  • Experience in interacting with cross functional study teams; understands when to escalate problems.
  • Thorough knowledge of clinical research concepts, practices, and FDA regulations and ICH. Guidelines regarding drug development, clinical research and medical writing standards.
  • Ability to work independently and work effectively under pressure.
  • Attentive to details.
  • Mastery of English language; excellent verbal and written communication skills.
  • Demonstrated ability to prioritize tasks, advance multiple projects simultaneously, and deliver high-quality documents according to timelines.

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Associate Director/Director, Clinical Data Management

Nurix has a place for an extraordinary, highly motivated, self-starter and accomplished Associate Director/Director of Clinical Data Management to become a part of the growing biometrics organization.

Summary

The Associate Director/Director of Clinical Data Management (CDM) will be responsible for the delivery and integrity of clinical data across Nurix’s multiple studies/programs. This remote role will also be supporting process development and improvement in building clinical data management infrastructure. The ideal candidate will ensure adherence to industry guidelines in all clinical data management activities for assigned programs, as well as assisting the Head of Biometrics in the development and implementation of departmental policies, operational guidelines, and administrative structure. They will also serve as the Clinical Data Management specialist within Global Clinical Development (GCD) and will lead the team with expertise in CDISC and GCDMP standards. The successful candidate should have a successful track record in managing vendors and effectively leading program clinical data management activities with the anticipated growth in the product pipeline. They must also possess excellent communication skills to interface with senior leadership and study teams on behalf of the department and work closely with medical study directors and clinical operations to provide and receive direction to ensure high quality and integrity in clinical data.

Additional key representative responsibilities will include, but not necessarily be limited to, the following:

Job Responsibilities

  • Manage vendors that have been contracted to handle Nurix’s clinical data and ensure the data are complete, accurate and delivered within the agreed upon timelines
  • Ensure inspection readiness by maintaining current documentation, adherence to industry guidelines, SOPs and compliance with training
  • Work collaboratively with internal and external team members within the program to coordinate the planning and execution of clinical data management activities
  • Create strategies for rapid study start and database lock to increase clinical data management productivity
  • Lead the design of the eCRFs and ensure that they align with the clinical protocol(s)
  • Ensure complete and accurate documentation such as eCRF specifications, eCRF completion guidelines, annotated CRFs, data validation specifications, data transfer agreements, and data management plans
  • Ensure data is reviewed on an on-going basis, including individual subject data within the EDC, datasets, TLFs, etc. that are generated for CSRs, DSURs, IBs, and other business needs
  • Collaborate with clinical development team and provide expertise regarding CDISC data standards, FDA and ICH guidelines, and GCDMP standards
  • Help establishing CDM processes, create key clinical data management SOPs
  • Provide technical leadership and guidance for clinical data management team and vendors around project conventions, standards, practices, and database specifications
  • Accountable for forecasting and management of budgets for resources and program costs
  • Hire, develop and supervise clinical data management resources, employees and consultants within area of responsibility; Sets training standards
  • Act as an independent contributor to perform all clinical data management activities of an assigned program, as necessary
  • Manages group of internal and/or external team members. Mentors and develops direct employees

Qualifications

  • Bachelor’s degree in a scientific discipline or equivalent (computer science, mathematics, statistics, epidemiology, biology, psychology). A Master’s degree in a related science field is preferred
  • Minimum of 15 years (for Director or 10 years for Associate Director) of clinical data management experience within pharmaceutical industry with a track record of success and progression
  • Direct experience working with Medidata Rave design and implementation
  • Proficient on regulatory requirements for clinical data management and the regulatory submission process
  • Extensive experience working with external vendors, including but not limited to acquisition, contracting, evaluation of vendor’s capabilities and ensuring the desired high-quality deliverables
  • Experience in managing direct reports is required
  • Demonstrated ability to operate and lead in a dynamic organization, build successful working relationships and effective stakeholder management in an environment that requires diverse educational and functional expertise

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Senior/Principal Scientist of Drug Metabolism and Pharmacokinetics

Nurix is currently seeking a Senior/Principal Scientist of DMPK (Drug Metabolism and Pharmacokinetics) to be a DMPK leader. We are looking for a talented, curious, and motivated scientist with a track record of pharmaceutical project support to provide DMPK and Clinical Pharmacology guidance to Oncology projects across our portfolio and to contribute to refining the application of ADME and PK principles to our novel therapeutic modality. The successful candidate will apply pharmacokinetic and clinical pharmacological expertise in a dynamic team setting to inform discovery and development. You will be the drug metabolism and pharmacokinetics (DMPK) lead on project teams developing small molecule modulators as cancer medicines. We are looking for a consummate team player seeking a collaborative environment in which to grow their career in drug discovery and development.

Job Responsibilities

  • Oversight of activities at CROs, including in vitro ADME and PK
  • Be the functional area representative for DMPK on project teams
  • Design, analyze and interpret preclinical DMPK studies in support of program goals
  • Use a broad array of DMPK data to enable integrated analyses of biopharmaceutics, drug metabolism, PK/PD, human PK/dose projections and DDI risk
  • Contribute to study reports and relevant sections of regulatory documents

Job Requirements

  • BS, MS or Ph.D. with 6-8 + years of experience with a focus in pharmacokinetics, pharmacology or related discipline
  • Technical depth and a broad understanding of drug metabolism in vitro assays including metabolic stability, enzyme inhibition/induction/phenotyping, protein binding, and pharmacokinetics with proficiency in Phoenix WinNonlin or similar
  • Experience optimizing and characterizing the ADME properties of small molecule drug candidates with expertise in the interplay between DMPK parameters, physicochemical and molecular properties
  • Experience leading DMPK on projects particularly in discovery and early development
  • Proficient in the management of activities at contract research organizations and comfortable working in virtual outsourced model
  • Excellent communication and organizational skills; comfortable navigating complexity and ambiguity in a fast-paced environment interacting with consultants, external vendors and internal cross-functional, global project teams.
  • Familiarity with external regulatory requirements, and experience authoring and reviewing PK sections of regulatory dossiers

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Temporary Associate, DEL Screening

We are seeking a researcher who is interested in working with scientists in our DNA-encoded chemical library (DEL) screening team to perform assays in support of our drug discovery process.  This work includes performing qPCR assays, Illumina next-generation sequencing (NGS) templates, and other molecular biology, protein biochemistry, and analytical biochemistry duties.

Required Qualification

The candidate we seek must have a degree in the life sciences with a strong background in biochemistry and molecular biology. Moreover, we are interested in someone who integrates well within a process-oriented team. The successful candidate should have very good organizational and communication skills. 

  • Experience: Two or more years of industry experience performing qPCR assays and preparing NGS sequencing samples
  • Specific Technical Proficiency in: qPCR assay (absolute method), PCR amplification reactions, DNA and protein quantitation, workflows involving multi-channel pipetting
  • Instrument Proficiency Desired: Real-time PCR instrumentation (QuantStudio7, Bio-Rad CFX384, etc.), Agilent TapeStation or Bioanalyzer, Nanodrop spectrophotometer, various plate readers, liquid chromatography-mass spectrometry a plus
  • Software Proficiency Required: Excel, Word, PowerPoint

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view 

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Apply Now

Scientist, DNA-encoded Chemical Library Screening

We are seeking a talented and highly-motivated individual with a background in chemical biology or assay development and an interest in drug discovery to join our collaborative team of scientists to discover novel chemical matter for use in targeted protein degradation. Using Nurix’s DNA-encoded library (DEL) platform, the successful candidate will design and implement small molecules screens to identify ligands of Nurix drug targets. As part of a multidisciplinary team of biologists, medicinal chemists, and computational chemists, they will play a key role in the subsequent analysis and evaluation of DEL screens and assist with assay and validation of ligands from DEL screens.

Key Responsibilities

  • Design and implement DEL screens of prioritized targets to identify novel binders
    • This position will offer the opportunity for the candidate to gain experience in DEL screening. Prior experience with this technology is helpful but NOT required.
  • Develop biochemical and biophysical assays in support of DEL screen design as well as small molecule binder validation and progression
  • Communicate findings to internal stakeholders through scientific presentations

Qualifications

  • Ph.D. scientist with 2+ years of post-degree industry or academic experience
  • Experience in the development, optimization and execution of biochemical or biophysical assays to interrogate protein interactions and enzymatic activity
  • High level of creativity and productivity with strong problem-solving skills.
  • Solid background of scientific accomplishment demonstrated by publications, patents, or presentations.
  • Excellent communication skills and ability to present rationale, key data, issues and accomplishments to other members of the scientific team.
  • Resourceful and open to diverse points of view
  • Good fit with Nurix culture and values of highly collaborative, team-oriented research

Title, salary, and responsibilities to be commensurate with experience. 

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Research Associate III/Senior Research Associate, Lead Discovery

We are seeking a highly motivated individual with a background in Biochemistry or Molecular Cell Biology to join our Lead Discovery team at Nurix.

  • Responsible for the development and optimization of biochemical assays to monitor the protein-ligand or enzymatic activity of target proteins
  • Implementation of those assays to quantify the activity and quality of proteins entering our DNA encoded library selection pipeline
  • Robotic automation of those assays to monitor the potency of large numbers of molecules in high-throughput fashion, guiding the validation and progression of screen hits in compound improvement campaigns
  • Working as part of highly collaborative project teams of biochemists, structural biologists, cell biologists, and medicinal chemists to advance small molecule modulators of therapeutic targets
    • Representation of the Lead Discovery function, helping to guide the biochemical assay development and reporting results back to the project teams

Qualifications

  • Bachelor’s or master’s degree in Biochemistry, Molecular and Cell Biology, or related field
  • 5+ years (Bachelor’s) or 2+ years (Master’s) of relevant experience
  • Experience developing and running biochemical assays to assess protein activity and monitor small molecule effects (e.g. enzymatic, ubiquitylation, protein-protein interaction, fluorescence polarization, TR-FRET, AlphaLISA, etc.)
  • Experience using robotic automation (e.g. acoustic dispensers, liquid handling platforms)
  • Protein purification (e.g. AKTA Purification of proteins from coli or SF9 cells)
  • Excellent organizational skills, attention to detail, and ability to multitask
  • Excellent oral and written communication
  • Strong desire to learn new techniques and the ability and interest to cross train in all aspects biochemical assay development
  • Experience and proficiency with data processing programs (i.e. Microsoft Excel, GraphPad Prism, ActivityBase, etc.)

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Clinical Trial Manager (CTM)/Sr. CTM

Nurix, Inc. is seeking a Clinical Trial Manager (CTM)/Sr. CTM to join the Clinical Operations team.  This individual will be responsible for management of global clinical programs. They will lead study team, vendors, clinical monitors and clinical sites throughout the life cycle of a clinical trial.

This individual will be able to manage clinical trial(s) and have broad involvement in work central to Nurix’s strategic goals. They will apply existing technical skills, learn new skills, and play a key role in nonclinical development of the programs and help grow the company and guide its direction. As an early hire, they’ll be influential in championing and developing Nurix’s culture.

The CTM/Sr. CTM is responsible for the successful implementation of a clinical trial, independently, from start-up to close-out. Experience in managing cross-functional teams, knowledge of applicable regulatory requirements and developing junior staff will be essential to the team’s success. The CTM/Sr. CTM will represent Clinical Operations at Project team meetings and may represent Nurix at professional events.

Job Responsibilities:

  • Accountable for all operational aspects of assigned clinical trial(s)
  • Responsible for selection of vendors/CROs and provide effective ongoing management to vendors/CROs to ensure compliance and execution of deliverables within the approved budget, study timeline, and study protocol
  • Works closely with investigative site personnel, CROs, and other study vendors
  • Monitor and track clinical trial progress and provide status update to stakeholders
  • Manage study contracting, budget, forecasting, accruals and payment process for all clinical trial vendors including investigational sites
  • Collaborate with Data Management to ensure correct CRFs content is collected, prepare/implement CRF completion guidelines, and coordinate delivery of data listings and study reports
  • Drafts and coordinates review of relevant documents including protocols, informed consents, case report forms, monitoring plans, investigator brochures and clinical study reports.
  • Must be able to participate in cross-functional strategic initiatives under limited supervision
  • Proactively identifies potential issues/risks and recommends/implements solutions
  • Provides leadership to the clinical operations team working on the assigned program

Experience and Skills

  • B.S./ B.A. in biological sciences, advanced degree preferred with 5+ years of relevant industry experience
  • Ability to travel as required for the program (10-15%)
  • Demonstrated knowledge of FDA, ICH and GCP regulations and guidelines
  • Experience in leading teams, including CROs, consultants and vendors
  • Must display strong analytical and problem-solving skills at a project level and collaborate with colleagues to generate solutions
  • Strong communication and influence skills and ability to create a clear sense of direction
  • Ability to deal with time demands, incomplete information or unexpected events
  • Outstanding organizational skills with the ability to multi-task and prioritize
  • Comfortable in a fast-paced small company environment and able to adjust workload based upon changing priorities

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Apply Now

Sr. Manager, PV Scientist

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Job Summary

The incumbent supports all aspects of medical surveillance and risk management activities for Nurix Products. Works cross functionally with internal (i.e., Clinical Development, Clinical Operations, Regulatory Affairs, and Data Management) and external stakeholders to monitor and maintain the safety profile of all Nurix products.

Responsibilities

  • In collaboration with Nurix physicians, provides medical surveillance and risk management activities for all Nurix products
  • Author and compiles pharmacovigilance aggregate reports (e.g., DSUR, PADER, PBRER) for all Nurix compounds and ensures all safety documents are submitted according to regulatory requirements
  • Supports the development of Investigators Brochure (IB) and analyze data for the RSI section of the IB
  • Participates in new study initiation to ensure PV requirements are met including but not limited to safety reporting, query resolution, SAE reconciliation, and safety reporting training.
  • Represents PV in cross-functional meetings and additional activities to support clinical development programs
  • Leads signal detection activities for a products emerging safety profile and presents safety data at Safety Review Committees (SRC)
  • Perform data analysis to evaluate safety signal and write up analysis results
  • Write and analyze data for responses to health authority queries
  • Supports process improvement and cross functional initiatives for safety science including SOPs and procedural documents
  • Performs QC on cases processed by vendor and provides feedback to PV vendor
  • Provide PV expertise by guiding, training, and overseeing pharmacovigilance vendor supporting pharmacovigilance activities
  • Provides safety reporting training to internal Nurix employees and contracted vendors
  • Contributes to the development of safety management plans and facilitates activities during study start-up phase, including cross functional interactions.
  • Contributes to the development of safety governance structure
  • Participates in audit/inspection preparedness activities and serve as subject matter expert during regulatory inspections

Required Qualifications

  • Minimum 5 years’ experience in Pharmacovigilance/Drug Safety environment and at least 3 years in PV/Safety Science
  • Bachelor’s degree in health-related discipline or equivalent (RN, R.Ph., Pharm D, or MD)
  • Experience with aggregate safety reporting (DSUR), safety surveillance, signal and/or risk management
  • Strong knowledge of US and International safety reporting regulations and requirements
  • Strong experience in case processing and QC of ICSR
  • Experience with the use of global safety database is required.
  • Experience leading safety data review meetings, creating agenda, and meeting minutes
  • Active participation in regulatory inspections and audits

Bonus Qualifications

  • Self-motivated, ability to take ownership of, and follow through with specific tasks
  • Ability to effectively communicate, collaborate, and excel in a fast-paced and rapidly growing department and organization
  • Highly organized with strong attention to details
  • Experience with clinical and post marketing safety activities

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Apply Now