Culture & Careers

Job Openings

Scientist, Informatics

Join us in the most challenging and rewarding science of our lives.

Position

As an Informatics Scientist, you will interface with fellow scientists across the organization to provide hands-on scientific application support. In this role, you will help fellow scientists effectively use Nurix’s existing tools and applications to capture, analyze, query and report chemical and biological data. You will partner with your Informatics colleagues to identify and implement database-backed solutions to address unmet automation and informatics needs.

Required Skills:

  • BS/MS in Chemistry, BioChemistry, Biology or a related field
  • Minimum 8 years’ experience working with chemical and biological information systems
  • Minimum 8 years’ experience working with databases (Oracle, MySQL, PostGRES, SQLServer) and SQL coding
  • Minimum 8 years’ experience working with data-analysis tools and applications such as Pipeline Pilot or Knime
  • Excellent communication and presentation skills on the phone, in 1×1 meetings, and in a group setting
  • Strong written communication skills to create business-appropriate emails, instant messages, requirements/specifications documents, presentation materials, etc.
  • Proficient in MS Office (Excel, Word, PowerPoint)

Preferred Skills:

  • Experience coding in any of the following: Perl, Python, Java, VB, C/C++
  • Business analysis
  • Data visualization
  • Change control

Apply Now

Senior Associate, Informatics

Join us in the most challenging and rewarding science of our lives.

Position

As a Senior Associate, Informatics, you will interface with fellow scientists across the organization to provide hands-on scientific application support. In this role, you will help fellow scientists effectively use Nurix’s existing tools and applications to capture, analyze, query and report chemical and biological data. You will partner with your Informatics colleagues to implement database-backed solutions to address unmet automation and informatics needs.

Required Skills:

  • BS/MS in Chemistry, BioChemistry, Biology or a related field
  • Minimum 2 years’ experience working with chemical and biological information systems
  • Minimum 2 years’ experience working with databases (Oracle, MySQL, PostGRES, SQLServer) and SQL coding
  • Minimum 2 years’ experience working with data-analysis tools and applications such as Pipeline Pilot or Knime
  • Excellent communication and presentation skills on the phone, in 1×1 meetings, and in a group setting
  • Strong written communication skills to create business-appropriate emails, instant messages, requirements/specifications documents, presentation materials, etc.
  • Proficient in MS Office (Excel, Word, PowerPoint)

Preferred Skills:

  • Experience coding in any of the following: Perl, Python, Java, VB, C/C++
  • Business analysis
  • Data visualization
  • Change control

Apply Now

Cheminformatics / Data Scientist

Join us in the most challenging and rewarding science of our lives.

Position

Much of Nurix’s lead finding efforts derive from our DNA Encoded Library group, which regularly screens large (billions of molecules) combinatorial chemical libraries against therapeutic targets of interest. We are seeking a talented and highly motivated cheminformatics/data scientist to lead exploration, analysis, and knowledge finding efforts for these dense, high quality datasets as we seek to increase the information and learnings extracted. Specific responsibilities will include:

  • Develop and improve computational models of SAR gained from DEL selection data, specifically through the implementation of cutting-edge machine learning frameworks
  • Develop summarization and communication techniques to efficiently transfer SAR knowledge identified from DEL selections to target specific project teams
  • Perform analyses on new DEL selection data and collaborate with DEL scientists in hit triage and selection
  • Implement analysis platforms hosting the new analysis methods, to allow for efficient automated and custom analyses
  • Collaborate with DEL scientists to design new data analysis routines and visuals to augment current interpretation of selection data
  • Support DEL scientists in additional cheminformatics tasks, such as filtering building block collections, performing similarity analyses, basic modeling of hits (ie, docking), etc.

Qualifications 

  • A Ph.D. in cheminformatics, computational chemistry or related discipline, or BS/MS with demonstrated industry experience
  • Experience in modeling complex chemical data in a drug discovery setting using expertise in cheminformatics, including knowledge of techniques such as QSAR and pharmacophore modeling
  • Mastery of big dataset analysis, and experience with appropriate tools for efficient data processing including
  • Significant coding/development experience in at least one high-level programming language (ie, Python, Java, R), as well as demonstrated knowledge of cheminformatics toolkits (ie, OEChem, RDKit, etc.)
  • Demonstrated experience developing and implementing predictive machine learning models based on chemical structure and biological activity data
  • Demonstrated understanding of basic cheminformatics, such as substructure searching/filtering, molecular property calculations, reaction enumeration, etc.
  • Strong communication skills, along with the ability to work well in multidisciplinary teams, are essential
  • Evidence of creative application of computational approaches to problems of biological or chemical interest is necessary
  • Experience with encoded libraries or combinatorial synthesis is a plus

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Apply Now

Temporary Research Associate I/II, DNA Encoded Chemistry, Library Discovery

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a talented and highly motivated scientist to join our Library Discovery team and help us augment our DNA encoded library collection. DEL synthesis requires a hybrid of techniques that are borrowed from chemistry environments: chemical reaction setup, LCMS analysis, SAR evaluation, split and pool library synthesis workflows, parallel reaction development, as well as from biology laboratories: aqueous buffer preparation, centrifuge use, ethanol precipitation of DNA, A260 DNA quantification, gel electrophoresis, bioanalyzer analysis, enzymatic DNA ligation. An exposure to some of these techniques is helpful in training into a DNA encoded scientist.

As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators.

Qualifications

  • BS or MS in life sciences (ex. chemistry, biochemistry, biology) with 0-5 years industrial chemistry experience (years of relevant experience will impact level of hire)
  • Training in synthetic organic chemistry methods and analytical tools, in particular LCMS
  • Interest in optimizing chemical reactions for use in DNA encoded library synthesis
  • High level of creativity and productivity with strong problem-solving skills 
  • High level of attention to detail and good organizational skills
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.

Fit with Nurix Culture and Values

  • Strongly team-oriented; highly collaborative
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Chief Medical Officer

Join us in the most challenging and rewarding science of our lives.

Position

The Chief Medical Officer will report directly to the Chief Executive Officer. This position will be engaged in defining and leading the overall clinical strategy, direction and vision of the organization. The successful candidate will lead interactions with regulatory agencies, clinical experts (including KOLs in the field), and work with cross-functional teams to design, develop and implement clinical studies. 

This is a unique opportunity to be a major contributor to the success of a dynamic and well-financed growth stage biotechnology company.

  • Provide strategic input for innovative clinical development plans, incorporating the current therapeutic area landscape
  • Orchestrate and manage clinical aspects of regulatory strategies and interactions with Health Authorities
  • Oversee the analysis and interpretation of clinical trial data and the reporting of clinical trial results
  • Lead interactions with academic thought leaders, investigators, cooperative groups, and other clinical stakeholders including investigator and clinical advisory boards
  • Provide clinical support and work with other members of the management team to develop and communicate the overall corporate strategy
  • Represent the Company and its programs to external audiences, including the medical and regulatory communities, as well as selected investment venues and current and prospective biopharmaceutical collaborators
  • Lead and supervise the Clinical Operations, Regulatory, and Quality Control functions

Professional Experience/Qualifications

  • History of success progressing therapeutic programs from IND-enabling studies through human proof of concept, and/or from Phase 1 to Phase 3 development or NDA approval
  • Multiple years of management experience leading a clinical group including clinical operations, regulatory, and quality control
  • Knowledge of relevant FDA regulations and guidelines and other health authorities; experience in interactions with FDA personnel is essential; experience in interactions with other health authorities a plus
  • Experience with the design, execution, and analysis of clinical oncology studies with small molecule targeted or immunological therapies
  • Experience in translational medicine, clinical pharmacology and early stage development is desirable
  • Excellent knowledge of the competitive environment for drugs in the oncology marketplace and in research and development pipelines
  • Must have a thorough knowledge of clinical research concepts, practices, and GCP and ICH guidelines
  • The successful candidate will possess excellent communication skills and can articulate the Company’s clinical and regulatory strategies and progress to a wide audience including the CEO, the Board of Directors, Company employees, and the investor community
  • Must be science- and data-driven, with an understanding of basic science relevant to clinical oncology
  • Ability to work collaboratively in a fast-paced matrix environment

Education

  • M.D./Ph.D. or M.D. with board certification or eligibility in oncology or hematology/oncology is preferred

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Scientist – Senior Scientist, Degrader Discovery

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a talented and highly motivated scientist with a background in E3 ligase biology and an interest in drug discovery to help us unlock novel E3 ligases for use in the emerging field of targeted protein degradation. In this role you will be responsible for leading ligand discovery campaigns using Nurix’s DNA encoded library (DEL) platform to identify novel ligands for E3 ligases. Working collaboratively with a dynamic multi-disciplinary project team, you will participate in degrader design, evaluation and advancement.

Qualifications

  • Ph.D. scientist with 2+ years of post-degree pharma/biotech/academic experience.
  • In depth knowledge of ubiquitin biology required.
  • Expertise in general biochemical and molecular biology including protein immobilization and qPCR. Experience with Nextgen sequencing is a plus.
  • Experience in the development, optimization and execution of biochemical and biophysical assays.
  • Hands on experience interrogating protein-protein or protein-ligand interactions.
  • Familiarity with principles of degrader technology and/or DNA encoded library discovery is highly preferred.
  • High level of creativity and productivity with strong problem-solving skills.
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Senior Research Associate – Scientist, Medicinal Chemistry

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry to join our Medicinal Chemistry team. You will work with a highly dynamic group that is focused on moving projects from the hit identification stage to the discovery of clinical candidates. The Nurix mission is to control protein fate to treat human diseases leveraging exciting technologies to target protein degradation.

The successful applicant will have demonstrated substantial experience in modern synthetic organic chemistry and standard analytical methods. Having developed an understanding of the physicochemical properties that drive drug discovery are highly desired.

As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of highly experienced scientists within Nurix as well as with external collaborators.

Qualifications

  • BA/BS or equivalent with typically 8+ years of relevant experience or MS with typically 4+ years of relevant experience or Ph.D. in synthetic organic chemistry with 0-4 years industrial chemistry experience (years of relevant experience will impact level of hire)
  • Creative skills in the design, performance and interpretation of chemistry experiments with strong synthetic problem-solving skills using a hypothesis-based approach
  • Excellent communication of project rationale, key experimental results, issues and accomplishments in appropriate verbal and written form
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Maintains an excellent scientific expertise in organic synthesis and a good knowledge of key medicinal chemistry principles
  • Good ability to manage own priorities and deliverables, both independently and in the team setting
  • Familiarity with tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making a strong plus but not required

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now