Culture & Careers

Job Openings

Scientist I/II, DNA Encoded Chemistry, Library Discovery

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry and familiarity with the application of DNA encoded chemistry to join our Library Discovery team.

You will join a group with two objectives: 1) Design and synthesize DNA encoded libraries and 2) Utilize these libraries to identify novel chemical matter with the potential to modulate the activity of UPS targets.

You will have demonstrated experience in synthetic organic chemistry and analytical methods. Experience with DNA encoded library synthesis, parallel reaction chemistry, split/pool methods, aqueous chemistry and linker chemistry related to the synthesis of drug conjugates are all valued skills. Familiarity with hit triage, hit to lead campaigns from other discovery platforms, and an understanding of the physicochemical properties that drive drug discovery are desired.

As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators.

Qualifications

  • PhD in synthetic organic chemistry with 0-8 years industrial chemistry experience (years of relevant experience will impact level of hire).
  • Expert in synthetic organic chemistry methods and analytical tools, in particular LCMS
  • High level of creativity and productivity with strong synthetic problem-solving skills.
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.
  • Familiarity with principles of combinatorial chemistry and DNA encoded library technology
  • Interest in optimizing chemical reactions for use in DNA encoded library synthesis.
  • Experience with chemistry involving biological macromolecules, i.e. antibodies and oligonucleotides, linker technologies, or the design and synthesis of chemical biology probes a plus.
  • Familiarity with working with large data sets and the tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making.

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Scientist, Informatics

Join us in the most challenging and rewarding science of our lives.

Position

As an Informatics Scientist, you will interface with fellow scientists across the organization to provide hands-on scientific application support. In this role, you will help fellow scientists effectively use Nurix’s existing tools and applications to capture, analyze, query and report chemical and biological data. You will partner with your Informatics colleagues to identify and implement database-backed solutions to address unmet automation and informatics needs.

Required Skills:

  • BS/MS in Chemistry, BioChemistry, Biology or a related field
  • Minimum 8 years’ experience working with chemical and biological information systems
  • Minimum 8 years’ experience working with databases (Oracle, MySQL, PostGRES, SQLServer) and SQL coding
  • Minimum 8 years’ experience working with data-analysis tools and applications such as Pipeline Pilot or Knime
  • Excellent communication and presentation skills on the phone, in 1×1 meetings, and in a group setting
  • Strong written communication skills to create business-appropriate emails, instant messages, requirements/specifications documents, presentation materials, etc.
  • Proficient in MS Office (Excel, Word, PowerPoint)

Preferred Skills:

  • Experience coding in any of the following: Perl, Python, Java, VB, C/C++
  • Business analysis
  • Data visualization
  • Change control

Apply Now

Scientist, Medicinal Chemistry – Library Discovery

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a highly skilled and motivated individual with a strong background in synthetic organic chemistry to join our library discovery group in the pursuit of novel small molecules. You will engage with a wide swath of Nurix’s therapeutic portfolio to advance screening hits to lead optimization campaigns. Specifically, you will design and synthesize novel chemical entities optimized for potency, selectivity and physicochemical properties. As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of scientists within Nurix and with external collaborators.

You should have a strong desire to learn new techniques and incorporate new methodologies into your work.  You must be self-driven, resourceful, organized and focused, and enjoy being a part of a dynamic team in a project-based environment solving challenging scientific problems to benefit patients.

Qualifications

  • Ph.D. in synthetic organic chemistry preferably with at least 2 years of biotechnology or pharmaceutical industry experience within a medicinal chemistry department
  • Expert in interpretation of screening data and execution of hit triage
  • Successful application of structure-based drug design leading to advanced leads / development candidates
  • Strong working knowledge of protein-ligand interactions, conformational and structural analysis, experienced in partnering closely with computational chemists through appropriate use of computational tools, models and visualization applications
  • Proven track record of innovative project contributions including peer-reviewed publications
  • High level of creativity and productivity with strong synthetic problem-solving skills
  • Excellent scientific expertise in organic synthesis, conversant with the current literature
  • Strong knowledge of medicinal chemistry principles with a solid understanding of key ADME, biochemical and pharmacological principles and able to effectively integrate and apply these to the optimization of multiple parameters during lead generation and lead optimization efforts
  • Familiarization with DNA-encoded library technology is preferred
  • Ability to champion the chemistry efforts into new directions to achieve project milestones
  • Experience with parallel synthesis and high throughput chemistry to prepare libraries of compounds is preferred
  • Experience directing external synthetic chemistry efforts
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Senior Associate, Informatics

Join us in the most challenging and rewarding science of our lives.

Position

As a Senior Associate, Informatics, you will interface with fellow scientists across the organization to provide hands-on scientific application support. In this role, you will help fellow scientists effectively use Nurix’s existing tools and applications to capture, analyze, query and report chemical and biological data. You will partner with your Informatics colleagues to implement database-backed solutions to address unmet automation and informatics needs.

Required Skills:

  • BS/MS in Chemistry, BioChemistry, Biology or a related field
  • Minimum 2 years’ experience working with chemical and biological information systems
  • Minimum 2 years’ experience working with databases (Oracle, MySQL, PostGRES, SQLServer) and SQL coding
  • Minimum 2 years’ experience working with data-analysis tools and applications such as Pipeline Pilot or Knime
  • Excellent communication and presentation skills on the phone, in 1×1 meetings, and in a group setting
  • Strong written communication skills to create business-appropriate emails, instant messages, requirements/specifications documents, presentation materials, etc.
  • Proficient in MS Office (Excel, Word, PowerPoint)

Preferred Skills:

  • Experience coding in any of the following: Perl, Python, Java, VB, C/C++
  • Business analysis
  • Data visualization
  • Change control

Apply Now

Senior/Executive, Medical Director, Clinical Development (MD)

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking an experienced clinician with strong leadership skills who is driven by science and the desire to develop novel therapies for cancer patients. The successful candidate will have expertise in the design and conduct of early phase oncology clinical trials and a strong interest in translational medicine.
Reporting to the Chief Development Officer, the Medical Director will be responsible for the design, implementation, monitoring, data analysis and reporting of clinical studies for Nurix’s oncology portfolio. As a member of the Development Leadership team, the successful candidate will play a key role in building and shaping the Development organization at Nurix. The Medical Director will also serve as a medical expert resource for drug discovery teams and business development activities. The role provides an opportunity for leadership growth in a dynamic small company environment.

Specific responsibilities include:

  • Provide strategic input for innovative clinical development plans, incorporating the current therapeutic area landscape
  • Lead the design and implementation of early stage clinical projects, with responsibility for medical aspects of phase 1-2 clinical trials
  • Serve as lead author of clinical documents: protocols, investigator’s brochures, case report form design and data analysis plans
  • Lead preparation of clinical sections of relevant regulatory filings to Health Authorities
  • Partner closely with the Clinical Operations head in the conduct and execution of Nurix’s clinical trials
  • Serve as Medical Monitor for clinical trials, reviewing safety and efficacy data for routine medical data review, trend review, and safety signals from ongoing trials
  • Support exploratory biomarker efforts to aid clinical and project data-driven decisions
  • Lead medical aspects of investigator and clinical advisory boards
  • Develop and manage relationships with key opinion leaders for clinical programs
  • Represent Nurix at external events, including scientific and medical conferences and business development activities

Requirements:

  • MD with board certification or eligibility in Oncology or Hematology/Oncology
  • Five to seven years of drug development experience in biotechnology or pharmaceutical industry, or a combination of academia and industry
  • Proven experience with clinical trial design, execution, medical monitoring, and reporting of controlled clinical trials in oncology including working with external service providers
  • Experience with design, execution, and analysis of Phase 1-2 clinical oncology studies with small molecule targeted or immunological therapies
  • Demonstrable knowledge of regulatory procedures and guidelines in the US and other geographic regions
  • Understanding of basic science relevant to clinical oncology
  • Ability to work collaboratively in a fast-paced matrix environment
  • Excellent written and oral communication skills

Apply Now

Translational Biomarker Scientist

Join us in the most challenging and rewarding science of our lives.

Position

The successful candidate will be responsible for the design and implementation of biomarker assays to support Nurix’s clinical development programs targeting protein fate for cancer targeted therapy and immunotherapy.  Collaborating with the Discovery and Development organizations, the translational biomarker scientist will be responsible for biomarker identification and characterization in preclinical studies, implementation of state-of-the-art biomarker methods, validation of clinical biomarker assays and tech transfer, and analysis and interpretation of biomarker data to guide early clinical development.

Specific responsibilities include:

  • Utilize broad technical expertise in cell and tumor biology, biochemistry and molecular biology to design, execute and interpret in vitro and ex vivo experiments to expand mechanistic understanding of Nurix’s clinical development assets.
  • Design and execute translational research studies to identify candidate pharmacodynamic and predictive biomarkers and mechanisms of resistance based on target biology, drug mechanism of action, and patient population
  • Collaborate with project teams, external investigators and contract research organizations to evaluate candidate biomarkers in nonclinical models and patient samples and select optimal assays for clinical evaluation
  • Contribute to relevant sections of clinical documents, regulatory submissions and publications
  • Monitor ongoing clinical biomarker results and provide timely scientific review of clinical biomarker data to guide project decisions
  • Highly motivated, innovative and strong team player. Excellent time management and organizational skills required

Education and Skills Requirements:

  • PhD degree or equivalent experience in a relevant scientific area with 3+ years’ experience in translational aspects of drug development
  • Ideally, candidate will have training and/or experience in developing, implementing and qualifying biomarker assays in Immunology, Immuno-oncology, Cancer biology and/or Hematology
  • Broad technical expertise in cell and tumor biology, biochemistry and molecular biology across diverse platforms is required
  • Prior role in multidisciplinary projects and teams with ability to integrate cross-functional information is an advantage
  • Excellent interpersonal, verbal and written communication skills, flexibility and demonstrated ability for creative thinking and proactive problem solving are essential for this role

Apply Now

Research Associate I/II, DNA Encoded Chemistry, Library Discovery

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a talented and highly motivated scientist to join our Library Discovery team and help us augment our DNA encoded library collection. DEL synthesis requires a hybrid of techniques that are borrowed from chemistry environments: chemical reaction setup, LCMS analysis, SAR evaluation, split and pool library synthesis workflows, parallel reaction development, as well as from biology laboratories: aqueous buffer preparation, centrifuge use, ethanol precipitation of DNA, A260 DNA quantification, gel electrophoresis, bioanalyzer analysis, enzymatic DNA ligation. An exposure to some of these techniques is helpful in training into a DNA encoded scientist.

As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators.

Qualifications

  • BS or MS in life sciences (ex. chemistry, biochemistry, biology) with 0-5 years industrial chemistry experience (years of relevant experience will impact level of hire)
  • Training in synthetic organic chemistry methods and analytical tools, in particular LCMS
  • Interest in optimizing chemical reactions for use in DNA encoded library synthesis
  • High level of creativity and productivity with strong problem-solving skills
  • High level of attention to detail and good organizational skills
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.

Fit with Nurix Culture and Values

  • Strongly team-oriented; highly collaborative
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Senior Accounting Manager

Join us in the most challenging and rewarding science of our lives.

Position

Nurix is seeking a Senior Accounting Manager to join its Finance team. You’ll have the unique growth opportunity to partner with the Director of Finance & Controller to build processes, collaborate with cross-functional teams and play a key role in developing the Finance team’s capabilities. Nurix is located in San Francisco’s Mission Bay and the position will report to the Director of Finance & Controller.

Responsibilities

  • Manage all accounting functions, which include:
  • Full GL accounting, payroll, and expense reporting
  • Positive pay with Silicon Valley Bank
  • Review A/P reports for check run
  • Assist with year-end tax filings including 1099’s and Use Tax return
  • Assist with overseeing the monthly, quarterly and year-end close
  • Review and manage journal entries, balance sheet reconciliations, accruals
  • Partner with Controller in the development and management of best practices, policies and procedures
  • Manage two consultants, AP and Senior Accountant
  • Assist with drafting PBC’s for the audit process and interact with auditors
  • Collaborate with business leaders within the company
  • Work on various project-based initiatives

Desired Skills & Experience

  • 6+ years of GL accounting experience with progressive responsibility
  • 3+ years of accounting team management experience
  • Experience with and understanding of US GAAP
  • Strong Excel skills
  • Ability to learn and grow skills quickly
  • Ability to adapt and re-prioritize in a fast-paced, small company environment
  • Excellent written and verbal communication skills
  • Ability to demonstrator strong leadership skills as well as coaching and developing others
  • Experience with accounting ERPs required (NetSuite preferred)
  • Experience with Paylocity and Expensify desirable
  • Experience in the Healthcare or Life Sciences industry desirable

Education

  • Bachelor degree
  • CPA license desirable

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Scientist I/II, Preclinical Pharmacology

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a highly skilled and motivated in vivo pharmacologist to lead efforts in oncology, inflammation, and immuno-oncology. The ideal candidate will have expertise in small molecule PK/PD studies, xenograft and syngeneic tumor models, inflammatory disease models, and immune cell profiling by flow cytometry. This role will support novel drug development projects from early lead optimization through clinical candidate selection. Duties include planning, execution and analysis of in vivo experiments, management of work within the preclinical pharmacology team, and management of projects at CROs. This individual will work closely with scientists from cross-functional disciplines and present findings to project teams. The candidate must be self-driven, highly organized, and enjoy working in a creative and dynamic team environment.

If you are intrigued by the opportunity to work with a passionate team of scientists focused on improving patient’s lives with first-in-class therapies, please consider applying.

Qualifications

  • Ph.D. in pharmacology, immunology, cancer biology or a related field. Scientist II level requires similar background with 3+ years of industry experience.
  • Expertise in oncology, immuno-oncology, inflammation and in vivo models of disease
  • Expertise with flow cytometer-based profiling of immune cells required
  • Expertise in small molecule drug development and PK/PD assay technologies
  • Expertise with hit-to-lead optimization and establishment of PK/PD relationships
  • Proven ability to manage projects, sub-teams, external collaborations, and CROs
  • Knowledge of transgenic model generation and phenotypic characterization desired
  • Writing preclinical reports or sections of IND a plus
  • Requires excellent communication and presentation skills

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Senior Scientist, Preclinical Pharmacology

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a highly skilled and motivated in vivo pharmacologist to lead efforts in oncology, inflammation, and immuno-oncology. The ideal candidate will have expertise in small molecule PK/PD studies, xenograft and syngeneic tumor models, inflammatory disease models, and immune cell profiling by flow cytometry. This role will lead efforts within the group to support novel drug discovery projects from early lead optimization through clinical candidate selection. Responsibilities include strategic planning for projects progressing towards in vivo profiling, assessment and development of genetic models for target validation and compound characterization, management of work within the Preclinical team (PK/PD/efficacy), and management of projects at CROs. This individual will work closely with scientists from cross-functional disciplines and present findings and strategy to project teams, the board, and external collaborators. The candidate must be an accomplished pharmacologist and biologist that has a track record of progressing projects through preclinical development.

If you are intrigued by the opportunity to work with a passionate team of scientists focused on improving patient’s lives with first-in-class therapies, please consider applying.

Qualifications

  • Ph.D. in pharmacology, immunology, cancer biology or a related field with 6+ years of industry experience.
  • Expertise in oncology, immuno-oncology, inflammation and in vivo models of disease
  • Proven ability to identify and develop disease models for preclinical drug development
  • Management experience of direct reports required
  • Experience as lead pharmacology representative on project teams required
  • Expertise with flow cytometer-based profiling of immune cells required
  • Expertise in small molecule drug development and PK/PD assay technologies
  • Expertise with hit-to-lead optimization and establishment of PK/PD relationships
  • Knowledge of transgenic model generation and phenotypic characterization desired
  • Experience writing preclinical reports for IND filings desired
  • Requires excellent communication and presentation skills

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now