Culture & Careers

Job Openings

Chief Medical Officer

Join us in the most challenging and rewarding science of our lives.

Position

The Chief Medical Officer will report directly to the Chief Executive Officer. This position will be engaged in defining and leading the overall clinical strategy, direction and vision of the organization. The successful candidate will lead interactions with regulatory agencies, clinical experts (including KOLs in the field), and work with cross-functional teams to design, develop and implement clinical studies. 

This is a unique opportunity to be a major contributor to the success of a dynamic and well-financed growth stage biotechnology company.

  • Provide strategic input for innovative clinical development plans, incorporating the current therapeutic area landscape
  • Orchestrate and manage clinical aspects of regulatory strategies and interactions with Health Authorities
  • Oversee the analysis and interpretation of clinical trial data and the reporting of clinical trial results
  • Lead interactions with academic thought leaders, investigators, cooperative groups, and other clinical stakeholders including investigator and clinical advisory boards
  • Provide clinical support and work with other members of the management team to develop and communicate the overall corporate strategy
  • Represent the Company and its programs to external audiences, including the medical and regulatory communities, as well as selected investment venues and current and prospective biopharmaceutical collaborators
  • Lead and supervise the Clinical Operations, Regulatory, and Quality Control functions

Professional Experience/Qualifications

  • History of success progressing therapeutic programs from IND-enabling studies through human proof of concept, and/or from Phase 1 to Phase 3 development or NDA approval
  • Multiple years of management experience leading a clinical group including clinical operations, regulatory, and quality control
  • Knowledge of relevant FDA regulations and guidelines and other health authorities; experience in interactions with FDA personnel is essential; experience in interactions with other health authorities a plus
  • Experience with the design, execution, and analysis of clinical oncology studies with small molecule targeted or immunological therapies
  • Experience in translational medicine, clinical pharmacology and early stage development is desirable
  • Excellent knowledge of the competitive environment for drugs in the oncology marketplace and in research and development pipelines
  • Must have a thorough knowledge of clinical research concepts, practices, and GCP and ICH guidelines
  • The successful candidate will possess excellent communication skills and can articulate the Company’s clinical and regulatory strategies and progress to a wide audience including the CEO, the Board of Directors, Company employees, and the investor community
  • Must be science- and data-driven, with an understanding of basic science relevant to clinical oncology
  • Ability to work collaboratively in a fast-paced matrix environment

Education

  • M.D./Ph.D. or M.D. with board certification or eligibility in oncology or hematology/oncology is preferred

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Scientist – Senior Scientist, Degrader Discovery

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a talented and highly motivated scientist with a background in E3 ligase biology and an interest in drug discovery to help us unlock novel E3 ligases for use in the emerging field of targeted protein degradation. In this role you will be responsible for leading ligand discovery campaigns using Nurix’s DNA encoded library (DEL) platform to identify novel ligands for E3 ligases. Working collaboratively with a dynamic multi-disciplinary project team, you will participate in degrader design, evaluation and advancement.

Qualifications

  • Ph.D. scientist with 2+ years of post-degree pharma/biotech/academic experience.
  • In depth knowledge of ubiquitin biology required.
  • Expertise in general biochemical and molecular biology including protein immobilization and qPCR. Experience with Nextgen sequencing is a plus.
  • Experience in the development, optimization and execution of biochemical and biophysical assays.
  • Hands on experience interrogating protein-protein or protein-ligand interactions.
  • Familiarity with principles of degrader technology and/or DNA encoded library discovery is highly preferred.
  • High level of creativity and productivity with strong problem-solving skills.
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Senior Research Associate – Scientist, Medicinal Chemistry

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry to join our Medicinal Chemistry team. You will work with a highly dynamic group that is focused on moving projects from the hit identification stage to the discovery of clinical candidates. The Nurix mission is to control protein fate to treat human diseases leveraging exciting technologies to target protein degradation.

The successful applicant will have demonstrated substantial experience in modern synthetic organic chemistry and standard analytical methods. Having developed an understanding of the physicochemical properties that drive drug discovery are highly desired.

As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of highly experienced scientists within Nurix as well as with external collaborators.

Qualifications

  • BA/BS or equivalent with typically 8+ years of relevant experience or MS with typically 4+ years of relevant experience or Ph.D. in synthetic organic chemistry with 0-4 years industrial chemistry experience (years of relevant experience will impact level of hire)
  • Creative skills in the design, performance and interpretation of chemistry experiments with strong synthetic problem-solving skills using a hypothesis-based approach
  • Excellent communication of project rationale, key experimental results, issues and accomplishments in appropriate verbal and written form
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Maintains an excellent scientific expertise in organic synthesis and a good knowledge of key medicinal chemistry principles
  • Good ability to manage own priorities and deliverables, both independently and in the team setting
  • Familiarity with tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making a strong plus but not required

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Research Associate I-II, Cell Biology/Immunology

Position

We are seeking a Research Associate with experience in cell biology and immunology to join our Nurix drug discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin system to explore the possibility of modulating targets previously believed to be “undruggable”.

Ubiquitin ligases play numerous roles in immune cell function, autoimmunity, inflammation and anti-tumor immunity. The successful candidate will support early drug discovery efforts in inflammation, oncology and immuno-oncology (IO). The candidate’s duties will include execution and analysis of in vitro cellular assays to support small molecule discovery efforts as well as new target ID. This individual will work closely with scientists within the group and present their findings to the department and project teams. The ideal candidate will be self-driven, eager to learn new techniques, highly organized and enjoys working in a creative and dynamic team environment.

Qualifications

  • Bachelor’s degree with 0-4 years experience, or Master’s degree with 0-2 years of industry experience
  • Hands-on experience with mammalian cell culture
  • Experience isolating and working with primary human and mouse immune cells is a plus
  • Experience with cellular assay techniques including ELISA, Western, FACS and/or multiplexing technologies (e.g. Luminex, Quantigene)
  • Experience with medium throughput assays, CRISPR technology, functional assays for human and mouse immune cells (e.g. T cells, NK cells, antigen presenting cells) is a plus
  • Detail oriented and good record keeping skills
  • Background with past experience in ubiquitin biology is a plus
  • Strongly aligned with Nurix’s culture and values

Fit with Nurix Culture and Values

  • Strong team orientation, highly collaborative and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Apply Now

Proteomics Senior Scientist

The Position

We are seeking a highly-skilled Senior Scientist with expertise in Proteomics to join Nurix’s Discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in oncology, immune-oncology and other therapeutic areas. The successful candidate will support Nurix’s drug discovery program and play a leading role in building and implementing proteomics capabilities.

This individual will work closely with an experienced team of interdisciplinary scientists and will have regular opportunities to present findings and opinions to project teams and senior management. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.

Primary Functions

  • Build and run in-house mass spectroscopy-based proteomics capabilities to identify and characterize proteins and their post-translational modifications
  • Utilize mass spectrometry techniques for protein identification and quantification for various sample types including complex mixtures using label-free and label-based techniques
  • Implement new technologies, and develop proteomics workflows including sample preparation and data analyses
  • Design proteomics-based experiments together with the project team, and lead the execution, analyses and interpretation of results
  • Maintain and troubleshoot mass spectrometers as needed

Qualifications

  • Ph.D. in Biochemistry, Cell or Molecular Biology, Chemical Biology or related field with 6+ years post-degree industry experience
  • Demonstrated expertise in operating relevant mass spectrometer instruments (e.g., from Agilent, Sciex and Thermo)
  • Demonstrated experience in designing, executing and analyzing quantitative proteomics experiments (e.g., protein abundance by SILAC and TMT)
  • Experience identifying and localizing post-translational modifications including phosphorylation and ubiquitylation from purified samples to complex mixtures
  • Knowledge of computational methods to analyze diverse mass spectroscopy datasets, including quantification, post-translational modifications and discovery
  • A proven track record (e.g., publication, industry experience, etc.) with excellent interpersonal skills and ability to work in a team environment
  • The successful candidate will be strongly aligned with Nurix’s culture and values; he/she will be team-oriented and highly collaborative with a hands-on approach
  • The candidate should be enthusiastic, driven, and have the ability to work independently and thrive in a dynamic start-up environment

Apply Now

Senior Scientist / Associate Director, Analytical Chemistry

Position:

We are seeking a highly skilled and motivated analytical chemist to join Nurix’s Medicinal Chemistry Team. The successful candidate will support our entire research portfolio including small molecule, heterobifunctional protein-degradation and DNA encoded library teams. Capabilities in our analytical department include structure elucidation by NMR, extensive chromatography applications including SFC as well as identification and characterization of in vitro and in vivo metabolites.

The ideal candidate will:

  • Work closely with the medicinal chemists providing analytical and chromatography expertise in the areas of small molecule purification, separation of enantiomeric mixtures using our in-house SFC and structural elucidation
  • Manage and supervise our high-throughput purification team
  • Troubleshoot and maintain instrumentation, manage instrument service agreements, and develop best practices for their use
  • Develop medicinal chemistry-enabling assays such as kinetic/thermodynamic solubility
  • Collaborate with IT to streamline database entry and manage the data pipeline
  • Be an active member of our project teams by attending project and department meetings and summarizing data
  • Monitor analytical activities of our CROs
  • Participate in experimental design and data analysis

Requirements:

  • Ph.D. in Analytical Chemistry with 5+ years of pharmaceutical/biotech industrial experience or MS with 10+ years of industrial experience.
  • Solid background in developing analytical methods for the purification, characterization, and testing of small molecules utilizing prep HPLC, NMR, and UPLC-MS is essential. Chiral SFC experience (analytical & preparative) is desirable.
  • NMR experience using 2D-NMR, HNMR, and 13CNMR experiments is desirable.
  • Ability to troubleshoot and repair prep HPLC, UPLC-MS and NMR instrumentation is essential.
  • Experience with solubility and chemical stability assessments desirable.
  • Contribute to in vitro and in vivo metabolite identification studies.
  • Excellent communication (oral and written), documentation (record keeping, lab notebook, reports), organization, and interpersonal skills is essential.

Apply Now

Temporary Formulation Development Associate (Part-time)

Position

We are currently seeking an associate to help with analytical chemistry in the formulation laboratory at Nurix Therapeutics.  This will include pre-formulation studies, stability studies, support for formulation development, routine dose analysis, and laboratory maintenance. 

The development associate will work under the guidance of their immediate supervisor and should be self-driven, innovative and thorough in performing a range of novel tasks.  A thorough understanding of how to perform analytical experiments typical of a small molecule formulation development lab is required, while experimental design will remain dynamic across a number of programs in early discovery through clinical development.

Qualifications

Degree in a relevant field (physical sciences or life sciences). Independent, self-motivated and integrates well within a team. Exceptional organizational skills with an ability to work in a high paced team environment to meet deadlines and prioritize work on multiple projects are needed as are excellent oral and written communication skills.

  • Experience with analytical sample preparation and analyzing samples by HPLC for assay and purity. (Empower® experience a plus)
  • Experience in running dissolution, stability and physical testing experiments on solid dosage forms preferred.
  • Experience in formulation for preclinical animal models (solutions and suspensions) and solid oral dosage forms (capsules and tablets) a plus.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Apply Now

Scientist I – Protein Sciences

Position

We are seeking a highly skilled and motivated Scientist with expertise in Protein Sciences to join Nurix’s Protein Sciences group. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in the areas of oncology and immuno-oncology, by utilizing the mechanistic and structural insights to guide drug discovery efforts. The successful candidate will provide scientific leadership and hands-on experience in Nurix’s protein expression and purification efforts to support biochemical, biophysical and structural efforts.   This individual will work closely with an experienced team of interdisciplinary scientists and have regular opportunities to present findings to the project team and senior management. The candidate should have a strong desire to learn new techniques and the ability to incorporate new methodologies into their work. The ideal candidate will be self-driven, resourceful, organized, focused, and enjoy working in a dynamic team environment driven to deliver quality proteins to enable existing drug discovery platforms.

Required Qualifications

  • PhD. in Biophysics, Biochemistry, Cell and Molecular Biology, or related field with 2+ years post-degree experience,
  • Extensive knowledge of protein construct design tailored to elucidate structure-function relations and identification of structural and functional modules,
  • Hands-on expertise on purification of proteins from bacterial, mammalian and insect expression systems for structural and functional applications,
  • Proficient in the operation of purification instrumentation (e.g. AKTA, ultracentrifugation) and purification techniques including but not limited to affinity chromatography, SEC, Ion-Exchange chromatography,
  • Hands-on expertise on protein characterization techniques including SDS-PAGE, Mass spectrometry, Dynamic light scattering, and Differential Scanning Fluorimetry,
  • The candidate should be enthusiastic, driven, have the ability to work independently in a team environment and thrive in a dynamic start-up environment,
  • The successful candidate will be aligned to Nurix’s culture and values; he/she will be team oriented and highly collaborative with a hands-on approach

 Preferred Qualifications

  • Experience with production of intrinsically disordered proteins (IDP’s),
  • General knowledge of immuno-oncology, structural biology, and drug discovery,
  • General knowledge of protein ubiquitylation biochemistry and pathways,
  • Hands-on experience of mammalian expression systems,
  • Experience with production of membrane associated proteins requiring the use of surfactants for purification,
  • Hands-on knowledge of protein purification automation (e.g. AKTA programming for multi-step purifications)
  • Have a record of published work and of presentation at conferences.

Apply Now

Senior Research Scientist – Protein Sciences

Position

We are seeking a highly skilled and motivated Scientist with expertise in Protein Sciences to join Nurix’s Protein Sciences group. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in the areas of oncology and immuno-oncology, by utilizing the mechanistic and structural insights to guide drug discovery efforts. The successful candidate will provide scientific leadership and hands-on experience in Nurix’s protein expression and purification efforts to support biochemical, biophysical and structural efforts.   This individual will work closely with an experienced team of interdisciplinary scientists and have regular opportunities to present findings to the project team and senior management. The candidate should have a strong desire to learn new techniques and the ability to incorporate new methodologies into their work. The ideal candidate will be self-driven, resourceful, organized, focused, and enjoy working in a dynamic team environment driven to deliver quality proteins to enable existing drug discovery platforms.

Required Qualifications

  • Master’s degree in Biochemistry, Cell and Molecular Biology, or related field with 6+ years industry experience (or Bachelor’s degree with 8+ years of industry experience),
  • Hands-on experience in protein expression in insect and/or mammalian cells
  • Hands-on expertise on purification of proteins from bacterial, mammalian and insect expression systems for structural and functional applications,
  • Proficient in the operation of purification instrumentation (e.g. AKTA, ultracentrifugation) and purification techniques including but not limited to affinity chromatography, SEC, Ion-Exchange chromatography,
  • Hands-on expertise on protein characterization techniques including SDS-PAGE, Mass spectrometry, Dynamic light scattering, and Differential Scanning Fluorimetry,
  • The candidate should be enthusiastic, driven, have the ability to work independently in a team environment and thrive in a dynamic start-up environment,
  • The successful candidate will be aligned to Nurix’s culture and values; he/she will be team oriented and highly collaborative with a hands-on approach

Preferred Qualifications

  • Experience with production of intrinsically disordered proteins (IDP’s),
  • General knowledge of immuno-oncology, structural biology, and drug discovery,
  • General knowledge of protein ubiquitylation biochemistry and pathways,
  • Hands-on experience of mammalian expression systems,
  • Experience with production of membrane associated proteins requiring the use of surfactants for purification,
  • Hands-on knowledge of protein purification automation (e.g. AKTA programming for multi-step purifications)
  • Have a record of published work and of presenting at conferences.

Apply Now

Senior Research Scientist / Scientist, Translational Medicine

Position

The successful candidate will be responsible for the design and implementation of biomarker assays to support Nurix’s clinical development programs targeting protein fate for cancer targeted therapy and immunotherapy.  Collaborating with the Discovery and Development organizations, the translational biomarker scientist will be responsible for biomarker identification and characterization in preclinical studies, implementation of state-of-the-art biomarker methods, validation of clinical biomarker assays and tech transfer, and analysis and interpretation of biomarker data to guide early clinical development. 

Specific responsibilities include:

  • Utilize broad technical expertise in cell and tumor biology, biochemistry and molecular biology to design, execute and interpret in vitro and ex vivo experiments to expand mechanistic understanding of Nurix’s clinical development assets.
  • Design and execute translational research studies to identify candidate pharmacodynamic and predictive biomarkers and mechanisms of resistance based on target biology, drug mechanism of action, and patient population
  • Collaborate with project teams, external investigators and contract research organizations to evaluate candidate biomarkers in nonclinical models and patient samples and select optimal assays for clinical evaluation
  • Contribute to relevant sections of clinical documents, regulatory submissions and publications
  • Monitor ongoing clinical biomarker results and provide timely scientific review of clinical biomarker data to guide project decisions
  • Highly motivated, innovative and strong team player. Excellent time management and organizational skills required

Education and Skills Requirements:

  • S. with 8+ years of industry experience or PhD in a relevant scientific area with 3+ years’ experience in translational aspects of drug development
  • Expertise with in vivo models of mechanism is required including oral, IV, SC, IP Dosing of small molecules and collection of tissues, blood etc.
  • Ideally, candidate will have training and/or experience in developing, implementing and qualifying biomarker assays in Immunology, Immuno-oncology, Cancer biology and/or Hematology including assays with primary cells and tissues
  • Broad technical expertise in cell and tumor biology, biochemistry and molecular biology across diverse platforms including FLOW is required
  • Prior role in multidisciplinary projects and teams with ability to integrate cross-functional information is an advantage
  • Excellent interpersonal, verbal and written communication skills, flexibility and demonstrated ability for creative thinking and proactive problem solving are essential for this role

Apply Now

Director of Regulatory Affairs

Position Summary:

The Head of Regulatory Affairs at Nurix will have primary responsibility for the oversight and management of Regulatory matters related to Nurix’s commercial and development product pipeline globally in coordination with key internal stakeholders. In conjunction with that, the Director of Regulatory Affairs will be responsible for the establishment and monitoring of budgets and timelines and will coordinate closely with other cross-functional development team members. Externally, the individual will interface with outside regulatory agencies and business partners regarding, regulatory and registration strategies.

Responsibilities

  • Develop and implement advanced and aggressive global regulatory strategies for multiple assets.
  • Responsible for managing the tactical execution of preparation, review and submission of documents to the FDA and other regulatory authorities.
  • Provide regulatory advice to multidisciplinary teams on the regulatory requirements to support clinical and nonclinical development, including preparation and maintenance of IND and CTA fillings
  • In collaboration with team, perform/manage critical analyses of GXP related data and independently develop strategic/tactical interpretation and implementation
  • Lead multidisciplinary teams in the development and execution of major regulatory documents such as Briefing Package and IMPD
  • Lead, coordinate, write, critically review and provide  input on regulatory filing documents (e.g., eCTD Module 2 summaries, integrated summary documents, Investigator’s Brochure, clinical study reports)
  • Lead and facilitate activities to insure prioritized objectives are successfully delivered, including team preparation for meetings with FDA, EMA, and other regulatory authorities.
  • Lead Regulatory Authority communications/interactions.
  • Interface with global regulatory authorities and consultants as needed
  • Maintain a a strong working knowledge of US, EU and ICH regulatory requirements in commercially relevant geographies; ability to apply knowledge both strategically and operationally to development projects in support of corporate goals.
  • Proactively identify program issues and implement appropriate regulatory strategies to mitigate risk
  • Oversee and ensure compliance with regulatory procedures and work practices
  • Develop and implement regulatory operating guidelines/SOPs and common work practices/strategies within the team
  • Insure support and recommend process improvements for internal regulatory documentation/tracking/archival systems
  • Train, mentor and supervise regulatory employees, consultants/contractors in Regulatory Affairs
  • Maintain a positive team spirit and lead by ethical principles
  • Perform other responsibilities as may be required by Nurix, consistent with a growing, dynamic company.
  • Domestic and international travel as required to establish/support vendor/ partner relationships to maximize the success of the programs (approx. 20%).

Qualifications

  • Bachelor’s degree in a technical field with a graduate degree preferred.
  • 15 years+ regulatory experience in pharmaceutical, biotech or specialty pharma companies. Oncology experience a plus.
  • Regulatory Affairs Certification (RAC) preferredExperience with pharmaceutical, nonclinical, and clinical development of NCEs Experience with pharmaceuticals and biologics preferred; medical device experience is a plus.
  • Demonstrated experience in the preparation and submission of INDs, CTAs, and NDAs and other global submission documents in support of clinical trials and marketing applications and their amendments in conformance with local regulatory requirements.
  • Expert knowledge with GXP/ICH requirements and Guidance in major markets, especially US and EU 
  • Experience with labeling requirements is a plus
  • Experience managing and coaching staff, able to motivate teams
  • Excellent written and verbal communication skills. Strategic thinker, planner with excellent  organizational skills
  • Desirable to have experience in small biotech-flexibility to wear multiple hats as needed
  • Ability to multitask, prioritize, and manage time efficiently in a fast-paced and entrepreneurial environment.
  • Proven ability to effectively work collaboratively in cross functional environment

Apply Now

Senior Research Associate, Translational Medicine

Position

The successful candidate will be responsible for the execution of biomarker assays to support Nurix’s clinical development programs targeting protein fate for cancer targeted therapy and immunotherapy.  Collaborating with the Discovery and Development organizations, the translational biomarker Research Associate will be responsible for executing preclinical studies, and analysis and interpretation of biomarker data to guide early clinical development. 

Specific responsibilities include:

  • Utilize broad technical expertise in cell and tumor biology, biochemistry and molecular biology to execute and interpret in vitro and ex vivo experiments to expand mechanistic understanding of Nurix’s clinical development assets.
  • Execute translational research studies to identify candidate pharmacodynamic and predictive biomarkers and mechanisms of resistance based on target biology, drug mechanism of action
  • Collaborate with project teams, external investigators and contract research organizations to evaluate candidate biomarkers in nonclinical models and patient samples and select optimal assays for clinical evaluation
  • Highly motivated, innovative and strong team player. Excellent time management and organizational skills required

Education and Skills Requirements:

  • S. with 6+ years of industry experience in a relevant scientific area of drug development
  • Expertise with in vivo models of mechanism is required including oral, IV, SC, IP Dosing of small molecules and collection of tissues, blood etc.
  • Ideally, candidate will have training and/or experience implementing and qualifying biomarker assays in Immunology, Immuno-oncology, Cancer biology and/or Hematology including assays with primary cells and tissues
  • Broad technical experience in cell and tumor biology, biochemistry and molecular biology across diverse platforms including FLOW is required
  • Prior role in multidisciplinary projects and teams with ability to integrate cross-functional information is an advantage
  • Excellent interpersonal, verbal and written communication skills, flexibility and demonstrated ability for creative thinking and proactive problem solving are essential for this role

Apply Now