Culture & Careers

Job Openings

Scientist I/II, DNA Encoded Chemistry, Library Discovery

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry and familiarity with the application of DNA encoded chemistry to join our Library Discovery team.

You will join a group with two objectives: 1) Design and synthesize DNA encoded libraries and 2) Utilize these libraries to identify novel chemical matter with the potential to modulate the activity of UPS targets.

You will have demonstrated experience in synthetic organic chemistry and analytical methods. Experience with DNA encoded library synthesis, parallel reaction chemistry, split/pool methods, aqueous chemistry and linker chemistry related to the synthesis of drug conjugates are all valued skills. Familiarity with hit triage, hit to lead campaigns from other discovery platforms, and an understanding of the physicochemical properties that drive drug discovery are desired.

As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators.

Qualifications

  • PhD in synthetic organic chemistry with 0-8 years industrial chemistry experience (years of relevant experience will impact level of hire).
  • Expert in synthetic organic chemistry methods and analytical tools, in particular LCMS
  • High level of creativity and productivity with strong synthetic problem-solving skills.
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.
  • Familiarity with principles of combinatorial chemistry and DNA encoded library technology
  • Interest in optimizing chemical reactions for use in DNA encoded library synthesis.
  • Experience with chemistry involving biological macromolecules, i.e. antibodies and oligonucleotides, linker technologies, or the design and synthesis of chemical biology probes a plus.
  • Familiarity with working with large data sets and the tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making.

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Scientist, Informatics

Join us in the most challenging and rewarding science of our lives.

Position

As an Informatics Scientist, you will interface with fellow scientists across the organization to provide hands-on scientific application support. In this role, you will help fellow scientists effectively use Nurix’s existing tools and applications to capture, analyze, query and report chemical and biological data. You will partner with your Informatics colleagues to identify and implement database-backed solutions to address unmet automation and informatics needs.

Required Skills:

  • BS/MS in Chemistry, BioChemistry, Biology or a related field
  • Minimum 8 years’ experience working with chemical and biological information systems
  • Minimum 8 years’ experience working with databases (Oracle, MySQL, PostGRES, SQLServer) and SQL coding
  • Minimum 8 years’ experience working with data-analysis tools and applications such as Pipeline Pilot or Knime
  • Excellent communication and presentation skills on the phone, in 1×1 meetings, and in a group setting
  • Strong written communication skills to create business-appropriate emails, instant messages, requirements/specifications documents, presentation materials, etc.
  • Proficient in MS Office (Excel, Word, PowerPoint)

Preferred Skills:

  • Experience coding in any of the following: Perl, Python, Java, VB, C/C++
  • Business analysis
  • Data visualization
  • Change control

Apply Now

Senior Associate, Informatics

Join us in the most challenging and rewarding science of our lives.

Position

As a Senior Associate, Informatics, you will interface with fellow scientists across the organization to provide hands-on scientific application support. In this role, you will help fellow scientists effectively use Nurix’s existing tools and applications to capture, analyze, query and report chemical and biological data. You will partner with your Informatics colleagues to implement database-backed solutions to address unmet automation and informatics needs.

Required Skills:

  • BS/MS in Chemistry, BioChemistry, Biology or a related field
  • Minimum 2 years’ experience working with chemical and biological information systems
  • Minimum 2 years’ experience working with databases (Oracle, MySQL, PostGRES, SQLServer) and SQL coding
  • Minimum 2 years’ experience working with data-analysis tools and applications such as Pipeline Pilot or Knime
  • Excellent communication and presentation skills on the phone, in 1×1 meetings, and in a group setting
  • Strong written communication skills to create business-appropriate emails, instant messages, requirements/specifications documents, presentation materials, etc.
  • Proficient in MS Office (Excel, Word, PowerPoint)

Preferred Skills:

  • Experience coding in any of the following: Perl, Python, Java, VB, C/C++
  • Business analysis
  • Data visualization
  • Change control

Apply Now

Senior/Executive, Medical Director, Clinical Development (MD)

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking an experienced clinician with strong leadership skills who is driven by science and the desire to develop novel therapies for cancer patients. The successful candidate will have expertise in the design and conduct of early phase oncology clinical trials and a strong interest in translational medicine.
Reporting to the Chief Development Officer, the Medical Director will be responsible for the design, implementation, monitoring, data analysis and reporting of clinical studies for Nurix’s oncology portfolio. As a member of the Development Leadership team, the successful candidate will play a key role in building and shaping the Development organization at Nurix. The Medical Director will also serve as a medical expert resource for drug discovery teams and business development activities. The role provides an opportunity for leadership growth in a dynamic small company environment.

Specific responsibilities include:

  • Provide strategic input for innovative clinical development plans, incorporating the current therapeutic area landscape
  • Lead the design and implementation of early stage clinical projects, with responsibility for medical aspects of phase 1-2 clinical trials
  • Serve as lead author of clinical documents: protocols, investigator’s brochures, case report form design and data analysis plans
  • Lead preparation of clinical sections of relevant regulatory filings to Health Authorities
  • Partner closely with the Clinical Operations head in the conduct and execution of Nurix’s clinical trials
  • Serve as Medical Monitor for clinical trials, reviewing safety and efficacy data for routine medical data review, trend review, and safety signals from ongoing trials
  • Support exploratory biomarker efforts to aid clinical and project data-driven decisions
  • Lead medical aspects of investigator and clinical advisory boards
  • Develop and manage relationships with key opinion leaders for clinical programs
  • Represent Nurix at external events, including scientific and medical conferences and business development activities

Requirements:

  • MD with board certification or eligibility in Oncology or Hematology/Oncology
  • Five to seven years of drug development experience in biotechnology or pharmaceutical industry, or a combination of academia and industry
  • Proven experience with clinical trial design, execution, medical monitoring, and reporting of controlled clinical trials in oncology including working with external service providers
  • Experience with design, execution, and analysis of Phase 1-2 clinical oncology studies with small molecule targeted or immunological therapies
  • Demonstrable knowledge of regulatory procedures and guidelines in the US and other geographic regions
  • Understanding of basic science relevant to clinical oncology
  • Ability to work collaboratively in a fast-paced matrix environment
  • Excellent written and oral communication skills

Apply Now

Research Associate I/II, DNA Encoded Chemistry, Library Discovery

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a talented and highly motivated scientist to join our Library Discovery team and help us augment our DNA encoded library collection. DEL synthesis requires a hybrid of techniques that are borrowed from chemistry environments: chemical reaction setup, LCMS analysis, SAR evaluation, split and pool library synthesis workflows, parallel reaction development, as well as from biology laboratories: aqueous buffer preparation, centrifuge use, ethanol precipitation of DNA, A260 DNA quantification, gel electrophoresis, bioanalyzer analysis, enzymatic DNA ligation. An exposure to some of these techniques is helpful in training into a DNA encoded scientist.

As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators.

Qualifications

  • BS or MS in life sciences (ex. chemistry, biochemistry, biology) with 0-5 years industrial chemistry experience (years of relevant experience will impact level of hire)
  • Training in synthetic organic chemistry methods and analytical tools, in particular LCMS
  • Interest in optimizing chemical reactions for use in DNA encoded library synthesis
  • High level of creativity and productivity with strong problem-solving skills
  • High level of attention to detail and good organizational skills
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.

Fit with Nurix Culture and Values

  • Strongly team-oriented; highly collaborative
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Cheminformatics / Data Scientist

Join us in the most challenging and rewarding science of our lives.

Position

Much of Nurix’s lead finding efforts derive from our DNA Encoded Library group, which regularly screens large (billions of molecules) combinatorial chemical libraries against therapeutic targets of interest. We are seeking a talented and highly motivated cheminformatics/data scientist to lead exploration, analysis, and knowledge finding efforts for these dense, high quality datasets as we seek to increase the information and learnings extracted. Specific responsibilities will include:

  • Develop and improve computational models of SAR gained from DEL selection data, specifically through the implementation of cutting-edge machine learning frameworks
  • Develop summarization and communication techniques to efficiently transfer SAR knowledge identified from DEL selections to target specific project teams
  • Perform analyses on new DEL selection data and collaborate with DEL scientists in hit triage and selection
  • Implement analysis platforms hosting the new analysis methods, to allow for efficient automated and custom analyses
  • Collaborate with DEL scientists to design new data analysis routines and visuals to augment current interpretation of selection data
  • Support DEL scientists in additional cheminformatics tasks, such as filtering building block collections, performing similarity analyses, basic modeling of hits (ie, docking), etc.

Qualifications 

  • A Ph.D. in cheminformatics, computational chemistry or related discipline, or BS/MS with demonstrated industry experience
  • Experience in modeling complex chemical data in a drug discovery setting using expertise in cheminformatics, including knowledge of techniques such as QSAR and pharmacophore modeling
  • Mastery of big dataset analysis, and experience with appropriate tools for efficient data processing including
  • Significant coding/development experience in at least one high-level programming language (ie, Python, Java, R), as well as demonstrated knowledge of cheminformatics toolkits (ie, OEChem, RDKit, etc.)
  • Demonstrated experience developing and implementing predictive machine learning models based on chemical structure and biological activity data
  • Demonstrated understanding of basic cheminformatics, such as substructure searching/filtering, molecular property calculations, reaction enumeration, etc.
  • Strong communication skills, along with the ability to work well in multidisciplinary teams, are essential
  • Evidence of creative application of computational approaches to problems of biological or chemical interest is necessary
  • Experience with encoded libraries or combinatorial synthesis is a plus

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Apply Now

Temporary Research Associate, Protein Science

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking an enthusiastic candidate with a B.S. in a biological science and 0-2 years research experience in an academic or industry lab to join Nurix’s Protein Science team for a temporary assignment of 6 months to 1 year. The ideal candidate must have basic knowledge and hands on experience in protein expression and purification. The successful candidate will be mentored by a senior member of the protein sciences team to conduct experiments related to protein expression and purification efforts to support biochemical, biophysical and structural efforts.

Primary Functions

This individual will work closely with scientists from cross-functional disciplines. The candidate should have a strong desire to learn new techniques and the ability and interest to cross train in all aspects of protein expression and purification. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.

Qualifications

  • Undergraduate degree in Biochemistry, Cell and Molecular Biology, or similar discipline completed within the last 2 years
  • Hands-on experience in protein expression and purification in an academic or industry setting, including basic knowledge of protein purification and characterization techniques (e.g. IMAC, SEC, IE, SDS-PAGE,UV-Vis), is highly desirable
  • Hands on experience with protein purification systems (e.g. AKTA, Unicorn) preferred
  • Prior knowledge and familiarity of expression platforms (bacteria and insect cells) is a plus
  • Must keep a detailed record of experiments in an electronic laboratory notebook (instruction provided)
  • Must be able to follow protocols and promptly communicate results and difficulties
  • The successful candidate will be aligned to Nurix’s culture and values; he/she will be team oriented and highly collaborative with a hands-on approach
  • The candidate should be enthusiastic, driven, team oriented and have a “can do” attitude

Apply Now