Culture & Careers

Job Openings

Proteomics Senior Scientist

The Position

We are seeking a highly-skilled Senior Scientist with expertise in Proteomics to join Nurix’s Discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in oncology, immune-oncology and other therapeutic areas. The successful candidate will support Nurix’s drug discovery program and play a leading role in building and implementing proteomics capabilities.

This individual will work closely with an experienced team of interdisciplinary scientists and will have regular opportunities to present findings and opinions to project teams and senior management. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.

Primary Functions

  • Build and run in-house mass spectroscopy-based proteomics capabilities to identify and characterize proteins and their post-translational modifications
  • Utilize mass spectrometry techniques for protein identification and quantification for various sample types including complex mixtures using label-free and label-based techniques
  • Implement new technologies, and develop proteomics workflows including sample preparation and data analyses
  • Design proteomics-based experiments together with the project team, and lead the execution, analyses and interpretation of results
  • Maintain and troubleshoot mass spectrometers as needed

Qualifications

  • Ph.D. in Biochemistry, Cell or Molecular Biology, Chemical Biology or related field with 6+ years post-degree industry experience
  • Demonstrated expertise in operating relevant mass spectrometer instruments (e.g., from Agilent, Sciex and Thermo)
  • Demonstrated experience in designing, executing and analyzing quantitative proteomics experiments (e.g., protein abundance by SILAC and TMT)
  • Experience identifying and localizing post-translational modifications including phosphorylation and ubiquitylation from purified samples to complex mixtures
  • Knowledge of computational methods to analyze diverse mass spectroscopy datasets, including quantification, post-translational modifications and discovery
  • A proven track record (e.g., publication, industry experience, etc.) with excellent interpersonal skills and ability to work in a team environment
  • The successful candidate will be strongly aligned with Nurix’s culture and values; he/she will be team-oriented and highly collaborative with a hands-on approach
  • The candidate should be enthusiastic, driven, and have the ability to work independently and thrive in a dynamic start-up environment

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Scientist, Lead Discovery – Targeted Protein Degradation

Position

We are seeking a talented and highly-motivated individual with a background in ubiquitin biology or targeted protein degradation and an interest in drug discovery to join our collaborative team of scientists to greatly expand the toolbox of ubiquitin E3 ligases that can be used for targeted protein degradation. Currently, only a small subset of the >600 E3 ligases are harnessed for this purpose. Using Nurix’s DNA-encoded library (DEL) platform, the successful candidate will design and implement small molecules screens to identify ligands of novel E3 ligases. As part of a multidisciplinary team of biologists, medicinal chemists, and computational chemists, they will play a key role in the subsequent design, evaluation, and advancement of degrader molecules from these novel E3 binders.

 Key Responsibilities

  • Develop rationale for the targeting of specific E3 ligases for use in targeted protein degradation
  • Design and implement DNA-encoded library screens of prioritized E3 ligases to identify novel binders
  • This position will offer the opportunity for the candidate to gain experience in DEL library screening. Prior experience with this technology is helpful but NOT required.
  • Develop biochemical and biophysical assays in support of DEL screen design as well as small molecule binder validation and progression
  • Be an active member of a team of biologists and medicinal and computation chemists that works to incorporate these newly discovered E3 ligase binders into targeted protein degradation molecules, establishing degradation of therapeutic targets both in vitro and in vivo
  • Serve as an internal expert of E3 ligase function with a robust knowledge of E3 ligase biology and the targeted protein degradation field
  • Communicate findings to internal stakeholders through scientific presentations

 Qualifications

  •  Ph.D. scientist with 2+ years of post-degree industry or academic experience
  • In depth knowledge of ubiquitin and E3 ligase biology
  • Experience in the development, optimization and execution of biochemical or biophysical assays to interrogate protein interactions and enzymatic activity
  • Familiarity with principles of targeted protein degradation is preferred.
  • High level of creativity and productivity with strong problem-solving skills.
  • Solid background of scientific accomplishment demonstrated by publications, patents, or presentations.
  • Excellent communication skills and ability to present rationale, key data, issues and accomplishments to other members of the scientific team.
  • Resourceful and open to diverse points of view
  • Good fit with Nurix culture and values of highly collaborative, team-oriented research

Apply Now

Senior Scientist, Lead Discovery – Targeted Protein Degradation

Position

We are seeking a talented and highly-motivated individual with a background in ubiquitin biology or targeted protein degradation and an interest in drug discovery to join our collaborative team of scientists to greatly expand the toolbox of ubiquitin E3 ligases that can be used for targeted protein degradation. Currently, only a small subset of the >600 E3 ligases are harnessed for this purpose. Using Nurix’s DNA-encoded library (DEL) platform, the successful candidate will design and implement small molecules screens to identify ligands of novel E3 ligases. As part of a multidisciplinary team of biologists, medicinal chemists, and computational chemists, they will play a key role in the subsequent design, evaluation, and advancement of degrader molecules from these novel E3 binders.

Key Responsibilities

  • Develop rationale for the targeting of specific E3 ligases for use in targeted protein degradation
  • Design and implement DNA-encoded library screens of prioritized E3 ligases to identify novel binders
  • This position will offer the opportunity for the candidate to gain experience in DEL library screening. Prior experience with this technology is helpful but NOT required.
  • Develop biochemical and biophysical assays in support of DEL screen design as well as small molecule binder validation and progression
  • Be an active member of a team of biologists and medicinal and computation chemists that works to incorporate these newly discovered E3 ligase binders into targeted protein degradation molecules, establishing degradation of therapeutic targets both in vitro and in vivo
  • Serve as an internal expert of E3 ligase function with a robust knowledge of E3 ligase biology and the targeted protein degradation field
  • Communicate findings to internal stakeholders through scientific presentations

Qualifications

  • Ph.D. scientist with 8+ years of post-degree industry experience
  • In depth knowledge of ubiquitin and E3 ligase biology
  • Experience in the development, optimization and execution of biochemical or biophysical assays to interrogate protein interactions and enzymatic activity
  • A proven track record of understanding protein function through biochemical or structural analysis is strongly preferred.
  • Familiarity with principles of targeted protein degradation is preferred.
  • High level of creativity and productivity with strong problem-solving skills.
  • Solid background of scientific accomplishment demonstrated by publications, patents, or presentations.
  • Excellent communication skills and ability to present rationale, key data, issues and accomplishments to other members of the scientific team.
  • Resourceful and open to diverse points of view
  • Good fit with Nurix culture and values of highly collaborative, team-oriented research

Apply Now

Biophysics Scientist

Position

We are seeking a highly skilled and motivated Scientist with expertise in Biophysics to join Nurix’s Discovery team.

You will provide scientific leadership in Nurix’s biophysics efforts to help support our hit identification, hit-to-lead and structural biology efforts. You will play a key role in collecting and interpreting biophysical assay data for ongoing discovery programs, but also will be responsible for implementing novel biophysical assays and techniques to expand our capabilities. You will work closely with an experienced team of interdisciplinary scientists and have regular opportunities to present findings to the project team and senior management.

You should have a strong desire to learn new techniques and incorporate new methodologies into your work.  You must be self-driven, resourceful, organized and focused, and enjoy being a part of a dynamic team in a project-based environment solving challenging scientific problems to benefit patients.

Qualifications

  • Ph.D. in Biochemistry, Biophysics or a related field, or an M.S. with at least three years of relevant work experience, or a B.S. with five years of relevant work experience
  • Experience using biophysical techniques to analyze protein-protein interactions as well as protein-small molecule interactions
  • Hands on experience with Surface Plasmon Resonance (SPR) or Grating-Coupled Interferometry (GCI)
  • Expertise with the kinetic and thermodynamic characterization of ligand binding as well as quantitative data management and analysis
  • Practical experience with biophysical techniques such as Microscale Thermophoresis (MST), Isothermal Titration Calorimetry (ITC), Differential Scanning Fluorimetry (DSF), and Nuclear Magnetic Resonance (NMR) is preferred
  • Excellent communication skills and ability to present rationale, key data, issues and accomplishments to other members of the scientific team
  • Good fit with Nurix culture and values of highly collaborative, team-oriented research

Application Process

Please include a two-page research summary that highlights the above qualifications along with your resume when submitting your application. 

Apply Now

Computational Chemist

Position

We are seeking a talented and highly motivated computational chemist with a strong background in Structure Based Drug Design to join our team. The Nurix mission is to treat human diseases by leveraging exciting new drug discovery technologies such as targeted protein degradation. Nurix Therapeutics is based in the San Francisco Mission Bay research campus. We have a broad pipeline of partnered and in-house programs in multiple therapeutic areas, including strong multi-target partnerships with Gilead Sciences and Sanofi. 

As part of a highly integrated team of computational chemists, structural biologists, medicinal chemists and discovery biologists, you will use state-of-the-art computational software, computer aided drug design and simulation techniques to help drive hit discovery. Your creative thinking will help to push forward the frontier of modelling in targeted protein degradation, lead optimization, and DNA Encoded Library technologies. The successful candidate will independently pursue research projects, implement novel computational workflows and support a dynamic multi-disciplinary team focused on moving projects from the hit identification stage to the discovery of clinical candidates.

Qualifications 

  • Ph.D. in Chemistry, Biology, Biophysics (or related fields) with demonstrated computational chemistry focus
  • Established skills in computer aided drug design
  • Practical working experience in computational chemistry software (e.g. Schrodinger, OpenEye, others)
  • Proven track record in one or more of the following: docking studies, virtual screening, druggability analysis, structure-based design for lead optimization, free energy perturbation and molecular dynamics simulation
  • Excellent communication of design rationale, key experimental results, issues and accomplishments in appropriate verbal and written form 
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations 
  • Maintains an excellent scientific expertise in the latest developments in computational chemistry
  • Good ability to manage own priorities and deliverables, both independently and in the team setting
  • Ability to work effectively in a highly interdisciplinary team
  • Software development skills in a modern programming language (eg Python) a strong plus
  • Industry or comparable academic experience in the field of computational chemistry required, small molecule drug design experience preferred (2+ years)

Fit with Nurix Culture and Values 

  • Strong team orientation; highly collaborative 
  • Solutions and results-oriented focus 
  • Hands-on approach; resourceful and open to diverse points of view 

Apply Now

IT Manager, Head of IT

Position Summary:

As IT Manager, Head of IT, you will proactively manage the IT function at Nurix.  In this role, you will be responsible for leading the IT operational support of the organization, project planning, and identifying and managing the resources to implement the corporate IT strategy.  Areas of responsibility include networking , storage, device/software provisioning, backup & recovery, communications, and education.

Required Skills:

  • 4+ years of experience
    • leading IT support leveraging Managed Service Providers (MSP)
    • setting and managing to annual budgets
    • planning, implementing, and completing IT Projects
    • managing a helpdesk
    • designing and implementing corporate intra/internets
  • Excellent communication and presentation skills on the phone, in 1×1 meetings, and in group settings
  • Strong written communication skills to create business-appropriate emails, instant messages, requirements/specifications documents, project plans, presentation materials, etc.
  • Proficient in MS Office (Excel, Word, PowerPoint)

Preferred Qualifications:

  • Experience in Life Sciences industry highly desirable
  • Business analysis
  • Change control
  • DevOps
  • Automation

Apply Now

Head of Chemistry Manufacturing and Controls (CMC)

Position Summary:

The CMC leader will build and lead a group responsible for CMC-related activities across the portfolio including process chemistry and route development, scale-up efforts during lead optimization, chemical manufacturing, pre-formulation, formulation and manufacture and supply of clinical trial materials. The ideal candidate will be a highly motivated leader with experience and interest in working in a small, entrepreneurial environment with broad responsibilities and opportunities.

Responsibilities

  • Overall responsibility for all drug substance and drug product activities from preclinical development through commercialization
  • Identification, selection and management of Contract Manufacturing Organizations (CMOs) for process optimization, cGMP manufacture of Drug Substance (API) and formulation development and cGMP manufacture of Drug Product (DP) in support of ongoing clinical programs
  • Delivery of robust, scalable and cost-effective manufacturing routes and drug product formulations that meet or exceed the target clinical profile
  • Implement stage appropriate analytical methods and protocols and ensure that all CROs and CMOs are using systems and processes in compliance with all relevant regulatory standards
  • Projection of API and DP needs for preclinical and clinical programs (with clinical team), and associated budgets (with finance team)
  • Management of supply chain and logistics in support of clinical studies
  • Execute plans for the validation and registration of API and DP as required by cGMP, ICH (International Conference of Harmonization) and FDA regulations
  • Prepare and/or review CMC sections of INDs, CTAs, NDAs, MAAs and other regulatory submissions; represent the company as the CMC expert before U.S. and European regulatory authorities
  • Prepare, review or edit cGMP batch records, CMC regulatory and Quality documents
  • Prepare technical reports, publications and oral presentations

Qualifications

  • PhD or MS with 10+ years of experience; Advanced degree in Pharmaceutical Chemistry, Organic Chemistry, Pharmaceutics, Pharmaceutical Science, or related scientific discipline
  • At least 10 years relevant experience in a pharmaceutical or biotechnology CMC/cGMP environment
  • Substantial experience leveraging US and International CRO/CMOs for the manufacture of cGMP APIs and DP to meet aggressive timelines
  • Substantial experience with projects in clinical development e.g. Phase 1 through Phase 3 including multiple pharmaceutical dosage forms (e.g. tablets, capsules, topicals, etc.)
  • Experienced with cGMP manufacturing and IND, CTA and NDA filings; thorough knowledge of relevant FDA and EMEA regulations
  • Experience in supply chain management.
  • Able to identify and resolve critical issues
  • Experience implementing technical, strategic and operational plans
  • Excellent written and verbal communication skills, exceptional interpersonal and management skills to collaborate with and direct the work of others on assigned projects (including both internal teams and external collaborators)
  • Qualities of servant leadership and self-awareness required

Apply Now

Associate Scientist, Formulation Development

We are currently seeking an experienced associate scientist in the development group to work on pre-clinical and clinical formulations of small molecules. This will include pre-formulation studies, stability studies, support for formulation development, routine dose analysis, and laboratory maintenance. The job is focused on oral dosage forms, but other routes may be appropriate.

The associate scientist will work under the guidance of their immediate supervisor and should be self-driven, innovative and thorough in performing a range of novel tasks. The scientist will work in project teams to design in-vivo experiments for screening of compounds. A thorough understanding of how to independently perform analytical experiments typical of an oral small molecule formulation development lab is required, while experimental design will remain dynamic across several programs in early discovery through clinical development.

Qualifications

  • B.S. degree in a relevant field (physical sciences or life sciences). Over 6 years of industrial experience in the pharmaceutical industry. Independent, self-motivated and integrates well within a team. Exceptional organizational skills with an ability to work in a high paced team environment to meet deadlines and prioritize work on multiple projects are needed as are excellent oral and written communication skills.
  • Experience in an analytical chemistry or small molecule formulation lab.
  • Experience with analytical sample preparation and analyzing chemical samples by HPLC for assay and purity. (Empower® experience a plus)
  • Experience in running dissolution, stability and physical testing experiments on solid dosage forms preferred.
  • Knowledge of PK parameters and formulation for early animal studies a plus.
  • Experience in formulation for preclinical animal models (solutions and suspensions) and solid oral dosage forms (capsules and tablets).

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now