Culture & Careers

Job Openings

To be a part of our dynamic team of skilled scientific investigators and talented work force, please check our open positions.

Research Associate/Senior Research Associate, Medicinal Chemistry

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry to join our Medicinal Chemistry team. You will work with a highly dynamic group that is focused on moving projects from the hit identification stage to the discovery of clinical candidates. The Nurix mission is to control protein fate to treat human diseases leveraging exciting technologies to target protein degradation.

The successful applicant will have demonstrated substantial experience in modern synthetic organic chemistry and standard analytical methods. Having developed an understanding of the physicochemical properties that drive drug discovery are highly desired.

As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of highly experienced scientists within Nurix as well as with external collaborators.

Qualifications

  • BA/BS or equivalent with typically 8+ years of relevant experience or MS with typically 4+ years of relevant experience
  • Creative skills in the design, performance and interpretation of chemistry experiments with strong synthetic problem-solving skills using a hypothesis-based approach
  • Excellent communication of project rationale, key experimental results, issues and accomplishments in appropriate verbal and written form
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Maintains an excellent scientific expertise in organic synthesis and a good knowledge of key medicinal chemistry principles
  • Good ability to manage own priorities and deliverables, both independently and in the team setting
  • Familiarity with tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making a strong plus but not required

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Scientist I – Discovery Biology – Contract

We are seeking a highly skilled and motivated immunologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. This individual will work closely with our drug discovery project scientists on lead optimization of novel compounds to evaluate the impact on immune cells and characterize their MOA. The candidate must be self-driven, organized, able to work well with other scientists, and able to thrive in an exciting environment in a rapidly-growing company.

Qualifications

  • Ph.D. in immunology, cancer biology or related field with 0-2+ years of industry experience for Scientist I level position
  • Research experience in the field of immunology with a focus on T cell biology
  • Expertise in functional assays measuring cellular activation, cytokine release, proliferation, and killing
  • Experience in high-dimensional flow cytometry to phenotypically characterize immune cells including both surface and intracellular staining.
  • Experience with in vivo tumor mouse models is desired but not required
  • Develop novel ideas/technologies, eager to learn, innovate.
  • Propose and implement resolutions to technical problems/issues.
  • Work with departmental and/or cross functional peers to execute on assignments

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative; solutions and results-oriented focus
  • Strong scientific curiosity and initiative; hands-on and resourceful
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Company

Nurix, Inc. is a science-minded, goal-oriented organization that is focused on bringing novel, first-in-class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the protein degradation machinery of the cell. The Nurix scientific team has established an innovative drug discovery platform based on recent advances in understanding of the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation, a function vital to the healthy life of a cell, uncovering therapeutic opportunities in multiple disease areas. Nurix’s Protein Regulation Platform enables the discovery of selective inhibitors or activators of the UPS, enabling the discovery of new class of drugs that can restore normal cellular homeostasis. Nurix entered into an exclusive collaboration with Sanofi and Gilead for the discovery and development of next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology. Nurix was founded by internationally recognized experts in the ubiquitin proteasome field and is funded by leading life science investors, Third Rock Ventures and The Column Group. The company is headquartered in San Francisco, California

Apply Now

Senior Scientist– Discovery Biology

We are seeking a highly skilled and motivated immunologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. This individual will work closely with our drug discovery project scientists on lead optimization of novel compounds to evaluate the impact on immune cells and characterize their MOA. The candidate must be self-driven, organized, able to work well with other scientists, and able to thrive in an exciting environment in a rapidly-growing company.

Qualifications

  • Ph.D. in immunology, cancer biology or related field (or Bachelor’s/Master’s degree with >8-10 years industry experience)
  • Research experience in the field of immunology with a focus on T cell and tumor biology
  • Expertise in functional assays measuring cellular activation, cytokine release, proliferation, and killing
  • Hands on experience in development, optimization and execution of high-dimensional flow cytometry to phenotypically characterize immune cells including both surface and intracellular staining, primary human and mouse cell isolation, ELISA, Western and multiplexing technologies
  • Experience with genetic validation in primary cells or model systems utilizing molecular techniques including shRNA/CRISPR knockdown to support target validation and mechanism of action studies for drug candidates
  • Background in ubiquitin biology with past experience is a plus
  • Develop novel ideas/technologies, eager to learn, innovate.
  • Propose and implement resolutions to technical problems/issues.
  • Work with departmental and/or cross functional peers to execute on assignments

 Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative; solutions and results-oriented focus
  • Strong scientific curiosity and initiative; hands-on and resourceful
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

 Company

Nurix, Inc. is a science-minded, goal-oriented organization that is focused on bringing novel, first-in-class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the protein degradation machinery of the cell. The Nurix scientific team has established an innovative drug discovery platform based on recent advances in understanding of the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation, a function vital to the healthy life of a cell, uncovering therapeutic opportunities in multiple disease areas.

Nurix’s Protein Regulation Platform enables the discovery of selective inhibitors or activators of the UPS, enabling the discovery of new class of drugs that can restore normal cellular homeostasis. Nurix entered into an exclusive collaboration with Sanofi and Gilead for the discovery and development of next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology.

Nurix was founded by internationally recognized experts in the ubiquitin proteasome field and is funded by leading life science investors, Third Rock Ventures and The Column Group. The company is headquartered in San Francisco, California

Apply Now

Scientist I – Cell Biology – Contract

We are seeking a highly skilled and motivated cell biologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology.  The successful candidate will support early drug discovery efforts in oncology, immuno-oncology (IO) and inflammation.  Responsibilities will include execution and analysis of in vitro cellular assays to support small molecule discovery efforts as well as new target identification and understanding of mechanisms of action. This individual will work closely with scientists within the group and present their findings to the department and project teams. The ideal candidate will be self-driven, eager to learn new techniques, highly organized and enjoys working in a creative and dynamic team environment. This is a 1-year contract role.

Qualifications

  • Ph.D. in cell biology, immunology or related field (Bachelor’s or Master’s degree with industry experience)
  • Hands-on experience in the development, optimization and execution of cellular assays applying multiple techniques including primary cell isolation, tissue culture, ELISA, flow cytometry, Western and multiplexing technologies (e.g. Luminex, MesoScale)
  • Demonstrated track record in functional assay development in oncology and/or immunology
  • Familiarity with primary cell tissue culture, molecular biology techniques, CRISPR engineering of cells and the use of siRNA/shRNA knockdown techniques to support mechanism of action studies for drug candidates and target identification
  • Ability to conceive, design and execute hypothesis-testing experiments that directly contribute to project success is essential
  • Detail oriented with excellent communication and presentation skills
  • Background in cancer cell biology required with previous experience in the ubiquitin-proteasome (UPS) system a plus

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative; solutions and results-oriented focus
  • Strong scientific curiosity and initiative; hands-on and resourceful
  • Self-drive and enthusiastic with the ability to thrive in a dynamic environment

Company

Nurix was founded by internationally recognized experts in the ubiquitin-proteasome (UPS) field and received its initial funding from leading life science investors Third Rock Ventures and The Column Group.  Nurix recently entered into a multi-year collaboration with Gilead and Sanofi focused on developing bi-functional molecules to degrade protein targets as novel therapeutics.   Additionally, Nurix has a strong internal drug discovery pipeline focused on oncology, immunology and inflammation.  Nurix plans to advance two molecules into clinical trials in early 2021. 

Apply Now

Director/Senior Director, Clinical Scientist

Nurix has a place for an extraordinary, highly motivated, and accomplished Director/Senior Director, Clinical Scientist.

As an integral member of the Clinical Development Team, this person will help to develop innovative solutions for the clinical development of Nurix’s pioneering protein modulation programs in hematology, oncology, and cell therapy. Working in close collaboration with the study teams, the incumbent will provide scientific guidance and support.

This role will is responsible for various aspects of clinical study design and execution including: protocol writing, building study infrastructure, staff training, data cleaning/analysis, investigator interaction and support of regulatory filings. In addition, this role will be responsible for providing supporting rationale for clinical development working closely with the Head of Development.

Job Responsibilities:

  • Participate in and contribute to cross-functional clinical development teams with strong ability to work closely with all team members, address study or other program-specific questions.
  • Develop the Global Development plan with senior clinical development staff
  • Implement Global Development Plan with strategic clinical science support
  • Assist in reviewing and authoring clinical protocol.  Read and interpret scientific and medical literature for the use in clinical documents and to assist clinical team decision making.
  • Prepare clinical portions of all relevant regulatory filings and meeting packages (INDs, Annual Reports, meeting requests, NDAs, etc.) for US and ex-US Health Authorities.
  • Integrate scientific knowledge and operational expertise to ensure translation of clinical research plans into efficiently delivered, high quality studies.
  • Acquire and utilize knowledge of clinical trial design and relevant disease indications to assist in study concept and protocol development. Contribute to discussions concerning scientific and procedural aspects of study design. Coordinate with departments to produce the final protocol and informed consent documents.
  • Compose medical data review plans, Data Safety Monitoring Board (DSMB), Safety Review Committee (SRC) charters, and specific sections of study manuals and investigator meeting materials.
  • Contribute significantly to the development of CRFs, data edit checks, patient profile design, ongoing data cleaning (query generation, coding review, SAE reconciliation) and data trend analysis.
  • Lead internal clinical data review meetings in conjunction with the medical monitor; lead the data preparation effort for dose escalation meeting, as applicable to study stage.
  • Coordinate and manage external medical advisory committees for the study team such as DSMBs and Scientific Steering Committees, in conjunction with the medical monitor.
  • Research and summarize published literature for continual learning and to prepare training materials for other clinical team members.
  • Contribute to statistical analysis plans, table, listing, figure design and the preparation of manuscripts and other presentations of study data, as appropriate.
  • Address investigator questions regarding protocol and related scientific issues and attend site initiation visits (SIVs), in coordination with the medical monitor.
  • Assist in determining the activities to support a project’s priorities within functional area
  • Trains other clinical scientists as needed.

Basic Qualifications

Advanced degree (MD, PhD, or PharmD) and 8+ year’s relevant drug development experience

Preferred Qualifications

  • Experience directly in the clinical science role, in a hematology/oncology indication for first-in-human and proof of concept studies in small molecules and/or cell therapy. Registrational or Phase 3 study experience is preferred.
  • In depth understanding of clinical operations and translational medicine.
  • Excellent interpersonal skills.
  • Able to translate technical concepts into accessible language and direction for the broader study team.
  • Excellent attention to detail, partnership and initiative, with flexibility to adapt to the needs of the organization; maintain meticulous attention to project deadlines.
  • Experienced in Microsoft Office (Excel, Word, PowerPoint, OneNote), and ideally also with job related programs such as Spotfire and Medidata Rave or similar.
  • Strong understanding of ICH GCP, as well as general knowledge of industry practices and standards
  • Commitment to patient safety and clinical compliance.

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view 

Apply Now

Scientist I, Medicinal Chemistry

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry to join our Medicinal Chemistry team. You will work with a highly dynamic group that is focused on moving projects from the hit identification stage to the discovery of clinical candidates. The Nurix mission is to control protein fate to treat human diseases leveraging exciting technologies to target protein degradation.

The successful applicant will have demonstrated substantial experience in modern synthetic organic chemistry and standard analytical methods. Having developed an understanding of the physicochemical properties that drive drug discovery are highly desired.

As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of highly experienced scientists within Nurix as well as with external collaborators.

Qualifications

  • Ph.D. in synthetic organic chemistry with 0-4 years industrial chemistry experience
  • Creative skills in the design, performance and interpretation of chemistry experiments with strong synthetic problem-solving skills using a hypothesis-based approach
  • Excellent communication of project rationale, key experimental results, issues and accomplishments in appropriate verbal and written form
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Maintains an excellent scientific expertise in organic synthesis and a good knowledge of key medicinal chemistry principles
  • Good ability to manage own priorities and deliverables, both independently and in the team setting
  • Familiarity with tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making a strong plus but not required

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Informatics Scientist

As an Informatics Scientist, you will interface with fellow scientists across Research and Development to provide hands-on scientific application support.  In this role, you will help fellow scientists effectively use Nurix’s tools and applications to capture, analyze, query and report R&D data and drive decisions.  You will partner with your Informatics colleagues to identify and implement database-backed solutions to address unmet automation and data management needs.

Required Skills

  • BS/MS/PhD in Chemistry, BioChemistry, Biology or a related field
  • Experience coding in any of the following: Perl, Python, Java, VB, C/C++
  • Minimum _8_ years’ experience working with chemical registration and biological assay data information systems
  • Minimum _8_ years’ experience working with data-analysis tools and applications such as Pipeline Pilot and/or Knime
  • Experience working in validated/regulated systems
  • Excellent communication and presentation skills on the phone, in 1×1 meetings, and in group settings
  • Strong written communication skills to create business-appropriate emails, instant messages, requirements/specifications documents, presentation materials, etc.
  • Proficient in MS Office (Excel, Word, PowerPoint)

Preferred Skills

  • Experience working with databases (Oracle, MySQL, PostgreS, SQLServer) and SQL coding
  • Experience with ChemCart, Dotmatics, ActivityBase, and/or CDD
  • Application of business analysis to document processes and define use cases
  • Project Management
  • Data visualization with applications such as Spotfire or Tableau

Fit with Nurix Culture and Values 

  • Strong team orientation; highly collaborative 
  • Solutions and results-oriented focus 
  • Hands-on approach; resourceful and open to diverse points of view 

Apply Now

Lead Discovery – Research Associate (Temp)

We are seeking a highly motivated individual with a 1+ years lab experience and background in Biochemistry or Molecular Cell Biology to join our Lead Discovery team at Nurix.

This position will perform a number of biochemical and protein-based assays in support of our early drug discovery efforts at Nurix. These will include characterizing the activity of novel small molecules in custom biochemical assays and characterizing protein behavior and stability under various buffer conditions, among other activities. In this role, the applicant will work as part of a highly collaborative, interdisciplinary team of biochemists, structural biologists, cell biologists, and medicinal and computational chemists and will have the opportunity to train in a number of new lab techniques.

The candidate should have a strong desire to learn new techniques and the ability and interest to cross train in all aspects biochemical assay development. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in the dynamic team environment here at Nurix.

Qualifications

  • Bachelor’s or master’s degree in Biochemistry, Molecular and Cell Biology, or related field
  • Familiarity with the concepts of enzyme catalysis, protein-ligand and protein-protein interactions, and the principles that govern these interactions
  • 1+ years of laboratory experience in the areas of biochemistry, protein chemistry, or biophysics. Examples of highly relevant experience include:
    • Work with biochemical assays (e.g. enzymatic, ubiquitylation, protein-protein interaction, fluorescence polarization, FRET, AlphaLISA, etc.)
    • Use of spectrophotometers or fluorescence plate readers (e.g. Perkin Elmer Envision, etc.)
    • Experience with laboratory automation or robotics (e.g. Agilent Bravo, Biomek FX, etc.)
    • Protein purification (e.g. AKTA Purification of proteins from coli or SF9 cells)
  • Experience and proficiency with data processing programs (i.e. Microsoft Excel, GraphPad Prism, etc.)

Fit with Nurix Culture and Values

  • Strong team orientation, highly collaborative and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Apply Now

Manager/Senior Manager/Associate Director – Drug Safety/PV Operations

This position offers a candidate the opportunity to take on a key leadership role in providing direction to the Drug Safety department for adverse event case management, support of study teams and projects, oversight of maintenance of drug safety database, and collaboration to support risk management and pharmacovigilance for all B Therapeutics Clinical Trials and post-marketing (where applicable).

Responsibilities:

  • Responsible for performing critical safety vendor oversight to ensure all pharmacovigilance activities are performed in an efficient, consistent and compliant manner.
  • Accountable for coordination of day-to-day operational ICSR activities in collaboration with designated management personnel at the vendor site(s).
  • Responsible for facilitation of training and development of vendor personnel (remotely and on-site at the vendor site) as required, driving the development of self-sufficiency at the vendor.
  • Manage Vendor Oversight including tracking of KPIs, metrics and QC of SAE/ICSR cases in Safety database.
  • Lead B Therapeutics Safety Operations in ensuring all safety reports received from all clinical trials are processed in a consistent and a fully compliant manner. Manage SAE/SUSAR reporting activities for all investigational drugs (Maintain oversight to ensure Global clinical trials case reporting process is efficient and compliant with reporting requirements).
  • Oversee maintenance of an externally hosted electronic safety database for tracking, storing, and reporting of serious adverse events from B Therapeutics clinical trials.
  • Ensure Global clinical trials case reporting process is efficient and compliant with reporting requirements detailed in the safety management plans (SMP)/ PV agreements and safety data exchange agreements.
  • Review incoming adverse events to determine action required
  • Overall accountability of partnership collaboration on the exchange of safety data, safety monitoring, and the safety profile of investigational drugs as defined in Pharmacovigilance Agreements
  • Lead preparation of safety-related plans with partners and CROs
  • Provide guidance and support to project teams for safety-related areas, including protocol development and study conduct
  • Contribute to preparation of relevant safety sections of clinical study reports, annual reports, expedited safety reports and other regulatory filing documents
  • Assist as needed with the preparation and updates to Investigator Brochures, DSURs, Protocols, ICFs, etc.
  • Lead Staff PV training and external CRO’s on drug safety principles and procedures, including training GVP Modules and key relevant US & EMA safety-related Guidance documents and procedures
  • Assist with response to safety-related queries from regulatory authorities or Ethics Committees, if needed
  • Collaborate to ensure alignment among case handling, aggregate reporting, and signal detection activities
  • Support the development and review of appropriate safety sections of key product documents including: IBs (including RSI determination), study protocols, ICF, CSRs, CCDS, RMP, REMS
  • Assist with the ongoing review TFLs and AE data from ongoing studies to evaluate common AEs, lab abnormalities, and summarize the results in the product safety reports
  • Conduct safety data review and analysis, summarize safety data in support of regulatory submission activities, signal detection and management activities, or in response to ad hoc safety inquiries from health authorities, track all safety related activities
  • Support projects or other initiatives from cross functional groups and departments (Clinical Development, Regulatory Affairs, Quality and Toxicity), ensure adequate safety support and timely update of safety information to drug safety physicians
  • Supports the development of B Therapeutics Drug Safety infrastructure, including new safety projects and set-up of safety systems applicable to safety data from the medical and scientific perspective
  • Oversee deviation and CAPA activities in relation to, but not limited to, late SUSAR or aggregate report submissions as well as deviations relating to case management processes as defined per the SMPs or SOPs
  • Participate in regulatory inspections and PV audits to ensure the quality, integrity and compliance with pharmacovigilance and safety reporting requirements

Requirements:

  • Education: Master in life sciences, PharmD, RPh, Ph.D., RN, PA
  • Experience: minimum 5-year experience in pharmacovigilance in a pharmaceutical or biotechnology company.
  • Solid understanding and working knowledge of US and ex-US pharmacovigilance regulatory requirements (e.g., US Code of Federal regulations; European Union GVP legislation; and ICH Guidelines)
  • Experienced in pre- and post-approval pharmacovigilance activities, including safety reporting, signal detection activities (safety data analysis, categorization, assessment).
  • Solid clinical knowledge and strong analytical ability to review, evaluate, interpret, and synthesize clinical and safety data.
  • Strong proficiency in verbal and written communication; great attention to detail, ability to meet project deadlines
  • Ability to work independently, to manage work priorities, to build collaborative team relationships at all levels and remain flexible to the needs of the teams/projects

Apply Now

Associate Director/Director, New Product Planning (NPP)

This position offers a candidate the opportunity to significantly contribute to the long-term commercial success of the portfolio, and is responsible for providing commercial assessments of key early stage product planning opportunities, market research activities, lifecycle planning, competitive positioning and preferred product presentation.

Key Responsibilities

  • Support and participate in the development of forward-looking strategies, market positioning and product profiles for Autoimmune and Oncology pipeline products by synthesizing primary and secondary inputs that will inform the development and lifecycle plan
  • Drive completion of NPP and market research initiatives and work closely with the project teams to track key milestone progress across pipeline programs
  • Serve as an active member of product teams in the early stage development of the Autoimmune and Oncology portfolio ensuring strategic commercial insight with internal business partners (research, clinical, CMC, etc) to optimize the market value of assets
  • Manage external consulting partners (e.g., strategy consultants, market research) to update commercial assessment tool(s) as needed and proactively seek out ways to improve assessments
  • Track, understand, and communicate the therapeutic market trends across multiple perspectives (e.g. commercial, managed markets, clinical, and scientific)
  • Proactively monitor and evaluate market developments and changes in competitive landscape for key therapeutic areas/markets
  • Provide early market assessments and develop value proposition, business cases and early forecasts to prioritize commercial indications for products in key therapeutic areas
  • Manage assigned budget

Basic Requirements and Education

  • Bachelor’s degree or equivalent, advanced degree (MBA) a plus
  • Background or degree in science a plus
  • Minimum of 8-10 years’ experience in commercial roles, e.g. NPP, specialty pharmaceutical marketing, market research; 3 – 5 years of oncology and/or autoimmune brand marketing and product launch experience preferred
  • Previous experience in a commercial assessment role that required comprehensive understanding of therapeutic markets from multiple customer perspectives (e.g., HCP, Payers, Patients) and/or different business perspectives (e.g., clinical, R&D, marketing)
  • Strong understanding of managed care, access, regulatory and pricing dynamics

Preferred Skills and Knowledge Requirements

  • Significant analytic skills, able to clearly interpret and distill scientific, clinical and commercial information
    • Basic understanding of key marketing and market research principles
    • Familiarity with secondary research and databases
  • Ability to effectively plan, prioritize, execute, follow up and anticipate challenges
  • Ability to work, influence, and gain consensus across multiple functions (e.g. research, clinical, regulatory, translational medicine)
  • Excellent organization, communication (written and oral) and facilitation skills
  • Self-motivated, builds trust easily and operates with integrity and ethics
  • Demonstrated learning agility
  • Strong history of delivering high quality, sustainable results using skills and capabilities

Apply Now

Scientist II/Senior Scientist, Preclinical Pharmacology

We are seeking a highly skilled and motivated in vivo pharmacologist to lead efforts in oncology, immuno-oncology, and inflammation. The ideal candidate will have expertise in small molecule PK/PD studies, xenograft and syngeneic tumor models, inflammatory disease models, and immune cell profiling by flow cytometry. This role will support novel drug development projects from early lead optimization through clinical candidate selection. Duties include planning, execution and analysis of in vivo experiments, management of work within the preclinical pharmacology team, and management of projects at CROs. This individual will work closely with scientists from cross-functional disciplines and present findings to project teams. The candidate must be self-driven, highly organized, and enjoy working in a creative and dynamic team environment. 

If you are intrigued by the opportunity to work with a passionate team of scientists focused on improving patient’s lives with first-in-class therapies, please consider applying.

Qualifications

  • Ph.D. in pharmacology, immunology, cancer biology or a related field. Scientist II requires 3+ years of industry experience; Senior Scientist requires 6+ years
  • Expertise in oncology, immuno-oncology, inflammation and in vivo models of disease
  • Proven ability to identify and develop disease models for preclinical drug development
  • Management experience of direct reports required
  • Experience as lead pharmacology representative on project teams required
  • Expertise with flow cytometer-based profiling of immune cells required
  • Expertise in small molecule drug development and PK/PD assay technologies
  • Expertise with hit-to-lead optimization and establishment of PK/PD relationships
  • Knowledge of transgenic model generation and phenotypic characterization desired
  • Experience writing preclinical reports for IND filings desired
  • Requires excellent communication and presentation skills

Apply Now

Manager/Sr. Manager Laboratory Automation and Sample Management

Nurix is seeking a highly skilled and motivated laboratory automation specialist to work as part of cross-functional teams in three areas: compound management, high throughput chemical synthesis and biological assay automation. The successful candidate will build and lead a compound and sample management function, being accountable for storage, retrieval and distribution of compounds for biological assay as well as chemical building blocks for parallel synthesis. Working closely with Medicinal Chemists, and DNA-encoded library chemists, the automation specialist will assist in transferring chemistry from benchtop to automated liquid handling systems and integrated robotic platforms. Working with assay scientist, the automation specialist will identify areas where cell-based and biochemical assays can be migrated from benchtop to automated liquid handling systems and integrated robotic platforms.

You will:

  • Collaborate with scientists from multiple disciplines (internal and external) to design and implement workflows for sample distribution
  • Work with Medicinal Chemists and DNA-encoded library chemists to automate parallel chemical synthesis, DEL synthesis and DEL hit resynthesis
  • Develop, write and train on Operating Procedures for compound management and sample distribution
  • Program methods for liquid handlers, tube sorters, barcode readers and other automation
  • Integrate laboratory automation with LIMS systems
  • Manage the receipt and storage of compounds and samples for biological assay, and parallel organic chemistry
  • Manage registration data QC for purchased compounds
  • Oversee the work of lab technicians

Education

  • BS Degree in Chemistry, Chemical Engineering, Biology or related discipline required

Experience & Attributes

  • Five (5) years of applicable experience within the life sciences industry
  • Experience with Hamilton Vantage liquid handling systems.
  • Proficient in method development using Hamilton’s Instinct V software
  • Track record of developing automated processes
  • Hands-on experience in compound management and an excellent understanding of underlying processes
  • Experience operating, programming and troubleshooting various instrumentation including acoustic dispensers span-8, 384 well pipetting systems, plate handlers, tube sorters.

Apply Now

Manager, Payroll and Equity

This is a newly created position to oversee both payroll and stock administration primarily. The successful candidate will be responsible for the day-to-day operations and transactions as well as month-end accounting close and reconciliations in a fast-paced and dynamic environment. The individual will work closely with various parties including employees, HR, legal, broker, transfer agent, outsourced stock admin firm and financial auditors.

Essential Duties and Responsibilities in Payroll Administration

  • Manage semi-monthly payroll for both exempt and non-exempt employees in a multi-state environment with accuracy
  • Prepare payroll and tax reports for Federal, states, and local agencies when required
  • Ensure compliance with policy and procedure as well as federal, state and local payroll tax   regulations
  • Coordinate with HR to assure seamless and timely integration of information for payroll processing and reporting
  • Perform FSA and ESPP reconciliations and resolve discrepancies
  • Prepare journal entries and monthly payroll reconciliations
  • Address employee inquiries in a timely manner
  • Assist with year-end audits, workers compensation audits, 401(k) audits, and regulatory filings
  • Maintain good recordkeeping of all payroll files and sound internal controls

Essential Duties and Responsibilities in Stock Administration

  • Prepare and process new equity awards, exercises, cancellations and releases promptly.   
  • Manage open enrollment process and purchases for ESPP.
  • Administer the stock option awards and ESPP plans, including ensuring appropriate payroll tax withholdings, timely estimated tax deposits and monitoring ESPP limits
  • Track and report W-2 income from stock exercises and dispositions
  • Execute trading blackout periods and enforcement of insider trading policy restrictions
  • Interact with transfer agent and stock investment broker to ensure that trades are settled timely
  • Maintain and update stock databases, prepare reports and perform analysis and reconciliations, assist with quarterly and year-end audits
  • Engage in process improvements opportunities to support business growth while maintaining sound internal controls and be in compliance with Sarbanes-Oxley Act
  • Assist in month end close and other ad hoc tasks or projects as assigned

Requirements

  • Bachelor’s Degree in Accounting or Finance
  • 7+ years of relevant experience in payroll processing, stock administration and related accounting analysis and month-end reconciliations
  • Ability to work well independently and as a team member in a time sensitive environment
  • Unquestionable ethics and discretion when dealing with confidential and sensitive data
  • Strong Excel skills
  • Exceptional ability to prioritize, organize and manage multiple projects simultaneously
  • Self-motivated and proactive, able to multi-task, and detail oriented
  • Strong verbal and written communication skills, as well as effective listening and interpersonal skills

Preferred Experience

  • Experience with NetSuite, Paylocity and ShareWorks is a plus
  • CPP or CEP designations a plus

Apply Now

Research Associate/Senior Research Associate, Discovery Biology

We are seeking a skilled and motivated individual with expertise in cell biology and immunology to join our Discovery Biology team. The successful candidate will support early drug discovery efforts in Immunology, Oncology, and Immuno-Oncology. These duties will include planning, execution and analysis of in vitro cellular assays to support small molecule discovery efforts, mechanistic studies, and new target identification. This individual will work closely with scientists from cross-functional disciplines and present findings to project teams. The ideal candidate will be self-driven, eager to learn new techniques, highly organized, focused, and enjoy working in a creative and dynamic team environment.

Required Qualifications

  • For RA: Bachelor’s or Master’s degree with 2-5 years of industry experience
  • For SRA: Master’s degree in Biochemistry, Cell and Molecular Biology, or related field with 6+ years industry experience (or Bachelor’s degree with 8+ years of industry experience)
  • Extensive hands-on experience with cell culture (cell lines or primary cells) and good aseptic technique
  • Hands-on experience in development, optimization and execution of multiple immune and cellular assays including primary cell isolation, ELISA, and western blot
  • Experience with molecular biology techniques and shRNA/CRISPR knockdown
  • Prior experience with quantitative medium-to-high throughput assays for assessing cellular phenotypes (FRET-based assays, luminescence assays, flow cytometry, MesoScale)
  • Strong organizational skills and experience presenting results to multi-disciplinary scientific teams

Bonus Qualifications

  • Flow cytometry experience strongly desired
  • Experience performing functional immune assays (e.g. migration, activation, cytokine secretion, differentiation, target cell killing) with primary human cells
  • Experience with additional cellular and molecular techniques such as high-content imaging or RNAseq
  • Background in ubiquitin biology or targeted protein degradation

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now