Culture & Careers

Job Openings

Scientist, Informatics

Join us in the most challenging and rewarding science of our lives.

Position

As an Informatics Scientist, you will interface with fellow scientists across the organization to provide hands-on scientific application support. In this role, you will help fellow scientists effectively use Nurix’s existing tools and applications to capture, analyze, query and report chemical and biological data. You will partner with your Informatics colleagues to identify and implement database-backed solutions to address unmet automation and informatics needs.

Required Skills:

  • BS/MS in Chemistry, BioChemistry, Biology or a related field
  • Minimum 8 years’ experience working with chemical and biological information systems
  • Minimum 8 years’ experience working with databases (Oracle, MySQL, PostGRES, SQLServer) and SQL coding
  • Minimum 8 years’ experience working with data-analysis tools and applications such as Pipeline Pilot or Knime
  • Excellent communication and presentation skills on the phone, in 1×1 meetings, and in a group setting
  • Strong written communication skills to create business-appropriate emails, instant messages, requirements/specifications documents, presentation materials, etc.
  • Proficient in MS Office (Excel, Word, PowerPoint)

Preferred Skills:

  • Experience coding in any of the following: Perl, Python, Java, VB, C/C++
  • Business analysis
  • Data visualization
  • Change control

Apply Now

Senior Associate, Informatics

Join us in the most challenging and rewarding science of our lives.

Position

As a Senior Associate, Informatics, you will interface with fellow scientists across the organization to provide hands-on scientific application support. In this role, you will help fellow scientists effectively use Nurix’s existing tools and applications to capture, analyze, query and report chemical and biological data. You will partner with your Informatics colleagues to implement database-backed solutions to address unmet automation and informatics needs.

Required Skills:

  • BS/MS in Chemistry, BioChemistry, Biology or a related field
  • Minimum 2 years’ experience working with chemical and biological information systems
  • Minimum 2 years’ experience working with databases (Oracle, MySQL, PostGRES, SQLServer) and SQL coding
  • Minimum 2 years’ experience working with data-analysis tools and applications such as Pipeline Pilot or Knime
  • Excellent communication and presentation skills on the phone, in 1×1 meetings, and in a group setting
  • Strong written communication skills to create business-appropriate emails, instant messages, requirements/specifications documents, presentation materials, etc.
  • Proficient in MS Office (Excel, Word, PowerPoint)

Preferred Skills:

  • Experience coding in any of the following: Perl, Python, Java, VB, C/C++
  • Business analysis
  • Data visualization
  • Change control

Apply Now

Cheminformatics / Data Scientist

Join us in the most challenging and rewarding science of our lives.

Position

Much of Nurix’s lead finding efforts derive from our DNA Encoded Library group, which regularly screens large (billions of molecules) combinatorial chemical libraries against therapeutic targets of interest. We are seeking a talented and highly motivated cheminformatics/data scientist to lead exploration, analysis, and knowledge finding efforts for these dense, high quality datasets as we seek to increase the information and learnings extracted. Specific responsibilities will include:

  • Develop and improve computational models of SAR gained from DEL selection data, specifically through the implementation of cutting-edge machine learning frameworks
  • Develop summarization and communication techniques to efficiently transfer SAR knowledge identified from DEL selections to target specific project teams
  • Perform analyses on new DEL selection data and collaborate with DEL scientists in hit triage and selection
  • Implement analysis platforms hosting the new analysis methods, to allow for efficient automated and custom analyses
  • Collaborate with DEL scientists to design new data analysis routines and visuals to augment current interpretation of selection data
  • Support DEL scientists in additional cheminformatics tasks, such as filtering building block collections, performing similarity analyses, basic modeling of hits (ie, docking), etc.

Qualifications 

  • A Ph.D. in cheminformatics, computational chemistry or related discipline, or BS/MS with demonstrated industry experience
  • Experience in modeling complex chemical data in a drug discovery setting using expertise in cheminformatics, including knowledge of techniques such as QSAR and pharmacophore modeling
  • Mastery of big dataset analysis, and experience with appropriate tools for efficient data processing including
  • Significant coding/development experience in at least one high-level programming language (ie, Python, Java, R), as well as demonstrated knowledge of cheminformatics toolkits (ie, OEChem, RDKit, etc.)
  • Demonstrated experience developing and implementing predictive machine learning models based on chemical structure and biological activity data
  • Demonstrated understanding of basic cheminformatics, such as substructure searching/filtering, molecular property calculations, reaction enumeration, etc.
  • Strong communication skills, along with the ability to work well in multidisciplinary teams, are essential
  • Evidence of creative application of computational approaches to problems of biological or chemical interest is necessary
  • Experience with encoded libraries or combinatorial synthesis is a plus

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Apply Now

Chief Medical Officer

Join us in the most challenging and rewarding science of our lives.

Position

The Chief Medical Officer will report directly to the Chief Executive Officer. This position will be engaged in defining and leading the overall clinical strategy, direction and vision of the organization. The successful candidate will lead interactions with regulatory agencies, clinical experts (including KOLs in the field), and work with cross-functional teams to design, develop and implement clinical studies. 

This is a unique opportunity to be a major contributor to the success of a dynamic and well-financed growth stage biotechnology company.

  • Provide strategic input for innovative clinical development plans, incorporating the current therapeutic area landscape
  • Orchestrate and manage clinical aspects of regulatory strategies and interactions with Health Authorities
  • Oversee the analysis and interpretation of clinical trial data and the reporting of clinical trial results
  • Lead interactions with academic thought leaders, investigators, cooperative groups, and other clinical stakeholders including investigator and clinical advisory boards
  • Provide clinical support and work with other members of the management team to develop and communicate the overall corporate strategy
  • Represent the Company and its programs to external audiences, including the medical and regulatory communities, as well as selected investment venues and current and prospective biopharmaceutical collaborators
  • Lead and supervise the Clinical Operations, Regulatory, and Quality Control functions

Professional Experience/Qualifications

  • History of success progressing therapeutic programs from IND-enabling studies through human proof of concept, and/or from Phase 1 to Phase 3 development or NDA approval
  • Multiple years of management experience leading a clinical group including clinical operations, regulatory, and quality control
  • Knowledge of relevant FDA regulations and guidelines and other health authorities; experience in interactions with FDA personnel is essential; experience in interactions with other health authorities a plus
  • Experience with the design, execution, and analysis of clinical oncology studies with small molecule targeted or immunological therapies
  • Experience in translational medicine, clinical pharmacology and early stage development is desirable
  • Excellent knowledge of the competitive environment for drugs in the oncology marketplace and in research and development pipelines
  • Must have a thorough knowledge of clinical research concepts, practices, and GCP and ICH guidelines
  • The successful candidate will possess excellent communication skills and can articulate the Company’s clinical and regulatory strategies and progress to a wide audience including the CEO, the Board of Directors, Company employees, and the investor community
  • Must be science- and data-driven, with an understanding of basic science relevant to clinical oncology
  • Ability to work collaboratively in a fast-paced matrix environment

Education

  • M.D./Ph.D. or M.D. with board certification or eligibility in oncology or hematology/oncology is preferred

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Scientist – Senior Scientist, Degrader Discovery

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a talented and highly motivated scientist with a background in E3 ligase biology and an interest in drug discovery to help us unlock novel E3 ligases for use in the emerging field of targeted protein degradation. In this role you will be responsible for leading ligand discovery campaigns using Nurix’s DNA encoded library (DEL) platform to identify novel ligands for E3 ligases. Working collaboratively with a dynamic multi-disciplinary project team, you will participate in degrader design, evaluation and advancement.

Qualifications

  • Ph.D. scientist with 2+ years of post-degree pharma/biotech/academic experience.
  • In depth knowledge of ubiquitin biology required.
  • Expertise in general biochemical and molecular biology including protein immobilization and qPCR. Experience with Nextgen sequencing is a plus.
  • Experience in the development, optimization and execution of biochemical and biophysical assays.
  • Hands on experience interrogating protein-protein or protein-ligand interactions.
  • Familiarity with principles of degrader technology and/or DNA encoded library discovery is highly preferred.
  • High level of creativity and productivity with strong problem-solving skills.
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Senior Research Associate – Scientist, Medicinal Chemistry

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry to join our Medicinal Chemistry team. You will work with a highly dynamic group that is focused on moving projects from the hit identification stage to the discovery of clinical candidates. The Nurix mission is to control protein fate to treat human diseases leveraging exciting technologies to target protein degradation.

The successful applicant will have demonstrated substantial experience in modern synthetic organic chemistry and standard analytical methods. Having developed an understanding of the physicochemical properties that drive drug discovery are highly desired.

As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of highly experienced scientists within Nurix as well as with external collaborators.

Qualifications

  • BA/BS or equivalent with typically 8+ years of relevant experience or MS with typically 4+ years of relevant experience or Ph.D. in synthetic organic chemistry with 0-4 years industrial chemistry experience (years of relevant experience will impact level of hire)
  • Creative skills in the design, performance and interpretation of chemistry experiments with strong synthetic problem-solving skills using a hypothesis-based approach
  • Excellent communication of project rationale, key experimental results, issues and accomplishments in appropriate verbal and written form
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Maintains an excellent scientific expertise in organic synthesis and a good knowledge of key medicinal chemistry principles
  • Good ability to manage own priorities and deliverables, both independently and in the team setting
  • Familiarity with tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making a strong plus but not required

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Research Associate I-II, Cell Biology/Immunology

Position

We are seeking a Research Associate with experience in cell biology and immunology to join our Nurix drug discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin system to explore the possibility of modulating targets previously believed to be “undruggable”.

Ubiquitin ligases play numerous roles in immune cell function, autoimmunity, inflammation and anti-tumor immunity. The successful candidate will support early drug discovery efforts in inflammation, oncology and immuno-oncology (IO). The candidate’s duties will include execution and analysis of in vitro cellular assays to support small molecule discovery efforts as well as new target ID. This individual will work closely with scientists within the group and present their findings to the department and project teams. The ideal candidate will be self-driven, eager to learn new techniques, highly organized and enjoys working in a creative and dynamic team environment.

Qualifications

  • Bachelor’s degree with 0-4 years experience, or Master’s degree with 0-2 years of industry experience
  • Hands-on experience with mammalian cell culture
  • Experience isolating and working with primary human and mouse immune cells is a plus
  • Experience with cellular assay techniques including ELISA, Western, FACS and/or multiplexing technologies (e.g. Luminex, Quantigene)
  • Experience with medium throughput assays, CRISPR technology, functional assays for human and mouse immune cells (e.g. T cells, NK cells, antigen presenting cells) is a plus
  • Detail oriented and good record keeping skills
  • Background with past experience in ubiquitin biology is a plus
  • Strongly aligned with Nurix’s culture and values

Fit with Nurix Culture and Values

  • Strong team orientation, highly collaborative and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Apply Now

Temporary Research Associate, Analytical Chemistry

Position

We are seeking a talented and highly motivated chemist with some experience and strong aptitude in analytical chemistry to join our Analytical Chemistry team. You will work with a highly dynamic group that is focused on moving projects from the hit identification stage to the discovery of clinical candidates. The Nurix mission is to control protein fate to treat human diseases leveraging exciting technologies to target protein degradation.

The successful applicant will have demonstrated some experience in modern analytical chemistry and standard analytical methods. Experience in analytical and preparative supercritical fluid chromatography (SFC) as well as reversed-phase LCMS are highly desired. Experience in analysis of in vitro ADME properties and NMR data acquisition are also desired.

As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of highly experienced scientists within Nurix.

Qualifications

• BA/BS or equivalent with up to 2+ years of relevant experience with 0-4 years industrial chemistry experience (years of relevant experience will impact level of hire);
• Can repeat and follow detailed scientific procedures with supervision;
• Knowledge of basic analytical chemistry concepts, practices and procedures, in particular as they relate to chromatography;
• Ability to take direction from experienced scientists and contributes in a team environment;
• Able to clearly present technical information verbally and in writing to supervisor;
• Good interpersonal skills and is willing to ask questions about procedures and concepts;
• Aptitude and willingness to gain more skills and knowledge in analytical chemistry in particular chromatography, but also NMR and in vitro ADME properties.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Apply Now

Proteomics Senior Scientist

The Position

We are seeking a highly-skilled Senior Scientist with expertise in Proteomics to join Nurix’s Discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in oncology, immune-oncology and other therapeutic areas. The successful candidate will support Nurix’s drug discovery program and play a leading role in building and implementing proteomics capabilities.

This individual will work closely with an experienced team of interdisciplinary scientists and will have regular opportunities to present findings and opinions to project teams and senior management. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.

Primary Functions

  • Build and run in-house mass spectroscopy-based proteomics capabilities to identify and characterize proteins and their post-translational modifications
  • Utilize mass spectrometry techniques for protein identification and quantification for various sample types including complex mixtures using label-free and label-based techniques
  • Implement new technologies, and develop proteomics workflows including sample preparation and data analyses
  • Design proteomics-based experiments together with the project team, and lead the execution, analyses and interpretation of results
  • Maintain and troubleshoot mass spectrometers as needed

Qualifications

  • Ph.D. in Biochemistry, Cell or Molecular Biology, Chemical Biology or related field with 6+ years post-degree industry experience
  • Demonstrated expertise in operating relevant mass spectrometer instruments (e.g., from Agilent, Sciex and Thermo)
  • Demonstrated experience in designing, executing and analyzing quantitative proteomics experiments (e.g., protein abundance by SILAC and TMT)
  • Experience identifying and localizing post-translational modifications including phosphorylation and ubiquitylation from purified samples to complex mixtures
  • Knowledge of computational methods to analyze diverse mass spectroscopy datasets, including quantification, post-translational modifications and discovery
  • A proven track record (e.g., publication, industry experience, etc.) with excellent interpersonal skills and ability to work in a team environment
  • The successful candidate will be strongly aligned with Nurix’s culture and values; he/she will be team-oriented and highly collaborative with a hands-on approach
  • The candidate should be enthusiastic, driven, and have the ability to work independently and thrive in a dynamic start-up environment

Apply Now