Culture & Careers

Job Openings

Head of Analytical Chemistry (Senior Scientist / Associate Director)

Position

We are seeking an experienced scientific leader to grow the world class Analytical Group within Nurix. The successful candidate will support our entire research portfolio including small molecule, heterobifunctional protein-degradation, DNA encoded library, and DMPK teams. We are seeking an exceptional person with extensive analytical and in vitro ADME experience to lead our Analytical Group. Current capabilities in our Analytical Department include structure elucidation by NMR, extensive purification capabilities including SFC, physicochemical profiling, and automated synthesis. We are expecting the successful candidate to provide leadership and a keen interest to add additional capacity and capability to the existing platform.

The ideal candidate will:

  • Provide leadership, strategic direction, and mentorship to the Analytical Chemistry Group
  • Supervise our high-throughput purification and SFC groups as well as automated synthesis teams.
  • Support project teams and individuals with structure confirmation experiments.
  • Develop a suite of medicinal chemistry-enabling in vitro ADME assays such as hepatocyte and microsomal clearance, plasma stability, kinetic/thermodynamic solubility, protein binding, and metabolite ID.
  • Provide initial assessments for analytical development such as forced degradation and in process impurities.
  • Monitor analytical and analytical development activities for our IND-enabling programs carried out in-house or at our CROs.
  • Troubleshoot and maintain instrumentation, manage instrument service agreements, and develop best practices for their use.
  • Be an active member of our project teams by attending project and department meetings and summarizing data.
  • Participate in experimental design and data analysis.

 Requirements:

  • Ph.D. in Analytical Chemistry or related field with 5+ years of pharmaceutical/biotech industrial experience or MS with 10+ years of industrial experience.
  • Proven track record of leadership and scientific accomplishments.
  • Extensive experience with in vitro ADME assays and LC-MSMS in vitro and in vivo metabolite identification is required.
  • Experience with solubility and chemical stability assessments is essential.
  • Experience with automation and liquid handling systems is preferred.
  • Solid background in developing analytical methods characterization, and testing of small molecules utilizing prep HPLC, NMR, and UPLC-MS is desirable.
  • Ability to troubleshoot and repair HPLC, UPLC-MS and NMR instrumentation is essential.
  • Excellent communication (oral and written), documentation (record keeping, lab notebook, reports), organization, and interpersonal skills is essential.
  • Qualities of servant leadership and self-awareness required.

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Chief Medical Officer

Join us in the most challenging and rewarding science of our lives.

Position

The Chief Medical Officer will report directly to the Chief Executive Officer. This position will be engaged in defining and leading the overall clinical strategy, direction and vision of the organization. The successful candidate will lead interactions with regulatory agencies, clinical experts (including KOLs in the field), and work with cross-functional teams to design, develop and implement clinical studies. 

This is a unique opportunity to be a major contributor to the success of a dynamic and well-financed growth stage biotechnology company.

  • Provide strategic input for innovative clinical development plans, incorporating the current therapeutic area landscape
  • Orchestrate and manage clinical aspects of regulatory strategies and interactions with Health Authorities
  • Oversee the analysis and interpretation of clinical trial data and the reporting of clinical trial results
  • Lead interactions with academic thought leaders, investigators, cooperative groups, and other clinical stakeholders including investigator and clinical advisory boards
  • Provide clinical support and work with other members of the management team to develop and communicate the overall corporate strategy
  • Represent the Company and its programs to external audiences, including the medical and regulatory communities, as well as selected investment venues and current and prospective biopharmaceutical collaborators
  • Lead and supervise the Clinical Operations, Regulatory, and Quality Control functions

Professional Experience/Qualifications

  • History of success progressing therapeutic programs from IND-enabling studies through human proof of concept, and/or from Phase 1 to Phase 3 development or NDA approval
  • Multiple years of management experience leading a clinical group including clinical operations, regulatory, and quality control
  • Knowledge of relevant FDA regulations and guidelines and other health authorities; experience in interactions with FDA personnel is essential; experience in interactions with other health authorities a plus
  • Experience with the design, execution, and analysis of clinical oncology studies with small molecule targeted or immunological therapies
  • Experience in translational medicine, clinical pharmacology and early stage development is desirable
  • Excellent knowledge of the competitive environment for drugs in the oncology marketplace and in research and development pipelines
  • Must have a thorough knowledge of clinical research concepts, practices, and GCP and ICH guidelines
  • The successful candidate will possess excellent communication skills and can articulate the Company’s clinical and regulatory strategies and progress to a wide audience including the CEO, the Board of Directors, Company employees, and the investor community
  • Must be science- and data-driven, with an understanding of basic science relevant to clinical oncology
  • Ability to work collaboratively in a fast-paced matrix environment

Education

  • M.D./Ph.D. or M.D. with board certification or eligibility in oncology or hematology/oncology is preferred

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Proteomics Senior Scientist

The Position

We are seeking a highly-skilled Senior Scientist with expertise in Proteomics to join Nurix’s Discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in oncology, immune-oncology and other therapeutic areas. The successful candidate will support Nurix’s drug discovery program and play a leading role in building and implementing proteomics capabilities.

This individual will work closely with an experienced team of interdisciplinary scientists and will have regular opportunities to present findings and opinions to project teams and senior management. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.

Primary Functions

  • Build and run in-house mass spectroscopy-based proteomics capabilities to identify and characterize proteins and their post-translational modifications
  • Utilize mass spectrometry techniques for protein identification and quantification for various sample types including complex mixtures using label-free and label-based techniques
  • Implement new technologies, and develop proteomics workflows including sample preparation and data analyses
  • Design proteomics-based experiments together with the project team, and lead the execution, analyses and interpretation of results
  • Maintain and troubleshoot mass spectrometers as needed

Qualifications

  • Ph.D. in Biochemistry, Cell or Molecular Biology, Chemical Biology or related field with 6+ years post-degree industry experience
  • Demonstrated expertise in operating relevant mass spectrometer instruments (e.g., from Agilent, Sciex and Thermo)
  • Demonstrated experience in designing, executing and analyzing quantitative proteomics experiments (e.g., protein abundance by SILAC and TMT)
  • Experience identifying and localizing post-translational modifications including phosphorylation and ubiquitylation from purified samples to complex mixtures
  • Knowledge of computational methods to analyze diverse mass spectroscopy datasets, including quantification, post-translational modifications and discovery
  • A proven track record (e.g., publication, industry experience, etc.) with excellent interpersonal skills and ability to work in a team environment
  • The successful candidate will be strongly aligned with Nurix’s culture and values; he/she will be team-oriented and highly collaborative with a hands-on approach
  • The candidate should be enthusiastic, driven, and have the ability to work independently and thrive in a dynamic start-up environment

Apply Now

Temporary Formulation Development Associate (Part-time)

Position

We are currently seeking an associate to help with analytical chemistry in the formulation laboratory at Nurix Therapeutics.  This will include pre-formulation studies, stability studies, support for formulation development, routine dose analysis, and laboratory maintenance. 

The development associate will work under the guidance of their immediate supervisor and should be self-driven, innovative and thorough in performing a range of novel tasks.  A thorough understanding of how to perform analytical experiments typical of a small molecule formulation development lab is required, while experimental design will remain dynamic across a number of programs in early discovery through clinical development.

Qualifications

Degree in a relevant field (physical sciences or life sciences). Independent, self-motivated and integrates well within a team. Exceptional organizational skills with an ability to work in a high paced team environment to meet deadlines and prioritize work on multiple projects are needed as are excellent oral and written communication skills.

  • Experience with analytical sample preparation and analyzing samples by HPLC for assay and purity. (Empower® experience a plus)
  • Experience in running dissolution, stability and physical testing experiments on solid dosage forms preferred.
  • Experience in formulation for preclinical animal models (solutions and suspensions) and solid oral dosage forms (capsules and tablets) a plus.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Apply Now

Director of Regulatory Affairs

Position Summary:

The Head of Regulatory Affairs at Nurix will have primary responsibility for the oversight and management of Regulatory matters related to Nurix’s commercial and development product pipeline globally in coordination with key internal stakeholders. In conjunction with that, the Director of Regulatory Affairs will be responsible for the establishment and monitoring of budgets and timelines and will coordinate closely with other cross-functional development team members. Externally, the individual will interface with outside regulatory agencies and business partners regarding, regulatory and registration strategies.

Responsibilities

  • Develop and implement advanced and aggressive global regulatory strategies for multiple assets.
  • Responsible for managing the tactical execution of preparation, review and submission of documents to the FDA and other regulatory authorities.
  • Provide regulatory advice to multidisciplinary teams on the regulatory requirements to support clinical and nonclinical development, including preparation and maintenance of IND and CTA fillings
  • In collaboration with team, perform/manage critical analyses of GXP related data and independently develop strategic/tactical interpretation and implementation
  • Lead multidisciplinary teams in the development and execution of major regulatory documents such as Briefing Package and IMPD
  • Lead, coordinate, write, critically review and provide  input on regulatory filing documents (e.g., eCTD Module 2 summaries, integrated summary documents, Investigator’s Brochure, clinical study reports)
  • Lead and facilitate activities to insure prioritized objectives are successfully delivered, including team preparation for meetings with FDA, EMA, and other regulatory authorities.
  • Lead Regulatory Authority communications/interactions.
  • Interface with global regulatory authorities and consultants as needed
  • Maintain a a strong working knowledge of US, EU and ICH regulatory requirements in commercially relevant geographies; ability to apply knowledge both strategically and operationally to development projects in support of corporate goals.
  • Proactively identify program issues and implement appropriate regulatory strategies to mitigate risk
  • Oversee and ensure compliance with regulatory procedures and work practices
  • Develop and implement regulatory operating guidelines/SOPs and common work practices/strategies within the team
  • Insure support and recommend process improvements for internal regulatory documentation/tracking/archival systems
  • Train, mentor and supervise regulatory employees, consultants/contractors in Regulatory Affairs
  • Maintain a positive team spirit and lead by ethical principles
  • Perform other responsibilities as may be required by Nurix, consistent with a growing, dynamic company.
  • Domestic and international travel as required to establish/support vendor/ partner relationships to maximize the success of the programs (approx. 20%).

Qualifications

  • Bachelor’s degree in a technical field with a graduate degree preferred.
  • 15 years+ regulatory experience in pharmaceutical, biotech or specialty pharma companies. Oncology experience a plus.
  • Regulatory Affairs Certification (RAC) preferredExperience with pharmaceutical, nonclinical, and clinical development of NCEs Experience with pharmaceuticals and biologics preferred; medical device experience is a plus.
  • Demonstrated experience in the preparation and submission of INDs, CTAs, and NDAs and other global submission documents in support of clinical trials and marketing applications and their amendments in conformance with local regulatory requirements.
  • Expert knowledge with GXP/ICH requirements and Guidance in major markets, especially US and EU 
  • Experience with labeling requirements is a plus
  • Experience managing and coaching staff, able to motivate teams
  • Excellent written and verbal communication skills. Strategic thinker, planner with excellent  organizational skills
  • Desirable to have experience in small biotech-flexibility to wear multiple hats as needed
  • Ability to multitask, prioritize, and manage time efficiently in a fast-paced and entrepreneurial environment.
  • Proven ability to effectively work collaboratively in cross functional environment

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Research Associate, Preclinical Pharmacology

Position Summary:

We are seeking a highly skilled and motivated Research Associate to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology, immuno-oncology, and inflammation. The ideal candidate will have expertise in small molecule PK/PD studies, xenograft and syngeneic tumor models, and inflammatory disease models. Duties include PK profiling, dose and schedule optimization, execution of PD biomarker assays, in vivo efficacy, and characterization immune cell phenotypes by flow cytometry. The candidate must be self-driven, organized, able to work well with project scientists, and able to thrive in an exciting environment in a rapidly-growing company.

If you are intrigued by the opportunity to work with a passionate team of scientists focused on improving patient’s lives with first-in-class therapies, please consider applying.

Qualifications

  • B.S. in biology, immunology or related field with 3+ years of industry experience.
  • Excellent hands-on in vivo skills: IV, PO dosing, tumor implantation, blood/tissue collection, etc.
  • Experience with xenograft or syngeneic tumor models
  • Expertise dosing small molecules and collecting samples for rodent PK studies desired
  • Proficiency with cell culture preferred
  • Experience with PD biomarker assessment a plus (e.g. Luminex, Western, flow, etc.)
  • Excellent communication and presentation skills
  • Excellent interpersonal skills and ability to work productively in a team-oriented environment

Apply Now

Office Administrator

Position Summary:

We are seeking an enthusiastic and detail-oriented individual with a strong desire to collaborate to join our team. The primary focus of this role is to provide administrative support to leaders. This includes screening and handling telephone calls, greeting visitors, maintaining the company’s Outlook calendar, scheduling meetings and candidate interviews, planning occasional events and assistance with special administrative projects.  This is a full-time benefited position.

Responsibilities:

  • Screen and handle phone calls in a professional and courteous manner
  • Greet visitors and assist in meeting room coordination
  • Manage senior leaders’ calendars
  • Prepare conference rooms for meetings
  • Order and arrange food for meetings
  • Occasional ordering of office supplies
  • Prepare workstations for new hire employees
  • Schedule candidate interviews
  • Plan occasional events
  • Additional assistance in special projects

Qualifications & Experience:

  • A minimum of 4 years’ front-desk and administrative support experience
  • A college degree or equivalent experience
  • Experience working in a start-up/small company environment
  • Strong desire to collaborate and problem solve
  • Technology savvy with Microsoft Office suite of applications and ability to quickly adopt new technologies
  • Ability to multitask and prioritize with ease
  • A sense of humor (essential)
  • Experience in Life Sciences industry highly desirable

Apply Now

Scientist I – Protein Sciences

Position

We are seeking a highly skilled and motivated Scientist with expertise in Protein Sciences to join Nurix’s Protein Sciences group. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in the areas of oncology and immuno-oncology, by utilizing the mechanistic and structural insights to guide drug discovery efforts. The successful candidate will provide scientific leadership and hands-on experience in Nurix’s protein expression and purification efforts to support biochemical, biophysical and structural efforts. This individual will work closely with an experienced team of interdisciplinary scientists and have regular opportunities to present findings to the project team and senior management. The candidate should have a strong desire to learn new techniques and the ability to incorporate new methodologies into their work. The ideal candidate will be self-driven, resourceful, organized, focused, and enjoy working in a dynamic team environment driven to deliver quality proteins to enable existing drug discovery platforms.

Required Qualifications

  • Ph.D. in Biophysics, Biochemistry, Cell and Molecular Biology, or related field with 2+ years postdegree experience,
  • Demonstrated ability to independently plan, lead and execute detailed protein production, purification and characterization procedures,
  • Extensive knowledge of protein construct design tailored to elucidate structure-function
    relations and identification of structural and functional modules,
  • Hands-on expertise on expression and purification of proteins from bacterial and insect
    expression systems for structural and functional applications,
  • Proficient in the operation of purification instrumentation (e.g. AKTA, ultracentrifugation) and
    purification techniques including but not limited to affinity chromatography, SEC, Ion-Exchange
    chromatography,
  • The candidate should be enthusiastic, driven, have the ability to work independently in a team environment and thrive in a dynamic start-up environment,
  • The successful candidate will be aligned to Nurix’s culture and values; he/she will be team oriented and highly collaborative with a hands-on approach

Preferred Qualifications

  • Experience with production of intrinsically disordered proteins (IDP’s),
  • General knowledge of immuno-oncology, structural biology, and drug discovery,
  • General knowledge of protein ubiquitylation biochemistry and pathways,
  • Hands-on experience of mammalian expression systems,
  • Experience with production of membrane associated proteins requiring the use of surfactants
    for purification,
  • Hands-on knowledge of protein purification automation (e.g. AKTA programming for multi-step
    purifications)
  • Have a record of published work and of presentation at conferences.

Apply Now

Senior Research Scientist – Protein Sciences

Position

We are seeking a highly skilled and motivated Scientist with expertise in Protein Sciences to join Nurix’s Protein Sciences group. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in the areas of oncology and immuno-oncology, by utilizing the mechanistic and structural insights to guide drug discovery efforts. The successful candidate will provide scientific leadership and hands-on experience in Nurix’s protein expression and purification efforts to support biochemical, biophysical and structural efforts. This individual will work closely with an experienced team of interdisciplinary scientists and have regular opportunities to present findings to the project team and senior management. The candidate should have a strong desire to learn new techniques and the ability to incorporate new methodologies into their work. The ideal candidate will be self-driven, resourceful, organized, focused, and enjoy working in a dynamic team environment driven to deliver
quality proteins to enable existing drug discovery platforms.

Required Qualifications

  • Master’s degree in Biochemistry, Cell and Molecular Biology, or related field with 6+ years
    industry experience (or Bachelor’s degree with 8+ years of industry experience),
  • Expert in protein expression in insect and/or mammalian cells,
  • Hands-on expertise on purification of proteins from bacterial, mammalian and insect expression
    systems for structural and functional applications,
  • Proficient in the operation of purification instrumentation (e.g. AKTA, ultracentrifugation) and
    purification techniques including but not limited to affinity chromatography, SEC, Ion-Exchange
    chromatography,
  • Hands-on expertise on protein characterization techniques including SDS-PAGE, WB, and
    Differential Scanning Fluorimetry,
  • The candidate should be enthusiastic, driven, have the ability to work independently in a team
    environment and thrive in a dynamic start-up environment,
  • The successful candidate will be aligned to Nurix’s culture and values; he/she will be team
    oriented and highly collaborative with a hands-on approach 

Preferred Qualifications

  • Experience with production of intrinsically disordered proteins (IDP’s),
  • General knowledge of immuno-oncology, structural biology, and drug discovery,
  • General knowledge of protein ubiquitylation biochemistry and pathways,
  • Hands-on experience of mammalian expression systems,
  • Experience with production of membrane associated proteins requiring the use of surfactants for purification,
  • Hands-on knowledge of protein purification automation (e.g. AKTA programming for multi-step purifications)
  • Have a record of published work and of presenting at conferences.

Apply Now

Scientist, Lead Discovery – Targeted Protein Degradation

Position

We are seeking a talented and highly-motivated individual with a background in ubiquitin biology or targeted protein degradation and an interest in drug discovery to join our collaborative team of scientists to greatly expand the toolbox of ubiquitin E3 ligases that can be used for targeted protein degradation. Currently, only a small subset of the >600 E3 ligases are harnessed for this purpose. Using Nurix’s DNA-encoded library (DEL) platform, the successful candidate will design and implement small molecules screens to identify ligands of novel E3 ligases. As part of a multidisciplinary team of biologists, medicinal chemists, and computational chemists, they will play a key role in the subsequent design, evaluation, and advancement of degrader molecules from these novel E3 binders.

 Key Responsibilities

  • Develop rationale for the targeting of specific E3 ligases for use in targeted protein degradation
  • Design and implement DNA-encoded library screens of prioritized E3 ligases to identify novel binders
  • This position will offer the opportunity for the candidate to gain experience in DEL library screening. Prior experience with this technology is helpful but NOT required.
  • Develop biochemical and biophysical assays in support of DEL screen design as well as small molecule binder validation and progression
  • Be an active member of a team of biologists and medicinal and computation chemists that works to incorporate these newly discovered E3 ligase binders into targeted protein degradation molecules, establishing degradation of therapeutic targets both in vitro and in vivo
  • Serve as an internal expert of E3 ligase function with a robust knowledge of E3 ligase biology and the targeted protein degradation field
  • Communicate findings to internal stakeholders through scientific presentations

 Qualifications

  •  Ph.D. scientist with 2+ years of post-degree industry or academic experience
  • In depth knowledge of ubiquitin and E3 ligase biology
  • Experience in the development, optimization and execution of biochemical or biophysical assays to interrogate protein interactions and enzymatic activity
  • Familiarity with principles of targeted protein degradation is preferred.
  • High level of creativity and productivity with strong problem-solving skills.
  • Solid background of scientific accomplishment demonstrated by publications, patents, or presentations.
  • Excellent communication skills and ability to present rationale, key data, issues and accomplishments to other members of the scientific team.
  • Resourceful and open to diverse points of view
  • Good fit with Nurix culture and values of highly collaborative, team-oriented research

Apply Now

Senior Scientist, Lead Discovery – Targeted Protein Degradation

Position

We are seeking a talented and highly-motivated individual with a background in ubiquitin biology or targeted protein degradation and an interest in drug discovery to join our collaborative team of scientists to greatly expand the toolbox of ubiquitin E3 ligases that can be used for targeted protein degradation. Currently, only a small subset of the >600 E3 ligases are harnessed for this purpose. Using Nurix’s DNA-encoded library (DEL) platform, the successful candidate will design and implement small molecules screens to identify ligands of novel E3 ligases. As part of a multidisciplinary team of biologists, medicinal chemists, and computational chemists, they will play a key role in the subsequent design, evaluation, and advancement of degrader molecules from these novel E3 binders.

Key Responsibilities

  • Develop rationale for the targeting of specific E3 ligases for use in targeted protein degradation
  • Design and implement DNA-encoded library screens of prioritized E3 ligases to identify novel binders
  • This position will offer the opportunity for the candidate to gain experience in DEL library screening. Prior experience with this technology is helpful but NOT required.
  • Develop biochemical and biophysical assays in support of DEL screen design as well as small molecule binder validation and progression
  • Be an active member of a team of biologists and medicinal and computation chemists that works to incorporate these newly discovered E3 ligase binders into targeted protein degradation molecules, establishing degradation of therapeutic targets both in vitro and in vivo
  • Serve as an internal expert of E3 ligase function with a robust knowledge of E3 ligase biology and the targeted protein degradation field
  • Communicate findings to internal stakeholders through scientific presentations

Qualifications

  • Ph.D. scientist with 8+ years of post-degree industry experience
  • In depth knowledge of ubiquitin and E3 ligase biology
  • Experience in the development, optimization and execution of biochemical or biophysical assays to interrogate protein interactions and enzymatic activity
  • A proven track record of understanding protein function through biochemical or structural analysis is strongly preferred.
  • Familiarity with principles of targeted protein degradation is preferred.
  • High level of creativity and productivity with strong problem-solving skills.
  • Solid background of scientific accomplishment demonstrated by publications, patents, or presentations.
  • Excellent communication skills and ability to present rationale, key data, issues and accomplishments to other members of the scientific team.
  • Resourceful and open to diverse points of view
  • Good fit with Nurix culture and values of highly collaborative, team-oriented research

Apply Now

Senior Research Associate/Scientist I-II, Medicinal Chemistry

Position

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry to join our Medicinal Chemistry team. You will work with a highly dynamic group that is focused on moving projects from the hit identification stage to the discovery of clinical candidates. The Nurix mission is to control protein fate to treat human diseases leveraging exciting technologies to target protein degradation. 

The successful applicant will have demonstrated substantial experience in modern synthetic organic chemistry and standard analytical methods. Having developed an understanding of the physicochemical properties that drive drug discovery are highly desired.  

As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of highly experienced scientists within Nurix as well as with external collaborators. 

Qualifications 

  •  BA/BS or equivalent with typically 8+ years of relevant experience or MS with typically 4+ years of relevant experience or Ph.D. in synthetic organic chemistry with 0-5 years industrial chemistry experience (years of relevant experience will impact level of hire) 
  • Creative skills in the design, performance and interpretation of chemistry experiments with strong synthetic problem-solving skills using a hypothesis-based approach 
  • Excellent communication of project rationale, key experimental results, issues and accomplishments in appropriate verbal and written form 
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations 
  • Maintains an excellent scientific expertise in organic synthesis and a good knowledge of key medicinal chemistry principles 
  • Good ability to manage own priorities and deliverables, both independently and in the team setting
  • Familiarity with tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making a strong plus but not required 

Fit with Nurix Culture and Values 

  •  Strong team orientation; highly collaborative 
  • Solutions and results-oriented focus 
  • Hands-on approach; resourceful and open to diverse points of view 

Apply Now