Culture & Careers

Job Openings

Research Associate, Preclinical Pharmacology

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a highly skilled and motivated Senior Research Associate to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. The ideal candidate will have expertise in small molecule PK, PD, and efficacy studies in oncology or immuno-oncology.

You will work closely with our drug discovery project scientists on early and late-stage lead optimization of novel compounds to support PK profiling, dose and schedule optimization, execution of PD biomarker assays, in vivo efficacy, and characterization immune cell phenotypes by flow cytometry.

You must be self-driven, organized, able to work well with project scientists, and able to thrive in an exciting environment in a rapidly-growing company.

Qualifications

  • B.S. in biology, immunology or related field with 3+ years of industry experience
  • Expertise dosing small molecules and collecting samples for rodent PK studies required
  • Excellent hands-on in vivo skills: IV, PO dosing, tumor implantation, blood/tissue collection, etc.
  • Experience with xenograft or syngeneic tumor models
  • Proficiency with cell culture preferred
  • Experience with PD biomarker assessment a plus (e.g. Luminex, Western, flow, etc.)
  • Excellent communication and presentation skills
  • Excellent interpersonal skills and ability to work productively in a highly dynamic environment

Fit with Nurix Culture and Values

  • Strong team orientation, highly collaborative; solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view
  • Self-driven and enthusiastic with the ability to thrive in a dynamic “start-up” environment

 
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Scientist I, High Throughput Mass Spectrometry

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a talented and motivated drug discovery scientist who will support small molecule discovery using mass spectrometry. You will develop and implement affinity selection mass spectrometry (ASMS) methods as part of hit validation from our DNA Encoded Library and Virtual Screening platformsto rapidly access chemical matter that modulates targets within the ubiquitin proteome system (UPS). You will use your strong understanding of protein biochemistry to inform the development of assays to assess novel protein-small moleculeand protein-protein interactions.

As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of scientists within Nurix as well as with external collaborators. You should have a strong desire to learn new techniques and incorporate new methodologies into your work. You must be self-driven, resourceful, organized and focused, and enjoy being a part of a dynamic team in a project-based environment solving challenging scientific problems to benefit patients.

Qualifications:

  • Ph.D. in chemistry, biochemistry, biology or another relevant life science.
  • Expertise in mass spectrometry techniques; relevant training with ASMS is especially desired.
  • Experience with operation, troubleshooting and maintenance of qTOF and sQ mass spectrometers and associated separation techniques (LC, SEC, SPE)
  • Familiarity with intact mass protein MS, and characterization of protein-small molecule adducts
  • Experience with the execution of biochemical and/or biophysical assays for evaluation of small molecule modulators.
  • Desire to lead initiatives in platform building and technology development.
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations.
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments in a matrix setting.

Secondary but desirable qualifications:

  • Familiarity with spreadsheet management and software such as Spotfire and DotMatics
  • Understanding of principles and practice of DNA encoded library technology
  • Expertise in interrogating biochemical mechanism of action, especially for proteins of the UPS

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Scientist I/II, DNA Encoded Chemistry, Library Discovery

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry and familiarity with the application of DNA encoded chemistry to join our Library Discovery team.

You will join a group with two objectives: 1) Design and synthesize DNA encoded libraries and 2) Utilize these libraries to identify novel chemical matter with the potential to modulate the activity of UPS targets.

You will have demonstrated experience in synthetic organic chemistry and analytical methods. Experience with DNA encoded library synthesis, parallel reaction chemistry, split/pool methods, aqueous chemistry and linker chemistry related to the synthesis of drug conjugates are all valued skills. Familiarity with hit triage, hit to lead campaigns from other discovery platforms, and an understanding of the physicochemical properties that drive drug discovery are desired.

As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators.

Qualifications

  • PhD in synthetic organic chemistry with 0-8 years industrial chemistry experience (years of relevant experience will impact level of hire).
  • Expert in synthetic organic chemistry methods and analytical tools, in particular LCMS
  • High level of creativity and productivity with strong synthetic problem-solving skills.
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.
  • Familiarity with principles of combinatorial chemistry and DNA encoded library technology
  • Interest in optimizing chemical reactions for use in DNA encoded library synthesis.
  • Experience with chemistry involving biological macromolecules, i.e. antibodies and oligonucleotides, linker technologies, or the design and synthesis of chemical biology probes a plus.
  • Familiarity with working with large data sets and the tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making.

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Medical Director, Clinical Development (MD)

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking an experienced clinician with strong leadership skills who is driven by science and the desire to develop novel therapies for cancer patients. The successful candidate will have expertise in the design and conduct of early phase oncology clinical trials and a strong interest in translational medicine.
Reporting to the Chief Development Officer, the Medical Director will be responsible for the design, implementation, monitoring, data analysis and reporting of clinical studies for Nurix’s oncology portfolio. As a member of the Development Leadership team, the successful candidate will play a key role in building and shaping the Development organization at Nurix. The Medical Director will also serve as a medical expert resource for drug discovery teams and business development activities. The role provides an opportunity for leadership growth in a dynamic small company environment.

Specific responsibilities include:

  • Provide strategic input for innovative clinical development plans, incorporating the current therapeutic area landscape
  • Lead the design and implementation of early stage clinical projects, with responsibility for medical aspects of phase 1-2 clinical trials
  • Serve as lead author of clinical documents: protocols, investigator’s brochures, case report form design and data analysis plans
  • Lead preparation of clinical sections of relevant regulatory filings to Health Authorities
  • Partner closely with the Clinical Operations head in the conduct and execution of Nurix’s clinical trials
  • Serve as Medical Monitor for clinical trials, reviewing safety and efficacy data for routine medical data review, trend review, and safety signals from ongoing trials
  • Support exploratory biomarker efforts to aid clinical and project data-driven decisions
  • Lead medical aspects of investigator and clinical advisory boards
  • Develop and manage relationships with key opinion leaders for clinical programs
  • Represent Nurix at external events, including scientific and medical conferences and business development activities

Requirements:

  • MD with board certification or eligibility in Oncology or Hematology/Oncology
  • Five to seven years of drug development experience in biotechnology or pharmaceutical industry, or a combination of academia and industry
  • Proven experience with clinical trial design, execution, medical monitoring, and reporting of controlled clinical trials in oncology including working with external service providers
  • Experience with design, execution, and analysis of Phase 1-2 clinical oncology studies with small molecule targeted or immunological therapies
  • Demonstrable knowledge of regulatory procedures and guidelines in the US and other geographic regions
  • Understanding of basic science relevant to clinical oncology
  • Ability to work collaboratively in a fast-paced matrix environment
  • Excellent written and oral communication skills

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Scientist, Medicinal Chemistry – Library Discovery

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a highly skilled and motivated individual with a strong background in synthetic organic chemistry to join our library discovery group in the pursuit of novel small molecules. You will engage with a wide swath of Nurix’s therapeutic portfolio to advance screening hits to lead optimization campaigns. Specifically, you will design and synthesize novel chemical entities optimized for potency, selectivity and physicochemical properties. As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of scientists within Nurix and with external collaborators.

You should have a strong desire to learn new techniques and incorporate new methodologies into your work.  You must be self-driven, resourceful, organized and focused, and enjoy being a part of a dynamic team in a project-based environment solving challenging scientific problems to benefit patients.

Qualifications

  • Ph.D. in synthetic organic chemistry preferably with at least 2 years of biotechnology or pharmaceutical industry experience within a medicinal chemistry department
  • Expert in interpretation of screening data and execution of hit triage
  • Successful application of structure-based drug design leading to advanced leads / development candidates
  • Strong working knowledge of protein-ligand interactions, conformational and structural analysis, experienced in partnering closely with computational chemists through appropriate use of computational tools, models and visualization applications
  • Proven track record of innovative project contributions including peer-reviewed publications
  • High level of creativity and productivity with strong synthetic problem-solving skills
  • Excellent scientific expertise in organic synthesis, conversant with the current literature
  • Strong knowledge of medicinal chemistry principles with a solid understanding of key ADME, biochemical and pharmacological principles and able to effectively integrate and apply these to the optimization of multiple parameters during lead generation and lead optimization efforts
  • Familiarization with DNA-encoded library technology is preferred
  • Ability to champion the chemistry efforts into new directions to achieve project milestones
  • Experience with parallel synthesis and high throughput chemistry to prepare libraries of compounds is preferred
  • Experience directing external synthetic chemistry efforts
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now