Culture & Careers

Job Openings

Senior Associate, Informatics

Join us in the most challenging and rewarding science of our lives.

Position

As a Senior Associate, Informatics, you will interface with fellow scientists across the organization to provide hands-on scientific application support. In this role, you will help fellow scientists effectively use Nurix’s existing tools and applications to capture, analyze, query and report chemical and biological data. You will partner with your Informatics colleagues to implement database-backed solutions to address unmet automation and informatics needs.

Required Skills:

  • BS/MS in Chemistry, BioChemistry, Biology or a related field
  • Minimum 2 years’ experience working with chemical and biological information systems
  • Minimum 2 years’ experience working with databases (Oracle, MySQL, PostGRES, SQLServer) and SQL coding
  • Minimum 2 years’ experience working with data-analysis tools and applications such as Pipeline Pilot or Knime
  • Excellent communication and presentation skills on the phone, in 1×1 meetings, and in a group setting
  • Strong written communication skills to create business-appropriate emails, instant messages, requirements/specifications documents, presentation materials, etc.
  • Proficient in MS Office (Excel, Word, PowerPoint)

Preferred Skills:

  • Experience coding in any of the following: Perl, Python, Java, VB, C/C++
  • Business analysis
  • Data visualization
  • Change control

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Chief Medical Officer

Join us in the most challenging and rewarding science of our lives.

Position

The Chief Medical Officer will report directly to the Chief Executive Officer. This position will be engaged in defining and leading the overall clinical strategy, direction and vision of the organization. The successful candidate will lead interactions with regulatory agencies, clinical experts (including KOLs in the field), and work with cross-functional teams to design, develop and implement clinical studies. 

This is a unique opportunity to be a major contributor to the success of a dynamic and well-financed growth stage biotechnology company.

  • Provide strategic input for innovative clinical development plans, incorporating the current therapeutic area landscape
  • Orchestrate and manage clinical aspects of regulatory strategies and interactions with Health Authorities
  • Oversee the analysis and interpretation of clinical trial data and the reporting of clinical trial results
  • Lead interactions with academic thought leaders, investigators, cooperative groups, and other clinical stakeholders including investigator and clinical advisory boards
  • Provide clinical support and work with other members of the management team to develop and communicate the overall corporate strategy
  • Represent the Company and its programs to external audiences, including the medical and regulatory communities, as well as selected investment venues and current and prospective biopharmaceutical collaborators
  • Lead and supervise the Clinical Operations, Regulatory, and Quality Control functions

Professional Experience/Qualifications

  • History of success progressing therapeutic programs from IND-enabling studies through human proof of concept, and/or from Phase 1 to Phase 3 development or NDA approval
  • Multiple years of management experience leading a clinical group including clinical operations, regulatory, and quality control
  • Knowledge of relevant FDA regulations and guidelines and other health authorities; experience in interactions with FDA personnel is essential; experience in interactions with other health authorities a plus
  • Experience with the design, execution, and analysis of clinical oncology studies with small molecule targeted or immunological therapies
  • Experience in translational medicine, clinical pharmacology and early stage development is desirable
  • Excellent knowledge of the competitive environment for drugs in the oncology marketplace and in research and development pipelines
  • Must have a thorough knowledge of clinical research concepts, practices, and GCP and ICH guidelines
  • The successful candidate will possess excellent communication skills and can articulate the Company’s clinical and regulatory strategies and progress to a wide audience including the CEO, the Board of Directors, Company employees, and the investor community
  • Must be science- and data-driven, with an understanding of basic science relevant to clinical oncology
  • Ability to work collaboratively in a fast-paced matrix environment

Education

  • M.D./Ph.D. or M.D. with board certification or eligibility in oncology or hematology/oncology is preferred

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Scientist – Senior Scientist, Degrader Discovery

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a talented and highly motivated scientist with a background in E3 ligase biology and an interest in drug discovery to help us unlock novel E3 ligases for use in the emerging field of targeted protein degradation. In this role you will be responsible for leading ligand discovery campaigns using Nurix’s DNA encoded library (DEL) platform to identify novel ligands for E3 ligases. Working collaboratively with a dynamic multi-disciplinary project team, you will participate in degrader design, evaluation and advancement.

Qualifications

  • Ph.D. scientist with 2+ years of post-degree pharma/biotech/academic experience.
  • In depth knowledge of ubiquitin biology required.
  • Expertise in general biochemical and molecular biology including protein immobilization and qPCR. Experience with Nextgen sequencing is a plus.
  • Experience in the development, optimization and execution of biochemical and biophysical assays.
  • Hands on experience interrogating protein-protein or protein-ligand interactions.
  • Familiarity with principles of degrader technology and/or DNA encoded library discovery is highly preferred.
  • High level of creativity and productivity with strong problem-solving skills.
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Senior Research Associate – Scientist, Medicinal Chemistry

Join us in the most challenging and rewarding science of our lives.

Position

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry to join our Medicinal Chemistry team. You will work with a highly dynamic group that is focused on moving projects from the hit identification stage to the discovery of clinical candidates. The Nurix mission is to control protein fate to treat human diseases leveraging exciting technologies to target protein degradation.

The successful applicant will have demonstrated substantial experience in modern synthetic organic chemistry and standard analytical methods. Having developed an understanding of the physicochemical properties that drive drug discovery are highly desired.

As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of highly experienced scientists within Nurix as well as with external collaborators.

Qualifications

  • BA/BS or equivalent with typically 8+ years of relevant experience or MS with typically 4+ years of relevant experience or Ph.D. in synthetic organic chemistry with 0-4 years industrial chemistry experience (years of relevant experience will impact level of hire)
  • Creative skills in the design, performance and interpretation of chemistry experiments with strong synthetic problem-solving skills using a hypothesis-based approach
  • Excellent communication of project rationale, key experimental results, issues and accomplishments in appropriate verbal and written form
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Maintains an excellent scientific expertise in organic synthesis and a good knowledge of key medicinal chemistry principles
  • Good ability to manage own priorities and deliverables, both independently and in the team setting
  • Familiarity with tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making a strong plus but not required

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Research Associate I-II, Cell Biology/Immunology

Position

We are seeking a Research Associate with experience in cell biology and immunology to join our Nurix drug discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin system to explore the possibility of modulating targets previously believed to be “undruggable”.

Ubiquitin ligases play numerous roles in immune cell function, autoimmunity, inflammation and anti-tumor immunity. The successful candidate will support early drug discovery efforts in inflammation, oncology and immuno-oncology (IO). The candidate’s duties will include execution and analysis of in vitro cellular assays to support small molecule discovery efforts as well as new target ID. This individual will work closely with scientists within the group and present their findings to the department and project teams. The ideal candidate will be self-driven, eager to learn new techniques, highly organized and enjoys working in a creative and dynamic team environment.

Qualifications

  • Bachelor’s degree with 0-4 years experience, or Master’s degree with 0-2 years of industry experience
  • Hands-on experience with mammalian cell culture
  • Experience isolating and working with primary human and mouse immune cells is a plus
  • Experience with cellular assay techniques including ELISA, Western, FACS and/or multiplexing technologies (e.g. Luminex, Quantigene)
  • Experience with medium throughput assays, CRISPR technology, functional assays for human and mouse immune cells (e.g. T cells, NK cells, antigen presenting cells) is a plus
  • Detail oriented and good record keeping skills
  • Background with past experience in ubiquitin biology is a plus
  • Strongly aligned with Nurix’s culture and values

Fit with Nurix Culture and Values

  • Strong team orientation, highly collaborative and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Apply Now

Temporary Research Associate, Analytical Chemistry

Position

We are seeking a talented and highly motivated chemist with some experience and strong aptitude in analytical chemistry to join our Analytical Chemistry team. You will work with a highly dynamic group that is focused on moving projects from the hit identification stage to the discovery of clinical candidates. The Nurix mission is to control protein fate to treat human diseases leveraging exciting technologies to target protein degradation.

The successful applicant will have demonstrated some experience in modern analytical chemistry and standard analytical methods. Experience in analytical and preparative supercritical fluid chromatography (SFC) as well as reversed-phase LCMS are highly desired. Experience in analysis of in vitro ADME properties and NMR data acquisition are also desired.

As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of highly experienced scientists within Nurix.

Qualifications

• BA/BS or equivalent with up to 2+ years of relevant experience with 0-4 years industrial chemistry experience (years of relevant experience will impact level of hire);
• Can repeat and follow detailed scientific procedures with supervision;
• Knowledge of basic analytical chemistry concepts, practices and procedures, in particular as they relate to chromatography;
• Ability to take direction from experienced scientists and contributes in a team environment;
• Able to clearly present technical information verbally and in writing to supervisor;
• Good interpersonal skills and is willing to ask questions about procedures and concepts;
• Aptitude and willingness to gain more skills and knowledge in analytical chemistry in particular chromatography, but also NMR and in vitro ADME properties.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Apply Now

Proteomics Senior Scientist

The Position

We are seeking a highly-skilled Senior Scientist with expertise in Proteomics to join Nurix’s Discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in oncology, immune-oncology and other therapeutic areas. The successful candidate will support Nurix’s drug discovery program and play a leading role in building and implementing proteomics capabilities.

This individual will work closely with an experienced team of interdisciplinary scientists and will have regular opportunities to present findings and opinions to project teams and senior management. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.

Primary Functions

  • Build and run in-house mass spectroscopy-based proteomics capabilities to identify and characterize proteins and their post-translational modifications
  • Utilize mass spectrometry techniques for protein identification and quantification for various sample types including complex mixtures using label-free and label-based techniques
  • Implement new technologies, and develop proteomics workflows including sample preparation and data analyses
  • Design proteomics-based experiments together with the project team, and lead the execution, analyses and interpretation of results
  • Maintain and troubleshoot mass spectrometers as needed

Qualifications

  • Ph.D. in Biochemistry, Cell or Molecular Biology, Chemical Biology or related field with 6+ years post-degree industry experience
  • Demonstrated expertise in operating relevant mass spectrometer instruments (e.g., from Agilent, Sciex and Thermo)
  • Demonstrated experience in designing, executing and analyzing quantitative proteomics experiments (e.g., protein abundance by SILAC and TMT)
  • Experience identifying and localizing post-translational modifications including phosphorylation and ubiquitylation from purified samples to complex mixtures
  • Knowledge of computational methods to analyze diverse mass spectroscopy datasets, including quantification, post-translational modifications and discovery
  • A proven track record (e.g., publication, industry experience, etc.) with excellent interpersonal skills and ability to work in a team environment
  • The successful candidate will be strongly aligned with Nurix’s culture and values; he/she will be team-oriented and highly collaborative with a hands-on approach
  • The candidate should be enthusiastic, driven, and have the ability to work independently and thrive in a dynamic start-up environment

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Senior Scientist / Associate Director, Analytical Chemistry

Position:

We are seeking a highly skilled and motivated analytical chemist to join Nurix’s Medicinal Chemistry Team. The successful candidate will support our entire research portfolio including small molecule, heterobifunctional protein-degradation and DNA encoded library teams. Capabilities in our analytical department include structure elucidation by NMR, extensive chromatography applications including SFC as well as identification and characterization of in vitro and in vivo metabolites.

The ideal candidate will:

  • Work closely with the medicinal chemists providing analytical and chromatography expertise in the areas of small molecule purification, separation of enantiomeric mixtures using our in-house SFC and structural elucidation
  • Manage and supervise our high-throughput purification team
  • Troubleshoot and maintain instrumentation, manage instrument service agreements, and develop best practices for their use
  • Develop medicinal chemistry-enabling assays such as kinetic/thermodynamic solubility
  • Collaborate with IT to streamline database entry and manage the data pipeline
  • Be an active member of our project teams by attending project and department meetings and summarizing data
  • Monitor analytical activities of our CROs
  • Participate in experimental design and data analysis

Requirements:

  • Ph.D. in Analytical Chemistry with 5+ years of pharmaceutical/biotech industrial experience or MS with 10+ years of industrial experience.
  • Solid background in developing analytical methods for the purification, characterization, and testing of small molecules utilizing prep HPLC, NMR, and UPLC-MS is essential. Chiral SFC experience (analytical & preparative) is desirable.
  • NMR experience using 2D-NMR, HNMR, and 13CNMR experiments is desirable.
  • Ability to troubleshoot and repair prep HPLC, UPLC-MS and NMR instrumentation is essential.
  • Experience with solubility and chemical stability assessments desirable.
  • Contribute to in vitro and in vivo metabolite identification studies.
  • Excellent communication (oral and written), documentation (record keeping, lab notebook, reports), organization, and interpersonal skills is essential.

Apply Now

Temporary Research Associate, Lead Discovery

Position

We are seeking a highly motivated individual with a background in Biochemistry or Molecular Cell Biology to join our Lead Discovery team at Nurix.

The successful candidate for this position will support early drug discovery efforts by characterizing the activity of novel compounds in custom biochemical assays. The types of assays employed will be enzymatic as well as protein-protein binding in nature and will employ modalities such as fluorescence polarization (FP) and fluorescence resonance energy transfer (FRET). These data will be central to the early development of small molecule modulators that power the drug discovery pipeline at Nurix and the applicant will work as part of a highly collaborative, interdisciplinary team of biochemists, structural biologists, cell biologists, and medicinal and computational chemists.

The candidate should have a strong desire to learn new techniques and the ability and interest to cross train in all aspects biochemical assay development. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in the dynamic team environment here at Nurix.

Qualifications

  • Bachelor’s or Master’s degree in Biochemistry, Molecular and Cell Biology, or related field
  • Familiarity with the concepts of enzyme catalysis, protein-ligand and protein-protein interactions, and the principles that govern these interactions
  • 1-2 years of laboratory experience (including undergraduate research) in the areas of biochemistry, protein chemistry, or biophysics. Examples of highly relevant experience include:
    • Work with biochemical assays (e.g. enzymatic, ubiquitylation, protein-protein interaction, fluorescence polarization, FRET, AlphaLISA, etc.)
    • Use of spectrophotometers or fluorescence plate readers (e.g. Perkin Elmer Envision, etc.)
    • Experience with laboratory automation or robotics (e.g. Agilent Bravo, Biomek FX, etc.)
    • Protein purification (e.g. AKTA Purification of proteins from coli or SF9 cells)
  • Familiarity with data processing programs (i.e. Microsoft Excel, GraphPad Prism, etc.)

Fit with Nurix Culture and Values

  • Strong team orientation, highly collaborative and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Apply Now

Temporary Formulation Development Associate

Position

We are currently seeking an associate to help with analytical chemistry in the formulation laboratory at Nurix Therapeutics.  This will include pre-formulation studies, stability studies, support for formulation development, routine dose analysis, and laboratory maintenance. 

The development associate will work under the guidance of their immediate supervisor and should be self-driven, innovative and thorough in performing a range of novel tasks.  A thorough understanding of how to perform analytical experiments typical of a small molecule formulation development lab is required, while experimental design will remain dynamic across a number of programs in early discovery through clinical development.

Qualifications

Degree in a relevant field (physical sciences or life sciences). Independent, self-motivated and integrates well within a team. Exceptional organizational skills with an ability to work in a high paced team environment to meet deadlines and prioritize work on multiple projects are needed as are excellent oral and written communication skills.

  • Experience with analytical sample preparation and analyzing samples by HPLC for assay and purity. (Empower® experience a plus)
  • Experience in running dissolution, stability and physical testing experiments on solid dosage forms preferred.
  • Experience in formulation for preclinical animal models (solutions and suspensions) and solid oral dosage forms (capsules and tablets) a plus.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Apply Now