Culture & Careers

Job Openings

Proteomics Senior Scientist

The Position

We are seeking a highly-skilled Senior Scientist with expertise in Proteomics to join Nurix’s Discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in oncology, immune-oncology and other therapeutic areas. The successful candidate will support Nurix’s drug discovery program and play a leading role in building and implementing proteomics capabilities.

This individual will work closely with an experienced team of interdisciplinary scientists and will have regular opportunities to present findings and opinions to project teams and senior management. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.

Primary Functions

  • Build and run in-house mass spectroscopy-based proteomics capabilities to identify and characterize proteins and their post-translational modifications
  • Utilize mass spectrometry techniques for protein identification and quantification for various sample types including complex mixtures using label-free and label-based techniques
  • Implement new technologies, and develop proteomics workflows including sample preparation and data analyses
  • Design proteomics-based experiments together with the project team, and lead the execution, analyses and interpretation of results
  • Maintain and troubleshoot mass spectrometers as needed

Qualifications

  • Ph.D. in Biochemistry, Cell or Molecular Biology, Chemical Biology or related field with 6+ years post-degree industry experience
  • Demonstrated expertise in operating relevant mass spectrometer instruments (e.g., from Agilent, Sciex and Thermo)
  • Demonstrated experience in designing, executing and analyzing quantitative proteomics experiments (e.g., protein abundance by SILAC and TMT)
  • Experience identifying and localizing post-translational modifications including phosphorylation and ubiquitylation from purified samples to complex mixtures
  • Knowledge of computational methods to analyze diverse mass spectroscopy datasets, including quantification, post-translational modifications and discovery
  • A proven track record (e.g., publication, industry experience, etc.) with excellent interpersonal skills and ability to work in a team environment
  • The successful candidate will be strongly aligned with Nurix’s culture and values; he/she will be team-oriented and highly collaborative with a hands-on approach
  • The candidate should be enthusiastic, driven, and have the ability to work independently and thrive in a dynamic start-up environment

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Biophysics Scientist

Position

We are seeking a highly skilled and motivated Scientist with expertise in Biophysics to join Nurix’s Discovery team.

You will provide scientific leadership in Nurix’s biophysics efforts to help support our hit identification, hit-to-lead and structural biology efforts. You will play a key role in collecting and interpreting biophysical assay data for ongoing discovery programs, but also will be responsible for implementing novel biophysical assays and techniques to expand our capabilities. You will work closely with an experienced team of interdisciplinary scientists and have regular opportunities to present findings to the project team and senior management.

You should have a strong desire to learn new techniques and incorporate new methodologies into your work.  You must be self-driven, resourceful, organized and focused, and enjoy being a part of a dynamic team in a project-based environment solving challenging scientific problems to benefit patients.

Qualifications

  • Ph.D. in Biochemistry, Biophysics or a related field, or an M.S. with at least three years of relevant work experience, or a B.S. with five years of relevant work experience
  • Experience using biophysical techniques to analyze protein-protein interactions as well as protein-small molecule interactions
  • Hands on experience with Surface Plasmon Resonance (SPR) or Grating-Coupled Interferometry (GCI)
  • Expertise with the kinetic and thermodynamic characterization of ligand binding as well as quantitative data management and analysis
  • Practical experience with biophysical techniques such as Microscale Thermophoresis (MST), Isothermal Titration Calorimetry (ITC), Differential Scanning Fluorimetry (DSF), and Nuclear Magnetic Resonance (NMR) is preferred
  • Excellent communication skills and ability to present rationale, key data, issues and accomplishments to other members of the scientific team
  • Good fit with Nurix culture and values of highly collaborative, team-oriented research

Application Process

Please include a two-page research summary that highlights the above qualifications along with your resume when submitting your application. 

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Computational Chemist

Position

We are seeking a talented and highly motivated computational chemist with a strong background in Structure Based Drug Design to join our team. The Nurix mission is to treat human diseases by leveraging exciting new drug discovery technologies such as targeted protein degradation. Nurix Therapeutics is based in the San Francisco Mission Bay research campus. We have a broad pipeline of partnered and in-house programs in multiple therapeutic areas, including strong multi-target partnerships with Gilead Sciences and Sanofi. 

As part of a highly integrated team of computational chemists, structural biologists, medicinal chemists and discovery biologists, you will use state-of-the-art computational software, computer aided drug design and simulation techniques to help drive hit discovery. Your creative thinking will help to push forward the frontier of modelling in targeted protein degradation, lead optimization, and DNA Encoded Library technologies. The successful candidate will independently pursue research projects, implement novel computational workflows and support a dynamic multi-disciplinary team focused on moving projects from the hit identification stage to the discovery of clinical candidates.

Qualifications 

  • Ph.D. in Chemistry, Biology, Biophysics (or related fields) with demonstrated computational chemistry focus
  • Established skills in computer aided drug design
  • Practical working experience in computational chemistry software (e.g. Schrodinger, OpenEye, others)
  • Proven track record in one or more of the following: docking studies, virtual screening, druggability analysis, structure-based design for lead optimization, free energy perturbation and molecular dynamics simulation
  • Excellent communication of design rationale, key experimental results, issues and accomplishments in appropriate verbal and written form 
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations 
  • Maintains an excellent scientific expertise in the latest developments in computational chemistry
  • Good ability to manage own priorities and deliverables, both independently and in the team setting
  • Ability to work effectively in a highly interdisciplinary team
  • Software development skills in a modern programming language (eg Python) a strong plus
  • Industry or comparable academic experience in the field of computational chemistry required, small molecule drug design experience preferred (2+ years)

Fit with Nurix Culture and Values 

  • Strong team orientation; highly collaborative 
  • Solutions and results-oriented focus 
  • Hands-on approach; resourceful and open to diverse points of view 

Apply Now

Senior Research Associate/Scientist, Formulation Development

We are currently seeking an experienced Senior Research Associate or Scientist in the development group to work on pre-clinical and clinical formulations of small molecules. This will include pre-formulation studies, stability studies, support for formulation development, routine dose analysis, and laboratory maintenance. The job is focused on oral dosage forms, but other routes may be appropriate.


The Senior Research Associate/Scientist will work under the guidance of their immediate supervisor and should be self-driven, innovative and thorough in performing a range of novel tasks. The scientist will work in project teams to design in-vivo experiments for screening of compounds. A thorough understanding of how to independently perform analytical experiments typical of an oral small molecule formulation development lab is required, while experimental design will remain dynamic across several programs in early discovery through clinical development.

Qualifications

  • B.S. degree in a relevant field (physical sciences or life sciences). Over 6 years of industrial experience in the pharmaceutical industry. Independent, self-motivated and integrates well within a team. Exceptional organizational skills with an ability to work in a high paced team environment to meet deadlines and prioritize work on multiple projects are needed as are excellent oral and written communication skills.
  • Experience in an analytical chemistry or small molecule formulation lab.
  • Experience with analytical sample preparation and analyzing chemical samples by HPLC for assay and purity. (Empower® experience a plus)
  • Experience in running dissolution, stability and physical testing experiments on solid dosage forms preferred.
  • Knowledge of PK parameters and formulation for early animal studies a plus.
  • Experience in formulation for preclinical animal models (solutions and suspensions) and solid oral dosage forms (capsules and tablets).

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Scientist (Sci-I, Sci-II, or Senior), Medicinal Chemistry

We are seeking talented and highly motivated individuals with a strong background in synthetic organic chemistry to join our medicinal chemistry group in the pursuit of novel small molecules to treat patients with unmet medical needs. The successful candidate will engage in rational structure-based drug discovery enabled by our computational and structural biology group. Specifically, this individual will design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics and in vivo efficacy. As members of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix and with external collaborators. Additionally, they will contribute effectively to patent, report and scientific publication writing.

Qualifications depending on experience:

  • Ph.D. in synthetic organic chemistry with 0-10 years of medicinal chemistry experience
  • Successful application of structure-based drug design leading to advanced leads, and/or development candidates. Strong working knowledge of protein-ligand interactions, conformational and structural analysis, experienced in partnering closely with computational chemists through appropriate use of computational tools, models and visualization applications.
  • High level of creativity and productivity with strong synthetic problem solving skills
  • Excellent scientific expertise in organic synthesis, conversant with the current literature
  • Ability to champion the chemistry efforts into new directions to achieve project milestones.
  • Solid track record of innovation and impact on programs, with direct contributions to company pipelines (including both successful advances and smart terminations).
  • Proven leadership capability in cross-functional team setting, either as project team leader or co-lead.
  • Strong evidence of conceptual thinking and active follow through, recognized by establishing new projects or new directions within projects, new strategies and/or enabling technologies for drug discovery. Vigorous scientific curiosity evidenced by contributions to diverse medicinal chemistry strategies.
  • Ability to make inventive contributions towards new chemical target structures or templates for programs, and employ sound judgment in the evaluation and strategic decision making around early screening or literature hits.
  • Excellent knowledge of medicinal chemistry principles with a solid understanding of the basic biology and pharmacology of programs, the ADME issues, and series SAR. Able to effectively integrate this knowledge and apply the key principles of medicinal chemistry, literature precedent, and drug design to direct medicinal chemistry programs to phase transitions or series go/no go decisions.
  • Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings and using this information to guide program strategy.
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.

Fit with Nurix Culture and Values

  • Strong team orientation and highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Scientist I-II, Cell Biology

We are seeking a cell biologist with an extensive experience to join our Nurix drug discovery team.  Nurix is devoted to unlocking the therapeutic potential of the ubiquitin system to explore the possibility of modulating targets previously believed to be “undruggable”. Ubiquitin ligases play numerous roles in immune cell function, autoimmunity, inflammation and anti-tumor immunity.  The successful candidate will support early drug discovery efforts in oncology, immuno-oncology (IO) and inflammation.  Responsibilities will include execution and analysis of in vitro cellular assays to support small molecule discovery efforts as well as new target identification and understanding of mechanisms of action. This individual will work closely with scientists within the group and present their findings to the department and project teams. The ideal candidate will be self-driven, eager to learn new techniques, highly organized and enjoys working in a creative and dynamic team environment. 

 Qualifications

  • Ph.D. in cell biology, immunology or related field (Bachelor’s or Master’s degree with industry experience); Scientist II level requires similar background with additional relevant industry experience
  • Hands-on experience in development, optimization and execution of cellular assays applying multiple techniques including primary cell isolation, tissue culture, ELISA, flow cytometry, Western and multiplexing technologies (e.g. Luminex, MesoScale)
  • Demonstrated track record in functional assay development in oncology and/or immunology
  • Familiarity with primary cell tissue culture, molecular biology techniques, CRISPR engineering of cells and the use of siRNA/shRNA knockdown techniques to support mechanism of action studies for drug candidates and target identification
  • Ability to conceive, design and execute hypothesis-testing experiments that directly contribute to project success is essential
  • Detail oriented with excellent communication and presentation skills
  • Background in cancer cell biology required with previous experience in the ubiquitin-proteasome (UPS) system a plus

Fit with Nurix Culture and Values

  • Strong team orientation, highly collaborative and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view
  • Excellent interpersonal skills
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Nurix was founded by internationally recognized experts in the ubiquitin-proteasome (UPS) field and received its initial funding from leading life science investors Third Rock Ventures and The Column Group.  Nurix recently entered into a multi-year collaboration with Gilead and Sanofi focused on developing bi-functional molecules to degrade protein targets as novel therapeutics.   Additionally, Nurix has a strong internal drug discovery pipeline focused on oncology, immunology and inflammation.  Nurix plans to advance two molecules into clinical trials in early 2021.

Apply Now

Research Associate/Senior Research Associate, Medicinal Chemistry

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry to join our Medicinal Chemistry team. You will work with a highly dynamic group that is focused on moving projects from the hit identification stage to the discovery of clinical candidates. The Nurix mission is to control protein fate to treat human diseases leveraging exciting technologies to target protein degradation.

The successful applicant will have demonstrated substantial experience in modern synthetic organic chemistry and standard analytical methods. Having developed an understanding of the physicochemical properties that drive drug discovery are highly desired.

As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of highly experienced scientists within Nurix as well as with external collaborators.

Qualifications

  • BA/BS or equivalent with typically 8+ years of relevant experience or MS with typically 4+ years of relevant experience or Ph.D. in synthetic organic chemistry with 0-4 years industrial chemistry experience (years of relevant experience will impact level of hire)
  • Creative skills in the design, performance and interpretation of chemistry experiments with strong synthetic problem-solving skills using a hypothesis-based approach
  • Excellent communication of project rationale, key experimental results, issues and accomplishments in appropriate verbal and written form
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Maintains an excellent scientific expertise in organic synthesis and a good knowledge of key medicinal chemistry principles
  • Good ability to manage own priorities and deliverables, both independently and in the team setting
  • Familiarity with tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making a strong plus but not required

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

High Throughput Automated Synthesis Specialist

Nurix is seeking a highly skilled and motivated automation specialist to lead our state-of-the-art robotic synthesis platform.  The ideal candidate will utilize robotic synthesis to provide highly impactful support across our entire research portfolio comprised of small molecule, heterobifunctional protein-degradation, and DNA encoded library (DEL) leads.  Working closely with analytical chemistry, this person will identify and hone workflows, maintain and program instrumentation, optimize parallel synthesis chemistries, and carry out robotic syntheses.  There are additional opportunities for project leadership. 

Position responsibilities:

  • Work independently and with medicinal chemists to develop, improve and simplify the automation process.
  • Identify, assess and implement state of the art automated platforms for parallel chemical synthesis.
  • Maintain automation systems and create new protocols.
  • Improve reaction chemistries allowing for multistep parallel syntheses.
  • Miniaturize chemistries for smaller plate formats
  • Work closely with informatics to implement a functional LIMS system to track synthesis routines.
  • Implement a sample management system to track and dispense reagents and final compounds to various workflows.
  • Provide automation expertise to other departments outside of Medicinal Chemistry.

Requirements:

  • Ph.D in organic chemistry or relevant field with 3+ years of pharmaceutical/biotech experience or MS or BA with 6+ years of relevant experience.
  • Experience working with Hamilton liquid handler systems or equivalent is mandatory.
  • Solid background in parallel synthesis is required. Understanding of medicinal chemistry concepts is also desired.
  • Strong computer skills are needed with expertise in excel and XSL programming.
  • Excellent communication and interpersonal skills.
  • Ability to troubleshoot and maintain instrumentation is mandatory.

Fit with Nurix Culture and Values

  • Strong team orientation, highly collaborative and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view
  • Excellent interpersonal skills
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Apply Now

Senior Research Associate/Scientist, Process Development

We seek a Senior Research Associate or Scientist with experience in cell therapy and/or process development to join Nurix’s NxACT Protocol Development Group in Pittsburgh. This position offers the candidate an opportunity to be part of a small but growing technical team in a highly motivating startup environment, instrumental in setting up the NxACT protocol development laboratory at the Pittsburgh location. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in oncology, immuno-oncology and other therapeutic areas. NxACT is promoting the next developments in drug-enhanced ACT.

This individual will work directly with the principal scientist at the NxACT Protocol Development Group in Pittsburgh and will have regular opportunities to present findings and opinions to project teams and senior management. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment. Career advancement will arise from the opportunity to grow the Protocol Development Group to a productive and necessary bridge to innovative clinical protocols in patients with cancer.

Primary Functions

  • Responsible for day to day laboratory operations including stocking and maintaining inventory for consumables, and equipment maintenance and oversee service contracts
  • Assist with process development improvements of the proprietary Nurix T cell platform
  • Execute sophisticated analytical assays to characterize T cell function and phenotype including repertoire analysis and flow/imaging cytometry
  • Contribute to the protocol development team by executing studies required to establish efficient and effective manufacturing processes of drug product including scale up.
  • Analyze results, solve problems and troubleshoot assays.
  • Author protocols and SOPs, maintain laboratory notebook records in adherence with documentation standards

Qualifications

  • B.S. with 4-5 years/M.S. with 1-2 years/Ph.D. degree in biochemistry, cell biology, immunology or related discipline.
  • Relevant work experience, preferably in a cell therapy biotech or pharmaceutical setting would be considered a plus.
  • Experience in analytical assay execution and development, particularly flow cytometry, ELISA, and cytotoxicity assays.
  • Excellent communication, technical writing and presentation skills and the flexibility to work on multiple projects as needed with documented ability to assess complex data sets
  • Experience working in cell culture operations including hands on experience with bioreactors (GREX, Prodigy, Wave) is a plus
  • The successful candidate will be strongly aligned with Nurix’s culture and values; he/she will be team-oriented and highly collaborative with a hands-on approach
  • The candidate should be enthusiastic, driven, and have the ability to work independently and thrive in a dynamic start-up environment

Fit with Nurix Culture and Values 

  • Strong team orientation; highly collaborative 
  • Solutions and results-oriented focus 
  • Hands-on approach; resourceful and open to diverse points of view 

Apply Now

Paralegal/Senior Paralegal

Our new Paralegal/Senior Paralegal will become the fourth member of our Legal Department and function as a key member of the team. The Paralegal/Senior Paralegal will support our contracting process, corporate governance and corporate filings.

Duties/Responsibilities:

  • Assist with the contracts process including maintaining the contracts system;
  • Prepare and review confidentiality agreements with attorney supervision;
  • Assist and maintain all corporate records;
  • Assist in the development of corporate policies, procedures and programs and in their trainings and compliance thereof;
  • Assist attorneys with transaction closings and maintenance of corporate records;
  • Provide administrative support for attorneys; and,
  • Successfully complete special projects and other assignments as requested.

Required Skills/Abilities:

  • Excellent verbal and written communication skills;
  • Understanding of legal language and principles, research methods, contracts, and other related matters;
  • Excellent interpersonal and customer service skills;
  • Excellent organizational skills and attention to detail;
  • Excellent time management skills with a proven ability to meet deadlines;
  • Strong analytical and problem-solving skills;
  • Ability to function well in a high-paced and at times stressful environment;
  • Ability to maintain confidentiality, and to exercise discretion and good judgment; and,
  • Proficient with Microsoft Office Suite or related software.

Education and Experience:

  • Qualified candidate must have a minimum of 5 years of experience as a contracts and/or corporate paralegal, with a focus on pharmaceutical and/or biotechnology products preferred;
  • Bachelor’s Degree required. Paralegal Certification preferred; and,
  • Other competencies sought:
    • Experience preparing confidentiality, consulting, master services agreements and the like;
    • Familiarity with records retention policies and document management systems;
    • Understanding of corporate formalities and related state-level reporting;
    • Some exposure to compliance programs in a pharmaceutical or biotech organization; and,
    • Ability to successfully balance the need to complete assigned tasks while limiting risk to the Company with the goal of supporting the creativity, enthusiasm and pace of internal business units at this growing pharmaceutical company.

Fit with Nurix Culture and Values

  • Strong team orientation, highly collaborative and results-oriented focus;
  • Hands-on approach; resourceful and open to diverse points of view;
  • Excellent interpersonal skills; and,
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment.

Nurix was founded by internationally recognized experts in the ubiquitin-proteasome (UPS) field and received its initial funding from leading life science investors Third Rock Ventures and The Column Group. Nurix recently entered into a multi-year collaboration with Gilead and Sanofi focused on developing bi-functional molecules to degrade protein targets as novel therapeutics. Additionally, Nurix has a strong internal drug discovery pipeline focused on oncology, immunology and inflammation. Nurix plans to advance two molecules into clinical trials in early 2021.

Apply Now

Director, Program and Portfolio Management

The Director of Program Management, provides project management expertise to cross functional Early Development Teams (EDT) through the oversight and facilitation of team interactions related to project operations and delivering on key program milestones.  This includes, but is not limited to, the development and management of project plans/timeline, issue and risk management, EDT coordination, facilitation and documentation of EDT meetings. The initial focus of this position will be to support the planning and execution of early development oncology projects, including adoptive cell therapy projects.

Responsibilities:

  • Proactively plans, coordinates and tracks the progress of IND stage and clinical stage cross-functional programs. Responsible for the initiation, planning, execution, monitoring, and closure of activities at the EDT level, including identification of risks and mitigation strategies/recommendations
  • Ensures effective, accurate, and timely communication across functional areas within the program, serves as a point of contact across multiple functions for program-related issues, including escalation of programs issues to ensure resolution
  • Partners with Program Team Leads to drive appropriate clinical development discussions at the cross-functional Early Development Team (EDT) level; responsible for agendas, minutes, action items tracking, and timelines to support productive EDT discussions
  • Partners with Clinical development lead to drive appropriate discussions at the Clinical Subteam level; responsible for agendas, minutes, and action item tracking
  • Partners with Regulatory lead to drive appropriate discussions supportive of regulatory submissions (e.g., IND, CTA, EOPX meetings, etc.); drives operational activities in support of regulatory submissions, including timeline creation and management
  • Serves as thought-partner to Program Team Leads and VP Program Management and Asset Strategy to drive creative thinking, formulate scenario-based development planning and strategy, and proactively identify and address programmatic gaps in thinking, process, or efficiency with a solution-based mindset
  • Creates and maintains global program plans, including near-term and long-term development timelines, budgets, resource projections, and project reporting supportive of the development strategy of clinical-stage assets (e.g. Product Development Plans, Target Product Profile)
  • Contributes to discussions or materials supportive of Executive Management Team (EMT) meetings, and/or Board of Directors (BoD) meetings
  • Demonstrates an empathic approach to problem-solving, with a willingness to work across all levels of leadership and functional areas in a growing, changing, and fast-moving environment
  • Demonstrates an ability to influence without authority in a grounded manner that results in productive discussions and effective decision-making
  • Leads Program Management efforts for multiple assets for one or more disease areas

Qualifications and Experience:

  • 10+ years experience in drug development; at least 6 years experience in project management
  • Depth of project management and drug development knowledge sufficient to allow her/him/them to drive activities with a high degree of independence; previous work and leadership experience across early to mid-stage clinical development preferred
  • Given start-up nature of organization, must be willing and able to perform both tactical, operational work (agendas, minutes, timelines) as well as engage and drive strategic dialogue across all stages of development and all levels of leadership
  • Demonstrated experience leading cross-functional teams; possesses a refined understanding of team dynamics, influencing without authority, motivating teams
  • Comfortable with change, readily adaptable and the ability to professionally navigate success and failure

Education and Experience: 

  • BS in a scientific discipline; advanced degree (MS, PhD, MBA) preferred
  • PMP or advanced project management training/certificate preferred
  • Proficient in relevant software, including but not limited to: MS Project, MS Office Suite, Smartsheets
  • Experience in oncology, cell-based therapies in particular, and autoimmune diseases preferred

Fit with Nurix Culture and Values 

  • Strong team orientation; highly collaborative 
  • Solutions and results-oriented focus 
  • Hands-on approach; resourceful and open to diverse points of view 

Apply Now