Culture & Careers

Job Openings

To be a part of our dynamic team of skilled scientific investigators and talented work force, please check our open positions.

Scientist I – Discovery Biology – Contract

We are seeking a highly skilled and motivated immunologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. This individual will work closely with our drug discovery project scientists on lead optimization of novel compounds to evaluate the impact on immune cells and characterize their MOA. The candidate must be self-driven, organized, able to work well with other scientists, and able to thrive in an exciting environment in a rapidly-growing company.

Qualifications

  • Ph.D. in immunology, cancer biology or related field with 0-2+ years of industry experience for Scientist I level position
  • Research experience in the field of immunology with a focus on T cell biology
  • Expertise in functional assays measuring cellular activation, cytokine release, proliferation, and killing
  • Experience in high-dimensional flow cytometry to phenotypically characterize immune cells including both surface and intracellular staining.
  • Experience with in vivo tumor mouse models is desired but not required
  • Develop novel ideas/technologies, eager to learn, innovate.
  • Propose and implement resolutions to technical problems/issues.
  • Work with departmental and/or cross functional peers to execute on assignments

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative; solutions and results-oriented focus
  • Strong scientific curiosity and initiative; hands-on and resourceful
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Company

Nurix, Inc. is a science-minded, goal-oriented organization that is focused on bringing novel, first-in-class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the protein degradation machinery of the cell. The Nurix scientific team has established an innovative drug discovery platform based on recent advances in understanding of the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation, a function vital to the healthy life of a cell, uncovering therapeutic opportunities in multiple disease areas. Nurix’s Protein Regulation Platform enables the discovery of selective inhibitors or activators of the UPS, enabling the discovery of new class of drugs that can restore normal cellular homeostasis. Nurix entered into an exclusive collaboration with Sanofi and Gilead for the discovery and development of next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology. Nurix was founded by internationally recognized experts in the ubiquitin proteasome field and is funded by leading life science investors, Third Rock Ventures and The Column Group. The company is headquartered in San Francisco, California

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Director/Senior Director, Clinical Scientist

Nurix has a place for an extraordinary, highly motivated, and accomplished Director/Senior Director, Clinical Scientist.

As an integral member of the Clinical Development Team, this person will help to develop innovative solutions for the clinical development of Nurix’s pioneering protein modulation programs in hematology, oncology, and cell therapy. Working in close collaboration with the study teams, the incumbent will provide scientific guidance and support.

This role will is responsible for various aspects of clinical study design and execution including: protocol writing, building study infrastructure, staff training, data cleaning/analysis, investigator interaction and support of regulatory filings. In addition, this role will be responsible for providing supporting rationale for clinical development working closely with the Head of Development.

Job Responsibilities:

  • Participate in and contribute to cross-functional clinical development teams with strong ability to work closely with all team members, address study or other program-specific questions.
  • Develop the Global Development plan with senior clinical development staff
  • Implement Global Development Plan with strategic clinical science support
  • Assist in reviewing and authoring clinical protocol.  Read and interpret scientific and medical literature for the use in clinical documents and to assist clinical team decision making.
  • Prepare clinical portions of all relevant regulatory filings and meeting packages (INDs, Annual Reports, meeting requests, NDAs, etc.) for US and ex-US Health Authorities.
  • Integrate scientific knowledge and operational expertise to ensure translation of clinical research plans into efficiently delivered, high quality studies.
  • Acquire and utilize knowledge of clinical trial design and relevant disease indications to assist in study concept and protocol development. Contribute to discussions concerning scientific and procedural aspects of study design. Coordinate with departments to produce the final protocol and informed consent documents.
  • Compose medical data review plans, Data Safety Monitoring Board (DSMB), Safety Review Committee (SRC) charters, and specific sections of study manuals and investigator meeting materials.
  • Contribute significantly to the development of CRFs, data edit checks, patient profile design, ongoing data cleaning (query generation, coding review, SAE reconciliation) and data trend analysis.
  • Lead internal clinical data review meetings in conjunction with the medical monitor; lead the data preparation effort for dose escalation meeting, as applicable to study stage.
  • Coordinate and manage external medical advisory committees for the study team such as DSMBs and Scientific Steering Committees, in conjunction with the medical monitor.
  • Research and summarize published literature for continual learning and to prepare training materials for other clinical team members.
  • Contribute to statistical analysis plans, table, listing, figure design and the preparation of manuscripts and other presentations of study data, as appropriate.
  • Address investigator questions regarding protocol and related scientific issues and attend site initiation visits (SIVs), in coordination with the medical monitor.
  • Assist in determining the activities to support a project’s priorities within functional area
  • Trains other clinical scientists as needed.

Basic Qualifications

Advanced degree (MD, PhD, or PharmD) and 8+ year’s relevant drug development experience

Preferred Qualifications

  • Experience directly in the clinical science role, in a hematology/oncology indication for first-in-human and proof of concept studies in small molecules and/or cell therapy. Registrational or Phase 3 study experience is preferred.
  • In depth understanding of clinical operations and translational medicine.
  • Excellent interpersonal skills.
  • Able to translate technical concepts into accessible language and direction for the broader study team.
  • Excellent attention to detail, partnership and initiative, with flexibility to adapt to the needs of the organization; maintain meticulous attention to project deadlines.
  • Experienced in Microsoft Office (Excel, Word, PowerPoint, OneNote), and ideally also with job related programs such as Spotfire and Medidata Rave or similar.
  • Strong understanding of ICH GCP, as well as general knowledge of industry practices and standards
  • Commitment to patient safety and clinical compliance.

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view 

Apply Now

Lead Discovery – Research Associate (Temp)

We are seeking a highly motivated individual with a 1+ years lab experience and background in Biochemistry or Molecular Cell Biology to join our Lead Discovery team at Nurix.

This position will perform a number of biochemical and protein-based assays in support of our early drug discovery efforts at Nurix. These will include characterizing the activity of novel small molecules in custom biochemical assays and characterizing protein behavior and stability under various buffer conditions, among other activities. In this role, the applicant will work as part of a highly collaborative, interdisciplinary team of biochemists, structural biologists, cell biologists, and medicinal and computational chemists and will have the opportunity to train in a number of new lab techniques.

The candidate should have a strong desire to learn new techniques and the ability and interest to cross train in all aspects biochemical assay development. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in the dynamic team environment here at Nurix.

Qualifications

  • Bachelor’s or master’s degree in Biochemistry, Molecular and Cell Biology, or related field
  • Familiarity with the concepts of enzyme catalysis, protein-ligand and protein-protein interactions, and the principles that govern these interactions
  • 1+ years of laboratory experience in the areas of biochemistry, protein chemistry, or biophysics. Examples of highly relevant experience include:
    • Work with biochemical assays (e.g. enzymatic, ubiquitylation, protein-protein interaction, fluorescence polarization, FRET, AlphaLISA, etc.)
    • Use of spectrophotometers or fluorescence plate readers (e.g. Perkin Elmer Envision, etc.)
    • Experience with laboratory automation or robotics (e.g. Agilent Bravo, Biomek FX, etc.)
    • Protein purification (e.g. AKTA Purification of proteins from coli or SF9 cells)
  • Experience and proficiency with data processing programs (i.e. Microsoft Excel, GraphPad Prism, etc.)

Fit with Nurix Culture and Values

  • Strong team orientation, highly collaborative and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Apply Now

Manager, Payroll and Equity

This is a newly created position to oversee both payroll and stock administration primarily. The successful candidate will be responsible for the day-to-day operations and transactions as well as month-end accounting close and reconciliations in a fast-paced and dynamic environment. The individual will work closely with various parties including employees, HR, legal, broker, transfer agent, outsourced stock admin firm and financial auditors.

Essential Duties and Responsibilities in Payroll Administration

  • Manage semi-monthly payroll for both exempt and non-exempt employees in a multi-state environment with accuracy
  • Prepare payroll and tax reports for Federal, states, and local agencies when required
  • Ensure compliance with policy and procedure as well as federal, state and local payroll tax   regulations
  • Coordinate with HR to assure seamless and timely integration of information for payroll processing and reporting
  • Perform FSA and ESPP reconciliations and resolve discrepancies
  • Prepare journal entries and monthly payroll reconciliations
  • Address employee inquiries in a timely manner
  • Assist with year-end audits, workers compensation audits, 401(k) audits, and regulatory filings
  • Maintain good recordkeeping of all payroll files and sound internal controls

Essential Duties and Responsibilities in Stock Administration

  • Prepare and process new equity awards, exercises, cancellations and releases promptly.   
  • Manage open enrollment process and purchases for ESPP.
  • Administer the stock option awards and ESPP plans, including ensuring appropriate payroll tax withholdings, timely estimated tax deposits and monitoring ESPP limits
  • Track and report W-2 income from stock exercises and dispositions
  • Execute trading blackout periods and enforcement of insider trading policy restrictions
  • Interact with transfer agent and stock investment broker to ensure that trades are settled timely
  • Maintain and update stock databases, prepare reports and perform analysis and reconciliations, assist with quarterly and year-end audits
  • Engage in process improvements opportunities to support business growth while maintaining sound internal controls and be in compliance with Sarbanes-Oxley Act
  • Assist in month end close and other ad hoc tasks or projects as assigned

Requirements

  • Bachelor’s Degree in Accounting or Finance
  • 7+ years of relevant experience in payroll processing, stock administration and related accounting analysis and month-end reconciliations
  • Ability to work well independently and as a team member in a time sensitive environment
  • Unquestionable ethics and discretion when dealing with confidential and sensitive data
  • Strong Excel skills
  • Exceptional ability to prioritize, organize and manage multiple projects simultaneously
  • Self-motivated and proactive, able to multi-task, and detail oriented
  • Strong verbal and written communication skills, as well as effective listening and interpersonal skills

Preferred Experience

  • Experience with NetSuite, Paylocity and ShareWorks is a plus
  • CPP or CEP designations a plus

Apply Now

Research Associate/Senior Research Associate, Discovery Biology

We are seeking a skilled and motivated individual with expertise in cell biology and immunology to join our Discovery Biology team. The successful candidate will support early drug discovery efforts in Immunology, Oncology, and Immuno-Oncology. These duties will include planning, execution and analysis of in vitro cellular assays to support small molecule discovery efforts, mechanistic studies, and new target identification. This individual will work closely with scientists from cross-functional disciplines and present findings to project teams. The ideal candidate will be self-driven, eager to learn new techniques, highly organized, focused, and enjoy working in a creative and dynamic team environment.

Required Qualifications

  • For RA: Bachelor’s or Master’s degree with 2-5 years of industry experience
  • For SRA: Master’s degree in Biochemistry, Cell and Molecular Biology, or related field with 6+ years industry experience (or Bachelor’s degree with 8+ years of industry experience)
  • Extensive hands-on experience with cell culture (cell lines or primary cells) and good aseptic technique
  • Hands-on experience in development, optimization and execution of multiple immune and cellular assays including primary cell isolation, ELISA, and western blot
  • Experience with molecular biology techniques and shRNA/CRISPR knockdown
  • Prior experience with quantitative medium-to-high throughput assays for assessing cellular phenotypes (FRET-based assays, luminescence assays, flow cytometry, MesoScale)
  • Strong organizational skills and experience presenting results to multi-disciplinary scientific teams

Bonus Qualifications

  • Flow cytometry experience strongly desired
  • Experience performing functional immune assays (e.g. migration, activation, cytokine secretion, differentiation, target cell killing) with primary human cells
  • Experience with additional cellular and molecular techniques such as high-content imaging or RNAseq
  • Background in ubiquitin biology or targeted protein degradation

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Director/Senior Medical Director

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B (CBL-B), an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Position

We are seeking a brilliant and highly motivated Director/Senior Medical Director who will provide strategic and tactical medical leadership and will deliver key clinical and scientific leadership to clinical development programs while ensuring the highest standard for safety and compliance with regulatory requirements and standard procedures. The ideal candidate should have experience working in a fast-paced dynamic environment.

  • Develop Clinical Development Plan (CDP) and act as the clinical lead for protocols and supportive activities to meet the CDP objectives
  • Provide training and ongoing input to all members of the clinical team on medical and scientific issues related to the appropriate therapeutic field
  • Provide clinical oversight for Company operational staff, contract research organizations (CROs), and clinical trial sites in all areas related to the therapeutic programs
  • Provide medical input and support for data management including design and review of case report forms
  • Provide medical input and support for Pharmacovigilance tasks such as development of the Investigator Brochure and annual drug safety reports
  • Participate in the development of Clinical Development Plans (CDP) and act as the clinical lead for protocols and supportive activities to meet the CDP objectives
  • Interact with principal investigators and opinion leaders to facilitate clinical trials research
  • Establish and approve scientific methods for design and implementation of applicable clinical protocols, data collection systems and final reports
  • Be responsible for adequate and ongoing review of clinical data
  • Acts to provide medical oversight and safety monitoring for ongoing clinical trials including participation in SAE reporting and serving on the safety committee
  • Provide medical support for all relevant regulatory discussions and activities, such as IND’s and NDA/MAAs
  • Participate in clinical study report conceptualization, development and writing for global regulatory submissions

Required Qualifications

  • MD, board certified preferably in oncology
  • Requires at least 5 years’ clinical trial experience in the setting of pharmaceutical industry with demonstrated experience and involvement in clinical trial design or execution
  • Relevant clinical research experience in academic settings will be reviewed in light of clinical development experience
  • Excellent communicator with proven leadership skills and the ability to interact in a cross functional environment
  • Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Apply Now

Protein Sciences – Research Associate to Research Associate III

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Position

We are seeking an enthusiastic candidate with a B.S. in a biological science and research experience in an academic or industry lab to join Nurix’s Protein Sciences team for a contract-to-hire position. The ideal candidate has hands-on experience in recombinant protein expression in insect and/or mammalian cells. Candidates without significant hands-on experience will be initially mentored by a senior member of the protein sciences team to conduct experiments related to protein production in these systems.  As a member of the protein sciences team, the candidate will be encouraged to actively participate in project teams across the organization.

Primary Functions

This individual will be responsible for the in-house production of recombinant proteins in mammalian and insect cell systems.  The role includes expression screening and optimization, large scale expression and small scale purification to ensure production of quality protein. In addition, the candidate will be encouraged to identify and implement platform improvements.  The successful candidate will work closely with scientists from cross-functional disciplines and with all members of the protein sciences team. The candidate should have a strong desire to learn new techniques and the ability and interest to cross train in all aspects of protein expression and purification. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.

Qualifications

  • Undergraduate degree in Biochemistry, Cell and Molecular Biology, or similar discipline.
  • Hands-on experience in recombinant protein expression screening, optimization and large scale expression in mammalian and insect cell lines in an academic or industry setting is highly desirable.
  • Hand-on experience in protein purification in an academic or industry setting, including basic knowledge of protein purification and characterization techniques (e.g. IMAC, SEC, IE, SDS-PAGE,UV-Vis), is highly desirable.
  • Must keep a detailed record of experiments in an electronic laboratory notebook (instruction provided).
  • Must be able to follow protocols and promptly communicate results and difficulties.
  • The successful candidate will be aligned to Nurix’s culture and values; he/she will be team oriented and highly collaborative with a hands-on approach.
  • The candidate should be enthusiastic, driven, team oriented and have a “can do” attitude.
  • Recent graduates (0-2 years) with a strong desire to learn are especially encouraged to apply.

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Apply Now

Regulatory Affairs – CMC Specialist, Cell Therapy Products

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Position

We are seeking to hire an experienced CMC regulatory specialist/manager to support the preparation and maintenance of CMC regulatory submissions to FDA and other Regulatory Agencies for Adoptive T Cell therapy products.

Key responsibilities:

  • Closely collaborate with the T-Cell process development and manufacturing teams to develop regulatory CMC documentation for IND submissions and /or submission to ex-US Regulatory Agencies
  • Maintain ongoing knowledge of FDA and international regulations and guidelines, as well as current practice for CMC submissions including those specific to Adoptive T-cell production, and advise manufacturing and QC teams accordingly
  • Review and compile regulatory CMC documentation for IND submissions within corporate timelines
  • Authoring CMC documentation/summaries from manufacturing, testing, and stability reports.
  • Coordinate eCTD building with publishing CRO
  • Contribute to Regulatory departmental SOPs

Required Qualifications

  • University degree in science, engineering, and/or biotechnology
  • At least 5 years of experience in Regulatory Affairs in the pharmaceutical industry
  • Working knowledge of FDA regulations and FDA/ICH guidelines pertaining to CMC submissions, in particular FDA guidance applying to Biologics
  • In depth understanding and prior experience with CMC submissions for adoptive T-cell therapy in pharmaceutical industry or academic center
  • Meticulous attention to detail
  • Ability to self-manage and organize a high workload.
  • Strong technical writing skills

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Apply Now

Research Associate/Scientist, Encoded Library Technology Development

About the Position

We are seeking a talented and highly motivated scientist to join our Library Discovery team and help us augment our DNA encoded library collection. The key objective for this position is to identify and solve key bottlenecks in the DEL pipeline and develop innovative next generation improvements to the underlying technology.  Broad scientific interests spanning biology, chemistry, and drug discovery highly desirable.  Responsibilities may also include library development and selection analysis.

Qualifications

  • BS, MS, or PhD in life sciences (ex. chemistry, biochemistry, biology) with 0-5 years industrial chemistry experience (years of relevant experience will impact level of hire).
  • Training in molecular biology methods and high throughput assay development
  • Interest and ability to apply solutions from disparate fields of science and engineering to solve problems in the DEL technology platform and drug discovery in general
  • Must have ability to work independently; Be highly self-directed and self-motivated
  • High level of creativity and productivity with strong problem-solving skills.
  • High level of attention to detail and good organizational skills.
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments to other members of the department.

Fit with Nurix Culture and Values

  • Strongly team-oriented; highly collaborative
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Senior IT System Administrator

The ideal candidate will help Nurix evolve a secure, robust environment for users to do their work, no matter where they are working. The ideal candidate will have a diverse background that includes infrastructure, support experience, vendor management skills and experience with MSPs (Managed Service Providers). 

Key Responsibilities

  • Be the owner of the networking, server & storage platforms, active directory, backup, and archive.
  • Represent the IT infrastructure team for project support
  • Ensure stable and secure infrastructure operations and standardization of components
  • Maintain compliance of GxP, SOX relevant systems
  • Ensure the delivery and availability of the IT infrastructure services and operations, within agreed SLAs.

Required Experience

  • A minimum of 7-10 years of hands-on experience in IT Administration and systems
  • Assess, evaluate, and maintain in-house and outsourced services.
  • Vendor management and interaction for hardware, software, and service troubleshooting and resolution.
  • Manage endpoints, services, and frequent/regular vendor SLA checks.
  • Ensure the continuous improvement and management of existing IT server platform services and policies.
  • Investigate new systems and models that can bring improvements
  • Routing and switching experience. Cisco Meraki a plus
  • Experience with cloud compute, DevOps and storage (AWS and/or Azure)
  • Hands-on experience with VMware products ESXi vSphere, vCenter.
  • Experience administering and managing Okta SSO / MFA
  • Experience with administrating Microsoft collaboration suite (Office 365 Mail, Teams, SharePoint, OneDrive)
  • IT Support 2nd or 3rd line support escalation
  • Migrate systems from on-premise and co-location sites to cloud infrastructure
  • Extensive knowledge and hands-on experience with Microsoft Server operating Systems & Active Directory.
  • Previous experience developing disaster recovery and business continuity solutions

Preferred Skills and Knowledge

  • Excellent interaction and communication skills; ability to communicate (both written and verbal) clearly and concisely with a cross-functional audience
  • Work schedule flexibility required as some work must be completed after business hours.
  • Experience with cloud compute and storage (AWS and Azure) and Linux
  • Knowledge of datacenter operations & database administration
  • Previous Experience in a healthcare, life-science, Biotech or Pharma regulated environment a plus
  • Experience working in a fast-moving, startup environment

Apply Now

Manager/Sr. Manager Cell Therapy Logistics

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Position

Nurix, Inc. is seeking a Manager/Sr. Manager of Cell Therapy Logistics to join the Clinical Supply Chain team.  This is a new role within the company.  The incumbent will be instrumental in its creation.  This individual will be responsible for all aspects of the planning and execution of logistics functions for Nurix’s clinical Cell Therapy programs.  This position reports to the Director, Clinical Supply Chain.  The role requires the ability to manage multiple activities simultaneously, balancing priorities, ability to work with ambiguity, and significant attention to details.

This individual will be involved in work central to Nurix’s strategic goals. They will apply existing technical skills, learn new skills, and play a role in development of the programs and help grow the company.

This position is primarily responsible for managing the critical, time sensitive aspects of Cell Therapy Logistics.  Responsibilities include: working with Clinical Operations and Transport Vendors for shipping  tumor samples to manufacturing sites from Clinical Sites, and return of Drug Product from manufacturing sites to Clinical Sites; coordination with CMC of the timing of manufacturing at production facilities; management of storage, and logistics vendors; inventory management of select Clinical Supplies at depots and sites; and, returns and destruction.

  • Participate in cross-functional team meetings internally and externally
  • Create and maintain a tracking process to ensure drug product traceability and chain of custody between clinical and manufacturing sites
  • Liaise with Clinical Operations/Sites to schedule pick up of Tumor Sample from Clinical/Manufacturing Sites
  • Liaise with Manufacturing/Vendors to ensure slot for Production of Cell Therapy Drug Product, and select Clinical Supplies
  • Collaborate with team members to resolve constraints or delays to mitigate potential risks
  • Collaboration with Quality Assurance to investigate exceptions in storage and logistics activities
  • Support the writing and revision of supply chain related Standard Operating Procedures
  • Participate in vendor selection
  • Accountable for process discrepancies
  • Facilitate technical troubleshooting when necessary, participate in investigations, and escalate as appropriate
  • Other duties as assigned

Required Qualifications

  • Bachelor’s Degree or equivalent, preferably in a science, manufacturing, supply chain, operations management or business management background, with 5+ years of related work experience
  • Experience with Cell therapy and gene therapies highly preferred
  • Good understanding of current Good Manufacturing Practices (cGMP), Food and Drug Administration (FDA), and other regulatory requirements (EMA, TGA)
  • Perform tasks in a manner consistent with the safety policies, quality systems, and GMP requirements
  • Ability to influence others and work independently and in a team environment
  • Work experience in a supply chain, planning, or manufacturing role
  • Ability to effectively plan, prioritize, execute, follow up, and anticipate challenges
  • Experience managing complex schedules and priorities in dynamic environments
  • Ability to work, influence, and gain consensus across multiple functions (Manufacturing, Regulatory, Quality, and Clinical)
  • Ability to operate and thrive in a fast-paced, start-up environment
  • Analytical, problem solving and critical thinking skills
  • Expertise in the use of MS Excel, Office, and PowerPoint
  • Good Documentation Practices
  • Excellent interpersonal, verbal, and written communication skills
  • Self-motivated, builds trust easily and operates with integrity and ethics
  • Occasional travel

Bonus Qualifications

  • Experience in Global Cell Therapy Trials
  • Experience in Packaging & Labeling
  • Adept at developing visual management tools to provide status updates on organizational performance

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Apply Now

High-Throughput Synthesis Scientist

Nurix is seeking a skilled and motivated chemist to join the growing high throughput chemistry team within the Medicinal Chemistry Department. The scientist will:

  • Be responsible for the design and execution of automated parallel synthesis experiments.
  • Interact with Medicinal Chemists and DNA Encoded Library (DEL) scientists to optimize and validate chemical routes for their transfer to parallel synthesis platforms using both solution phase and solid phase chemistry approaches.
  • Participate in the design, development, optimization, validation and integration of complex automation configurations for high-throughput applications on parallel synthesis.
  • Be highly organized and demonstrate clear verbal and written communication

Key Responsibilities:

  • Synthesis of chemical arrays using automated synthesis platforms.
  • Integrate and establish workflow with automation robots, such as liquid handler, solid dispenser, parallel synthesizer and high throughput analytical systems.
  • Streamline workflows and develop automated laboratory processes.
  • Participate in the design of new automated workflows with the team as the need arise
  • Contribute to maintaining automation systems and developing new protocols.
  • Collaborate with medicinal chemistry teams and/or DEL scientists to apply automated chemistry capabilities to accelerate the discovery chemistry program.
  • Participate in the design of new chemical arrays for Medicinal Chemistry projects.
  • Contributing to scientific strategies and goals within a project team setting.
  • Provide training to medicinal chemists on usage of instrumentation when necessary

Desired Skills and Experience

Bachelor’s degree or higher in a relevant field. Title commensurate with education and experience.

  • A minimum of 1 year of experience in designing, building and integrating complex automation configurations for high-throughput applications in pharmaceutical, biotech or related industry is preferred
  • Practical knowledge of the application of parallel synthesis techniques to synthetic or medicinal chemistry is required
  • Knowledge of solid phase chemistry principles and/or solid support bound catalysts/reagent used in solution phase chemistry is preferred but not mandatory.
  • The ability to work in a cross-functional environment with a can-do attitude to drive productivity and efficiency is required
  • Experience with operating and programming liquid handling robotics platforms is required
  • The ability to operate, maintain and troubleshoot minor issues with high throughput synthesis systems is required
  • Practical knowledge of Hamilton Instinct V XSL programming is strongly preferred
  • Experience with high throughput synthesis systems (e.g., ChemSpeed, UnChained Labs etc.) is preferred
  • Experience with modern cheminformatics tools, computational tools, enumeration tools and other scientific software for drug discovery is preferred

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CMC Project Manager/Senior Manager

The candidate will be a key leader within Program Management, and support CMC (Chemistry, Manufacturing and Control) projects and information management for one or more of the small molecule programs within Nurix development portfolio.

In this newly created position, the CMC Project Manager will be responsible for providing consistent project status to internal and external stakeholders for CMC projects within the Nurix portfolio, and ensuring integration and alignment into overall program timelines. Reporting to the VP Program Management and Asset Strategy, the leader in this role will partner internally with cross-functional stakeholders, and externally with contracted vendor organizations (for example: contract development and manufacturing organizations, CDMO’s). The individual will work closely with the development and clinical supply teams for one or more projects: to develop, update and optimize CMC project plans, facilitate and lead formal and informal communication internally and with external partners, and promote an environment of efficient, visible, execution that includes optionality as challenges arise.

Responsibilities:

  • Coordinates the design and execution of cross-functional CMC project plans for early clinical development to commercial readiness for small molecule therapeutics.
  • Maintains frequent communication with the cross-functional CMC project team members and key internal stakeholders so that all parties are aware of current project status, issues, contingencies, and milestones.
  • Proactively identifies CMC critical path, risks and impediments to successful development and drives the identification and development of solutions to mitigate these risks.
  • Prepares summary information on CMC project progress, timeline updates and risk assessment for integration into Early Development Teams and overall program timelines; periodic presentations to program oversight committees.
  • With team members and in accordance with corporate objectives, facilitates the setting of program CMC strategy and objectives, key milestones and scope.
  • Leads CMC team meetings and ensures that clear agendas are set, and actions and decisions are documented, communicated and committed to, enabling timeline achievement
  • Builds strong working relationships across departments, with key stakeholders to ensure transparency and to facilitate communication.
  • Establishes project management best practices and assists in the implementation of infrastructure necessary for successful project management such as the preparation of SOPs relating to written processes and procedures and the establishment of electronic document standards.

In addition to the CMC Project Manager responsibilities, Sr. Manager responsibilities will include:

  • Independently develops the project plan based on work breakdown structure.
  • Serves as the primary point of contact for CMC project management activities internally and externally.
  • Supports discussions regarding clinical and commercial supply agreements. Support sourcing process as needed.
  • Assesses CMC project performance using appropriate tools and techniques and identifies/quantifies any variances to the approved CMC project plan
  • Performs other duties as assigned

Qualifications:

  • Minimally, a B.S. degree in life sciences, chemistry, engineering or equivalent
  • A minimum of 5 years as a contributor for a technical program related to biotech, pharmaceuticals, or materials manufacturing as a contributor and at least 5 years as a leader/manager
  • Extensive intermediate to advanced computer skills (Power Point, excel, Work, MS Project, SharePoint)
  • Demonstrated track record providing strategic and tactical support to development and supply chain functional groups within a company
  • Experience working with CMC Teams and managing relationships with CMOs/CROs, preferred
  • In-depth knowledge of the pharmaceutical industry and drug development and approval process a significant plus
  • Early stage clinical development and IND experience is preferred; late stage development and commercial readiness a plus.
  • Strong organizational, communication (verbal and written) and forecasting skills
  • Confident and respectful when interacting with all levels of management: stays focused and on-point, and raises problems or challenges in a productive, solution-minded manner
  • Diplomatic and calm under pressure; able to deal with uncertainty in a constructive manner and generate options for moving forward
  • Unquestionable ethics and integrity
  • Excellent interpersonal skills including people management, time management, and prioritization
  • Proven ability in negotiating/influencing and collaboration

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Senior Director/Vice President, Nurix Adoptive Cell Therapy (NxACT)

The successful candidate will be responsible for the execution of enabling activities toward overseeing manufacture and delivery of drug-enhanced cell-based therapies. Nurix’s clinical development programs target protein fate for cancer immunotherapy on its San Francisco campus. Working with the Discovery and Process Development (located at the Pittsburgh campus) organizations, the translational SD/VP:NxACT will be responsible for overseeing and developing additional contract manufacturing sites, overseeing contracts/contract fulfilment, analysis and interpretation of data to guide development of a premier cell therapy organization based on the best scientific information available from internal and contracted sources. 

Specific responsibilities include:

  • Utilize broad technical expertise in cell and tumor immunology, biochemistry and molecular biology to oversee and implement Nurix’s clinical cell therapy development assets.
  • Oversee translational research studies to identify and validate Nurix advanced cell therapy development programs.
  • Oversee and integrate human drug enhanced tumor infiltrating lymphocytes (DeTIL) and tech transfer into manufacturing using advanced methods of T cell expansion, and cell culture
  • Prioritize early small molecule drug candidates for their ability to enhance growth and focus of anti-tumor DeTIL as therapeutic reagents
  • Oversee intersection between CMO and PD in Pittsburgh (NxACT), making sure we are GMP/GLP compliant there and here, establishing measures of DeTIL-01 process, assessment of infusion product, persistence (Phenotype, nanostring, iRepertoire, ATACseq) to enable continuous process improvement
  • Implement novel cell therapy strategy with CMO/academic partners manufacturing cells prior to registration campaign; provide oversight and contract development, negotiation
  • Build Out Manufacturing Including Expanded QC
  • Develop and implement hiring plan, operational elements for Process Development and Manufacturing
  • Develop technology transfer from PD to manufacturing and registration strategy for DeTIL
  • Develop gap analysis for wholly integrated Immuno-Oncology Company developing, assessing and driving fully differentiated TPPs for cancer

Education and Skills Requirements:

  • S. with advanced degree M.D./Ph.D. with >10 years/ experience in cell biology, immunology or related discipline. Industry and management experience is a plus.
  • Understanding of biology supporting adoptive cellular therapy as a therapeutic modality.
  • Demonstratable experience in multi-color flow cytometry interpretation and characterization of cellular subsets in human blood and tissue is required.
  • Ideally, candidate will have training and/or experience in designing and implementing translational research efforts in in vitro functional cell culture assays, including assessments of cytotoxicity, cytokine production and proliferative capacity.
  • Ability to troubleshoot and interpret complex data in an independent fashion
  • Prior role in multidisciplinary projects and teams with ability to integrate cross-functional information is an advantage
  • Excellent interpersonal, verbal and written communication skills, creative thinking, problem solving, flexibility and demonstrated ability to harness existing data sets to inform translational research are essential for this role.
  • Collaborative spirit and ability to work with project teams, external investigators and contract research organizations.
  • Highly motivated, innovative and strong team player. Excellent time management and organizational skills required.

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Translation Medicine Biosample Specialist

Nurix Therapeutics, Inc. is seeking a Biosample Specialist to join the Translation Medicine team. This is a full-time position, and the individual will report to the Senior Manager of Biosample Management. This individual will work cross functionally, with both internal and external stakeholders, to plan, coordinate, and oversee all operational activities required to manage the lifecycle of the clinical biosamples.

Responsibilities:

  • Participate in the protocol and informed consent form review process to ensure logistical feasibility of biosample handling, alignment with planned analyses and ICH/GCP compliance
  • Participate in the CRF development process to ensure biomarker sampling information is appropriately collected for sample tracking and reconciliation purposes
  • Provide input on kit design, sample processing, collection, storage and shipping to ensure that the investigator sites can meet the sample handling needs of the study
  • Navigate the sample management platform to track the life cycle of the samples, identify trends and gaps and obtain sample metrics
  • In partnership with the Study Lead, provide adequate training and guidance to the investigator sites and study monitors for biosample collection, handling and shipment
  • Provide input on laboratory vendor contracts and data transfer agreements and monitor data delivery timelines and receipt
  • Plan, coordinate and oversee sample shipments and query resolution at laboratory vendors
  • Serve as an active member of the Clinical Study Teams and provide regular biosample metrics and status updates

Experience and Skills:

  • B.S./ B.A. in biological sciences with 3+ years of relevant industry experience
  • Knowledge of FDA & ICH/GCP regulations and guidelines
  • Proficiency in MS office including Word, Excel, PowerPoint and other applications
  • Proven track record of sample management, data management and contract management skills
  • Ability to manage work flows and data sets
  • Good initiative and ability to work independently
  • Ability to work in a fast paced environment
  • Excellent written and interpersonal communication skills
  • Detail oriented with the ability to manage multiple competing priorities
  • Effective team player and ability to collaborate with cross functional clinical study teams

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Scientist I – Cell Biology – Contract

We are seeking a highly skilled and motivated immunologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology for a longer-term engagement (and possible temp-to-hire opportunity). This individual will work closely with our drug discovery project scientists on lead optimization of novel compounds to evaluate the impact on immune cells and characterize their MOA. The candidate must be self-driven, organized, able to work well with other scientists, and able to thrive in an exciting environment in a rapidly growing company.

Qualifications

  • D. in immunology, cancer biology or related field with 0-2+ years of industry experience for Scientist I level position
  • Research experience in the field of immunology with a focus on innate immunity
  • Expertise in functional assays measuring cellular activation, cytokine release, proliferation, and killing
  • Experience in high-dimensional flow cytometry to phenotypically characterize immune cells including both surface and intracellular staining.
  • Experience with in vivo tumor mouse models is desired but not required
  • Develop novel ideas/technologies, eager to learn, innovate.
  • Propose and implement resolutions to technical problems/issues.
  • Work with departmental and/or cross functional peers to execute on assignments

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative; solutions and results-oriented focus
  • Strong scientific curiosity and initiative; hands-on and resourceful
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Company

Nurix, Inc. is a science-minded, goal-oriented organization that is focused on bringing novel, first-in-class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the protein degradation machinery of the cell. The Nurix scientific team has established an innovative drug discovery platform based on recent advances in understanding of the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation, a function vital to the healthy life of a cell, uncovering therapeutic opportunities in multiple disease areas.

Nurix’s Protein Regulation Platform enables the discovery of selective inhibitors or activators of the UPS, enabling the discovery of new class of drugs that can restore normal cellular homeostasis. Nurix entered into an exclusive collaboration with Sanofi and Gilead for the discovery and development of next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology. 

Nurix was founded by internationally recognized experts in the ubiquitin proteasome field and is funded by leading life science investors, Third Rock Ventures and The Column Group. The company is headquartered in San Francisco, California.

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