Culture & Careers

Job Openings

To be a part of our dynamic team of skilled scientific investigators and talented work force, please check our open positions.

Senior Research Associate/Scientist I, Biophysics

Position

We are seeking a highly skilled and motivated Scientist with expertise in Biophysics to join Nurix’s Discovery team.

You will provide scientific leadership in Nurix’s biophysics efforts to help support our hit identification, hit-to-lead and structural biology efforts. You will play a key role in collecting and interpreting biophysical assay data for ongoing discovery programs, but also will be responsible for implementing novel biophysical assays and techniques to expand our capabilities. You will work closely with an experienced team of interdisciplinary scientists and have regular opportunities to present findings to the project team and senior management.

You should have a strong desire to learn new techniques and incorporate new methodologies into your work.  You must be self-driven, resourceful, organized and focused, and enjoy being a part of a dynamic team in a project-based environment solving challenging scientific problems to benefit patients.

Qualifications

  • Ph.D. in Biochemistry, Biophysics or a related field, or an M.S. with at least three years of relevant work experience, or a B.S. with five years of relevant work experience
  • Experience using biophysical techniques to analyze protein-protein interactions as well as protein-small molecule interactions
  • Hands on experience with Surface Plasmon Resonance (SPR) or Grating-Coupled Interferometry (GCI)
  • Expertise with the kinetic and thermodynamic characterization of ligand binding as well as quantitative data management and analysis
  • Practical experience with biophysical techniques such as Microscale Thermophoresis (MST), Isothermal Titration Calorimetry (ITC), Differential Scanning Fluorimetry (DSF), and Nuclear Magnetic Resonance (NMR) is preferred
  • Excellent communication skills and ability to present rationale, key data, issues and accomplishments to other members of the scientific team
  • Good fit with Nurix culture and values of highly collaborative, team-oriented research

Application Process

Please include a two-page research summary that highlights the above qualifications along with your resume when submitting your application. 

Apply Now

Computational Chemist

Position

We are seeking a talented and highly motivated computational chemist with a strong background in Structure Based Drug Design to join our team. The Nurix mission is to treat human diseases by leveraging exciting new drug discovery technologies such as targeted protein degradation. Nurix Therapeutics is based in the San Francisco Mission Bay research campus. We have a broad pipeline of partnered and in-house programs in multiple therapeutic areas, including strong multi-target partnerships with Gilead Sciences and Sanofi. 

As part of a highly integrated team of computational chemists, structural biologists, medicinal chemists and discovery biologists, you will use state-of-the-art computational software, computer aided drug design and simulation techniques to help drive hit discovery. Your creative thinking will help to push forward the frontier of modelling in targeted protein degradation, lead optimization, and DNA Encoded Library technologies. The successful candidate will independently pursue research projects, implement novel computational workflows and support a dynamic multi-disciplinary team focused on moving projects from the hit identification stage to the discovery of clinical candidates.

Qualifications 

  • Ph.D. in Chemistry, Biology, Biophysics (or related fields) with demonstrated computational chemistry focus
  • Established skills in computer aided drug design
  • Practical working experience in computational chemistry software (e.g. Schrodinger, OpenEye, others)
  • Proven track record in one or more of the following: docking studies, virtual screening, druggability analysis, structure-based design for lead optimization, free energy perturbation and molecular dynamics simulation
  • Excellent communication of design rationale, key experimental results, issues and accomplishments in appropriate verbal and written form 
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations 
  • Maintains an excellent scientific expertise in the latest developments in computational chemistry
  • Good ability to manage own priorities and deliverables, both independently and in the team setting
  • Ability to work effectively in a highly interdisciplinary team
  • Software development skills in a modern programming language (eg Python) a strong plus
  • Industry or comparable academic experience in the field of computational chemistry required, small molecule drug design experience preferred (2+ years)

Fit with Nurix Culture and Values 

  • Strong team orientation; highly collaborative 
  • Solutions and results-oriented focus 
  • Hands-on approach; resourceful and open to diverse points of view 

Apply Now

Research Associate/Senior Research Associate, Medicinal Chemistry

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry to join our Medicinal Chemistry team. You will work with a highly dynamic group that is focused on moving projects from the hit identification stage to the discovery of clinical candidates. The Nurix mission is to control protein fate to treat human diseases leveraging exciting technologies to target protein degradation.

The successful applicant will have demonstrated substantial experience in modern synthetic organic chemistry and standard analytical methods. Having developed an understanding of the physicochemical properties that drive drug discovery are highly desired.

As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of highly experienced scientists within Nurix as well as with external collaborators.

Qualifications

  • BA/BS or equivalent with typically 8+ years of relevant experience or MS with typically 4+ years of relevant experience
  • Creative skills in the design, performance and interpretation of chemistry experiments with strong synthetic problem-solving skills using a hypothesis-based approach
  • Excellent communication of project rationale, key experimental results, issues and accomplishments in appropriate verbal and written form
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Maintains an excellent scientific expertise in organic synthesis and a good knowledge of key medicinal chemistry principles
  • Good ability to manage own priorities and deliverables, both independently and in the team setting
  • Familiarity with tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making a strong plus but not required

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Scientist I – Discovery Biology – Contract

We are seeking a highly skilled and motivated immunologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. This individual will work closely with our drug discovery project scientists on lead optimization of novel compounds to evaluate the impact on immune cells and characterize their MOA. The candidate must be self-driven, organized, able to work well with other scientists, and able to thrive in an exciting environment in a rapidly-growing company.

Qualifications

  • Ph.D. in immunology, cancer biology or related field with 0-2+ years of industry experience for Scientist I level position
  • Research experience in the field of immunology with a focus on T cell biology
  • Expertise in functional assays measuring cellular activation, cytokine release, proliferation, and killing
  • Experience in high-dimensional flow cytometry to phenotypically characterize immune cells including both surface and intracellular staining.
  • Experience with in vivo tumor mouse models is desired but not required
  • Develop novel ideas/technologies, eager to learn, innovate.
  • Propose and implement resolutions to technical problems/issues.
  • Work with departmental and/or cross functional peers to execute on assignments

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative; solutions and results-oriented focus
  • Strong scientific curiosity and initiative; hands-on and resourceful
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Company

Nurix, Inc. is a science-minded, goal-oriented organization that is focused on bringing novel, first-in-class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the protein degradation machinery of the cell. The Nurix scientific team has established an innovative drug discovery platform based on recent advances in understanding of the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation, a function vital to the healthy life of a cell, uncovering therapeutic opportunities in multiple disease areas. Nurix’s Protein Regulation Platform enables the discovery of selective inhibitors or activators of the UPS, enabling the discovery of new class of drugs that can restore normal cellular homeostasis. Nurix entered into an exclusive collaboration with Sanofi and Gilead for the discovery and development of next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology. Nurix was founded by internationally recognized experts in the ubiquitin proteasome field and is funded by leading life science investors, Third Rock Ventures and The Column Group. The company is headquartered in San Francisco, California

Apply Now

Senior Scientist– Discovery Biology

We are seeking a highly skilled and motivated immunologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. This individual will work closely with our drug discovery project scientists on lead optimization of novel compounds to evaluate the impact on immune cells and characterize their MOA. The candidate must be self-driven, organized, able to work well with other scientists, and able to thrive in an exciting environment in a rapidly-growing company.

Qualifications

  • Ph.D. in immunology, cancer biology or related field (or Bachelor’s/Master’s degree with >8-10 years industry experience)
  • Research experience in the field of immunology with a focus on T cell and tumor biology
  • Expertise in functional assays measuring cellular activation, cytokine release, proliferation, and killing
  • Hands on experience in development, optimization and execution of high-dimensional flow cytometry to phenotypically characterize immune cells including both surface and intracellular staining, primary human and mouse cell isolation, ELISA, Western and multiplexing technologies
  • Experience with genetic validation in primary cells or model systems utilizing molecular techniques including shRNA/CRISPR knockdown to support target validation and mechanism of action studies for drug candidates
  • Background in ubiquitin biology with past experience is a plus
  • Develop novel ideas/technologies, eager to learn, innovate.
  • Propose and implement resolutions to technical problems/issues.
  • Work with departmental and/or cross functional peers to execute on assignments

 Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative; solutions and results-oriented focus
  • Strong scientific curiosity and initiative; hands-on and resourceful
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment

 Company

Nurix, Inc. is a science-minded, goal-oriented organization that is focused on bringing novel, first-in-class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the protein degradation machinery of the cell. The Nurix scientific team has established an innovative drug discovery platform based on recent advances in understanding of the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation, a function vital to the healthy life of a cell, uncovering therapeutic opportunities in multiple disease areas.

Nurix’s Protein Regulation Platform enables the discovery of selective inhibitors or activators of the UPS, enabling the discovery of new class of drugs that can restore normal cellular homeostasis. Nurix entered into an exclusive collaboration with Sanofi and Gilead for the discovery and development of next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology.

Nurix was founded by internationally recognized experts in the ubiquitin proteasome field and is funded by leading life science investors, Third Rock Ventures and The Column Group. The company is headquartered in San Francisco, California

Apply Now

Scientist I – Cell Biology – Contract

We are seeking a highly skilled and motivated cell biologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology.  The successful candidate will support early drug discovery efforts in oncology, immuno-oncology (IO) and inflammation.  Responsibilities will include execution and analysis of in vitro cellular assays to support small molecule discovery efforts as well as new target identification and understanding of mechanisms of action. This individual will work closely with scientists within the group and present their findings to the department and project teams. The ideal candidate will be self-driven, eager to learn new techniques, highly organized and enjoys working in a creative and dynamic team environment. This is a 1-year contract role.

Qualifications

  • Ph.D. in cell biology, immunology or related field (Bachelor’s or Master’s degree with industry experience)
  • Hands-on experience in the development, optimization and execution of cellular assays applying multiple techniques including primary cell isolation, tissue culture, ELISA, flow cytometry, Western and multiplexing technologies (e.g. Luminex, MesoScale)
  • Demonstrated track record in functional assay development in oncology and/or immunology
  • Familiarity with primary cell tissue culture, molecular biology techniques, CRISPR engineering of cells and the use of siRNA/shRNA knockdown techniques to support mechanism of action studies for drug candidates and target identification
  • Ability to conceive, design and execute hypothesis-testing experiments that directly contribute to project success is essential
  • Detail oriented with excellent communication and presentation skills
  • Background in cancer cell biology required with previous experience in the ubiquitin-proteasome (UPS) system a plus

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative; solutions and results-oriented focus
  • Strong scientific curiosity and initiative; hands-on and resourceful
  • Self-drive and enthusiastic with the ability to thrive in a dynamic environment

Company

Nurix was founded by internationally recognized experts in the ubiquitin-proteasome (UPS) field and received its initial funding from leading life science investors Third Rock Ventures and The Column Group.  Nurix recently entered into a multi-year collaboration with Gilead and Sanofi focused on developing bi-functional molecules to degrade protein targets as novel therapeutics.   Additionally, Nurix has a strong internal drug discovery pipeline focused on oncology, immunology and inflammation.  Nurix plans to advance two molecules into clinical trials in early 2021. 

Apply Now

Director/Senior Director, Clinical Scientist

Nurix has a place for an extraordinary, highly motivated, and accomplished Director/Senior Director, Clinical Scientist.

As an integral member of the Clinical Development Team, this person will help to develop innovative solutions for the clinical development of Nurix’s pioneering protein modulation programs in hematology, oncology, and cell therapy. Working in close collaboration with the study teams, the incumbent will provide scientific guidance and support.

This role will is responsible for various aspects of clinical study design and execution including: protocol writing, building study infrastructure, staff training, data cleaning/analysis, investigator interaction and support of regulatory filings. In addition, this role will be responsible for providing supporting rationale for clinical development working closely with the Head of Development.

Job Responsibilities:

  • Participate in and contribute to cross-functional clinical development teams with strong ability to work closely with all team members, address study or other program-specific questions.
  • Develop the Global Development plan with senior clinical development staff
  • Implement Global Development Plan with strategic clinical science support
  • Assist in reviewing and authoring clinical protocol.  Read and interpret scientific and medical literature for the use in clinical documents and to assist clinical team decision making.
  • Prepare clinical portions of all relevant regulatory filings and meeting packages (INDs, Annual Reports, meeting requests, NDAs, etc.) for US and ex-US Health Authorities.
  • Integrate scientific knowledge and operational expertise to ensure translation of clinical research plans into efficiently delivered, high quality studies.
  • Acquire and utilize knowledge of clinical trial design and relevant disease indications to assist in study concept and protocol development. Contribute to discussions concerning scientific and procedural aspects of study design. Coordinate with departments to produce the final protocol and informed consent documents.
  • Compose medical data review plans, Data Safety Monitoring Board (DSMB), Safety Review Committee (SRC) charters, and specific sections of study manuals and investigator meeting materials.
  • Contribute significantly to the development of CRFs, data edit checks, patient profile design, ongoing data cleaning (query generation, coding review, SAE reconciliation) and data trend analysis.
  • Lead internal clinical data review meetings in conjunction with the medical monitor; lead the data preparation effort for dose escalation meeting, as applicable to study stage.
  • Coordinate and manage external medical advisory committees for the study team such as DSMBs and Scientific Steering Committees, in conjunction with the medical monitor.
  • Research and summarize published literature for continual learning and to prepare training materials for other clinical team members.
  • Contribute to statistical analysis plans, table, listing, figure design and the preparation of manuscripts and other presentations of study data, as appropriate.
  • Address investigator questions regarding protocol and related scientific issues and attend site initiation visits (SIVs), in coordination with the medical monitor.
  • Assist in determining the activities to support a project’s priorities within functional area
  • Trains other clinical scientists as needed.

Basic Qualifications

Advanced degree (MD, PhD, or PharmD) and 8+ year’s relevant drug development experience

Preferred Qualifications

  • Experience directly in the clinical science role, in a hematology/oncology indication for first-in-human and proof of concept studies in small molecules and/or cell therapy. Registrational or Phase 3 study experience is preferred.
  • In depth understanding of clinical operations and translational medicine.
  • Excellent interpersonal skills.
  • Able to translate technical concepts into accessible language and direction for the broader study team.
  • Excellent attention to detail, partnership and initiative, with flexibility to adapt to the needs of the organization; maintain meticulous attention to project deadlines.
  • Experienced in Microsoft Office (Excel, Word, PowerPoint, OneNote), and ideally also with job related programs such as Spotfire and Medidata Rave or similar.
  • Strong understanding of ICH GCP, as well as general knowledge of industry practices and standards
  • Commitment to patient safety and clinical compliance.

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view 

Apply Now

Scientist I, Medicinal Chemistry

We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry to join our Medicinal Chemistry team. You will work with a highly dynamic group that is focused on moving projects from the hit identification stage to the discovery of clinical candidates. The Nurix mission is to control protein fate to treat human diseases leveraging exciting technologies to target protein degradation.

The successful applicant will have demonstrated substantial experience in modern synthetic organic chemistry and standard analytical methods. Having developed an understanding of the physicochemical properties that drive drug discovery are highly desired.

As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of highly experienced scientists within Nurix as well as with external collaborators.

Qualifications

  • Ph.D. in synthetic organic chemistry with 0-4 years industrial chemistry experience
  • Creative skills in the design, performance and interpretation of chemistry experiments with strong synthetic problem-solving skills using a hypothesis-based approach
  • Excellent communication of project rationale, key experimental results, issues and accomplishments in appropriate verbal and written form
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Maintains an excellent scientific expertise in organic synthesis and a good knowledge of key medicinal chemistry principles
  • Good ability to manage own priorities and deliverables, both independently and in the team setting
  • Familiarity with tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making a strong plus but not required

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Corporate Counsel

We are looking for a highly motivated Corporate Counsel capable of assuming primary responsibility for certain corporate legal matters. You will work closely with the General Counsel and Corporate Secretary, outside corporate counsel, the finance team, the executive committee and the board of directors.

Responsibilities

  • Assisting with establishing and monitoring corporate compliance and governance practices.
  • Providing legal counsel in connection with and managing SEC reporting and disclosures including reviewing and advising on 10-Ks and 10-Qs, drafting 8-Ks, drafting proxy statements, and overseeing Section 16 reporting.
  • Establishing and running stockholder meeting processes.
  • Preparing legal materials for Board and Board committee meetings and drafting minutes of Board and Board committee meetings.
  • Assisting with financing transactions.
  • Assisting with other legal matters of the company as required.

Required Qualifications

  • J.D. and excellent knowledge and understanding of corporate and securities law
  • At least 5 years of experience, including at least 3 years at a law firm in a corporate and securities practice.
  • Strong SEC disclosure drafting skills/
  • Excellent ability to issue spot and integrate business goals with legal advice
  • Strong verbal and written communication skills, including the ability to communicate concisely.
  • Ability to work well in a cross-functional team environment.
  • Solutions and results-oriented focus.
  • Hands-on approach; resourceful and open to diverse points of view.

Bonus Qualifications

  • Previous in-house experience in a biotechnology/life sciences company.
  • Experience drafting and negotiating agreements such as master service agreements, clinical trial agreements and manufacturing agreements

Apply Now

Informatics Scientist

As an Informatics Scientist, you will interface with fellow scientists across Research and Development to provide hands-on scientific application support.  In this role, you will help fellow scientists effectively use Nurix’s tools and applications to capture, analyze, query and report R&D data and drive decisions.  You will partner with your Informatics colleagues to identify and implement database-backed solutions to address unmet automation and data management needs.

Required Skills

  • BS/MS/PhD in Chemistry, BioChemistry, Biology or a related field
  • Experience coding in any of the following: Perl, Python, Java, VB, C/C++
  • Minimum _8_ years’ experience working with chemical registration and biological assay data information systems
  • Minimum _8_ years’ experience working with data-analysis tools and applications such as Pipeline Pilot and/or Knime
  • Experience working in validated/regulated systems
  • Excellent communication and presentation skills on the phone, in 1×1 meetings, and in group settings
  • Strong written communication skills to create business-appropriate emails, instant messages, requirements/specifications documents, presentation materials, etc.
  • Proficient in MS Office (Excel, Word, PowerPoint)

Preferred Skills

  • Experience working with databases (Oracle, MySQL, PostgreS, SQLServer) and SQL coding
  • Experience with ChemCart, Dotmatics, ActivityBase, and/or CDD
  • Application of business analysis to document processes and define use cases
  • Project Management
  • Data visualization with applications such as Spotfire or Tableau

Fit with Nurix Culture and Values 

  • Strong team orientation; highly collaborative 
  • Solutions and results-oriented focus 
  • Hands-on approach; resourceful and open to diverse points of view 

Apply Now

Scientist/Sr. Scientist, DNA Encoded Chemistry, Library Discovery

Nurix is a science-focused company that is committed to bringing novel, first-in-class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating E3 ubiquitin ligases within the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation – a function vital to the healthy life of a cell – offering therapeutic opportunities in multiple disease areas. Nurix’s scientific team has established an innovative drug discovery platform to identify selective inhibitors or activators of the UPS, enabling the development of novel therapeutics that can restore normal cellular homeostasis. In particular, Nurix has positioned itself as a leader in the burgeoning field of UPS degraders. Nurix was founded by internationally recognized experts in the UPS field before entering into multi-year strategic collaborations with multiple pharma partners to discover and develop next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology. Nurix became a publicly traded company in July of 2020 and is based in San Francisco’s biotechnology hub, Mission Bay – where academia and industry come together for cutting-edge life-saving research.

Position

We are seeking a talented and highly motivated scientist with expertise in the synthesis of DNA encoded libraries and a strong background in synthetic organic chemistry and to join our Library Discovery team. You will join a group with two objectives:

  1. Design and synthesize DNA encoded libraries and
  2. Utilize these libraries to identify novel chemical matter with the potential to modulate the activity of UPS targets. You will first and foremost have previous experience in conducting DNA encoded library synthesis.

You may have also had experience conducting parallel reaction chemistry, split/pool methods, aqueous chemistry and linker chemistry related to the synthesis of drug conjugates.  You will be interested in strategies to most efficiently navigate drug-like chemical space and will lead discovery programs that will use Nurix’s DNA encoded libraries as the principal means of molecular search.  As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of scientists within Nurix as well as with external collaborators.

Qualifications

  • Ph.D. and/or postdoctoral studies that required synthesis of DNA encoded libraries with 0-5 years industry experience or B.S. with 2-7 years industrial DNA encoded libraries synthesis experience (years of relevant experience will impact level of hire)
  • Expert in synthetic organic chemistry methods and analytical tools, in particular LCMS
  • High level of creativity and productivity with strong synthesis problem-solving skills
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations, as organization publication policy has permitted
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department
  • Experience with chemistry involving biological macromolecules, i.e. antibodies and oligonucleotides, linker technologies, or the design and synthesis of chemical biology probes a plus
  • Familiarity with working with large data sets and the tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Apply Now

Scientist (Senior Sci to Principal Sci), Medicinal Chemistry

We are seeking a curious and motivated individual to join the Medicinal Chemistry group. This individual will drive the chemistry effort to enable novel ligases for targeted protein degradation. With a strong background in synthetic organic chemistry, the successful candidate will have experience in early-stage hit-to-lead optimization, structure-based drug design, and the ability to push multiple projects within the platform simultaneously.  As members of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix including the DNA-encoded library, biophysics, biochemistry, and cellular pharmacology groups. Additionally, they will contribute effectively to patent, report and scientific publication writing.

Qualifications depending on experience

  • Ph.D. in synthetic organic chemistry with 6+ years of medicinal chemistry experience
  • Successful application of structure-based drug design leading to advanced leads, and/or development candidates. Strong working knowledge of protein-ligand interactions, conformational and structural analysis, experienced in partnering closely with computational chemists through appropriate use of computational tools, models and visualization applications.
  • Ability to lead/manage multiple projects simultaneously
  • High level of creativity and productivity with strong synthetic problem-solving skills
  • Excellent scientific expertise in organic synthesis, conversant with the current literature
  • Ability to champion the chemistry efforts into new directions to achieve project milestones.
  • Solid track record of innovation and impact on programs, with direct contributions to company pipelines (including both successful advances and smart terminations).
  • Proven leadership capability in cross-functional team setting, either as project team leader or co-lead.
  • Strong evidence of conceptual thinking and active follow through, recognized by establishing new projects or new directions within projects, new strategies and/or enabling technologies for drug discovery. Vigorous scientific curiosity evidenced by contributions to diverse medicinal chemistry strategies.
  • Excellent knowledge of medicinal chemistry principles with a solid understanding of the basic biology and pharmacology of programs, the ADME issues, and series SAR. Able to effectively integrate this knowledge and apply the key principles of medicinal chemistry, literature precedent, and drug design to direct medicinal chemistry programs to phase transitions or series go/no go decisions
  • Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings and using this information to guide program strategy
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department

Fit with Nurix Culture and Values

  • Strong team orientation and highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Apply Now

Scientist II/Senior Scientist, Cell Biology

We are seeking a highly skilled and motivated cell biologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology.  The successful candidate will support early drug discovery efforts in oncology, immuno-oncology (IO) and inflammation.  Responsibilities will include execution and analysis of in vitro cellular assays to support small molecule discovery efforts as well as new target identification and understanding of mechanisms of action. This individual will work closely with scientists within the group and present their findings to the department and project teams. The ideal candidate will be self-driven, eager to learn new techniques, highly organized and enjoys working in a creative and dynamic team environment. 

Qualifications

  • Ph.D. in cell biology, immunology or related field (Bachelor’s or Master’s degree with 6 – 8 years industry experience)
  • Hands-on experience in the development, optimization and execution of cellular assays applying multiple techniques including primary cell isolation, tissue culture, ELISA, flow cytometry, Western and multiplexing technologies (e.g. Luminex, MesoScale)
  • Demonstrated track record in functional assay development in oncology and/or immunology
  • Familiarity with primary cell tissue culture, molecular biology techniques, CRISPR engineering of cells and the use of siRNA/shRNA knockdown techniques to support mechanism of action studies for drug candidates and target identification
  • Ability to conceive, design and execute hypothesis-testing experiments that directly contribute to project success is essential
  • Detail oriented with excellent communication and presentation skills
  • Background in cancer cell biology required with previous experience in the ubiquitin-proteasome (UPS) system a plus

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative; solutions and results-oriented focus
  • Strong scientific curiosity and initiative; hands-on and resourceful
  • Self-drive and enthusiastic with the ability to thrive in a dynamic environment

Company

Nurix was founded by internationally recognized experts in the ubiquitin-proteasome (UPS) field and received its initial funding from leading life science investors Third Rock Ventures and The Column Group.  Nurix recently entered into a multi-year collaboration with Gilead and Sanofi focused on developing bi-functional molecules to degrade protein targets as novel therapeutics.   Additionally, Nurix has a strong internal drug discovery pipeline focused on oncology, immunology and inflammation.  Nurix plans to advance two molecules into clinical trials in early 2021. 

Apply Now

Clinical Trial Associate, Clinical Operations

Nurix was founded by internationally recognized experts in the ubiquitin-proteasome (UPS) field and received its initial funding from leading life science investors Third Rock Ventures and The Column Group.  Nurix recently entered into a multi-year collaboration with Gilead and Sanofi focused on developing bi-functional molecules to degrade protein targets as novel therapeutics.   Additionally, Nurix has a strong internal drug discovery pipeline focused on oncology, immunology and inflammation.  Nurix plans to advance two molecules into clinical trials in early 2021.

Position

The Clinical Trial Associate supports Clinical Operations by performing a variety of administrative and operational activities associated with all phases of clinical trials.

Required Qualifications

  • Bachelor’s degree (BS/BA) or equivalent combination of education and work experience in science related field
  • Clinical Operations or clinical research-related experience is desired (1-2 years)
  • Familiarity with document filing/management in an electronic Trial Master File preferred
  • Strong attention to detail in composing and proofing materials, establishing priorities, scheduling, and meeting deadlines
  • Excellent verbal and written communication skills
  • Proficiency with MS Word, Excel, Outlook, and PowerPoint

Responsibilities:

  • Assist in the development, review, and formatting of study-specific documents, including plans, manuals, CRFs, patient documents, reference documents, and study tools
  • Develop study-specific TMF plan(s) and manage/oversee collecting, tracking, and archiving of Essential Documents throughout the life of the study
  • Conduct quality reviews of the TMF and work with CRO to resolve discrepancies
  • Assist in the coordination and tracking of clinical supplies and laboratory samples
  • Participate in the review of clinical data in the clinical database, data listings, and reports
  • Assist with data reconciliation of various systems, as required
  • Coordinate preparation of study-specific training materials, as required
  • Maintain and update study trackers/metrics on an on-going basis
  • Facilitate the preparation of meeting agendas and take meeting minutes for clinical team meetings
  • Attend Investigator Meetings and/or support meeting planning
  • Complete additional tasks as assigned and agreed upon

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Apply Now

Senior Research Associate/Scientist I, Nurix Adoptive Cell Therapy (NxACT)

Nurix was founded by internationally recognized experts in the ubiquitin-proteasome (UPS) field and received its initial funding from leading life science investors Third Rock Ventures and The Column Group.  Nurix recently entered into a multi-year collaboration with Gilead and Sanofi focused on developing bi-functional molecules to degrade protein targets as novel therapeutics.   Additionally, Nurix has a strong internal drug discovery pipeline focused on oncology, immunology and inflammation.  Nurix plans to advance two molecules into clinical trials in early 2021.

Position

The successful candidate will be responsible for the execution of research activities toward the development of drug-enhanced cell-based therapies for Nurix’s clinical development programs targeting protein fate for cancer targeted therapy and immunotherapy on its San Francisco campus. Collaborating with the Discovery and Process Development (located at the Pittsburgh campus) organizations, the translational SRA/Sci I will be responsible for executing preclinical studies, analysis and interpretation of data to guide indication selection for early clinical development. 

Specific responsibilities include:

  • Utilize broad technical expertise in cell and tumor immunology, biochemistry and molecular biology to investigate, develop and optimize new methods to expand mechanistic understanding of Nurix’s clinical development assets.
  • Execute translational research studies to identify cancer indications of interest for Nurix development programs.
  • Generate and characterize human drug enhanced tumor infiltrating lymphocytes (DeTIL) using advanced methods of T cell expansion, and cell culture
  • Examine early small molecule drug candidates for their ability to enhance growth and focus of anti-tumor DeTIL as therapeutic reagents

Education and Skills Requirements:

  • B.S. with 8+ years/M.S. with 3-4 years/Ph.D. degree in cell biology, immunology or related discipline. Industry experience is a plus.
  • Understanding of biology supporting adoptive cellular therapy as a therapeutic modality.
  • Demonstratable experience in multi-color flow cytometry panel design and characterization of cellular subsets in human blood and tissue is required.
  • Ideally, candidate will have training and/or experience in designing and implementing in vitro functional cell culture assays, including assessments of cytotoxicity, cytokine production and proliferative capacity.
  • Ability to troubleshoot and interpret complex data in an independent fashion
  • Prior role in multidisciplinary projects and teams with ability to integrate cross-functional information is an advantage
  • Excellent interpersonal, verbal and written communication skills, creative thinking, problem solving, flexibility and demonstrated ability to harness existing data sets to inform translational research are essential for this role.
  • Collaborative spirit and ability to work with project teams, external investigators and contract research organizations.
  • Highly motivated, innovative and strong team player. Excellent time management and organizational skills required.

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Manager/Senior Manager, Compound Management

Nurix is seeking a highly skilled and motivated Compound Manager to build and lead a compound and sample management function. The compound manager will be accountable for storage, retrieval and distribution of compounds for biological assay as well as chemical building blocks for parallel synthesis. Working closely with Medicinal Chemistry, DEL, Biology, Informatics and Laboratory Services, the compound manager will:

  • Manage the receipt and storage of compounds and samples for biological assay
  • Manage the receipt and storage of compounds for parallel synthesis
  • Manage registration data QC for purchased compounds
  • Evaluate customer needs for sample format and delivery
  • Collaborate with scientists from multiple disciplines (internal and external) to design and implement workflows for sample distribution
  • Develop, write and train on Operating Procedures for compound management and sample distribution
  • Develop methods for liquid handlers, tube sorters, barcode readers and other automation
  • Oversee the work of lab technicians

Education

  • B.S. Degree in Chemistry, Chemical Engineering, Biology or related discipline required
  • M.S. or other postgraduate degree in similar fields preferred

Experience & Attributes

  • Five (5) years of applicable experience within the life sciences industry
  • Hands-on experience in compound management and an excellent understanding of underlying processes
  • Experience operating, programming and troubleshooting various instrumentation including acoustic dispensers span-8, 384 well pipetting systems, plate handlers, tube sorters.

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

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Regulatory Affairs Associate

Nurix was founded by internationally recognized experts in the ubiquitin-proteasome (UPS) field and received its initial funding from leading life science investors Third Rock Ventures and The Column Group.  Nurix recently entered into a multi-year collaboration with Gilead and Sanofi focused on developing bi-functional molecules to degrade protein targets as novel therapeutics.   Additionally, Nurix has a strong internal drug discovery pipeline focused on oncology, immunology and inflammation.  Nurix plans to advance two molecules into clinical trials in early 2021.

Position

We are seeking to hire a Regulatory Affairs Associate who will support the preparation and maintenance of regulatory submissions to FDA and other Regulatory Agencies. The function will work closely with the CMC, nonclinical, and clinical team members, track and assemble submission components, and build INDs with the regulatory publishing function.

Key responsibilities:

  • Responsible for timely planning, coordination, and execution of regulatory submissions
  • Conduct regulatory review of submission documents
  • Coordinate document workstream with external publishing group
  • Represent Regulatory Affairs on cross-functional teams and provide regulatory guidance
  • Lead preparation of IND annual reports/DSUR and contribute to authoring
  • Prepare IND amendments (e.g. monthly clinical site packages)
  • Develop and maintain regulatory knowledge and advise on changing regulatory requirements
  • Track commitments from Regulatory Agency submissions and/or Agency Feedback
  • Manage and maintain regulatory archive
  • Contribute to developing regulatory SOPs

Education/skills requirements

  • University degree in science, engineering, and/or biotechnology
  • At least 2 years of experience in Regulatory Affairs in the pharmaceutical industry
  • Familiar with FDA regulations and FDA/ICH guidelines
  • Working knowledge of regulatory compliance for essential clinical site documents.
  • Experience with ex-US regulations is a plus
  • Meticulous attention to detail
  • Ability to self-manage varying workloads across several programs
  • Strong interpersonal and communication skills

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Apply Now

Development Administrator

Nurix was founded by internationally recognized experts in the ubiquitin-proteasome (UPS) field and recently completed its Initial Public Offering.  Nurix also has two strategic multi-year collaborations with Gilead and Sanofi focused on the discovery and development of bi-functional molecules to degrade protein targets as novel therapeutics.   Additionally, Nurix has a strong internal, wholly-owned discovery and development pipeline focused on oncology, immunology and inflammation.  Nurix plans to advance two molecules into clinical trials in early 2021.

Position

This individual will perform a variety of administrative activities in support of Senior Leader(s) in the Clinical Development Group. Maintains and modifies schedules, manages meeting and travel logistics. Will assist with the planning, coordination and tracking of various projects. May handle special projects and execute research and data analysis tasks. Coordinates activities between departments and outside parties. Interfaces with employees at all organizational levels to gather information and prepares reports. Work is generally of a critical or confidential nature. Handles details of a highly confidential and critical nature.

  • Schedule meetings manage inbox and calendars using MS Outlook including the use of meeting technologies such as video conferencing and audio-conferencing tools (ex. MS Teams and GoTo Meeting).
  • Handle day-to-day administrative responsibilities including initiation and tracking of Contract Request Forms, Purchase Orders, editing and formatting of Word and PowerPoint documents
  • Prepare complex, domestic and international travel arrangements including booking flights, accommodations, car service and associated expense reports
  • Ability to manage files and team collaboration sites, such as SharePoint, including managing access lists, directories and basic assistance with the usage of collaboration locations
  • Liaise with senior level executives and their staff to coordinate activities and meetings
  • Ability to handle extremely confidential and proprietary information with utmost discretion
  • Ability to prioritize and follow-up on urgent matters in a timely manner
  • Act as gatekeeper: screen inquiries and respond as appropriate to ensure timely response
  • Coordinate both small and large meetings, conference calls and video conferences including advanced preparation of materials and collaborating with IT for audio/visual facilities set-up
  • Provide support for other departments within the organization as business needs evolve
  • Other duties as assigned

Required Qualifications

  • The ideal candidate will have a strong work ethic, positive attitude, be professional, organized and detail oriented. This is a team-oriented position that plays an integral role in facilitating processes and procedures. They will also demonstrate the ability to handle and maintain confidential and sensitive information and work independently with minimal direction.
  • Associates Degree or bachelor’s degree in, Life Sciences or other related area required
  • At least 4 – 6 years of practical experience in biotechnology or pharmaceutical industry
  • Candidate must possess excellent interpersonal, written and verbal communication skills
  • Demonstrated ability to manage projects to completion in a timely fashion
  • Highly proactive and willing to take initiative
  • Ability to maintain confidentiality
  • Excellent written and oral communication skills
  • Proficient at Word, PowerPoint and Excel
  • Possess a high degree of personal responsibility
  • Must be flexible and willing to provide administrative support to additional/other departments
  • Must remain professional and composed while multi-tasking under pressure
  • Ability to prioritize, identify problems and seek solutions

Bonus Qualifications

  • Exposure to the biotech, pharma or research industries preferred.

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Apply Now

Clinical Program Manager

Nurix, Inc. is seeking a Clinical Program Manager (CPM) to join the Clinical Operations team.  This individual will be responsible for management of global clinical programs. They will lead study team, vendors, clinical monitors and clinical sites throughout the life cycle of a clinical program.

This individual will be able to manage multiple study teams across a program and have broad involvement in work central to Nurix’s strategic goals. They will apply existing technical skills, learn new skills, and play a key role in nonclinical development of the programs and help grow the company and guide its direction. As an early hire, They’ll be influential in championing and developing Nurix’s culture.

CPM is responsible for the successful implementation of a clinical program, including providing mentorship and oversight of all aspects of international clinical trials within designated program budgets and timelines. Experience in leading staff as well as mentoring and developing junior staff will be essential to the team’s success. The CPM will represent Clinical Operations at Project team meetings and may represent company at professional events.

Responsibilities:

  • Accountable for all operational aspects of clinical trials within the assigned program
  • Provides guidance and oversight for the successful management of all aspects of international clinical trials within designated program budgets and timelines.
  • Examine functional issues from a broader organizational perspective and develop a strategy to implement with a cross-functional team
  • Provides program level oversight to vendors, including CRO, central lab, and imaging.
  • Proactively identifies potential issues/risks across the program and recommends/implements solutions.
  • Participates in the selection, training and evaluation of clinical trial managers and clinical trial management associates to ensure the efficient operation of the function.
  • Attends and presents at cross-functional meetings as needed to represent Clinical Operations and program level items
  • Provides mentorship and career development to direct reports.
  • Provides leadership to the clinical operations team working on the assigned program.

Experience and Skills:

  • B.S./ B.A. in biological sciences, advanced degree preferred with 8+ years of relevant industry experience
  • Ability to travel as required for the program (10-15%)
  • Demonstrated knowledge of FDA, ICH and GCP regulations and guidelines
  • Experience in leading teams, including CROs, consultants and vendors.
  • Proficient in developing trial plans and implementing operational changes across multiple studies
  • Highly developed leadership skills to successfully lead multiple direct reports
  • Must display strong analytical and problem-solving skills at a program level and collaborate with colleagues to generate solutions
  • Strong communication and influence skills and ability to create a clear sense of direction
  • Ability to deal with time demands, incomplete information or unexpected events
  • Outstanding organizational skills with the ability to multi-task and prioritize
  • Comfortable in a fast-paced small company environment and able to adjust workload based upon changing priorities

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

Apply Now