Associate Director, Regulatory & Medical Writing

Help shape how Nurix communicates its science to health authorities and the world. As Associate Director, Regulatory & Medical Writing, you’ll independently lead the authoring, review, and approval of critical regulatory documents across our pipeline — from clinical protocols to health authority submissions. It’s a chance to bring clarity and strategic messaging to the documents that move our therapies through development and toward patients.

Position Description

The Opportunity

• Author and manage authoring of Regulatory & Medical Writing documents together with cross-functional collaborators; ensure content consistency within a document and across documents for a particular asset, including the development of strategic messaging and data presentation in accordance with Nurix standards and health authority requirements, for documents such as:
• Clinical study protocols and clinical protocol amendments
• Clinical study reports
• Investigator’s brochures and annual updates
• IND submissions and annual reports
• Lay-person summaries
• Integrated summary reports
• Clinical, nonclinical, and multidisciplinary information amendments
• NDA, BLA, MAA, and (e)CTD submissions
• Risk Management Plans
• Health authority responses
• Briefing documents, ODDs, BTDs/PRIME, FTD, and similar designations
• Review, edit, and QC documents developed by other authors or medical writers
• Manage the author, review, and approval process for multiple deliverables at a given time; ensure quality and timely completion, with attention to consistency of content, messaging, format, and style
• Lead Regulatory & Medical Writing activities for assigned programs, including partnering with the Head of Regulatory & Medical Writing on resource planning, document timelines, issue resolution, and process improvement initiatives
• Represent Regulatory & Medical Writing on interdisciplinary teams for assigned programs/projects, providing strategic input and status updates
• Manage external Regulatory & Medical Writing resources for assigned programs/projects, as needed

What You’ll Bring

• 6 to 8+ years of Regulatory and/or Medical Writing, or other relevant pharmaceutical/biotechnology industry experience in the Clinical Development phase, authoring and overseeing documents submitted to health authorities
• Experience identifying and interpreting information/data for inclusion in documents such as clinical study protocols, Investigator’s Brochures, clinical study reports, Lay Summaries, and ICFs
• Involvement with ex-US submissions for clinical trial applications and marketing applications is a plus
• Ability to work effectively and lead in cross-functional working groups
• Excellent communication skills, organizational skills, and attention to detail
• Adaptable and flexible, willing and able to adjust to multiple demands and shifting priorities; ability to meet day-to-day challenges with confidence and professionalism
• Knowledge of health authority requirements, ICH guidelines, and submission-ready standards relevant to document authoring, including eCTD and submission lifecycle management
• Proficiency in project planning tools such as MS Project or Smartsheet, collaborative authoring or document review tools, and Veeva RIM Suite
• Expertise in Microsoft Word (including use of customized toolbars/templates) and document management systems

Salary Range:  $216,400 - $234,800

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Director, Drug Safety

Join Nurix’s pharmacovigilance team to help ensure patient safety across our clinical pipeline of targeted protein degradation therapies. As Director, Drug Safety, you’ll lead aggregate safety analysis, benefit–risk assessments, and safety strategy for assigned programs — shaping how we evaluate risk and bring new medicines safely to patients. It’s a chance to influence critical safety decisions at the intersection of clinical medicine, data, and drug development.

The Opportunity

Medical Safety Leadership

• Serve as the medical safety lead for assigned products, providing clinical and pharmacovigilance expertise to safety strategy and activities
• Lead aggregate safety data analysis for signal detection, signal evaluation, and risk characterization
• Conduct medical review and interpretation of safety data, contributing to benefit–risk assessments
• Monitor emerging safety signals and proactively address potential safety risks through appropriate internal and external communication

Regulatory and Safety Documentation

• Oversee medical review of Individual Case Safety Reports (ICSRs)
• Author and review regulatory safety documents, including Development Safety Update Reports (DSURs) and safety sections of INDs and regulatory briefing books
• Contribute to safety responses to regulatory authorities and participate in regulatory interactions
• Provide clinical leadership during inspections and audits related to safety and risk management

Clinical Development Support

• Provide clinical input into safety aspects of clinical trial protocols, informed consent forms, and investigator brochures
• Collaborate with clinical development, regulatory affairs, medical affairs, and other stakeholders to ensure a consistent global safety strategy

Governance and Cross-Functional Collaboration

• Serve on safety governance committees, supporting strategic decision-making for risk mitigation and benefit–risk evaluation

What You’ll Bring

• Advanced clinical or scientific degree, such as MD, DO, PharmD, or equivalent relevant training and experience
• Clinical experience preferred
• 5–10 years of experience in pharmacovigilance/drug safety within the pharmaceutical or biotechnology industry
• Experience supporting early clinical development and small biotechnology companies
• Demonstrated expertise in aggregate safety analysis and benefit–risk evaluation
• Strong knowledge of global pharmacovigilance regulations and guidance (ICH, FDA, EMA, MHRA)
• Experience interacting with global health authorities on safety matters
• Familiarity with signal detection and safety surveillance tools and databases
• Strong communication, collaboration, and cross-functional leadership skills
• Ability to interpret complex clinical and safety data and translate insights into regulatory and business strategy
• Ability to work effectively and collaboratively in a fast-paced, growing organization across functional boundaries

Salary Range:  Non-MD $247,300 - $280,400 |  MD  $295,000 - $317,100

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Director, Head of Investigative Toxicology

Build Nurix’s in-house in vitro toxicology capability from the ground up. As Director, Head of Investigative Toxicology, you’ll establish the assays, infrastructure and mechanistic understanding to identify target- and modality-related safety liabilities earlier in discovery, shaping lead selection for our growing pipeline of targeted protein degrader programs. This is a hands-on, lab-based leadership role.

Position Description

The Opportunity

• Nurix Therapeutics is seeking a Head of Investigative Toxicology to establish and lead our in-house in vitro toxicology testing capability. Reporting into the Preclinical Toxicology leadership team, this individual will build the assays, infrastructure, and mechanistic understanding needed to characterize target- and modality-related safety liabilities earlier in discovery, reducing reliance on external CROs for early screening and de-risking. This is a hands-on, lab-based leadership role for a scientist who wants to build a function from the ground up, working in close partnership with Discovery Biology, Chemistry, DMPK, and Pharmacology to inform lead selection and optimization for our growing pipeline of targeted protein degrader programs. The position reports to the Senior Vice President, Nonclinical Toxicology.

In Vitro Toxicology Capability Build

• Design, establish, and validate an in-house in vitro toxicology testing platform, including assay selection, equipment procurement, protocol development, and standard operating procedures
• Develop and implement in vitro toxicology (primary and immortalized cell culture, hepatocyte and iPSC cardiomyocyte models) assays to screen for cytotoxicity and off-target liabilities
• Define the technical roadmap and prioritize which in vitro assays to bring in-house versus continue to source through CRO partners, balancing scientific value, cost, and speed
• Own day-to-day lab operations for the function, including equipment maintenance, vendor and reagent management, and data management systems

Investigative & Mechanistic Toxicology

• Serve as the in vitro/investigative toxicology representative on discovery project teams, providing mechanistic insight into target and modality-related safety findings
• Design and interpret investigative studies to elucidate mechanisms of toxicity, including neosubstrate and off-target degradation risk relevant to targeted protein degrader molecules
• Partner with DMPK, Pharmacology, and Discovery Biology to integrate in vitro toxicology data into candidate selection, structure-activity relationship (SAR), and lead optimization decisions
• Translate in vitro findings into risk assessments and clear recommendations for project teams and research leadership

Team & Culture

• Hire, mentor, and develop scientific staff as the in vitro toxicology function grows
• Represent in vitro/investigative toxicology in Research Leadership meetings and contribute to the broader nonclinical safety strategy
• Foster a collaborative, science-driven culture consistent with Nurix’s values of rigor, creativity, and patient focus

What You’ll Bring

Required Qualifications

• PhD in Toxicology, Pharmacology, Molecular Biology, or a closely related life sciences discipline; postdoctoral training preferred
• 10+ years of relevant nonclinical safety, investigative toxicology, or molecular/cellular toxicology experience in the pharmaceutical or biotechnology industry, including direct, hands-on laboratory experience with in vitro and/or complex in vitro (MPS) model systems
• Demonstrated experience building, validating, and implementing new in vitro assay platforms or laboratory capabilities in an industry setting
• Strong working knowledge of mechanisms of drug-induced toxicity and the in vitro tools used to investigate them (e.g., high content imaging, primary and immortalized cell culture, hepatocyte/cardiomyocyte models, genotoxicity assays)
• Proven ability to translate in vitro data into actionable risk assessments and communicate findings clearly to cross-functional project teams and senior leadership
• Experience managing CRO relationships and evaluating build-versus-buy decisions for laboratory capabilities

Preferred Qualifications

• Experience with targeted protein degradation (TPD) or other novel small molecule modalities, including neosubstrate/off-target degradation risk assessment
• Experience establishing or scaling a laboratory function within a growing, clinical-stage biotech
• Familiarity with New Approach Methodologies (NAMs) and organ-on-chip/microphysiological systems
• People management or mentoring experience
• Strong publication record in investigative or molecular toxicology

Salary Range: $240,100 - $281,700

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

 Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

About the role

This is the operating leader for IT infrastructure and operations at Nurix, reporting to the SVP of Information Technology. You will own the function end to end: infrastructure, cybersecurity operations, end user services, and IT service management as one integrated scope. You partner with a fractional CISO on security strategy and policy while owning the operational execution. You work closely with the IT business partner leaders who own the application portfolios and partner directly with R&D and the broader scientific organization on their infrastructure needs.

You lead a team that spans enterprise architecture, system administration, and cybersecurity operations, with the service desk delivered through a mix of staff and managed service providers. You will manage both individual contributors and managers from day one. You set the standards and delegate delivery across this hybrid team of internal staff and managed service providers, empowering the people below you rather than running their queues, to support a fast-moving enterprise.

What you'll do

In your first year you will:

• Consolidate the managed service provider portfolio across infrastructure, security, and the help desk into a smaller, more accountable set of partners.
• Build a cybersecurity operations function from current contractor and MDR coverage.
• Establish a governance model with research and scientific computing, and bring research infrastructure into IT alignment. Working with the enterprise architect, inventory and remediate AWS systems: ParallelCluster and other HPC, container platforms (EKS, ECS), SageMaker, and identity bridges.
• Own a formal identity and access management program, including clean handoffs to IT operations and the business partner teams.
• Refresh the service experience end to end and raise vendor management discipline as scope grows.

Requirements:

• 12+ years of progressive technology services leadership, including 5+ years at the Director or Senior Director level.
• Direct experience leading multi-function technology services (infrastructure, cyber operations, and ITSM) as one integrated scope rather than separate towers.
• Comfort partnering with a CISO or fractional CISO on policy while owning operational execution. We are looking for an operator who builds security in partnership, not someone who pushes controls through operations.
• Deep experience across AWS plus the Microsoft Entra and Microsoft 365 stack.
• Familiarity with the infrastructure behind scientific and ML computing, AWS ParallelCluster and HPC, SageMaker, EKS and ECS, and DevOps and infrastructure-as-code practices, at a level sufficient to set standards and partner credibly with the scientific organization.
• A measurable track record managing a managed service provider portfolio, including real consolidation or vendor transitions with accountability for outcomes.
• Experience building out infrastructure in fast-moving, resource-constrained environments.
• Experience in a regulated industry (biotech, pharma, medical device, healthcare, financial services, or comparable).
• Bachelor's degree or equivalent practical experience.

Nice to have

• Biotech or pharmaceutical industry experience.
• Support for an FDA Pre-Approval Inspection or BIMO inspection in an IT or security capacity.
• Experience standing up a security operations function from contractor or MSP coverage.
• Partnership with a separate scientific computing organization (informatics, bioinformatics, cheminformatics, machine learning).
• Hands-on with an MDR provider such as RedCanary, Kroll, or Arctic Wolf.
• Jira Service Management or ServiceNow at scale.
• Public company SOX IT general controls experience.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Ability to function in a dynamic environment
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range: $ 260K – $300K plus bonus and equity

Location: Brisbane, CA - Onsite 

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Director, Nonclinical Toxicology Operations 

Nurix Therapetics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position Summary:

Nurix Therapeutics is seeking a Director of Preclinical Safety and Toxicology Operations to drive planning and execution of nonclinical safety and toxicology activities within our Research and Early Development division. The role will be responsible for operations activities including owning timelines, budgets, contracts, and cross-functional coordination for a portfolio of targeted protein degradation programs.  The ideal candidate will be adept at partnering closely with subject matter experts, preclinical Project Leads, clinical Asset Team Leaders, and the SVP of Preclinical Toxicology who will provide oversight and scientific direction.

The role has two complementary halves. The first is operational support to the nonclinical Safety and Toxicology function — helping study directors and toxicology leads scope and design studies, selecting and managing CROs, negotiating and administering contracts, and keeping study execution on schedule and on budget. The second is program-level project management for drug discovery projects as they transition from late lead optimization through IND filing, integrating chemistry, DMPK, pharmacology, safety, CMC, and regulatory timelines into a single credible plan.

You will thrive here if you are highly organized, scientifically fluent, comfortable holding teams and stakeholders to a schedule, and energized by turning complex, interdependent work into clear milestones and decisions.

Key Responsibilities:

Toxicology study support and vendor management 

• Partner with Toxicology Leads and Study Directors to scope, design, and schedule GLP and non-GLP in vivo and in vitro safety studies, including exploratory tox, DRF, GLP repeat-dose toxicology, safety pharmacology, and genetic toxicology.
• Identify, qualify, and manage CROs and specialty vendors; coordinate bid solicitation, bid defense, and vendor selection in partnership with Toxicology, Procurement, and Legal.
• Own the contract lifecycle: draft and route work orders, MSAs, change orders, and amendments; track scope changes against budget; reconcile invoices and support accruals and forecasting.
• Build and maintain integrated study timelines; monitor study milestones, sample logistics, bioanalytical turnaround, and report delivery, escalating slippage early with options rather than surprises.
• Coordinate protocol and report review cycles, ensuring documents move efficiently through internal review, QA, and sign-off.
• Track deliverables required for regulatory submissions, including study reports, certificates of analysis, and test article documentation.
• Demonstrated ability to ensure safety issues are communicated rapidly and with appropriate escalation to the drug safety/project team, leadership and relevant agencies.

Program management, late lead optimization to IND

• Serve as project manager for assigned discovery and development programs from late lead optimization through candidate selection, IND-enabling studies, and IND filing.
• Develop and maintain integrated program plans, critical paths, and resource views spanning medicinal chemistry, analytical chemistry, computational chemistry, DMPK, pharmacology, toxicology, CMC, and regulatory.
• Run project team meetings: set agendas, capture actions and decision rationale in meeting minutes, and follow through to closure.
• Maintain program dashboards, milestone trackers, and risk registers; surface risks with mitigation and contingency plans.
• Prepare materials and pre-reads for portfolio reviews, governance meetings, and leadership updates; ensure a single, consistent version of program status.
• Coordinate scenario and what-if planning to support go/no-go decisions, candidate selection, and IND timing.

Cross-functional leadership and process 

• Act as a connective hub across functions and sites, resolving interface issues before they become timeline issues.
• Contribute to continuous improvement of project management practices, templates, and tools within the group.

Qualifications: 

Education 

• Required: M.S. or Ph.D. in a life sciences discipline (toxicology, pharmacology, biology, chemistry, pharmaceutical sciences, or related).
• Preferred: formal project management credential such as PMP.

Experience 

• Typically, 10+ years of relevant biotech or pharmaceutical experience, including demonstrable project management ownership of multidisciplinary programs.
• Track record managing CROs and external vendors, including contracting, budget tracking, and performance management.
• Direct experience supporting and coordinating IND-enabling activities
• Working knowledge of small molecule drug discovery and development, nonclinical safety assessment, and GLP requirements, with scientific fluency sufficient to plan, question, and integrate the work.
• Experience in targeted protein degradation, oncology, or immunology is an advantage.

Skills and attributes 

• Proficiency with project management tools and methods, including integrated timelines, critical path analysis, and resource planning (e.g., MS Project, Smartsheet, Planisware, or equivalent). Familiarity with AI tools a plus.
• Exceptional organizational skills and attention to detail, with the judgment to know what matters and what does not.
• Clear, concise written and verbal communication; able to present status and risk to senior leadership without embellishment.
• Ability to influence and drive accountability without direct authority across a group of senior, highly experienced scientists.
• Comfort with ambiguity and shifting priorities in a fast-moving discovery environment.

Reporting and Location 

• Reporting to SVP of Nonclinical Toxicology, Based at Nurix Therapeutics, Brisbane, CA, with on-site presence expected to support close partnership with laboratory and program teams.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:   $220,700 - $252,667

Location:         Brisbane, CA - Onsite 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position:

Nurix Therapeutics, Inc. is seeking a highly experienced Director of Pharmaceutical Development. The role leads small molecule drug product development focused on oral and topical dosage forms. Responsibilities span QbD-based formulation and process development from early phase through commercial launch. The position requires strong cross-functional collaboration and hands-on CDMO management. 

Responsibilities:

Formulation & Process Development

• Lead QbD-based formulation and process development for small molecule drug programs with a focus on oral and topical dosage forms across all development phases.
• Apply expertise in BCS Class II/IV compound development and enabling formulation technologies, including amorphous solid dispersions (spray-dried dispersions, hot-melt extrusion), lipid-based drug delivery systems (SMEDDS, SEDDS, lipid suspensions), and nano-formulations to address solubility and bioavailability challenges.
• Define and document the Quality Target Product Profile (QTPP) and identify Critical Quality Attributes (CQAs) to guide formulation strategy.
• Conduct systematic risk assessments to identify Critical Material Attributes (CMAs) and Critical Process Parameters (CPPs) using FMEA and other risk assessment tools.
• Develop and optimize manufacturing processes appropriate to the dosage form, ensuring scalability and process robustness.

Scale-Up & Technology Transfer

• Lead manufacturing scale-up activities from laboratory to pilot and commercial scale, ensuring robust and reproducible processes.
• Troubleshoot manufacturing deviations, out-of-specification results, and process failures; drive root cause analysis and implement corrective actions.

Late-Stage Development & Regulatory

• Drive late-stage development activities (Phase 2b through commercial launch) including clinical supply manufacturing, process performance qualification (PPQ), and continued process verification (CPV).
• Author and review CMC sections of regulatory submissions including INDs, NDAs, and MAAs.
• Ensure all development activities comply with current GMP regulations and internal quality standards.

CDMO Management & Cross-Functional Leadership

• Manage external CDMO partnerships, including vendor qualification, technical oversight, and performance governance to ensure project timelines, quality standards, and budget commitments are met.
• Serve as the primary technical point of contact between pharmaceutical development and cross-functional teams including Analytical Development, Clinical Operations, Regulatory Affairs, Quality, Supply Chain, and Commercial.
• Provide scientific leadership and mentorship to junior scientists, associates, and project team members.

Requirements

• Ph.D. in Pharmaceutical Sciences, Pharmaceutics, Chemical Engineering, Chemistry, or a closely related discipline strongly preferred with 12 years of industry experience.
• 12+ years of progressive pharmaceutical development experience in an industry setting (biotechnology, pharmaceutical, or CDMO).
• Deep expertise in small molecule drug product development with a focus on oral and topical dosage forms, especially enabled formulation development (e.g., amorphous solid dispersions, lipid-based systems, nano-formulations).
• Comprehensive hands-on experience with QbD methodologies: QTPP definition, CQA identification, CMA/CPP risk assessment, DoE, design space development, and control strategy establishment.
• Significant late-stage development experience (Phase 2b/3 and NDA/MAA submission) is required.
• Proven track record of authoring and/or reviewing CMC regulatory submissions (INDs, NDAs, CTDs) and successfully responding to agency queries.
• Direct CDMO management experience, including technical oversight, project governance, and relationship management.
• Knowledge of lifecycle management, post-approval changes, and SUPAC guidance.
• For the Director level: demonstrated people management experience leading a team of scientists/managers, department-level strategic planning, and budget/resource ownership across multiple concurrent programs.
• Primarily office and laboratory environment; occasional GMP manufacturing facility access required.
• Approximately 25% travel required, including domestic and international trips to CDMO sites, clinical manufacturing sites, regulatory agency meetings, and scientific conferences.
• Must be able to gown for cleanroom/GMP environments

Core Competencies

• Scientific Leadership — Recognized internal and external thought leader in pharmaceutical development; drives scientific innovation and excellence.
• Strategic Thinking — Ability to anticipate technical and regulatory risks and develop proactive mitigation strategies that protect project timelines.
• Cross-Functional Collaboration — Demonstrated ability to build strong working relationships and influence without authority across diverse internal and external stakeholders.
• Project Management — Experienced in managing multiple complex projects simultaneously in a fast-paced, deadline-driven environment.
• Communication — Exceptional written and verbal communication skills; able to present complex scientific data clearly to both technical and non-technical audiences, including senior leadership and regulatory agencies.
• People Development — Commitment to mentoring and developing scientific talent within the organization. 

Salary Range:  $218,000 – 260,000

Location:  This position is on site in the Brisbane, CA office.

Fit with Nurix Culture and Values:

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

 Director, Quality Assurance

Lead GMP quality assurance for Nurix's small molecule CMC programs and serve as the primary quality interface with our CDMO partners. You'll be accountable for the quality and timely supply of clinical materials and for inspection readiness, while building and mentoring the QA team as we advance through late-stage development toward commercialization.

Position Description

The Opportunity

• Report to the Senior Vice President, Quality, in a high-visibility role with direct accountability across Quality, CMC, Regulatory Affairs, and external manufacturing partners; operate both strategically and hands-on in a dynamic clinical-stage environment
• Provide strategic quality leadership for CMC development programs, ensuring GMP compliance with FDA, ex-US regulatory authorities, and ICH guidelines across drug substance and drug product development
• Serve as the primary quality interface with CDMOs and contract laboratories, overseeing quality operations including review and approval of deviations, investigations, batch records, lot disposition, technical protocols and reports, methods, and specifications
• Lead and develop a team of Quality Assurance professionals; set clear performance expectations, mentor, and build organizational capability to support pipeline advancement and commercialization readiness
• Drive timely identification, investigation, and resolution of quality events and deviations, and oversee CAPA execution and effectiveness verification to prevent recurrence
• Support the change control process, ensuring changes that affect manufacturing, testing, and regulatory filings are captured, and escalate issues with broad cross-functional impact
• Support regulatory inspection readiness; serve as a quality representative during FDA, EMA, and other agency inspections and develop observation responses
• Contribute to CMC sections of regulatory filings (INDs, NDAs/BLAs) in partnership with Regulatory Affairs, and partner with CMC and Regulatory Affairs to align quality deliverables with pipeline milestones and program timelines
• Support implementation and optimization of the electronic quality management system (eQMS) platform and contribute to system improvement initiatives
• Maintain current knowledge of evolving regulatory expectations and industry standards, and translate requirements into practical operational guidance for the organization

What You’ll Bring

• Bachelor's degree in chemistry, pharmaceutical sciences, life sciences, or a related field
• 12+ years of progressive Quality Assurance experience in the pharmaceutical or biopharmaceutical industry, with experience in a formal leadership role
• Deep technical expertise in GMP requirements for small molecule drug substances and drug products across clinical development stages
• Demonstrated experience managing CDMO relationships and overseeing quality operations at contract manufacturing and laboratory organizations
• Thorough knowledge of FDA regulations (21 CFR Parts 210/211), ICH guidelines (Q7, Q8, Q9, Q10, Q11), and EudraLex Volume 4 (GMP), and their practical application to CMC development
• Proven track record managing quality events, deviations, CAPA programs, and change control in a clinical or commercial pharmaceutical setting
• Experience supporting or leading regulatory agency inspections (FDA, EMA, or equivalent); experience as lead QA representative during pre-approval inspections preferred
• Demonstrated ability to lead, develop, and motivate Quality Assurance teams in a fast-paced, ambiguous, clinical-stage environment
• Excellent project management skills, with the ability to manage multiple high-priority deliverables simultaneously
• Strong verbal and written communication skills; able to present complex quality and compliance topics clearly to diverse stakeholders, including executive leadership
• Willingness to travel to CDMO and laboratory sites domestically and internationally, as needed
• Preferred: experience in a clinical-stage biotech environment scaling quality operations through late-stage development and toward commercialization
• Preferred: experience with electronic QMS platforms (e.g., Veeva Vault) and document management systems
• Preferred: expertise in both development-phase and pre-commercial-phase quality assurance standards and expectations

Location:        Onsite – Brisbane, CA

Salary Range:  $228,100 - $252,000

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Director, Quality Compliance and Supplier Quality

Lead the Quality programs that keep Nurix inspection-ready as we advance through late-stage clinical development and toward commercialization. As Director, Quality Compliance and Supplier Quality, you’ll own the audit, supplier oversight, complaint, recall and inspection readiness programs that protect our GxP compliance across our CDMOs, contract laboratories and suppliers. This high-visibility role calls for both strategic leadership and hands-on execution.

Position Description

The Opportunity

• The Director, Quality Compliance and Supplier Quality is a leadership role within the Quality organization, accountable for the programs that demonstrate and protect the company’s state of GMP/GLP/GDP/GCP/GVP (collectively GxP) compliance: the internal and external audit programs, supplier qualification and lifecycle management, product complaint handling, recall and market action readiness, regulatory inspection readiness, and regulatory intelligence. This leader will ensure that the company’s reliance on contract development and manufacturing organizations (CDMOs), contract laboratories, critical raw material and component suppliers, and other GxP service providers is supported by a risk-based, inspection-ready oversight model.
• Reporting to the Senior Vice President, Quality Assurance and Compliance, the Director will apply quality assurance and risk assessment tools described in ICH Q9, ICH E6, and relevant regulations to identify and communicate compliance risks and ensure corrective actions are documented and driven to effective closure. The role is accountable for assessing and communicating outsourced-activity risks described in ICH and relevant global regulations: assessing the suitability and competence of each contract acceptor, defining quality responsibilities in written agreements, and monitoring performance over the lifecycle product or clinical trial.
• This is a high-visibility role with direct accountability across Quality, CMC, Clinical Operations, Supply Chain/Procurement, Regulatory Affairs, and external partners. The Director will lead a team of compliance and supplier quality professionals (contractors and staff) and is expected to operate both strategically and hands-on in a dynamic environment as the company advances through late-stage clinical development and toward commercialization while maintaining the agility necessary to introduce early phase assets into the pipeline.

Quality Compliance Strategy and Governance

• Provide strategic leadership for the quality compliance program, ensuring GxP compliance with FDA, ex-US regulatory authorities, and ICH guidelines across drug substance, drug product, and clinical supply, and clinical activities
• Apply a risk-based compliance framework, applying ICH Q9(R1) and ICH E6 (R3) quality risk management principles to the assessment of outsourced activities and GxP operations
• Maintain quality metrics, KPIs, and trending (audit findings, supplier performance, complaints, CAPA effectiveness); prepare and present data at Quality Management Review and to executive leadership
• Escalate significant compliance risks, with clear risk assessments and recommended actions

Internal Audit Program

• Own the internal audit program end to end: annual, risk-based audit schedule; audit planning and scope; execution; reporting; CAPA verification; and program governance
• Audit internal GxP processes and systems (e.g., deviation and CAPA management, change control, document control and records management, training, batch record and lot disposition review, data integrity, computerized systems, and clinical supply operations)
• Track and trend audit observations to identify systemic issues; drive remediation with process owners and verify effectiveness of corrective and preventive actions
• Establish auditor qualification, training, and independence requirements; manage internal auditors and any qualified third-party auditors
• Use audit results and trend data to prioritize quality system improvements and inform inspection readiness activities

External Audit Program

• Establish, manage, and continuously improve the external GxP audit program with audit frequency and depth set by assessed risk
• Lead or coordinate on-site, remote, and hybrid audits, including for-cause and pre-qualification audits of Nurix suppliers; review audit reports, evaluate supplier responses, and drive CAPA to closure; escalate unresolved risk to Quality leadership
• Support mock pre-approval inspections and pre-inspection audits at CDMOs ahead of regulatory filings
• Coordinate with the Qualified Person (QP) or QP service provider as needed to support EU/UK clinical certification, including audit access and information requests
• Manage the audit calendar, audit resourcing, and budget; maintain audit reports and certificates in the eQMS
• Support sponsor, partner, and licensing-partner audits of the company, including response coordination and commitments tracking

Supplier Qualification and Lifecycle Management

• Own the end-to-end supplier lifecycle for GxP suppliers and service providers: selection support, risk classification, qualification, onboarding, performance monitoring, requalification, change management, and disqualification or exit
• Maintain the Approved Supplier List (ASL) and supplier risk register, with documented evidence of each qualification decision
• Provide quality input into vendor selection, and contracting in partnership with CMC, Clinical Operations, Supply Chain, and Procurement
• Establish supplier scorecards, performance metrics, and periodic business and quality reviews; lead supplier development and improvement plans where performance falls short
• Extend supplier oversight to computerized systems and data-driven service providers (e.g., cloud/SaaS platforms, laboratory systems), including data integrity and data governance expectations consistent with EU GMP Annex 11 and FDA data integrity expectations
• Verify that outsourced activities are controlled so the company can demonstrate to regulators that it retains accountability for work performed on its behalf

Product Quality Complaints

• Own the product quality complaint handling program, ensuring written procedures and records meet 21 CFR § 211.198 and applicable ex-US requirements for investigational products
• Define intake, triage, risk classification, investigation, and closure requirements for complaints received from clinical sites, patients, distributors, CDMOs, and partners; ensure quality unit review and documented justification when no investigation is performed
• Ensure timely investigation, root cause analysis, and CAPA, and that complaint handling responsibilities and timelines are clearly defined in Quality Agreements with contract manufacturers and distributors
• Establish complaint trending and signal detection, and escalate adverse trends to management and, where applicable, to Regulatory Affairs, Clinical, and Pharmacovigilance/Drug Safety

Recalls and Market Actions

• Own the product recall, retrieval, and market action procedures for clinical and (as applicable) commercial products, aligned with FDA guidance, and ex-US requirements
• Lead the cross-functional recall/crisis management team: determine recall need, support health hazard evaluations with Clinical, Medical, and Safety, define recall depth and strategy, and coordinate regulatory notifications and communications
• Plan and execute mock recalls and traceability exercises, including clinical supply retrieval from depots and investigational sites, and track lessons learned to closure
• Ensure recall effectiveness checks, reconciliation, and post-recall CAPA are completed and documented

Inspection Readiness and Hosting

• Lead the company-wide regulatory inspection readiness program for FDA, EMA, MHRA, and other health authority inspections, including pre-approval inspections (PAIs) and BIMO inspections
• Maintain the inspection management process: front room/back room structure, storyboards, subject matter expert preparation and training, document request tracking, and daily debriefs
• Manage inspection observation responses (e.g., FDA Form 483 and equivalents), commitments tracking, and follow-up to closure
• Conduct readiness assessments, gap analyses, and mock inspections; apply lessons from internal and external audits and publicly available enforcement trends to strengthen readiness
• Prepare executives and cross-functional leaders for inspection participation

Regulatory Intelligence

• Establish and maintain a structured regulatory intelligence process: monitor FDA, EMA, MHRA, PIC/S, ICH, WHO, and other authorities for new and changing GxP requirements, guidance, and enforcement trends
• Analyze FDA Warning Letters, Form 483 observations, and inspection outcomes for industry trends relevant to the company and its suppliers (e.g., complaint handling, data integrity, supplier oversight, CAPA effectiveness)
• Perform gap assessments of new requirements against current procedures; translate requirements into practical guidance, procedure updates, and training; and track implementation to completion
• Brief Quality leadership, CMC, and Regulatory Affairs on emerging expectations, and propose phase-appropriate approaches as the company moves toward commercialization

Leadership and Collaboration

• Lead, develop, and mentor a team of compliance, audit, and supplier quality professionals; set clear performance expectations and build organizational capability for commercialization readiness
• Manage external consultants and third-party auditors, including budget and quality of deliverables
• Build trusted relationships with internal partners in CMC, Regulatory Affairs, Clinical Operations, Supply Chain, Legal, and Pharmacovigilance
• Prepare and manage the compliance and supplier quality budget and resource plans

What You’ll Bring

Required Qualifications

• Bachelor’s degree in chemistry, pharmaceutical sciences, life sciences, engineering, or a related field
• 10+ years of progressive Quality Assurance or Quality Compliance experience in the pharmaceutical or biopharmaceutical industry, including at least 5 years leading audit, supplier quality, or compliance programs
• Demonstrated experience building or managing supplier qualification and audit programs, including oversight of CDMOs, contract laboratories, and CROs
• Thorough working knowledge of FDA regulations (21 CFR Parts 11, 210/211, 312, 314), 21 CFR Part 7 (recalls), and ICH guidelines (E6(R3), Q7, Q8, Q9(R1), Q10, Q11, Q12), as well as EudraLex Volume 4 (including Chapter 7 and Annex 11), PIC/S guidance, and Regulation (EU) No 536/2014 (Clinical Trials Regulation)
• Proven experience with product complaint handling and CAPA programs in a clinical or commercial setting
• Experience supporting or leading regulatory agency inspections (FDA, EMA, or equivalent)
• Lead auditor experience for GxP audits (on-site and remote) with strong report-writing and observation-classification skills
• Demonstrated ability to lead, develop, and motivate teams in a fast-paced, ambiguous environment
• Excellent project management skills and the ability to manage multiple high-priority deliverables simultaneously
• Strong verbal and written communication skills; able to present complex compliance topics clearly to diverse stakeholders, including executive leadership
• Willingness to travel to CDMO, supplier, and laboratory sites domestically and internationally, as needed (estimated [10-20]%)

Preferred Qualifications

• Experience in a clinical-stage biotech environment scaling quality operations through late-stage development and toward commercialization
• Experience with electronic QMS platforms (e.g., Veeva Vault QMS) and document management systems
• Experience with GLP and GCP supplier oversight, and with clinical supply chain and GDP requirements
• Professional certifications such as ASQ Certified Quality Auditor (CQA), ASQ Certified Pharmaceutical GMP Professional (CPGP), or equivalent lead auditor training
• Experience supporting virtual or outsourced manufacturing models

Salary Range: $243,900 - $262,600

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements

Location:        Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• You lead through complexity: you bring clarity, judgment, and calm to high-stakes compliance decisions, earning trust from your team, your suppliers, and your cross-functional partners
• You are a builder and a connector: you see quality compliance as an enabler of scientific progress and patient outcomes, not a gatekeeper function, and you work collaboratively to solve problems at their source
• You invest in your team: you recognize that a capable, engaged Quality organization is foundational to our mission, and you take developing others as seriously as you take regulatory compliance

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

 Director, Total Rewards

Position Description

Nurix is seeking a Director, Total Rewards to lead the strategy, design, and execution of our compensation and benefits programs. This is a high-visibility, high-impact role reporting directly to the Chief Human Resources Officer, with the opportunity to shape and scale total rewards infrastructure. The ideal candidate combines deep technical expertise in compensation and benefits with strong business acumen and sound judgment.

The Opportunity

Compensation Strategy & Programs

• Own the design, implementation, and administration of Nurix’s base pay, incentive compensation, equity, and executive compensation programs
• Partner with the CHRO to lead annual compensation cycles, including merit increases, bonus funding and payout, and equity refresh grants
• Conduct and manage market benchmarking and job leveling to ensure competitive, equitable pay practices across the organization
• Monitor pay equity across the organization and lead proactive pay equity analyses and remediation
• Stay current on evolving compensation regulations (e.g., pay transparency, pay equity laws) and ensure company practices remain compliant across jurisdictions

Benefits Strategy & Programs

• Design and manage a competitive, cost-effective benefits portfolio, including health and welfare plans, retirement programs (401(k)), leave policies, and wellness offerings
• Own vendor and broker relationships, lead renewal negotiations, and evaluate new offerings to ensure programs remain market-competitive and fiscally responsible
• Ensure benefits programs are compliant with ERISA, ACA, ADA, FMLA, COBRA, and other applicable federal and state regulations
• Lead open enrollment planning and execution, including employee communication and education strategies

Leadership & Cross-Functional Partnership

• Serve as the subject-matter expert (SME) and trusted advisor to the CHRO, Head of Talent, HRBPs, and people managers on compensation and benefits matters
• Partner closely with Finance on compensation budgeting, forecasting, and equity/stock plan expense modeling
• Partner with Legal on equity plan administration, 409A matters, and regulatory compliance
• Develop and deliver clear, effective communications and training to help managers and employees understand total rewards programs
• In partnership with Head of HR Operations, evaluate and implement HRIS/compensation tools and systems to improve efficiency, data integrity, and reporting capabilities

What You’ll Bring

• Bachelor’s degree required; advanced degree or relevant certification (CCP, CBP, CEBS) preferred
• 8-10+ years of progressive experience in compensation and benefits, including at least 3-5 years in a total rewards leadership role
• Prior experience in biotech, pharmaceutical, or life sciences companies strongly preferred; experience in a clinical-stage or newly commercial company is a plus
• Deep knowledge of equity compensation structures (RSUs, ISOs/NSOs, ESPP) common in biotech
• Strong analytical skills with the ability to translate complex data into clear insights and recommendations
• Excellent judgment and discretion when handling highly sensitive compensation and personnel data
• Proven ability to build programs and processes in a growing, fast-paced environment
• Strong communication and stakeholder management skills, with the ability to influence at all levels of the organization, including the Board

Salary Range:  $250,800 – $278,800 annually

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:        Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Executive Business Partner

Position Description

The Executive Business Partner (EBP) provides high-level administrative support and strategic project ownership to the Chief Scientific Officer (CSO) of a growing mid-sized pharmaceutical company. This position requires a highly organized, detail-oriented, and proactive individual who can handle complex scheduling, manage multiple priorities, and communicate effectively across various levels of the organization while also owning discrete strategic and operational initiatives on the CSO's behalf, acting as a trusted proxy in cross-functional settings, and providing leadership to the administrative function supporting Research department leaders. The ideal candidate will have exceptional problem-solving abilities, strong written and verbal communication skills, sound independent judgment, and experience managing both the daily operations and selecting strategic priorities of a senior executive's office. This position plays a crucial role in ensuring the smooth and efficient functioning of the CSO's office, driving forward initiatives that extend the CSO's reach and impact across the organization, and building a cohesive, high-functioning administrative team across Research.

The Opportunity

• Calendaring and time management: Own and prioritize the CSO’s calendar, scheduling meetings, travel, and appointments. Proactively resolve scheduling conflicts without letting deadlines slip and keep appointments on track.
• Communication and information triage: Serve as the primary point of contact between the CSO and both internal and external stakeholders. Draft and edit correspondence and presentations. Use AI-assisted summarization and triage to reduce a high-volume inbox and document flow into a prioritized, decision-ready view.
• Strategic and project support:
  • Lead or co-lead discrete cross-functional projects assigned by the CSO — such as offsite strategy, advisory board content, or org initiatives — from scoping through execution.
  • Act as a proxy for the CSO in selecting internal meetings: representing priorities, capturing decisions, and driving follow-through without requiring the CSO’s direct involvement.
  • Partner with functional leaders across HR, Finance, IT, and Facilities to problem-solve operational issues before they reach the CSO.
• Team leadership and administrative function oversight:
  • Manage and mentor one direct report — Administrative role dedicated to supporting Research department leaders — including workload distribution, performance management, and professional development.
  • Establish shared standards, tools, and processes across the Research administrative team to ensure consistency, coverage, and quality regardless of which leader is being supported.
  • Serve as the escalation point for scheduling conflicts, resourcing gaps, or coverage needs across the team, and coordinate backup support during absences.
  • Build a cohesive administrative function across Research that operates as a unified team rather than siloed 1:1 support — sharing best practices, cross-training on key processes, and presenting consistent experience to Research leadership.
• Travel and logistics: Coordinate complex domestic and international travel arrangements, including flights, accommodations, ground transportation, and itineraries, ensuring optimal time management.
• Meeting support: Plan and organize meetings, including preparing agendas, gathering materials, and taking detailed minutes. Follow up on action items and ensure timely completion.
• Document management: Maintain and organize files and documents, ensuring quick retrieval and confidentiality. Handle sensitive information with discretion.
• Office operations and ad hoc support: Assist in organizing R&D events, advisory boards, offsites, conferences, or seminars, including logistics, materials preparation, and on-site support. Coordinate with executive assistants across the leadership team and take on discrete projects on the CSO’s behalf.

What You’ll Bring

• Minimum of associate’s degree required. Bachelor's Degree preferred.
• At least 8+ years of experience in an executive administrative or business partner role, including at least 3 years supporting a C-level or functional-head role in the pharmaceutical, healthcare, or scientific industry.
• Prior experience managing or mentoring administrative staff, with the ability to set standards and coach for consistency across a team.
• Demonstrated ability to exercise independent judgment on behalf of an executive, including representing their priorities and making decisions in their absence.
• Strong organizational and multitasking skills and attention to detail, with a keen ability to prioritize tasks and meet deadlines.
• Proven experience managing complex calendars and schedules for senior executives, as well as leading discrete projects with cross-functional stakeholders.
• Exceptional written and verbal communication skills, with the ability to liaise professionally with all levels of the organization.
• Advanced proficiency in Microsoft 365 Suite (Outlook, Teams, PowerPoint, Word, Excel, OneNote, SharePoint, and To Do), as well as travel systems like Navan and expense trackers like Expensify.
• Ability to work independently and as part of a team, demonstrating initiative and problem-solving skills.
• Ability to maintain confidentiality and exercise discretion.
• Flexible and adaptable to changing priorities in a fast-paced environment.
• A proactive approach to anticipating the needs of the CSO and offering solutions in advance.

Additional Skills (Preferred):

• AI fluency — comfort using AI assistants (e.g., Claude, Copilot) to draft, summarize, and triage high volumes of email and documents, and a track record of adopting new tools quickly.
• Comfort with scientific vocabulary — you do not need a science background, but you do need to be unbothered by learning the language of drug discovery and clinical development.

Salary Range:  $163,700 – $180,538

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Scientist I, Bioanalytical

Help drive Nurix’s drug discovery programs by turning complex biological samples into the high-quality bioanalytical data that guides decisions. You will develop and run LC-MS/MS assays for targeted protein degrader candidates and work closely with pharmacology, chemistry and biology teams.

Position Description

Nurix Therapeutics is searching for a motivated Scientist I to join our Bioanalytical team. The successful candidate will contribute to the bioanalytical efforts to support Nurix drug discovery programs involving in vivo and in vitro studies. The primary responsibility will be to conduct quantitative bioanalysis for in vivo samples. The scope of the daily responsibilities for this position includes, but is not limited to, developing bioanalytical methods, quantitating drug candidates and their metabolites, endogenous biomarkers in biological matrix (e.g. blood, plasma, tissues, tumor, CSF, etc.), and reporting high-quality data. The successful candidate will have extensive experience in bioanalytical method development and sample analysis using LC-MS/MS and other analytical techniques.

The Opportunity

• Provide bioanalytical support for in vivo PK, PK/PD, efficacy studies, non-GLP toxicology and in vitro studies
• Conduct bioanalytical method development and qualification to support drug, metabolite and biomarker analysis
• Independently develop LC-MS/MS methods to quantitate small molecules in in vitro and in vivo samples and execute sample analysis
• Independently operate, troubleshoot and maintain LC-MS/MS and analytical equipment
• Participate in multidisciplinary project teams and partner closely with other departments, including pharmacology, chemistry and biology to understand bioanalytical needs for PK support
• Maintain accurate and detailed laboratory notebooks
• Ability to think and plan strategically, and excellent interpersonal skills and ability to work in a team environment

What You’ll Bring

• BS or equivalent with 10 or more years’ relevant experience, or MS with 6 or more years’ relevant experience, or PhD with up to 4 years’ relevant experience working in a discovery setting using quantitative LC-MS/MS within a pharmaceutical or biotechnology company
• Demonstrated experience in small molecule biomarkers as well as drug candidate bioanalytical assay development/sample quantitative analysis in complex biological matrices using LC-MS/MS
• Proven experience running and troubleshooting LC-MS/MS-based quantitative workflows on Sciex platforms and software
• Excellent written, verbal communications and interpersonal skills to collaborate with internal and external partners in a matrix environment
• Ability to work in a fast-paced, collaborative environment and manage multiple priorities

Preferred Qualifications

• Experience in targeted protein degradation or heterobifunctional degrader platforms
• Extensive experience with H/UPLC and mass spectrometry
• Extensive experience with sample analysis to support PK, PK/PD, efficacy, distribution, metabolism, and non-GLP toxicology studies
• Extensive experience in developing and implementing quantitative LC-MS/MS based assays for small molecules in complex biological matrices
• Excellent oral and written communication skills
• Experience reviewing result files and reports from bioanalytical contract research organizations
• Experience with maintaining detailed up to date lab notebooks and technical documentation

Location:          Onsite – Brisbane, CA

Salary Range:  $141,500 - $175,600

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Scientist I, Bioanalytical – Drug Antibody Conjugates (DACs)

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position:

Nurix Therapeutics is seeking a Scientist to lead bioanalytical strategies supporting the discovery and development of next-generation degrader antibody conjugates (DACs). This role will focus on LC-MS/MS and hybrid assay strategies for quantitative and qualitative analysis of complex bioconjugates across in vitro and in vivo studies to understand DAC pharmacokinetics, pharmacodynamics, and biotransformation.

The successful candidate will operate at the interface of small and large molecule bioanalysis, and will contribute to assay development, method qualification, and execution, applying advanced LC-MS/MS and hybrid approaches to support in vitro and in vivo studies across discovery and early development

Key Responsibilities:

• Lead the development, qualification, and execution of bioanalytical methods for DAC modalities, including intact conjugates, total antibody, conjugated payload, and released degrader species in complex biological matrices.
• Design and implement LC-MS/MS-based workflows using Sciex platforms for sensitive and selective quantitation of small molecule payloads, linker-derived species, and catabolites
• Apply high-resolution mass spectrometry platforms for DAC characterization and metabolite identification
• Develop hybrid LBA–LC-MS/MS strategies to address challenges in conjugate quantitation and differentiation of molecular species.
• Design, execute and interpret in vitro studies, including plasma and lysosomal stability, linker cleavage kinetics, protease-mediated processing, and degradation assays.
• Lead bioanalytical support for in vivo studies, including PK, tissue distribution, and tumor exposure in preclinical species integrating DAC components to inform exposure-response relationships.
• Characterize biotransformation pathways of DACs, including identification of linker cleavage products, payload metabolites, and antibody modifications.
• Partner closely with DMPK, Proteomics, Pharmacology and Chemistry teams to inform molecular design through data-driven insights on stability, exposure, and degradation efficiency.
• Author and review technical reports, regulatory documentation, and study summaries with a high level of scientific rigor and clarity.
• Troubleshoot analytical challenges related to matrix effects, low-level quantitation, and conjugate heterogeneity.
• Mentor junior scientists and contribute to building bioanalytical capabilities and best practices within the organization.
• Evaluate and implement emerging technologies to advance characterization of targeted protein degrader modalities.
• Lead the identification, selection, and oversight of contract research organizations (CROs) for bioanalytical method development, assay transfer, and phase‑appropriate qualification.

Preferred Qualifications & Experience:

• Experience in targeted protein degradation or heterobifunctional degrader platforms.
• Experience with hybrid LBA–LC-MS/MS assays and ligand-binding assays (ELISA, MSD).
• Understanding of linker chemistry, conjugation strategies, and degradation mechanisms for bioconjugates.
• Exposure to regulatory bioanalytical guidance (FDA, EMA) for large molecules and conjugates.

Requirements:

• Ph.D. with 5+ years or M.S. with 8+ years of relevant industry experience in Bioanalysis, Analytical chemistry, or related field.
• Deep expertise in LC-MS/MS bioanalysis, including method development, qualification/validation, and troubleshooting for complex modalities.
• Proven experience with Sciex platforms (e.g., 7600 ZenoTOF, 6500+, 7500) and high-resolution MS.
• Strong background in ADCs, DACs, or related bioconjugates, including characterization and payload quantitation.
• Experience supporting both in vitro ADME and in vivo PK studies, with demonstrated ability to interpret integrated datasets.
• Proficiency in sample preparation techniques for large molecules and bioconjugates (e.g., immunocapture, enzymatic digestion, hybrid workflows).
• Strong data analysis, visualization, and reporting skills (e.g., vendor software, GraphPad Prism).
• Excellent written and verbal communication skills, with experience in technical documentation.
• Ability to work in a fast-paced, collaborative environment and manage multiple priorities.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:   $123,800 - $143,100

Location:         Brisbane, CA - Onsite 

Scientist I, Medicinal Chemistry

Join Nurix's medicinal chemistry group to design and synthesize novel small molecules for patients with unmet medical needs. You'll apply structure-based drug design, supported by our computational and structural biology teams, as part of a dynamic, multidisciplinary project team.

Position Description

The Opportunity

• Design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics, and in vivo efficacy, using modern synthetic methods and creative strategies to access challenging molecules
• Engage in rational structure-based drug discovery enabled by our computational and structural biology group
• Apply strong problem-solving skills to troubleshoot challenges and identify practical solutions
• Design and execute high-quality experiments, critically analyze results, and use data to form hypotheses and guide next steps
• Advance structure-activity relationship (SAR) studies by contributing to compound design
• Collaborate with scientists in computational chemistry, structural biology, biochemistry and biophysics, cellular biology, pharmacology, DMPK, and toxicology, as well as external collaborators, to integrate multidisciplinary data and advance project objectives
• Stay current with advances in synthetic and medicinal chemistry and apply relevant methods to project work
• Communicate scientific rationale, results, challenges, and recommendations clearly to chemistry colleagues and cross-functional project teams

What You’ll Bring

• PhD with up to 4 years of relevant experience, MS with 6 or more years of relevant experience, or BS or equivalent with 10 or more years of relevant experience
• Strong expertise in synthetic organic chemistry, with demonstrated ability to design and execute complex, multistep organic synthesis
• Strong scientific and synthetic problem-solving skills and the ability to independently troubleshoot challenging chemistry
• Scientific curiosity, creativity, and the ability to rapidly learn and apply new concepts, technologies, and approaches
• Strong interpersonal and teamwork skills, with demonstrated ability to contribute in a collaborative, multidisciplinary research environment
• Excellent written and verbal communication skills, with the ability to clearly communicate scientific concepts, results, and conclusions
• Knowledge of medicinal chemistry principles, structure-based drug design, pharmacology, and/or ADME/PK, consistent with prior experience

Salary Range:  $130,200 - $141,400

The posted range applies to roles based in The Woodlands, TX area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – The Woodlands, TX

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Senior Analyst, FP&A

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

In this role you will own FP&A and finance business-partner support for Nurix's Research and G&A functions, including budgeting, forecasting, reporting, variance analysis, and accounting close support. It is a high-ownership individual-contributor role for someone who wants to take full responsibility for their areas while partnering closely across the organization.

Nurix is a late-stage clinical organization developing targeted protein degradation medicines across a wholly owned and partnered pipeline, so the right candidate is comfortable in a fast-paced, evolving environment and eager to take on new scope as the business grows. Strong attention to detail, cross-functional partnering, problem-solving, and time management are essential. Must be proactive, deadline-oriented, and a self-starter.

Essential Duties / Responsibilities

• Own the budgeting and forecasting process for Research and G&A in partnership with department and functional leaders
• Deliver timely, accurate quarterly reporting and budget-vs-actual analysis for assigned areas with clear variance commentary, and partner with the business monthly to review forecast changes
• Manage the quarterly accrual close for Research, working with business partners and external vendors to develop and validate accruals in line with SOX controls and GAAP
• Own revenue recognition for Research collaboration agreements (ASC 606), partnering with Accounting
• Support the annual financial planning and long-range planning processes
• Partner across Finance, Accounting, Research, and G&A functions to support decision-making and ad-hoc analysis
• Build and improve financial models and scenario analyses for Research and G&A, including program-level budget and resource-allocation scenarios
• Evaluate current processes and systems and drive efficiency improvements, including through automation and AI tooling

Experience, Knowledge and Skills

• 3+ years of experience in an FP&A or Finance function; biotech/pharma a plus
• Willingness to learn paired with a genuine appetite to take ownership of their areas
• Experience with Planful (or a comparable FP&A planning platform) and NetSuite (or a comparable ERP) a plus
• Interest in improving processes through automation/AI a plus
• High proficiency in Excel and PowerPoint
• Excellent written and verbal communication and presentation skills
• Analytical, resilient, and flexible, with a solutions and implementation focus, able to work with minimal supervision in a demanding environment

Education

• Bachelor's in Finance, Economics, Accounting, or a related field
• CPA or MBA a plus

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary:       $130,000 - $158,900

Location:    Brisbane, CA - Onsite 

Senior Director, Nonclinical Toxicology

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

The Opportunity

• Design and management of exploratory and GLP toxicology and safety pharmacology studies. Handle multiple projects in a timely and effective manner at various stages of discovery, preclinical, and clinical development. Write, interact, and/or contribute to all applicable Regulatory Documents/Authorities and Asset Teams.
• Lead toxicology strategy and tactics in discovery, preclinical development and clinical development with a focus on understanding/assessing the human risk of novel therapeutic targets and/or understanding mode of action for toxicity in nonclinical studies
• Participate in multi-disciplinary team efforts and implement program-specific toxicology strategies to support compound and program progression
• Monitor outsourced GLP and non-GLP studies ensuring compliance with the protocol, amendments, regulations, safety guidelines, and standard operating procedures
• Write and review toxicology protocols, reports, and documentation for regulatory filings, and participate in regulatory interactions
• Apply a broad understanding of toxicology, pharmacology, ADME, and knowledge of applicable regulatory guidelines to the design of appropriate toxicology studies and development plans
• Provide creative approaches to expedite nonclinical development strategies
• Provide a critical review of toxicology study protocols, data and study reports
• Serve as the Toxicology representative on multi-functional project teams supporting discovery and development phase projects
• Contribute to the preparation of high-quality regulatory documents supporting global clinical development and marketing authorizations
• Effectively communicate toxicology study results to project teams and senior level management
• Travel required as needed

What You’ll Bring

Required Qualifications

• PhD in Toxicology, Pharmacology, or a related field with a minimum of 10 years, or M.S. degree with a minimum of 15 years, of pharmaceutical or biotechnology industry experience as part of a drug development project team
• Extensive experience in discovery and development of small molecules, degraders, and antibody drug conjugates is desirable
• Experience in designing, monitoring and interpreting nonclinical toxicology/safety pharmacology studies
• Experience in writing and reviewing nonclinical sections of regulatory documents (CTA, IND, IB, NDA, BLA, etc.) and direct interactions with worldwide regulatory agencies
• Extensive drug development experience with strong decision making and problem-solving skills
• Excellent written and verbal communication skills, which includes ability to communicate complex toxicology and safety issues clearly to key stakeholders
• Experience in health-authority interactions and developing regulatory strategies that require a high degree of scientific and strategic judgments
• Competency in incorporating the use of NAMs in toxicological evaluations to strengthen translational decision making

Bonus Qualifications

• Board certification in toxicology is highly desired

Salary Range:  $312,900 - $344,900

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Senior Director, Quality Control

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position Description

Nurix Therapeutics is seeking an experienced Senior Director, Quality Control to join the Analytical Development and Quality Control group. This individual will establish and lead a QC operational function, establishing operations, systems, and a team to support programs from CMC development through commercial manufacturing.

The ideal candidate brings deep expertise in small molecule QC, strong regulatory acumen, and proven experience managing external CDMO and CTL relationships. This role will represent QC in health authority inspections and audits, and will work cross-functionally with Quality, Analytical Development, and Manufacturing to ensure product quality and patient safety across the portfolio.

Key responsibilities

• Build and lead the QC function: Establish QC systems and infrastructure; recruit, manage, and mentor internal QC staff and contractors
• Set QC strategy across the product lifecycle: Define and execute QC strategy spanning CMC development through commercial programs, ensuring alignment with company milestones and submission timelines
• Oversee QC operations internally and externally: Direct method validation, release and stability testing, data review, deviations, investigations, change control, and CAPA internally and at CDMOs, and CTLs
• Identify and manage quality risk: Proactively identify, assess, and escalate risks related to patient safety, product quality, shelf life, supply continuity, or GMP compliance; drive risk mitigation strategies in partnership with Analytical Development, Quality, and Manufacturing functions
• Lead QC through audits and inspections: Serve as QC lead during health authority inspections and internal audits; collaborate with Quality to conduct audits of GMP manufacturing and testing sites, including CDMOs and CTLs
• Support regulatory submissions and health authority interactions: Contribute to global regulatory filings; collaborate on responses to health authority information requests, regulatory commitments, and post-approval changes
• Direct stability programs: Develop and execute stability strategy in collaboration with Analytical Development leads, ensuring alignment with ICH guidelines and regional regulatory requirements
• Manage reference materials and retains: Oversee qualification and inventory of reference standards; develop sampling plans and manage sample retain programs
• Drive continuous improvement: Identify and implement process improvements, data integrity enhancements, and quality system upgrades (e.g., eQMS) to support a scalable, inspection-ready QC organization
• Travel up to 15% to CDMO, CTL, and manufacturing sites and supplier and scientific conferences

Qualifications

• Advanced degree in Chemistry, Pharmaceutics, Chemical Engineering, or related discipline. BS/MS with 16+ years of relevant experience, or PhD with 14+ years of relevant experience
• 5+ years in a QC leadership or management role, with demonstrated ability to build and mentor teams
• Deep experience in small molecule pharmaceutical development, including method lifecycle management and oversight of validation, release, and stability operations
• Proven experience managing external manufacturing and testing operations at CDMOs and CTLs
• Expertise with analytical methods such as HPLC, GC, dissolution, and microbiological testing
• Direct experience leading through health authority inspections and internal audits and conducting audits of manufacturing and testing sites.
• Deep working knowledge of cGMP, ICH guidelines, and USP/EP/JP compendial standards
• Experience contributing to global regulatory filings and health authority correspondence (e.g., responses to information requests, post-approval changes)
• Strong interpersonal and cross-functional collaboration skills, with the ability to influence and build consensus across Quality, Supply Chain, Analytical Development, and Manufacturing functions

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:   $280,200 - $319,800

Location:         Woodlands TX or Brisbane, CA - Onsite 

Senior Manager, Analytical Development and Quality Control – Drug Product

Lead drug product analytical development for Nurix’s oncology and inflammation & immunology programs, from method development through late-phase tech transfer, validation, and regulatory filings. You will guide CDMO and CRO partners and shape analytical and QC strategy for complex formulations, including amorphous solid dispersions and lipid-based systems, in close partnership with cross-functional teams.

Position Description

Nurix Therapeutics seeks an experienced Senior Manager to join the Analytical Development and Quality Control group. The Senior Manager will be responsible for drug product (DP) analytical development, including method development, oversight of method validation at CDMOs, and lifecycle management in support of Nurix’s oncology and inflammation & immunology (I&I) programs. The role provides technical oversight of analytical method development, validation, and testing at external CDMO/CRO partners, authors analytical development reports and IND/IMPD/NDA sections, supports late-phase tech transfer and validation activities, and contributes to analytical development for new drug products and dosage forms. The ideal candidate has expertise in chromatographic and dissolution method development, stability studies, and phase-appropriate validation and control strategies, along with demonstrated experience supporting late-phase development and regulatory submissions.

The Opportunity

• Lead analytical method development, validation, and lifecycle management for drug product formulations, including amorphous solid dispersions (ASDs) and lipid-based systems
• Support PPQ activities, commercialization, commercial QC, and lifecycle management for drug product analytical methods and control strategies
• Design and oversee DP development, registration batch, and commercial stability programs, including protocol development and trend analysis
• Author and review DP analytical development reports to support regulatory submissions and marketing authorization
• Oversee and support analytical activities, including method development, validation, and QC testing conducted at CDMOs and contract testing laboratories (CTLs)
• Contribute to investigations (e.g., OOS, OOE, OOT), root cause analysis, and CAPAs
• Perform critical review of analytical data, protocols, reports, specifications, and related documentation
• Trend stability data and support establishment of retest periods and shelf life using statistical methods
• Collaborate in the development and justification of material control strategies and specifications
• Author technical documents, including analytical development reports, specifications, validation and stability protocols/reports, certificates of analysis (COAs), and storage statements
• Author and review analytical sections of regulatory submissions (e.g., IND/IMPD/NDA)
• Collaboratively author responses to health authority requests for information
• Act as a key contributor to multidisciplinary teams, including Chemical Development, Pharmaceutical Development, Regulatory, Quality, Preclinical, Supply Chain, Medicinal Chemistry, and DMPK
• Maintain and organize analytical documentation and data to ensure traceability, data integrity, and inspection readiness
• Follow cGMP requirements and internal SOPs
• Travel up to 5%, as required

What You’ll Bring

• PhD in Chemistry, Pharmaceutics, or a related field with 8+ years of industrial CMC experience
• Strong experience in drug product analytical development and validation
• Experience with analytical development for amorphous solid dispersions (ASDs) and/or lipid-based formulations
• Experience in CDMO and contract testing lab oversight
• Experience supporting regulatory submissions (e.g., IND, IMPD, NDA) and global regulatory filings
• Fluency with ICH guidelines, cGMPs, and pharmacopeial chapters
• Ability to work effectively in a cross-functional environment
• Strong technical writing skills (e.g., development reports, regulatory documents)
• Ability to manage multiple priorities in a fast-paced environment
• Excellent communication and cross-functional collaboration skills

Salary Range:  $161,100 - $185,600

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Senior Manager / Associate Director, Regulatory Affairs CMC (Small Molecules)

Shape the CMC regulatory path for Nurix's small molecule portfolio, from clinical development through marketed lifecycle. You'll combine hands-on authoring of Module 3 (Quality) content with real strategic influence as the CMC regulatory voice on cross-functional teams, with room at the Associate Director level to own strategy and mentor junior regulatory staff.

Position Description

The Opportunity

• Report to the Senior Director, Regulatory Affairs CMC (Head of Regulatory CMC, Small Molecules) as a key member of the Regulatory Affairs team
• Develop, communicate, and execute global CMC regulatory strategies for assigned programs (drug substance and drug product) across the product lifecycle
• Author, review, and compile high-quality CMC (Module 3 / Quality) content for regulatory submissions, including IND/IMPD and equivalent global filings, amendments, annual reports, and responses to health authority questions
• Assess the regulatory impact of manufacturing, analytical, formulation, and supply chain changes, and recommend filing strategies and categorization (e.g., substantial, non-substantial, annual reportable)
• Provide proactive CMC regulatory guidance and risk assessment to development, technical operations, and commercial teams
• Partner with Technical Operations/Manufacturing, Analytical Development, Quality Control, Quality Assurance, Supply Chain, and CMOs/CDMOs (where applicable) to align technical activities with regulatory requirements
• Represent CMC Regulatory on project and CMC sub-teams, and manage submission timelines and deliverables in coordination with regulatory operations and publishing
• Ensure submission content is accurate, consistent, scientifically sound, and compliant with ICH guidelines and regional requirements (FDA, EMA, and other markets relevant to the portfolio)
• Contribute to regulatory intelligence by monitoring evolving guidance and precedent and translating it into practical advice
• Oversee quality assurance processes to ensure compliance with regulatory standards, and participate in cross-functional initiatives that improve regulatory submission processes and systems
• At the Associate Director level, take greater strategic ownership and, where applicable, provide line management or mentoring of junior regulatory staff

What You’ll Bring

• Bachelor's degree in chemistry, pharmacy, pharmaceutical sciences, chemical engineering, or a related life sciences field is required; an advanced degree (M.S., Ph.D., or Pharm.D.) is preferred
• Minimum 6+ years in regulatory affairs with a substantial focus on CMC, and 10+ years of overall pharmaceutical/biotech industry experience
• Demonstrated experience authoring and/or compiling CMC (Module 3) content for regulatory submissions for small molecule products
• Working knowledge of ICH quality guidelines and of FDA and/or EMA CMC requirements; familiarity with other global regions is a plus
• Solid understanding of pharmaceutical development, manufacturing processes, and analytical methods for small molecules
• Strong written communication and scientific/technical writing skills
• Ability to manage multiple projects and competing timelines with attention to detail
• Effective cross-functional collaboration and stakeholder management
• Comfort operating with autonomy while escalating appropriately

Salary Range:  $187,800 - $208,600

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Senior Manager / Associate Director, Regulatory Affairs (Strategy, Hematology Oncology) 

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Job Summary:

In this role, you will be a core member of the Regulatory team and will be responsible for helping build and execute on global regulatory strategy, objectives, policies and programs pertaining to development and future marketing of products.

Responsibilities:

• Provides regulatory strategic direction and support for assigned global development programs/development program activities
• Assists Sr. Regulatory Affairs staff with their development program activities and deliverables
• Designs and implements regulatory strategies with Regulatory Affairs staff to obtain and maintain product investigative and marketing applications for assigned programs, as well as their life cycle management
• Acts as regulatory representative on early and/or late phase clinical studies, ensuring compliant execution of trials
• Strong competency in understanding regulatory requirements and emerging regulatory landscapes associated with US and global regulatory authorities
• Experienced in responding to inquiries from global regulatory authorities as well as the preparation and conduct of meetings with global regulatory authorities
• Assist in the preparation and maintenance of Annual Reports, Development Safety Update Reports (DSURs), Investigator’s Brochures and other documents required for INDs, CTAs, NDAs and other related regulatory development and marketing applications
• Assist in the cataloging and maintenance of regulatory application submissions
• Conduct research and stay up-to-date on regulatory requirements and changes
• Collaborate with cross-functional teams to ensure product compliance throughout the development lifecycle
• Monitor and assess regulatory risks and develop mitigation strategies
• Oversee quality assurance processes to ensure compliance with regulatory standards
• Review SOPs pertaining to Regulatory
• Works strategically with all regulatory functions to develop detailed, actionable submission plans, tracks major submission deliverables, and ensures consistent management submission documents, health authority communications, and all other regulatory information supporting Nurix’s investigational and marketing applications
• Plays an essential part in defining requirements for, implementing, and supporting future systems and tools to be employed by Nurix in the areas of document management, submission content planning, and regulatory information management
• Tracks the status of major deliverables for regulatory submissions (e.g., study reports, summary documents, labeling) along with their dependencies
• Develops and maintains submission plan templates to ensure Nurix regulatory submissions are consistently planned and executed across programs
• Participates in cross-functional process initiatives impacting regulatory submission processes and systems
• Manages consultants and contractors as needed

Experience and Skills:

• Bachelor's degree in life-sciences or related scientific discipline; advanced degree preferred Manager:
• Must have minimum of 8 years in Regulatory affairs strategy
• Strong demonstration of knowledge of drug development, FDA, EMA and ICH guidelines and regulations
• Experience providing hands-on support for planning clinical trial and marketing applications to health authorities including but not limited to FDA, EMA
• Ability to read, analyze and interpret scientific and technical information, as well as regulatory
• Ability to understand and explain detailed regulatory affairs and compliance programs and/or to effectively present information to senior regulatory management, other departments or external
• Ability to comply with changing regulatory
• Proven track record of supporting Regulatory affairs in the planning and execution of major filings and ongoing maintenance of clinical trial and marketing applications
• Strong project management and critical thinking skills
• Experience applying project management techniques and tools (e.g., MS Project, Smartsheet, Excel trackers) to the planning and execution of regulatory submissions
• Excellent organizational and communication skills, both written and verbal
• Ability to work independently as well as part of a team environment
• Positive attitude, energetic and proactive
• Proven ability to manage multiple projects, identify and resolve regulatory issues
• Strong interpersonal skills and the ability to effectively work with others

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:   SM $187,800 - $208,638   AD $199,500 - $231,200

Location:          Brisbane, CA - Onsite 

Senior Manager, electronic Quality Management System (eQMS)

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Job Summary:

We are seeking a Senior Manager, electronic Quality Management System (eQMS) to provide quality expertise supporting the development and commercialization of Nurix’s products in compliance with relevant US, EU, and ICH requirements. In this role, you will be responsible for actively managing, developing, implementing, and reporting on Quality Systems, including Deviations, Investigations, CAPAs, Change Controls, Complaints, Quality Metrics, and electronic Quality Management Systems (eQMS).  You will serve as a subject matter expert (SME) and strategic partner across Technical Operations, Clinical, Regulatory Affairs, and other cross-functional teams, with overall responsibility for the execution, scalability, and continuous improvement of Nurix’s Quality Management System as the organization grows and matures.

Job Responsibilities:

• Manage and maintain processes, SOPs, and workflows for Deviations, Investigations, CAPA, Change Control, Complaints, Quality Metrics, and other core QMS programs.
• Led end-to-end implementation and deployment of Veeva Vault eQMS replacing legacy systems and aligning core quality processes (CAPA, Change Control, Deviations, and Audits) across enterprise sites.
• Lead or support the implementation, configuration, validation, and optimization of the electronic Quality Management System (eQMS), ensuring phase-appropriate design and scalability.
• Provide hands-on expertise in the day-to-day execution, review, and management of QMS records within the eQMS.
• Partner with internal stakeholders to define data governance, system configuration, user roles, and reporting requirements for quality systems.
• Ensure data integrity, traceability, and compliance of quality system data in accordance with regulatory expectations (e.g., ALCOA+ principles).
• Monitor overall quality system effectiveness, identify gaps or inefficiencies, and drive continuous improvement initiatives.
• Recommend updates to quality policies and procedures and implement process improvements aligned with organizational growth and regulatory readiness.
• Develop, compile, analyze, and present quality metrics and KPIs for routine management review.
• Perform trending and data analysis to identify risks, systemic issues, and opportunities for improvement.
• Create and deliver training programs related to QMS processes, data integrity, and eQMS functionality.
• Support inspection readiness and ensure adherence to cGMPs, regulatory mandates, and internal quality standards.
• Build and maintain strong cross-functional relationships and foster a culture of engagement, transparency, and quality ownership.
• Perform other duties as assigned.

Experience and Skills:

• Bachelor’s degree in Computer Science, Life Sciences, or a related field, or equivalent relevant experience.
• Demonstrated experience implementing, administering, and improving an eQMS, including system configuration, validation support, and lifecycle management.
• Minimum of 6 years of experience in the pharmaceutical or biotechnology industry, including 4+ years in Quality Systems / Quality Assurance.
• Strong working knowledge of quality system data management, reporting, and data integrity principles.
• First-hand experience managing and reviewing deviations, investigations, CAPAs, and change controls in a regulated environment.
• Experience using validated computerized systems to manage regulated quality records.
• Proven ability to develop and implement enhancements to electronic Quality Systems to improve usability, compliance, and reporting.
• Strong proficiency with Microsoft Office Suite and related business applications.
• Ability to manage multiple priorities in a fast-paced, evolving environment with strong attention to detail.
• Highly organized, self-motivated, and capable of working independently while effectively collaborating cross-functionally.
• Excellent written and verbal communication skills, with the ability to influence and interact effectively at all levels of the organization.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:   $158,700 - $172,100

Location:          Brisbane, CA - Onsite 

Senior/Principal Scientist, Medicinal Chemistry  

About the Position 

We are seeking a talented and highly motivated individual with a strong background in synthetic organic chemistry to join our medicinal chemistry group in the pursuit of degrader-based small molecules to treat patients with unmet medical needs. This individual will design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics and in vivo efficacy, and will engage in rational structure-based drug discovery enabled by our computational and structural biology groups. As a member of a dynamic multi-disciplinary team, this person will collaborate with a broad group of scientists within Nurix and with external collaborators. Additionally, they will contribute to patent, report and scientific publication writing. Furthermore, they will initiate and/or lead process improvements within the chemistry department or cross-functionally. 

 Qualifications 

• Ph.D. in synthetic organic chemistry with 8 – 10+ years pharmaceutical medicinal chemistry industrial experience. 
• Track record of delivering advanced leads/ development candidates. 
• Excellent knowledge of medicinal chemistry principles with a solid understanding of the biology and pharmacology of programs, ADME concepts, and series SAR. Able to effectively integrate this knowledge to direct drug discovery programs to phase transitions or series go/no go decisions. 
• Strong working knowledge of protein-ligand interactions, conformational and structural analysis. Experienced in partnering closely with computational chemists in the use of computational tools, models and visualization applications.  
• Expert in organic synthesis, knowledgeable of the current literature, with strong synthetic problem-solving skills. 
• Proven leadership capability in a cross-functional team setting, either as project team leader or co-lead. 
• Ability to make inventive contributions towards new chemical target structures or templates for programs and evaluate early screening or literature hits.  
• Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings and using this information to guide program strategy. 
• Excellent communication skills and the ability to present rationale, key data, issues and accomplishments to the company. 
• Experience supervising direct reports to a high level of productivity and mentoring for career development is a plus.  
• Ability to manage priorities and advance multiple projects simultaneously. 
• Strong evidence of conceptual thinking and active follow through, recognized by establishing new projects or new directions within projects, new strategies and/or enabling technologies for drug discovery.  

Fit with Nurix Culture and Values 

• Strong team orientation; highly collaborative 
• Ability to function in a dynamic environment 
• Solutions and results-oriented focus 
• Hands-on approach; resourceful and open to diverse points of view 

Salary Range:  $165,700 - $176,900 (Senior Scientist), $187,300 - $204,800 (Principal Scientist)

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Senior Research Associate, Preclinical Pharmacology

Run in vivo studies that move Nurix's degrader programs toward the clinic. You'll execute mouse efficacy, PK/PD, and mechanism-of-action studies in oncology and inflammation models and generate the Western blot and flow cytometry data that show how our molecules work.

Position Description

 The Opportunity

• Join the Research – Preclinical Pharmacology team as a full-time, onsite, hands-on member, reporting to a Scientist / Principal Scientist, Preclinical Pharmacology
• Perform mouse handling and in-life procedures, including dosing by oral (PO), intraperitoneal (IP), subcutaneous (SC), and intravenous (IV) routes, tumor cell implantation, tumor and body-weight measurements, and in-life and terminal blood collection
• Execute PK/PD, tolerability, and efficacy studies in oncology xenograft/syngeneic models and in murine models of inflammation, under the direction of study leads
• Prepare and formulate test articles and vehicles for dosing; monitor animal health, document observations, and escalate adverse events promptly
• Perform necropsy and collect, process, and bank tissues and blood for downstream biomarker and pharmacodynamic analyses
• Prepare tissue and cell lysates and perform Western blotting (including quantitative and automated capillary formats) to measure target degradation and pathway modulation
• Develop, run, and analyze multi-color flow cytometry panels for immune and tumor-cell phenotyping from blood, spleen, tumor, and other tissues
• Maintain and expand cell lines using sterile cell culture technique; support cell-based assays and the generation of cells for in vivo implantation
• Record experiments accurately and in a timely manner in the electronic lab notebook; analyze, graph, and summarize data and present results at team meetings
• Collaborate with Biology, Chemistry, DMPK, and Translational teams to design studies and troubleshoot models and assays
• Adhere to IACUC protocols, animal welfare regulations, and laboratory safety requirements, and maintain required training and certifications
• Contribute to the optimization and qualification of new models and assays and to the training of junior team members
• Maintain laboratory equipment and supplies and support vivarium coordination, including occasional weekend or off-shift study coverage; other essential duties as assigned; minimal travel (<5%)

What You’ll Bring

• BS/MS in Biology, Pharmacology, Immunology, Cancer Biology, or a related field, with a BS or equivalent plus 8 or more years of relevant experience, or an MS plus 4 or more years of relevant experience
• Industry (biotech or pharma) experience conducting in vivo pharmacology studies in mice
• Proficiency in mouse handling and dosing by PO, IP, SC, and IV routes, as well as blood collection and tissue harvest
• Hands-on experience with oncology models (e.g., xenograft, syngeneic) and with murine models of inflammation or immunology
• Demonstrated proficiency in Western blotting and flow cytometry, including sample preparation, staining, and data analysis
• Proficiency in sterile mammalian cell culture technique
• Working knowledge of IACUC regulations and humane animal care practices
• Strong organizational and documentation skills, with attention to detail and the ability to manage multiple studies simultaneously
• Collaborative, adaptable, and comfortable in a fast-paced, team-oriented research environment
• Ability to work in an animal facility and tolerate exposure to laboratory animals, and to work occasional weekends or off-shift hours as studies require
• Bonus: experience with targeted protein degradation (molecular glues, PROTACs) or other small-molecule oncology or immunology programs
• Bonus: experience with multi-spectral flow cytometry, automated Western (e.g., Jess/Wes), ELISA, or MSD cytokine/biomarker assays
• Bonus: experience with orthotopic, disseminated, PDX, or humanized mouse models, or with in vivo imaging
• Bonus: experience with inflammation models such as collagen-induced arthritis, colitis, or cytokine-challenge models
• Bonus: familiarity with PK/PD relationships, compound formulation, and dose-response study design
• Bonus: proficiency with GraphPad Prism and electronic lab notebook systems

Salary Range:  $131,400 - $139,900

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position

Nurix Therapeutics seeks an experienced Senior Scientist to join the Analytical Development and Quality Control group. The Senior Scientist will lead analytical and QC activities in IND-enabling and early phase clinical studies. The Senior Scientist will develop analytical test methods, characterize drug substance and drug product attributes, identify and characterize technical risk, and collaborate in risk mitigation work. The Senior Scientist will oversee and execute analytical development, validation, and testing both internally and at external CDMO/CRO partners and author relevant sections of regulatory filings.

The ideal candidate must have expertise in chromatographic method development, stability studies, and phase-appropriate validation and control. The ideal candidate should have a record of contribution to first-in-human INDs and experience in vendor oversight..

This position is onsite at Nurix headquarters in Brisbane, CA.

Responsibilities:

• Characterization of drug substance and drug product attributes, identification of technical risks, and collaboration towards risk mitigation strategy
• Method development for and analytical characterization of drug substances, drug products, and product stability
• Management and/or execution of method development internally and at CDMOs/CTLs
• Management of method validation, QC testing, and reference standards at CDMOs/CTLs
• Management of forced degradation, long term stability, and predictive stability studies
• Contribution to OOS/OOE/OOT investigations
• Critical review of data, protocols, reports, specifications, and other documentation
• Trending stability data and establishing retest periods/shelf life using statistical methods
• Collaboration in the development of material control strategies and specifications
• Follow cGMP requirements and internal SOPs

Qualifications:

• Advanced degree in a relevant discipline (Chemistry, Pharmaceutics, or related field)
• Senior Scientist: BS/MS degree with 14+ years or PhD with 8+ years of industrial CMC experience
• Expertise in HPLC method development is essential
• Additional experience in techniques such as gas chromatography, NMR, mass spectrometry, particle size analysis, solid state characterization, dissolution, ICP-MS/OES, and/or FTIR
• Experience in analytical method development and validation
• Experience in management of analytical activities at CDMOs/CROs
• Solid understanding of control strategy, method validation, and retest/expiry
• Experience managing stability programs, reference standards, and retest/expiry
• Familiarity with ICH guidelines, cGMPs, and pharmacopeial chapters
• Familiarity with deviation management and change control
• Ability to critically interpret data and articulate technical concepts in multidisciplinary settings
• Ability to ensure assigned activities are completed in satisfaction of project timelines
• Strong interpersonal skills that foster collaboration within and outside of the organization
• Ability to travel domestically and internationally

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range:  $162K – $186K 

Senior Scientist, Chemical Development

Help move Nurix’s portfolio from the bench to the clinic. As a Senior Scientist in Chemical Development, you’ll scout routes, build scalable processes, and work with CROs/CDMOs to supply drug substance for early clinical trials, spending up to half your time hands-on in the lab. It’s a role with broad responsibilities and real opportunity in a small, entrepreneurial environment.

Position Description

The Opportunity

• Own chemical development activities across the portfolio, including process development and manufacture of regulatory starting materials (RSMs) and supporting production of Drug Substance (DS) for clinical trial materials, with a focus on the early development space
• Route scouting of pre-clinical and clinical candidates
• Support the pre-clinical research team by developing robust and scalable processes to support initial scale-up for animal studies
• Work up to 50% of the time in the lab to support early route scouting and discovery scale-up efforts toward CMC transition
• Author tech transfer documents and work with CROs/CDMOs to effectively and efficiently reproduce chemistry at various sites
• Support RSM and DS manufacturing activities at CRO/CDMO sites, including scale-up of candidate compounds to support candidate selection during drug discovery
• Support phase-appropriate process characterization, identify critical quality attributes, and implement controls, including selection and justification of RSMs, to ensure that all CROs and CMOs are using systems and processes in compliance with all relevant regulatory standards and to ensure consistency of DS quality
• Prepare and/or review CMC sections of INDs, CTAs, NDAs, MAAs and other regulatory submissions
• Travel up to 10%

What You’ll Bring

• A highly motivated chemist with experience and interest in working in a small, entrepreneurial environment with broad responsibilities and opportunities
• PhD with 2-7 years of experience or MS with 5+ years of experience; advanced degree in Organic Chemistry, Chemical Engineering, Pharmaceutical Chemistry, Pharmaceutics, Pharmaceutical Science, or related scientific discipline
• 2-5 years relevant experience in a pharmaceutical or biotechnology CMC/cGMP environment preferred
• Experience leveraging US and International CRO/CMOs for the manufacture of RSMs and DS to meet aggressive timelines
• Strong working knowledge of synthetic organic chemistry and the ability to leverage it toward route development and rapid synthetic triage
• Experience with payload linker development for ADC is a plus
• Experience analyzing experimental and analytical data
• Able to identify and resolve critical issues
• Experience implementing technical, strategic, and operational plans
• Excellent written and verbal communication skills, exceptional interpersonal and management skills to collaborate with and direct the work of others on assigned projects (including both internal teams and external collaborators)
• Strongly team oriented

Location:        Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Senior Scientist, Medicinal Chemistry

 Drive medicinal chemistry strategy for Nurix's discovery programs, from hit optimization through development candidate nomination. You'll design novel compounds, interpret complex SAR across multidisciplinary datasets, and help set new scientific directions, with opportunities to lead chemistry workstreams and mentor colleagues.

Position Description

The Opportunity

• Design novel chemical entities and medicinal chemistry strategies, applying structure-based drug design to optimize potency, selectivity, physicochemical properties, ADME/PK, safety, and in vivo efficacy
• Design synthetic strategies for complex molecules using modern and creative synthetic methods
• Develop and interpret SAR by integrating chemical, structural, computational, biochemical, cellular, pharmacological, and ADME/PK data; independently identify key questions, design experiments, and recommend compound or series advancement, redesign, or termination
• Partner closely with computational chemists, structural biologists, and colleagues across biology, pharmacology, and DMPK to advance project objectives
• Develop innovative concepts that establish new directions and address complex challenges, drawing on emerging literature, patents, and competitive intelligence to inform compound design and strategy
• Lead chemistry workstreams within multidisciplinary teams, independently manage priorities and external collaborations, and contribute to project strategy and key scientific decisions
• Provide scientific guidance, coaching, and mentorship to other scientists
• Communicate scientific rationale, data, and recommendations clearly to project teams, leadership, and broader scientific audiences
• Contribute to intellectual property generation, patent preparation, and scientific publications; represent assigned projects at external forums; and lead improvements in laboratory practices and workflows

What You’ll Bring

• BS or MS with 14+ years of relevant experience, or PhD with 8+ years of relevant experience
• Strong expertise in medicinal chemistry and synthetic organic chemistry, with demonstrated ability to apply synthetic strategies to complex discovery challenges, including compound design, SAR development, multiparameter optimization, and structure-based drug design in close collaboration with computational chemistry and structural biology
• Ability to integrate potency, selectivity, structural, physicochemical, ADME/PK, and pharmacology data, with a solid understanding of biology and pharmacology, to guide compound design and project strategy
• Scientific creativity and a track record of innovation, including advancement of chemical series, advanced leads, or development candidates
• Strong problem-solving and project management skills: identifying critical questions, forming hypotheses, designing experiments, and translating results into actionable strategies across projects of significant scope and complexity
• Ability to establish new chemical, scientific, or strategic directions from experimental data, structural insights, literature, patents, and emerging science, and to influence decisions within multidisciplinary teams
• Experience providing scientific guidance, coaching, or mentorship, with strong skills in applying literature, patent, and competitive intelligence to program strategy
• Excellent written and verbal communication skills for multidisciplinary teams, senior leadership, and external audiences

Salary Range:  $147,500 - $157,500

The posted range applies to roles based in The Woodlands, TX area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location:          Onsite – The Woodlands, TX

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Senior Scientist / Principal Scientist, Induced Proximity

Help shape Nurix’s induced proximity strategy beyond targeted protein degradation. In this hands-on role, you’ll design and run the assays that validate targets, characterize mechanisms and inform go/no-go decisions, working alongside chemistry, biology and biochemistry partners. It’s a chance to grow your scientific, and potentially leadership, experience in a fast-evolving area of drug discovery with direct exposure to platform-level strategy.

Position Description

The Opportunity

• Nurix Therapeutics, Inc. is seeking a motivated scientist to support and help execute the non-degradative induced proximity research strategy. This individual will contribute hands-on scientific expertise to programs beyond targeted protein degradation, helping advance target validation, mechanism characterization, and candidate optimization efforts. Working closely with the Senior Vice President of Induced Proximity and cross-functional partners in chemistry, biology, and biochemistry, this person will help translate strategic priorities into experimental plans, generate and interpret data that inform go/no-go decisions, and contribute ideas on emerging modalities and technologies worth exploring. This is an opportunity to grow scientific and possibly future leadership experience within a fast-evolving area of drug discovery, with direct exposure to strategic decision-making at the platform level.
• Design, execute, and troubleshoot experiments at the bench; building and running biochemical, biophysical, and cell-based assays to interrogate induced proximity mechanisms and drive program decisions
• Contribute to identification, validation, and prioritization of targets amenable to induced proximity approaches (protein sequestration, gene regulation, stabilizers, and related mechanisms)
• Evaluate and integrate new and emerging induced proximity modalities into the strategic roadmap
• Partner with computational/structural biology to advance rational design and predictive modeling of ternary complex formation
• Present experimental data, interpretations, and recommendations to project teams and executive leadership
• Ensure programs meet key milestones from discovery through candidate nomination and IND-enabling work
• Stay current on the competitive and scientific landscape; publish/present externally to build company visibility as needed

What You’ll Bring

Required Qualifications

• Ph.D. in biology, biochemistry, molecular biology, or a related field
• 5+ years of relevant industry drug discovery experience, including significant direct work on induced proximity modalities (targeted protein degradation, molecular glues, bifunctional degraders, or similar)
• Hands-on biophysical and biochemical assay development to quantify ternary complex formation and cooperativity (e.g. TR-FRET/HTRF, NanoBRET, AlphaLISA, SPR, ITC, MST, and DSF)
• Experience in biochemical assay development of the relevant proximity-induced reaction (e.g. ubiquitination, phosphorylation, acetylation, etc.)
• Cell-based mechanistic pharmacology: Western blot, HiBiT/NanoLuc kinetic readouts, flow cytometry, reporter assays, and dose–response and washout/resynthesis studies to establish on-target mechanism
• Cell line engineering and functional genomics utilizing CRISPR knockout/knock-in, CRISPRa/CRISPRi, and siRNA to validate targets and interrogate effector dependencies
• Target engagement and protein-stability methods: CETSA, NanoBRET target engagement, co-IP/pulldown, and cycloheximide-chase or half-life measurement
• Deep mechanistic understanding of ternary complex biology and cooperativity, the ubiquitin–proteasome and autophagy–lysosomal pathways, non-degradative proximity mechanisms (protein sequestration, stabilization, induced phosphorylation/dephosphorylation, transcriptional regulation), and structure-based drug design
• Rigorous experimental design and quantitative data analysis, including assay qualification and QC (e.g., Z′, dynamic range), curve fitting in GraphPad Prism or equivalent, screening-data handling (Genedata Screener or similar), and disciplined ELN documentation
• Strong track record of cross-functional collaboration (biology, chemistry, DMPK)
• Excellent scientific communication skills, including experience presenting to senior leadership

Preferred Qualifications

• Ph. D. in a relevant scientific field (Biochemistry, Biology, chemical biology, etc.) with 4 or more years of relevant post-graduate industry or academic research experience, or MS with 8 or more years of relevant industry experience.
• Publication record and/or patents in induced proximity or targeted degradation space
• Experience with computational tools for ternary complex prediction or AI/ML-driven drug design
• Familiarity with a broad range of non-degradative modalities beyond classical bifunctional degraders (e.g., glues, LYTACs, AUTACs, MrTACs, RIPTACs, TCIPs, Tracers, DACs)

Salary Range:  $162,000 - $175,700 (Senior Scientist), $187,700 - $208,600

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Location: Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Ability to work collaboratively across multiple groups within the organization
• Excellent organization and communication with effective presentation skills
• Self-driven and enthusiastic with proficiencies to deliver in a dynamic environment
• Curious mindset with a willingness and flexibility to learn new skills
• High level of creativity and productivity with strong problem-solving skills

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

 Talent Acquisition Analyst - Contract

Recruiting data tells a story — you’re the one who makes leadership actually see it. You’ll move fluidly between building dashboards, crafting the decks that shape hiring strategy, and jumping in on scheduling when the team needs an extra hand, with a front-row seat to how a growing biotech scales its talent function.

Position Description

This role sits at the intersection of recruiting operations, analytics, and executive reporting — turning recruiting data into clear insights for leadership and building the tools that inform hiring strategy. It’s a great fit for someone who enjoys variety and is comfortable moving between data analysis, presentation-building, and hands-on coordination.

The Opportunity

Analytics & Reporting

• Build, maintain, and distribute recruiting dashboards and reports, including pipeline metrics, time-to-fill, source effectiveness, and offer acceptance rates
• Monitor and audit data integrity across the Applicant Tracking System (Greenhouse) and related recruiting platforms, flagging discrepancies and recommending corrections
• Analyze recruiting funnel data to identify trends, bottlenecks, and opportunities for process improvement
• Partner with the Head of Talent Acquisition to prepare ad hoc analyses and data visualizations for leadership and Board-level reporting

Presentations & Executive Support

• Create polished PowerPoint decks and other materials to communicate hiring progress, headcount trends, and talent acquisition strategy to senior leadership
• Translate complex recruiting data into clear, compelling narratives for non-technical and executive audiences
• Support special projects and initiatives led by the Head of Talent Acquisition, including workforce planning and org design analyses

Recruiting Operations & Process

• Maintain and improve Talent Acquisition process documentation, SOPs, and quick-reference guides
• Support system enhancements and evaluate new tools to improve efficiency and data quality across the recruiting lifecycle
• Identify opportunities to leverage automation and AI tools to streamline recruiting workflows

Interview Scheduling Backup

• Provide backup support for phone, Zoom, and onsite interview scheduling during peak volume or Recruiting Coordinator absences
• Partner closely with the Recruiting Coordinator to ensure a seamless, consistent candidate experience across all scheduling touchpoints

What You’ll Bring

• Bachelor’s degree in Business, Data Analytics, Information Systems, or a related field or equivalent expereince
• 2-4 years of experience in talent acquisition, recruiting operations, HR analytics, or a related function; biotech/pharma or life sciences experience preferred
• Strong Excel/Google Sheets skills and experience building polished PowerPoint presentations for leadership audiences
• Hands-on experience with an ATS (Greenhouse strongly preferred) and comfort pulling, cleaning, and interpreting recruiting data
• Excellent attention to detail and data accuracy, with the ability to spot and resolve inconsistencies
• Strong organizational and time management skills, with the ability to juggle multiple concurrent priorities
• Clear, confident communication skills, with the ability to present data-driven insights to non-technical audiences
• A flexible, team-oriented mindset and willingness to step into scheduling/coordination work as needed

Location:          Onsite – Brisbane, CA

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view