Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

The Position

The Associate Director of Clinical Biomarkers will play a pivotal role in advancing biomarker strategies to support the clinical development of Nurix’s innovative therapies targeting protein homeostasis. As a leader in the Clinical Biomarkers team, the successful candidate will collaborate across research, clinical development, and external partnerships to drive the biomarker strategy for early phase clinical trials. This role involves leading the design, execution, and interpretation of biomarker assays. These efforts will contribute to patient selection, pharmacodynamic assessments, and the elucidation of drug mechanisms of action.

Specific responsibilities include:

• Lead the development, validation, and execution of clinical biomarker strategies to inform patient stratification, response prediction, and resistance mechanisms across Nurix’s clinical programs.
• Leverage deep expertise in cell and tumor biology, molecular biology, inflammation and immuno-oncology to design and interpret both preclinical and clinical biomarker studies.
• Oversee biomarker assay development, including assay qualification and execution on diverse platforms, to support pharmacodynamic and predictive biomarker analysis in clinical trials.
• Lead the evaluation and implementation of novel biomarker assays in both nonclinical models and patient-derived samples, ensuring alignment with clinical trial objectives.
• Collaborate closely with multidisciplinary teams, including research scientists, clinical development, external collaborators, and contract research organizations (CROs), to ensure seamless integration of biomarker data into clinical development plans.
• Provide scientific and strategic input into clinical trial designs, ensuring biomarker data are effectively utilized to guide therapeutic decisions and optimize patient outcomes.
• Mentor and manage junior scientists, fostering a collaborative and innovative research environment.
• Demonstrate strong motivation, creativity, and teamwork, with excellent time management and organizational skills.

Education and Skills Requirements:

• Advanced degree (M.S, Ph.D. preferred) with 8+ years of experience in a relevant scientific area within the pharmaceutical or biotech industry; candidates with a strong translational biomarker background in Immunology, Oncology, or Hematology are preferred.
• Proven expertise in the development, qualification, and implementation of clinical biomarker assays, particularly in the areas of inflammation, immuno-oncology, cancer biology, or related therapeutic areas.
• Extensive technical experience across diverse platforms, including flow cytometry, molecular biology, proteomics, and tissue-based assays; hands-on experience with clinical samples is a plus.
• Demonstrated leadership in cross-functional teams, with a track record of integrating biomarker data to influence clinical decision-making.
• Strong organizational and project management skills, with the ability to lead multiple projects simultaneously in a fast-paced environment.
• Excellent communication and interpersonal skills, with the ability to present complex biomarker data to both scientific and clinical audiences, as well as external stakeholders.
• Innovative mindset with a proactive approach to problem-solving and a strong motivation to drive scientific excellence in biomarker research.

Salary Range:  205K – 232K

Location:  Brisbane, CA - Onsite 

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/). 

Associate Director, Clinical Pharmacology 

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels. 

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation.

Position

The Associate Director in the Clinical Pharmacology group will contribute to pharmacometric efforts across early and late-stage programs. As an early member of the Clinical Pharmacology group, you will have an opportunity to influence the direction of the clinical pharmacology group at Nurix. The successful applicant shall be proficient in developing and executing PK/PD modeling and simulation activities, such as but not limited to population PK/PD modeling, physiologically-based PK (PBPK) modeling and quantitative systems pharmacology (QSP) modeling. This includes data analysis and interpretation and presentation of findings to optimize doses, dosage regimens and study designs. The candidate will also author and review clinical pharmacology documents for submission and/or response to regulatory agencies. The candidate will be influential across multiple functions including individual contributors, development program teams, and the executive team.

Responsibilities

• Utilize quantitative approaches to impact model-informed drug discovery and development in areas such as human dose projections, dose regimen identification and optimization
• Lead and conduct pharmacometric workstreams such as but not limited to noncompartmental analyses, exposure-response analyses, population PK/PD modeling, PBPK modeling and QSP modeling, and running model-based simulations
• Conduct exploratory modeling activities to support decision-making and clinical strategy
• Collaborate across functions within the company and oversee contract vendors to advance pharmacometric efforts and activities
• Oversee and contribute to clinical pharmacology sections of clinical study protocols, SAPs, CSRs, stand-alone PK/PD reports, Clinical development plans
• Author and review clinical pharmacology documents for submission and/or response to regulatory agencies
• Actively identify state-of-the-art quantitative approaches in the field for potential applications to projects, including the use of artificial intelligence/machine learning (AI/ML) techniques

Qualifications

• PharmD or PhD or MS in a field related to Pharmacometrics with 8+ years of industry or similar experience in Pharmacometrics, Clinical Pharmacology or Quantitative Systems Pharmacology
• Extensive hands-on experience in using modeling and simulation techniques in pharmaceutical development, such as population PK/PD modeling, PBPK modeling or QSP modeling  
• Exceptional oral and written communication skills and excellent problem-solving skills
• Previous experience in authoring and reviewing clinical pharmacology documents for submission and/or response to regulatory agencies
• Demonstrated past performance of functioning efficiently in a dynamic, cooperative, team-oriented environment showcasing emotional intelligence (respect and empathy)
• High proficiency in using common software and data analysis packages (e.g., R, WinNonlin, Simcyp, GastroPlus, Monolix, NONMEM)
• Nurix is headquartered in Brisbane, California. This is an onsite position.

Salary Range:  208K– 240K plus bonus & equity.

Location:  Brisbane, CA – Onsite

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).