Targeted Protein Modulation (TPM): Engaging ligases to treat disease
Nurix is leading the field in Targeted Protein Modulation
Nurix has built a drug discovery engine focused on the modulation of E3 ligases to modulate protein levels directly and specifically in cells. Targeted Protein Modulation comprises two key modalities: Targeted Protein Degradation, which aims to harness the function of E3 ligases and redirect their activity to degrade disease causing proteins, and Targeted Protein Elevation, which aims to increase the level of desirable proteins by directly inhibiting the specific E3 ligase that regulates its degradation. Nurix has leveraged these two powerful modalities to create a robust pipeline of proprietary and partnered drug development programs.
Nurix Drugs Engage Ligases for Targeted Protein Modulation
TPM = TPD + TPE